yes

Main.xaml

<Window x:Class="WpfApplication1.MainWindow"
        xmlns="http://schemas.microsoft.com/winfx/2006/xaml/presentation"
        xmlns:x="http://schemas.microsoft.com/winfx/2006/xaml"
        Title="MainWindow" Height="350" Width="525">
    <StackPanel Orientation="Vertical">
        <Label Content="{Binding TestString}" />
        <Button Content="Click Me" Click="Button_Click" />
    </StackPanel>
</Window>

Main.xaml.cs

using System;
using System.Collections.Generic;
using System.ComponentModel;
using System.Linq;
using System.Text;
using System.Threading;
using System.Threading.Tasks;
using System.Windows;
using System.Windows.Controls;
using System.Windows.Data;
using System.Windows.Documents;
using System.Windows.Input;
using System.Windows.Media;
using System.Windows.Media.Imaging;
using System.Windows.Navigation;
using System.Windows.Shapes;

namespace WpfApplication1
{
    /// <summary>
    /// Interaction logic for MainWindow.xaml
    /// </summary>
    public partial class MainWindow : Window, INotifyPropertyChanged
    {
        public MainWindow()
        {
            InitializeComponent();

            DataContext = this;
        }

        #region Property Changes

        public event PropertyChangedEventHandler PropertyChanged;

        private string _testString;

        public string TestString
        {
            get { return _testString; }
            set
            {
                _testString = value;
                OnPropertyChanged("TestString");
            }
        }

        public void OnPropertyChanged(string propertyName, object before = null, object after = null)
        {
            //Perform property validation
            var propertyChanged = PropertyChanged;
            if (propertyChanged != null)
            {
                propertyChanged(this, new PropertyChangedEventArgs(propertyName));
            }
        }

        #endregion

        public void ThreadTest()
        {
            TestString = DateTime.Now.ToString();
        }

        private void Button_Click(object sender, RoutedEventArgs e)
        {

            var MyThread = new Thread(new ThreadStart(ThreadTest));
            MyThread.Start();
        }
    }
}