Here are the steps that worked for me to setup HeliosDisplayManagement for an NVidia Surround arrangement and a non-surround arrangement.
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Download installer from the releases page.
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Run Helios Display Management, and click "clone", then edit the cloned arrangement and change the name to what you want (can also be done through editing xml. Do this again for the other monitor arrangement (e.g., clone a surround arrangement, then turn off surround through NVidia control panel, then clone the non-surround arrangement).