The Computational Biology Group of ETH Zürich (CBG-ETHZ), member of the Swiss Institute of Bioinformatics (SIB), has developed the SIB Software Resource V-pipe: an Apache-licensed computational pipeline for the analysis of virus next-generation sequencing (NGS) data, specializing in samples of mixed viral populations.
This bioinformatics workflow has important applications in several different settings:
- In clinical virology, information about the detection and quantification of viral quasispecies in a single patient sample can assist clinicians in the optimization of the treatment for this patient.
- In clinical epidemiology, sequencing test samples during a viral outbreak provides information about the viral variants found in the population, which helps better understanding of the epidemic dynamics and gui