For all practical purposes, you must multitarget. There is a huge chunk of the MSBuild ecosystem that's stuck on the .NET Framework build of MSBuild - everyone using tooling inside Visual Studio meets this criteria. If you don't support both Full and Core MSBuild distributions you're artificially cutting out your user base.
For 'normal' .NET SDK projects, multitargeting means setting multiple TargetFrameworks in your project file. When you do this, builds will be triggered for both TFM, and the overall results can be packaged as a single artifact.