Use a "random" name for the PDB instead of vc141.pdb
.
Visual Studio Option:
/Fd$(IntDir)$(TargetName)-$([System.DateTime]::Now.ToString("HH_mm_ss_fff")).pdb
Premake5 configuration (at top of premake5.lua):
local function programDataBaseFileName(prj)
premake.w('$(IntDir)$(TargetName)-$([System.DateTime]::Now.ToString("HH_mm_ss_fff")).pdb')