This virtualhosts snippet will make your nodejs app run on the traditional port 80, so mynodeapp.com:3000 will simply work on mynodeapp.com without adding :3000. it's that simple :) remember to enable apache modules proxy and proxy_http ($ sudo a2enmod proxy && sudo a2enmod proxy_http)

node_apache.apacheconf

<VirtualHost *:80>
     ServerAdmin isl@m.magdy
     ServerName js.io
     ServerAlias js.io

     ProxyRequests off

     <Proxy *>
          Order deny,allow
          Allow from all
     </Proxy>

     <Location />
           ProxyPass http://127.0.0.1:3000/
           ProxyPassReverse http://127.0.0.1:3000/
     </Location>
     DocumentRoot /var/www/
</VirtualHost>