When creating a PDF it depends on the application writing the PDF whether decomposed Unicode characters ("combining sequences") are correctly positioned.
The basic way (that most applications use) is to just treat the separate Unicode characters as if they were normal characters. This leads to incorrectly positioned combining marks as the glyph width of the combining mark is not suitable for all characters it can be combined with.
A better way would be to perform Unicode normalization (see http://unicode.org/reports/tr15/), more specifically Normalization Form C (NFC) which composes characters if possible (in contrast to NFD which decomposes them). However, this may lead to changes in the meaning of some characters (see the link and scroll down to figure 3).
The best way would be to use fonts that contain all needed information to correctly position combining characters. Many modern OpenType fonts include such information in internal structures (like the GPOS table). Note that the application writing the P