First, if it's not already in your repository, get the Google Closure Template compiler at their documentation website:
Create a new Sublime Text 2 build system (Tools > Build System > New Build System...), pasting in the code above.
Set the 3rd "cmd" item in the sublime-build file to reflect the compiler location.
NOTE: With the current setup, it will build any .soy file into a .js file and place it in the parent folder. This is perfect for having a site structure like this:
Also, I recommend downloading SublimeOnSaveBuild (https://github.com/alexnj/SublimeOnSaveBuild) to automatically build your soy files on save. For this to work properly you will need to add ".soy" extensions to your package settings (https://github.com/alexnj/SublimeOnSaveBuild#configuring).
For syntax highlighting, add the package repository https://github.com/anvie/SoyTemplate and install SoyTemplate
For the required comment syntax snippets, install the DocBlockr package