#Next-gen Javascript Applications...
I've been developing "full-stack" Javascript applications for a while now, primarily using AngularJS in the browser, coupled with Ionic Framework for mobile apps, powered by SailsJS running on Node.js. I'm a huge fan of Javascript - I've always found it "gets out of my way" more than any other language, allowing me to get ideas out of my head with a minimum of friction. Unchecked though, JS applications can become unwieldy because of that same flexibility.
I think the reason both Sails and Angular work so well for me is that they provide the right kind of structure - just enough reinforcement to keep me inline and structured, without forcing arbitrary rules on stuff.
The Angular team recently released their design documents for the 2.0 version. Any release is many months away, but as it's being designed in a very modular fashion, a number of the pieces are already available. I've been playing around with them for the past couple of weeks along with ES6