gistfile1.cs

using System.Linq;
using System.Reflection;
using System.Reflection.Emit;

namespace DP115Test
{
    using System;

    class Program
    {
        static void Main(string[] args)
        {
            var assembly = AppDomain.CurrentDomain.DefineDynamicAssembly( new AssemblyName( "Foo" ), AssemblyBuilderAccess.RunAndSave );
            var type = assembly
                .DefineDynamicModule( "FooModule", "FooModule.dll", true )
                .DefineType( "AClass", TypeAttributes.Public | TypeAttributes.AutoClass | TypeAttributes.AnsiClass | TypeAttributes.BeforeFieldInit, typeof( object ), new[] { typeof( IFoo ) } );
            var method = type.DefineMethod("IFoo.SomeMethod", MethodAttributes.Private | MethodAttributes.HideBySig | MethodAttributes.NewSlot | MethodAttributes.Virtual | MethodAttributes.Final, CallingConventions.HasThis);
            var typeParameters = method.DefineGenericParameters( new[] { "TBase", "TInherited" } );
            typeParameters[ 1 ].SetBaseTypeConstraint( typeParameters[ 0 ] );
            method.SetReturnType( typeof( void ) );
            method.GetILGenerator().Emit( OpCodes.Ret );
            type.DefineMethodOverride( method, typeof( IFoo ).GetMethods().Single() );
            var createdType = type.CreateType();
            assembly.Save( "FooModule.dll" );

            var instance = Activator.CreateInstance( createdType ) as IFoo;
            instance.SomeMethod<IComparable<string>, string>();
        }
    }

    public interface IFoo
    {
        void SomeMethod<TBase, TInherited>() where TInherited : TBase;
    }
}