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| @article{chennupati_intra-_2010, | |
| title = {Intra- and Intercompartmental Movement of {gamma}{delta} T Cells: Intestinal Intraepithelial and Peripheral {gamma}{delta} T Cells Represent Exclusive Nonoverlapping Populations with Distinct Migration Characteristics}, | |
| shorttitle = {Intra- and Intercompartmental Movement of {gamma}{delta} T Cells}, | |
| url = {http://www.jimmunol.org/cgi/content/abstract/jimmunol.1001652v1}, | |
| doi = {10.4049/jimmunol.1001652}, | |
| abstract = {Unlike the {\textasciitilde}1\% of {gamma}{delta} {TCR-positive} T cells being regularly present in blood and secondary lymphoid organs (peripheral {gamma}{delta} T cells), {\textasciitilde}50-60\% of small intestinal intraepithelial lymphocytes {(iIELs)} in the mouse express the {gamma}{delta} {TCR} ({gamma}{delta} {iIELs).} In this study, we investigated the overlap and exchange of {gamma}{delta} {iIELs} and {gamma}{delta} T cells found in peripheral secondary lymphoid organs. Using two-photon laser-scanning microscopy, we found {gamma}{delta} T cells within peripheral lymph nodes to be highly motile, whereas {gamma}{delta} {iIELs} were characterized by a locally confined scanning behavior. Our results implied a strict separation of peripheral {gamma}{delta} T cells and {gamma}{delta} {iIELs.} Nevertheless, {gamma}{delta} {iIELs} could be efficiently regenerated from bone marrow-derived precursors in irradiated or T cell-deficient adult mice. However, outside the intestinal epithelium, survival of {gamma}{delta} {iIELs} was very poor. In {CCR9-deficient} mice, homing of {gamma}{delta} {iIELs} was impaired, but did not lead to an accumulation of {gamma}{delta} {iIEL-like} cells in the periphery. Conversely, in situations in which specific {gamma}{delta} {iIEL} niches were empty, adoptive transfer of isolated {gamma}{delta} {iIELs} led to a sustained engraftment of transferred {gamma}{delta} {iIELs} in the intestinal epithelium for at least 100 d. Furthermore, we demonstrated by heterotopic intestinal transplantation experiments that an exchange of {gamma}{delta} {iIELs} only rarely happens in the steady state of adult mice. We therefore conclude that peripheral versus intestinal intraepithelial {gamma}{delta} T cells are exclusive, nonoverlapping populations that virtually do not exchange with each other.}, | |
| urldate = {2010-10-04}, | |
| journal = {J Immunol}, | |
| author = {Chennupati, Vijaykumar and Worbs, Tim and Liu, Xiaosun and Malinarich, Frano H. and Schmitz, Susanne and Haas, Jan D. and Malissen, Bernard and Forster, Reinhold and Prinz, Immo}, | |
| month = sep, | |
| year = {2010}, | |
| pages = {jimmunol.1001652}, | |
| file = {Chennupati et al. - 2010 - Intra- and Intercompartmental Movement of {gamma}{.pdf:/Users/hunt08/Documents/Notebook/zotero/storage/GCQ5HJ4S/Chennupati et al. - 2010 - Intra- and Intercompartmental Movement of {gamma}{.pdf:application/pdf;HighWire Full Text PDF:/Users/hunt08/Documents/Notebook/zotero/storage/QZ9NMEUV/Chennupati et al. - 2010 - Intra- and Intercompartmental Movement of {gamma}{.pdf:application/pdf} | |
| } |
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| <dcterms:abstract>Unlike the ~1% of {gamma}{delta} TCR-positive T cells being regularly present in blood and secondary lymphoid organs (peripheral {gamma}{delta} T cells), ~50-60% of small intestinal intraepithelial lymphocytes (iIELs) in the mouse express the {gamma}{delta} TCR ({gamma}{delta} iIELs). In this study, we investigated the overlap and exchange of {gamma}{delta} iIELs and {gamma}{delta} T cells found in peripheral secondary lymphoid organs. Using two-photon laser-scanning microscopy, we found {gamma}{delta} T cells within peripheral lymph nodes to be highly motile, whereas {gamma}{delta} iIELs were characterized by a locally confined scanning behavior. Our results implied a strict separation of peripheral {gamma}{delta} T cells and {gamma}{delta} iIELs. Nevertheless, {gamma}{delta} iIELs could be efficiently regenerated from bone marrow-derived precursors in irradiated or T cell-deficient adult mice. However, outside the intestinal epithelium, survival of {gamma}{delta} iIELs was very poor. In CCR9-deficient mice, homing of {gamma}{delta} iIELs was impaired, but did not lead to an accumulation of {gamma}{delta} iIEL-like cells in the periphery. Conversely, in situations in which specific {gamma}{delta} iIEL niches were empty, adoptive transfer of isolated {gamma}{delta} iIELs led to a sustained engraftment of transferred {gamma}{delta} iIELs in the intestinal epithelium for at least 100 d. Furthermore, we demonstrated by heterotopic intestinal transplantation experiments that an exchange of {gamma}{delta} iIELs only rarely happens in the steady state of adult mice. We therefore conclude that peripheral versus intestinal intraepithelial {gamma}{delta} T cells are exclusive, nonoverlapping populations that virtually do not exchange with each other.</dcterms:abstract> | |
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| <dc:date>September 24, 2010</dc:date> | |
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