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clusterrgrammer_colab-observable-ccle-ipynb.ipynb
{
"nbformat": 4,
"nbformat_minor": 0,
"metadata": {
"colab": {
"name": "Clusterrgrammer_Colab-Observable-CCLE.ipynb.ipynb",
"provenance": [],
"collapsed_sections": [],
"authorship_tag": "ABX9TyOb678IaKTfDRvL3sK42zkh",
"include_colab_link": true
},
"kernelspec": {
"name": "python3",
"display_name": "Python 3"
},
"language_info": {
"name": "python"
}
},
"cells": [
{
"cell_type": "markdown",
"metadata": {
"id": "view-in-github",
"colab_type": "text"
},
"source": [
"<a href=\"https://colab.research.google.com/gist/cornhundred/3e1e5ab4e67e60571f72dbd4cf52abae/clusterrgrammer_colab-observable-ccle-ipynb.ipynb\" target=\"_parent\"><img src=\"https://colab.research.google.com/assets/colab-badge.svg\" alt=\"Open In Colab\"/></a>"
]
},
{
"cell_type": "markdown",
"metadata": {
"id": "c7p-ouAKugrw"
},
"source": [
"# Clustergrammer on Colab via Observable: CCLE\n"
]
},
{
"cell_type": "code",
"metadata": {
"id": "UxQGPZcPuco7",
"colab": {
"base_uri": "https://localhost:8080/"
},
"outputId": "bf42f14f-f156-4bb9-a7df-c51b93d400f5"
},
"source": [
"!pip install observable_jupyter\n",
"!pip install -q clustergrammer2\n",
"from observable_jupyter import embed\n",
"\n",
"# Avoids scroll-in-the-scroll in the entire Notebook\n",
"from IPython.display import Javascript\n",
"def resize_colab_cell():\n",
" display(Javascript('google.colab.output.setIframeHeight(0, true, {maxHeight: 5000})'))\n",
"get_ipython().events.register('pre_run_cell', resize_colab_cell)\n",
"\n",
"import numpy as np\n",
"import pandas as pd\n",
"from clustergrammer2 import net"
],
"execution_count": 1,
"outputs": [
{
"output_type": "stream",
"text": [
"Collecting observable_jupyter\n",
" Downloading https://files.pythonhosted.org/packages/36/a2/dc2051704f4e8a4d5fd8365e32b270e125410da8181dcfeb5efb7111ca1e/observable_jupyter-0.1.8-py3-none-any.whl\n",
"Installing collected packages: observable-jupyter\n",
"Successfully installed observable-jupyter-0.1.8\n",
"\u001b[K |████████████████████████████████| 19.1MB 1.2MB/s \n",
"\u001b[?25h>> clustergrammer2 backend version 0.17.0\n"
],
"name": "stdout"
},
{
"output_type": "stream",
"text": [
"/usr/local/lib/python3.7/dist-packages/statsmodels/tools/_testing.py:19: FutureWarning: pandas.util.testing is deprecated. Use the functions in the public API at pandas.testing instead.\n",
" import pandas.util.testing as tm\n"
],
"name": "stderr"
}
]
},
{
"cell_type": "code",
"metadata": {
"colab": {
"base_uri": "https://localhost:8080/",
"height": 147
},
"id": "PzQ78xsSuupE",
"outputId": "a9187588-5392-4bf1-b00b-7c021147a98c"
},
"source": [
"!git clone https://github.com/ismms-himc/clustergrammer2-notebooks.git"
],
"execution_count": 2,
"outputs": [
{
"output_type": "display_data",
"data": {
"application/javascript": [
"google.colab.output.setIframeHeight(0, true, {maxHeight: 5000})"
],
"text/plain": [
"<IPython.core.display.Javascript object>"
]
},
"metadata": {
"tags": []
}
},
{
"output_type": "stream",
"text": [
"Cloning into 'clustergrammer2-notebooks'...\n",
"remote: Enumerating objects: 23, done.\u001b[K\n",
"remote: Counting objects: 100% (23/23), done.\u001b[K\n",
"remote: Compressing objects: 100% (16/16), done.\u001b[K\n",
"remote: Total 1226 (delta 9), reused 18 (delta 7), pack-reused 1203\u001b[K\n",
"Receiving objects: 100% (1226/1226), 474.17 MiB | 23.33 MiB/s, done.\n",
"Resolving deltas: 100% (798/798), done.\n",
"Checking out files: 100% (113/113), done.\n"
],
"name": "stdout"
}
]
},
{
"cell_type": "code",
"metadata": {
"colab": {
"base_uri": "https://localhost:8080/",
"height": 417
},
"id": "PoMWzGU_uxGI",
"outputId": "48ed037d-483d-4681-917d-2ab95913e5ba"
},
"source": [
"df = pd.read_csv('/content/clustergrammer2-notebooks/data/CCLE/CCLE_500x1037.csv', index_col=0)\n",
"df.head()"
],
"execution_count": 3,
"outputs": [
{
"output_type": "display_data",
"data": {
"application/javascript": [
"google.colab.output.setIframeHeight(0, true, {maxHeight: 5000})"
],
"text/plain": [
"<IPython.core.display.Javascript object>"
]
},
"metadata": {
"tags": []
}
},
{
"output_type": "execute_result",
"data": {
"text/html": [
"<div>\n",
"<style scoped>\n",
" .dataframe tbody tr th:only-of-type {\n",
" vertical-align: middle;\n",
" }\n",
"\n",
" .dataframe tbody tr th {\n",
" vertical-align: top;\n",
" }\n",
"\n",
" .dataframe thead th {\n",
" text-align: right;\n",
" }\n",
"</style>\n",
"<table border=\"1\" class=\"dataframe\">\n",
" <thead>\n",
" <tr style=\"text-align: right;\">\n",
" <th></th>\n",
" <th>('cell line: LN18', 'tissue: central_nervous_system', 'histology: glioma', 'sub-histology: astrocytoma_Grade_IV', 'gender: M')</th>\n",
" <th>('cell line: 769P', 'tissue: kidney', 'histology: carcinoma', 'sub-histology: clear_cell_renal_cell_carcinoma', 'gender: F')</th>\n",
" <th>('cell line: 786O', 'tissue: kidney', 'histology: carcinoma', 'sub-histology: clear_cell_renal_cell_carcinoma', 'gender: M')</th>\n",
" <th>('cell line: CAOV3', 'tissue: ovary', 'histology: carcinoma', 'sub-histology: adenocarcinoma', 'gender: F')</th>\n",
" <th>('cell line: HEPG2', 'tissue: liver', 'histology: carcinoma', 'sub-histology: hepatocellular_carcinoma', 'gender: M')</th>\n",
" <th>('cell line: MOLT4', 'tissue: haematopoietic_and_lymphoid_tissue', 'histology: lymphoid_neoplasm', 'sub-histology: acute_lymphoblastic_T_cell_leukaemia', 'gender: M')</th>\n",
" <th>('cell line: NCIH524', 'tissue: lung', 'histology: carcinoma', 'sub-histology: small_cell_carcinoma', 'gender: M')</th>\n",
" <th>('cell line: NCIH209', 'tissue: lung', 'histology: carcinoma', 'sub-histology: small_cell_carcinoma', 'gender: M')</th>\n",
" <th>('cell line: MIAPACA2', 'tissue: pancreas', 'histology: carcinoma', 'sub-histology: ductal_carcinoma', 'gender: M')</th>\n",
" <th>('cell line: MCAS', 'tissue: ovary', 'histology: carcinoma', 'sub-histology: adenocarcinoma', 'gender: F')</th>\n",
" <th>('cell line: SBC5', 'tissue: lung', 'histology: carcinoma', 'sub-histology: small_cell_carcinoma', 'gender: NA')</th>\n",
" <th>('cell line: COLO829', 'tissue: skin', 'histology: malignant_melanoma', 'sub-histology: NS', 'gender: M')</th>\n",
" <th>('cell line: VCAP', 'tissue: prostate', 'histology: carcinoma', 'sub-histology: adenocarcinoma', 'gender: M')</th>\n",
" <th>('cell line: COLO704', 'tissue: ovary', 'histology: carcinoma', 'sub-histology: NS', 'gender: F')</th>\n",
" <th>('cell line: IPC298', 'tissue: skin', 'histology: malignant_melanoma', 'sub-histology: NS', 'gender: F')</th>\n",
" <th>('cell line: CAPAN2', 'tissue: pancreas', 'histology: carcinoma', 'sub-histology: ductal_carcinoma', 'gender: M')</th>\n",
" <th>('cell line: EFM192A', 'tissue: breast', 'histology: carcinoma', 'sub-histology: NS', 'gender: F')</th>\n",
" <th>('cell line: HS766T', 'tissue: pancreas', 'histology: carcinoma', 'sub-histology: ductal_carcinoma', 'gender: M')</th>\n",
" <th>('cell line: EFO27', 'tissue: ovary', 'histology: carcinoma', 'sub-histology: mucinous_carcinoma', 'gender: F')</th>\n",
" <th>('cell line: A2780', 'tissue: ovary', 'histology: carcinoma', 'sub-histology: adenocarcinoma', 'gender: F')</th>\n",
" <th>('cell line: NCIH196', 'tissue: lung', 'histology: carcinoma', 'sub-histology: small_cell_carcinoma', 'gender: M')</th>\n",
" <th>('cell line: IGROV1', 'tissue: ovary', 'histology: carcinoma', 'sub-histology: adenocarcinoma', 'gender: F')</th>\n",
" <th>('cell line: NCIH889', 'tissue: lung', 'histology: carcinoma', 'sub-histology: small_cell_carcinoma', 'gender: F')</th>\n",
" <th>('cell line: NCIH211', 'tissue: lung', 'histology: carcinoma', 'sub-histology: small_cell_carcinoma', 'gender: F')</th>\n",
" <th>('cell line: HS571T', 'tissue: ovary', 'histology: carcinoma', 'sub-histology: NS', 'gender: F')</th>\n",
" <th>('cell line: MDAPCA2B', 'tissue: prostate', 'histology: carcinoma', 'sub-histology: adenocarcinoma', 'gender: M')</th>\n",
" <th>('cell line: SKMEL24', 'tissue: skin', 'histology: malignant_melanoma', 'sub-histology: NS', 'gender: M')</th>\n",
" <th>('cell line: K029AX', 'tissue: skin', 'histology: malignant_melanoma', 'sub-histology: NS', 'gender: NA')</th>\n",
" <th>('cell line: HT1376', 'tissue: urinary_tract', 'histology: carcinoma', 'sub-histology: transitional_cell_carcinoma', 'gender: F')</th>\n",
" <th>('cell line: NCIH2171', 'tissue: lung', 'histology: carcinoma', 'sub-histology: small_cell_carcinoma', 'gender: M')</th>\n",
" <th>('cell line: PANC1005', 'tissue: pancreas', 'histology: carcinoma', 'sub-histology: ductal_carcinoma', 'gender: M')</th>\n",
" <th>('cell line: EVSAT', 'tissue: breast', 'histology: carcinoma', 'sub-histology: NS', 'gender: F')</th>\n",
" <th>('cell line: HS695T', 'tissue: skin', 'histology: malignant_melanoma', 'sub-histology: NS', 'gender: M')</th>\n",
" <th>('cell line: CHL1', 'tissue: skin', 'histology: malignant_melanoma', 'sub-histology: NS', 'gender: NA')</th>\n",
" <th>('cell line: LOUNH91', 'tissue: lung', 'histology: carcinoma', 'sub-histology: squamous_cell_carcinoma', 'gender: F')</th>\n",
" <th>('cell line: LK2', 'tissue: lung', 'histology: carcinoma', 'sub-histology: squamous_cell_carcinoma', 'gender: M')</th>\n",
" <th>('cell line: TOV21G', 'tissue: ovary', 'histology: carcinoma', 'sub-histology: clear_cell_carcinoma', 'gender: F')</th>\n",
" <th>('cell line: SKMEL3', 'tissue: skin', 'histology: malignant_melanoma', 'sub-histology: NS', 'gender: F')</th>\n",
" <th>('cell line: ASPC1', 'tissue: pancreas', 'histology: carcinoma', 'sub-histology: ductal_carcinoma', 'gender: F')</th>\n",
" <th>('cell line: OVSAHO', 'tissue: ovary', 'histology: carcinoma', 'sub-histology: adenocarcinoma', 'gender: F')</th>\n",
" <th>...</th>\n",
" <th>('cell line: LN428', 'tissue: central_nervous_system', 'histology: glioma', 'sub-histology: astrocytoma_Grade_IV', 'gender: NA')</th>\n",
" <th>('cell line: SLR24', 'tissue: kidney', 'histology: carcinoma', 'sub-histology: renal_cell_carcinoma', 'gender: NA')</th>\n",
" <th>('cell line: EWS502', 'tissue: bone', 'histology: Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour', 'sub-histology: NS', 'gender: NA')</th>\n",
" <th>('cell line: SALE', 'tissue: lung', 'histology: other', 'sub-histology: immortalized_epithelial', 'gender: NA')</th>\n",
" <th>('cell line: HCC2814', 'tissue: lung', 'histology: carcinoma', 'sub-histology: squamous_cell_carcinoma', 'gender: NA')</th>\n",
" <th>('cell line: SKRC31', 'tissue: kidney', 'histology: carcinoma', 'sub-histology: renal_cell_carcinoma', 'gender: NA')</th>\n",
" <th>('cell line: TIG3TD', 'tissue: lung', 'histology: other', 'sub-histology: immortalized_embryonic_fibroblast', 'gender: NA')</th>\n",
" <th>('cell line: TC32', 'tissue: bone', 'histology: Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour', 'sub-histology: NS', 'gender: NA')</th>\n",
" <th>('cell line: SF172', 'tissue: central_nervous_system', 'histology: glioma', 'sub-histology: astrocytoma_Grade_IV', 'gender: NA')</th>\n",
" <th>('cell line: PRECLH', 'tissue: prostate', 'histology: other', 'sub-histology: immortalized_epithelial', 'gender: NA')</th>\n",
" <th>('cell line: U343', 'tissue: central_nervous_system', 'histology: glioma', 'sub-histology: astrocytoma_Grade_IV', 'gender: NA')</th>\n",
" <th>('cell line: RCC4', 'tissue: kidney', 'histology: carcinoma', 'sub-histology: clear_cell_renal_cell_carcinoma', 'gender: NA')</th>\n",
" <th>('cell line: LN215', 'tissue: central_nervous_system', 'histology: glioma', 'sub-histology: astrocytoma_Grade_IV', 'gender: NA')</th>\n",
" <th>('cell line: LN464', 'tissue: central_nervous_system', 'histology: glioma', 'sub-histology: astrocytoma_Grade_IV', 'gender: NA')</th>\n",
" <th>('cell line: SLR25', 'tissue: kidney', 'histology: carcinoma', 'sub-histology: renal_cell_carcinoma', 'gender: NA')</th>\n",
" <th>('cell line: U178', 'tissue: central_nervous_system', 'histology: glioma', 'sub-histology: astrocytoma_Grade_IV', 'gender: NA')</th>\n",
" <th>('cell line: F5', 'tissue: central_nervous_system', 'histology: meningioma', 'sub-histology: NS', 'gender: NA')</th>\n",
" <th>('cell line: HEKTE', 'tissue: kidney', 'histology: other', 'sub-histology: immortalized_epithelial', 'gender: NA')</th>\n",
" <th>('cell line: SLR26', 'tissue: kidney', 'histology: carcinoma', 'sub-histology: renal_cell_carcinoma', 'gender: NA')</th>\n",
" <th>('cell line: SKRC20', 'tissue: kidney', 'histology: carcinoma', 'sub-histology: renal_cell_carcinoma', 'gender: NA')</th>\n",
" <th>('cell line: SF767', 'tissue: central_nervous_system', 'histology: glioma', 'sub-histology: astrocytoma_Grade_III', 'gender: NA')</th>\n",
" <th>('cell line: A1207', 'tissue: central_nervous_system', 'histology: glioma', 'sub-histology: NS', 'gender: NA')</th>\n",
" <th>('cell line: LN319', 'tissue: central_nervous_system', 'histology: glioma', 'sub-histology: astrocytoma_Grade_III', 'gender: NA')</th>\n",
" <th>('cell line: HCC364', 'tissue: lung', 'histology: carcinoma', 'sub-histology: adenocarcinoma', 'gender: NA')</th>\n",
" <th>('cell line: UMRC6', 'tissue: kidney', 'histology: carcinoma', 'sub-histology: renal_cell_carcinoma', 'gender: NA')</th>\n",
" <th>('cell line: LN382', 'tissue: central_nervous_system', 'histology: glioma', 'sub-histology: astrocytoma_Grade_IV', 'gender: NA')</th>\n",
" <th>('cell line: IOMMLEE', 'tissue: central_nervous_system', 'histology: meningioma', 'sub-histology: NS', 'gender: NA')</th>\n",
" <th>('cell line: UMRC2', 'tissue: kidney', 'histology: carcinoma', 'sub-histology: clear_cell_renal_cell_carcinoma', 'gender: NA')</th>\n",
" <th>('cell line: DFCI024', 'tissue: lung', 'histology: carcinoma', 'sub-histology: adenocarcinoma', 'gender: NA')</th>\n",
" <th>('cell line: HCC1897', 'tissue: lung', 'histology: carcinoma', 'sub-histology: squamous_cell_carcinoma', 'gender: NA')</th>\n",
" <th>('cell line: SLR21', 'tissue: kidney', 'histology: carcinoma', 'sub-histology: renal_cell_carcinoma', 'gender: NA')</th>\n",
" <th>('cell line: LNZ308', 'tissue: central_nervous_system', 'histology: glioma', 'sub-histology: astrocytoma_Grade_IV', 'gender: NA')</th>\n",
" <th>('cell line: LN340', 'tissue: central_nervous_system', 'histology: glioma', 'sub-histology: astrocytoma_Grade_IV', 'gender: NA')</th>\n",
" <th>('cell line: HCC827GR5', 'tissue: lung', 'histology: carcinoma', 'sub-histology: adenocarcinoma', 'gender: NA')</th>\n",
" <th>('cell line: SLR20', 'tissue: kidney', 'histology: carcinoma', 'sub-histology: renal_cell_carcinoma', 'gender: NA')</th>\n",
" <th>('cell line: HK2', 'tissue: kidney', 'histology: other', 'sub-histology: immortalized_epithelial', 'gender: NA')</th>\n",
" <th>('cell line: EW8', 'tissue: bone', 'histology: Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour', 'sub-histology: NS', 'gender: NA')</th>\n",
" <th>('cell line: UOK101', 'tissue: kidney', 'histology: carcinoma', 'sub-histology: clear_cell_renal_cell_carcinoma', 'gender: NA')</th>\n",
" <th>('cell line: JHESOAD1', 'tissue: oesophagus', 'histology: carcinoma', 'sub-histology: barrett_associated_adenocarcinoma', 'gender: NA')</th>\n",
" <th>('cell line: CH157MN', 'tissue: central_nervous_system', 'histology: meningioma', 'sub-histology: NS', 'gender: NA')</th>\n",
" </tr>\n",
" </thead>\n",
" <tbody>\n",
" <tr>\n",
" <th>KRT19</th>\n",
" <td>5.81</td>\n",
" <td>4.37</td>\n",
" <td>11.64</td>\n",
" <td>12.83</td>\n",
" <td>11.90</td>\n",
" <td>4.07</td>\n",
" <td>4.17</td>\n",
" <td>11.47</td>\n",
" <td>12.52</td>\n",
" <td>14.23</td>\n",
" <td>4.40</td>\n",
" <td>4.07</td>\n",
" <td>9.74</td>\n",
" <td>3.88</td>\n",
" <td>3.81</td>\n",
" <td>14.18</td>\n",
" <td>14.26</td>\n",
" <td>13.84</td>\n",
" <td>14.25</td>\n",
" <td>4.36</td>\n",
" <td>4.17</td>\n",
" <td>13.14</td>\n",
" <td>7.11</td>\n",
" <td>10.19</td>\n",
" <td>7.42</td>\n",
" <td>13.23</td>\n",
" <td>3.51</td>\n",
" <td>3.77</td>\n",
" <td>12.98</td>\n",
" <td>9.43</td>\n",
" <td>14.34</td>\n",
" <td>12.99</td>\n",
" <td>3.80</td>\n",
" <td>4.19</td>\n",
" <td>13.41</td>\n",
" <td>12.06</td>\n",
" <td>6.57</td>\n",
" <td>3.79</td>\n",
" <td>14.23</td>\n",
" <td>5.59</td>\n",
" <td>...</td>\n",
" <td>4.19</td>\n",
" <td>11.48</td>\n",
" <td>4.27</td>\n",
" <td>13.10</td>\n",
" <td>10.91</td>\n",
" <td>13.16</td>\n",
" <td>5.06</td>\n",
" <td>4.29</td>\n",
" <td>13.52</td>\n",
" <td>10.77</td>\n",
" <td>4.97</td>\n",
" <td>11.51</td>\n",
" <td>3.70</td>\n",
" <td>4.71</td>\n",
" <td>5.48</td>\n",
" <td>3.76</td>\n",
" <td>12.03</td>\n",
" <td>12.50</td>\n",
" <td>12.80</td>\n",
" <td>4.40</td>\n",
" <td>14.34</td>\n",
" <td>4.32</td>\n",
" <td>4.14</td>\n",
" <td>13.69</td>\n",
" <td>5.09</td>\n",
" <td>3.81</td>\n",
" <td>3.79</td>\n",
" <td>3.82</td>\n",
" <td>13.01</td>\n",
" <td>12.04</td>\n",
" <td>13.55</td>\n",
" <td>4.26</td>\n",
" <td>5.50</td>\n",
" <td>14.41</td>\n",
" <td>4.04</td>\n",
" <td>12.59</td>\n",
" <td>4.40</td>\n",
" <td>4.06</td>\n",
" <td>14.41</td>\n",
" <td>5.71</td>\n",
" </tr>\n",
" <tr>\n",
" <th>EPCAM</th>\n",
" <td>4.09</td>\n",
" <td>3.91</td>\n",
" <td>6.71</td>\n",
" <td>12.67</td>\n",
" <td>11.70</td>\n",
" <td>4.30</td>\n",
" <td>10.43</td>\n",
" <td>12.62</td>\n",
" <td>4.03</td>\n",
" <td>12.70</td>\n",
" <td>6.27</td>\n",
" <td>4.46</td>\n",
" <td>12.81</td>\n",
" <td>3.93</td>\n",
" <td>4.37</td>\n",
" <td>12.91</td>\n",
" <td>12.17</td>\n",
" <td>6.87</td>\n",
" <td>11.37</td>\n",
" <td>4.39</td>\n",
" <td>3.69</td>\n",
" <td>11.62</td>\n",
" <td>12.44</td>\n",
" <td>13.16</td>\n",
" <td>4.91</td>\n",
" <td>11.19</td>\n",
" <td>3.68</td>\n",
" <td>4.16</td>\n",
" <td>9.00</td>\n",
" <td>12.00</td>\n",
" <td>12.97</td>\n",
" <td>11.89</td>\n",
" <td>4.02</td>\n",
" <td>4.14</td>\n",
" <td>5.96</td>\n",
" <td>12.87</td>\n",
" <td>7.86</td>\n",
" <td>4.16</td>\n",
" <td>13.14</td>\n",
" <td>11.65</td>\n",
" <td>...</td>\n",
" <td>4.43</td>\n",
" <td>10.62</td>\n",
" <td>4.28</td>\n",
" <td>12.59</td>\n",
" <td>12.62</td>\n",
" <td>8.80</td>\n",
" <td>4.28</td>\n",
" <td>3.75</td>\n",
" <td>12.82</td>\n",
" <td>12.16</td>\n",
" <td>4.31</td>\n",
" <td>10.98</td>\n",
" <td>4.24</td>\n",
" <td>3.69</td>\n",
" <td>11.48</td>\n",
" <td>3.95</td>\n",
" <td>4.92</td>\n",
" <td>9.10</td>\n",
" <td>9.45</td>\n",
" <td>10.98</td>\n",
" <td>11.95</td>\n",
" <td>4.33</td>\n",
" <td>3.98</td>\n",
" <td>10.32</td>\n",
" <td>4.10</td>\n",
" <td>3.92</td>\n",
" <td>4.18</td>\n",
" <td>3.76</td>\n",
" <td>8.21</td>\n",
" <td>13.42</td>\n",
" <td>11.80</td>\n",
" <td>3.96</td>\n",
" <td>3.78</td>\n",
" <td>13.35</td>\n",
" <td>6.56</td>\n",
" <td>11.41</td>\n",
" <td>4.11</td>\n",
" <td>7.73</td>\n",
" <td>13.48</td>\n",
" <td>4.19</td>\n",
" </tr>\n",
" <tr>\n",
" <th>TACSTD2</th>\n",
" <td>4.14</td>\n",
" <td>4.14</td>\n",
" <td>4.16</td>\n",
" <td>13.68</td>\n",
" <td>5.04</td>\n",
" <td>4.44</td>\n",
" <td>4.41</td>\n",
" <td>4.56</td>\n",
" <td>4.58</td>\n",
" <td>12.52</td>\n",
" <td>4.67</td>\n",
" <td>3.88</td>\n",
" <td>9.26</td>\n",
" <td>4.48</td>\n",
" <td>4.23</td>\n",
" <td>13.85</td>\n",
" <td>12.24</td>\n",
" <td>12.05</td>\n",
" <td>4.04</td>\n",
" <td>3.95</td>\n",
" <td>4.29</td>\n",
" <td>4.26</td>\n",
" <td>4.15</td>\n",
" <td>5.62</td>\n",
" <td>7.96</td>\n",
" <td>12.54</td>\n",
" <td>4.11</td>\n",
" <td>4.19</td>\n",
" <td>13.82</td>\n",
" <td>4.44</td>\n",
" <td>13.24</td>\n",
" <td>12.02</td>\n",
" <td>4.02</td>\n",
" <td>3.97</td>\n",
" <td>7.73</td>\n",
" <td>11.31</td>\n",
" <td>4.05</td>\n",
" <td>4.04</td>\n",
" <td>4.27</td>\n",
" <td>4.26</td>\n",
" <td>...</td>\n",
" <td>4.30</td>\n",
" <td>4.05</td>\n",
" <td>4.66</td>\n",
" <td>13.74</td>\n",
" <td>11.26</td>\n",
" <td>4.45</td>\n",
" <td>4.20</td>\n",
" <td>4.10</td>\n",
" <td>12.61</td>\n",
" <td>12.28</td>\n",
" <td>4.02</td>\n",
" <td>4.26</td>\n",
" <td>4.14</td>\n",
" <td>3.99</td>\n",
" <td>4.16</td>\n",
" <td>3.94</td>\n",
" <td>3.91</td>\n",
" <td>9.66</td>\n",
" <td>4.19</td>\n",
" <td>4.24</td>\n",
" <td>13.20</td>\n",
" <td>4.50</td>\n",
" <td>3.99</td>\n",
" <td>6.27</td>\n",
" <td>4.33</td>\n",
" <td>4.03</td>\n",
" <td>4.33</td>\n",
" <td>4.91</td>\n",
" <td>10.00</td>\n",
" <td>12.66</td>\n",
" <td>10.93</td>\n",
" <td>4.29</td>\n",
" <td>3.90</td>\n",
" <td>13.21</td>\n",
" <td>10.75</td>\n",
" <td>4.35</td>\n",
" <td>4.42</td>\n",
" <td>4.29</td>\n",
" <td>13.65</td>\n",
" <td>4.20</td>\n",
" </tr>\n",
" <tr>\n",
" <th>MAL2</th>\n",
" <td>3.90</td>\n",
" <td>11.55</td>\n",
" <td>8.63</td>\n",
" <td>12.21</td>\n",
" <td>11.17</td>\n",
" <td>4.18</td>\n",
" <td>9.48</td>\n",
" <td>10.71</td>\n",
" <td>4.36</td>\n",
" <td>12.92</td>\n",
" <td>5.04</td>\n",
" <td>4.24</td>\n",
" <td>12.64</td>\n",
" <td>4.63</td>\n",
" <td>4.30</td>\n",
" <td>12.61</td>\n",
" <td>12.71</td>\n",
" <td>8.22</td>\n",
" <td>11.57</td>\n",
" <td>4.31</td>\n",
" <td>4.72</td>\n",
" <td>12.39</td>\n",
" <td>11.60</td>\n",
" <td>12.64</td>\n",
" <td>4.47</td>\n",
" <td>8.95</td>\n",
" <td>4.02</td>\n",
" <td>4.50</td>\n",
" <td>11.85</td>\n",
" <td>9.63</td>\n",
" <td>13.22</td>\n",
" <td>12.85</td>\n",
" <td>4.56</td>\n",
" <td>11.54</td>\n",
" <td>5.37</td>\n",
" <td>12.44</td>\n",
" <td>11.47</td>\n",
" <td>6.36</td>\n",
" <td>4.22</td>\n",
" <td>11.81</td>\n",
" <td>...</td>\n",
" <td>4.02</td>\n",
" <td>9.88</td>\n",
" <td>4.23</td>\n",
" <td>11.98</td>\n",
" <td>11.34</td>\n",
" <td>10.66</td>\n",
" <td>3.96</td>\n",
" <td>4.25</td>\n",
" <td>11.96</td>\n",
" <td>11.02</td>\n",
" <td>3.91</td>\n",
" <td>9.99</td>\n",
" <td>5.10</td>\n",
" <td>4.04</td>\n",
" <td>11.51</td>\n",
" <td>4.17</td>\n",
" <td>4.28</td>\n",
" <td>8.47</td>\n",
" <td>6.92</td>\n",
" <td>7.93</td>\n",
" <td>12.44</td>\n",
" <td>4.30</td>\n",
" <td>3.96</td>\n",
" <td>8.04</td>\n",
" <td>10.16</td>\n",
" <td>4.04</td>\n",
" <td>4.55</td>\n",
" <td>10.68</td>\n",
" <td>4.71</td>\n",
" <td>12.46</td>\n",
" <td>11.59</td>\n",
" <td>3.81</td>\n",
" <td>3.86</td>\n",
" <td>12.53</td>\n",
" <td>4.01</td>\n",
" <td>10.55</td>\n",
" <td>5.19</td>\n",
" <td>5.15</td>\n",
" <td>13.35</td>\n",
" <td>4.73</td>\n",
" </tr>\n",
" <tr>\n",
" <th>TGFBI</th>\n",
" <td>12.66</td>\n",
" <td>12.41</td>\n",
" <td>14.28</td>\n",
" <td>11.29</td>\n",
" <td>13.04</td>\n",
" <td>4.70</td>\n",
" <td>5.74</td>\n",
" <td>4.93</td>\n",
" <td>7.79</td>\n",
" <td>11.07</td>\n",
" <td>4.08</td>\n",
" <td>10.48</td>\n",
" <td>5.30</td>\n",
" <td>4.73</td>\n",
" <td>10.01</td>\n",
" <td>13.63</td>\n",
" <td>7.66</td>\n",
" <td>10.48</td>\n",
" <td>8.13</td>\n",
" <td>5.03</td>\n",
" <td>7.43</td>\n",
" <td>4.68</td>\n",
" <td>4.58</td>\n",
" <td>5.57</td>\n",
" <td>13.87</td>\n",
" <td>4.50</td>\n",
" <td>14.08</td>\n",
" <td>11.65</td>\n",
" <td>10.63</td>\n",
" <td>5.03</td>\n",
" <td>11.29</td>\n",
" <td>5.10</td>\n",
" <td>13.92</td>\n",
" <td>10.59</td>\n",
" <td>14.70</td>\n",
" <td>10.15</td>\n",
" <td>11.56</td>\n",
" <td>6.24</td>\n",
" <td>11.90</td>\n",
" <td>7.41</td>\n",
" <td>...</td>\n",
" <td>8.31</td>\n",
" <td>14.49</td>\n",
" <td>4.62</td>\n",
" <td>12.53</td>\n",
" <td>13.19</td>\n",
" <td>14.29</td>\n",
" <td>13.73</td>\n",
" <td>6.87</td>\n",
" <td>11.97</td>\n",
" <td>12.73</td>\n",
" <td>14.71</td>\n",
" <td>14.49</td>\n",
" <td>14.40</td>\n",
" <td>10.87</td>\n",
" <td>12.66</td>\n",
" <td>10.11</td>\n",
" <td>10.76</td>\n",
" <td>13.89</td>\n",
" <td>14.31</td>\n",
" <td>14.26</td>\n",
" <td>9.29</td>\n",
" <td>12.85</td>\n",
" <td>4.87</td>\n",
" <td>14.12</td>\n",
" <td>12.80</td>\n",
" <td>13.26</td>\n",
" <td>11.03</td>\n",
" <td>12.96</td>\n",
" <td>11.93</td>\n",
" <td>14.51</td>\n",
" <td>13.82</td>\n",
" <td>13.47</td>\n",
" <td>14.08</td>\n",
" <td>12.00</td>\n",
" <td>6.20</td>\n",
" <td>12.57</td>\n",
" <td>4.64</td>\n",
" <td>13.77</td>\n",
" <td>11.37</td>\n",
" <td>13.59</td>\n",
" </tr>\n",
" </tbody>\n",
"</table>\n",
"<p>5 rows × 1037 columns</p>\n",
"</div>"
],
"text/plain": [
" ('cell line: LN18', 'tissue: central_nervous_system', 'histology: glioma', 'sub-histology: astrocytoma_Grade_IV', 'gender: M') ... ('cell line: CH157MN', 'tissue: central_nervous_system', 'histology: meningioma', 'sub-histology: NS', 'gender: NA')\n",
"KRT19 5.81 ... 5.71 \n",
"EPCAM 4.09 ... 4.19 \n",
"TACSTD2 4.14 ... 4.20 \n",
"MAL2 3.90 ... 4.73 \n",
"TGFBI 12.66 ... 13.59 \n",
"\n",
"[5 rows x 1037 columns]"
]
},
"metadata": {
"tags": []
},
"execution_count": 3
}
]
},
{
"cell_type": "code",
"metadata": {
"colab": {
"base_uri": "https://localhost:8080/",
"height": 1071
},
"id": "vwaZdrzeuyvs",
"outputId": "14a444e3-9949-45dd-d3b1-ab6144c9e2b6"
},
"source": [
"net.load_df(df)\n",
"net.cluster()\n",
"embed('@cornhundred/clustergrammer-test', cells=['clustergrammer'], inputs={'network': net.viz})"
],
"execution_count": 4,
"outputs": [
{
"output_type": "display_data",
"data": {
"application/javascript": [
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],
"text/plain": [
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" fields = iterateMap;\n",
" } else if (object instanceof Set) {\n",
" tag = \\`Set(\\${object.size})\\`;\n",
" fields = iterateSet;\n",
" } else if (arrayish) {\n",
" tag = \\`\\${object.constructor.name}(\\${object.length})\\`;\n",
" fields = iterateArray;\n",
" } else if ((n = immutableName(object))) {\n",
" tag = \\`Immutable.\\${n.name}\\${n.name === \"Record\" ? \"\" : \\`(\\${object.size})\\`}\\`;\n",
" arrayish = n.arrayish;\n",
" fields = n.arrayish\n",
" ? iterateImArray\n",
" : n.setish\n",
" ? iterateImSet\n",
" : iterateImObject;\n",
" } else if (proto) {\n",
" tag = tagof(object);\n",
" fields = iterateProto;\n",
" } else {\n",
" tag = tagof(object);\n",
" fields = iterateObject;\n",
" }\n",
"\n",
" const span = document.createElement(\"span\");\n",
" span.className = \"observablehq--expanded\";\n",
" if (name) {\n",
" span.appendChild(inspectName(name));\n",
" }\n",
" const a = span.appendChild(document.createElement(\"a\"));\n",
" a.innerHTML = \\`<svg width=8 height=8 class='observablehq--caret'>\n",
" <path d='M4 7L0 1h8z' fill='currentColor' />\n",
" </svg>\\`;\n",
" a.appendChild(document.createTextNode(\\`\\${tag}\\${arrayish ? \" [\" : \" {\"}\\`));\n",
" a.addEventListener(\"mouseup\", function(event) {\n",
" event.stopPropagation();\n",
" replace(span, inspectCollapsed(object, null, name, proto));\n",
" });\n",
"\n",
" fields = fields(object);\n",
" for (let i = 0; !(next = fields.next()).done && i < 20; ++i) {\n",
" span.appendChild(next.value);\n",
" }\n",
"\n",
" if (!next.done) {\n",
" const a = span.appendChild(document.createElement(\"a\"));\n",
" a.className = \"observablehq--field\";\n",
" a.style.display = \"block\";\n",
" a.appendChild(document.createTextNode(\\` … more\\`));\n",
" a.addEventListener(\"mouseup\", function(event) {\n",
" event.stopPropagation();\n",
" span.insertBefore(next.value, span.lastChild.previousSibling);\n",
" for (let i = 0; !(next = fields.next()).done && i < 19; ++i) {\n",
" span.insertBefore(next.value, span.lastChild.previousSibling);\n",
" }\n",
" if (next.done) span.removeChild(span.lastChild.previousSibling);\n",
" dispatch(span, \"load\");\n",
" });\n",
" }\n",
"\n",
" span.appendChild(document.createTextNode(arrayish ? \"]\" : \"}\"));\n",
"\n",
" return span;\n",
" }\n",
"\n",
" function* iterateMap(map) {\n",
" for (const [key, value] of map) {\n",
" yield formatMapField(key, value);\n",
" }\n",
" yield* iterateObject(map);\n",
" }\n",
"\n",
" function* iterateSet(set) {\n",
" for (const value of set) {\n",
" yield formatSetField(value);\n",
" }\n",
" yield* iterateObject(set);\n",
" }\n",
"\n",
" function* iterateImSet(set) {\n",
" for (const value of set) {\n",
" yield formatSetField(value);\n",
" }\n",
" }\n",
"\n",
" function* iterateArray(array) {\n",
" for (let i = 0, n = array.length; i < n; ++i) {\n",
" if (i in array) {\n",
" yield formatField(i, valueof(array, i), \"observablehq--index\");\n",
" }\n",
" }\n",
" for (const key in array) {\n",
" if (!isindex(key) && isown(array, key)) {\n",
" yield formatField(key, valueof(array, key), \"observablehq--key\");\n",
" }\n",
" }\n",
" for (const symbol of symbolsof(array)) {\n",
" yield formatField(\n",
" formatSymbol(symbol),\n",
" valueof(array, symbol),\n",
" \"observablehq--symbol\"\n",
" );\n",
" }\n",
" }\n",
"\n",
" function* iterateImArray(array) {\n",
" let i1 = 0;\n",
" for (const n = array.size; i1 < n; ++i1) {\n",
" yield formatField(i1, array.get(i1), true);\n",
" }\n",
" }\n",
"\n",
" function* iterateProto(object) {\n",
" for (const key in getOwnPropertyDescriptors(object)) {\n",
" yield formatField(key, valueof(object, key), \"observablehq--key\");\n",
" }\n",
" for (const symbol of symbolsof(object)) {\n",
" yield formatField(\n",
" formatSymbol(symbol),\n",
" valueof(object, symbol),\n",
" \"observablehq--symbol\"\n",
" );\n",
" }\n",
"\n",
" const proto = getPrototypeOf(object);\n",
" if (proto && proto !== objectPrototype) {\n",
" yield formatPrototype(proto);\n",
" }\n",
" }\n",
"\n",
" function* iterateObject(object) {\n",
" for (const key in object) {\n",
" if (isown(object, key)) {\n",
" yield formatField(key, valueof(object, key), \"observablehq--key\");\n",
" }\n",
" }\n",
" for (const symbol of symbolsof(object)) {\n",
" yield formatField(\n",
" formatSymbol(symbol),\n",
" valueof(object, symbol),\n",
" \"observablehq--symbol\"\n",
" );\n",
" }\n",
"\n",
" const proto = getPrototypeOf(object);\n",
" if (proto && proto !== objectPrototype) {\n",
" yield formatPrototype(proto);\n",
" }\n",
" }\n",
"\n",
" function* iterateImObject(object) {\n",
" for (const [key, value] of object) {\n",
" yield formatField(key, value, \"observablehq--key\");\n",
" }\n",
" }\n",
"\n",
" function formatPrototype(value) {\n",
" const item = document.createElement(\"div\");\n",
" const span = item.appendChild(document.createElement(\"span\"));\n",
" item.className = \"observablehq--field\";\n",
" span.className = \"observablehq--prototype-key\";\n",
" span.textContent = \\` <prototype>\\`;\n",
" item.appendChild(document.createTextNode(\": \"));\n",
" item.appendChild(inspect(value, undefined, undefined, undefined, true));\n",
" return item;\n",
" }\n",
"\n",
" function formatField(key, value, className) {\n",
" const item = document.createElement(\"div\");\n",
" const span = item.appendChild(document.createElement(\"span\"));\n",
" item.className = \"observablehq--field\";\n",
" span.className = className;\n",
" span.textContent = \\` \\${key}\\`;\n",
" item.appendChild(document.createTextNode(\": \"));\n",
" item.appendChild(inspect(value));\n",
" return item;\n",
" }\n",
"\n",
" function formatMapField(key, value) {\n",
" const item = document.createElement(\"div\");\n",
" item.className = \"observablehq--field\";\n",
" item.appendChild(document.createTextNode(\" \"));\n",
" item.appendChild(inspect(key));\n",
" item.appendChild(document.createTextNode(\" => \"));\n",
" item.appendChild(inspect(value));\n",
" return item;\n",
" }\n",
"\n",
" function formatSetField(value) {\n",
" const item = document.createElement(\"div\");\n",
" item.className = \"observablehq--field\";\n",
" item.appendChild(document.createTextNode(\" \"));\n",
" item.appendChild(inspect(value));\n",
" return item;\n",
" }\n",
"\n",
" function hasSelection(elem) {\n",
" const sel = window.getSelection();\n",
" return (\n",
" sel.type === \"Range\" &&\n",
" (sel.containsNode(elem, true) ||\n",
" sel.anchorNode.isSelfOrDescendant(elem) ||\n",
" sel.focusNode.isSelfOrDescendant(elem))\n",
" );\n",
" }\n",
"\n",
" function inspectCollapsed(object, shallow, name, proto) {\n",
" let arrayish = isarray(object);\n",
" let tag, fields, next, n;\n",
"\n",
" if (object instanceof Map) {\n",
" tag = \\`Map(\\${object.size})\\`;\n",
" fields = iterateMap\\$1;\n",
" } else if (object instanceof Set) {\n",
" tag = \\`Set(\\${object.size})\\`;\n",
" fields = iterateSet\\$1;\n",
" } else if (arrayish) {\n",
" tag = \\`\\${object.constructor.name}(\\${object.length})\\`;\n",
" fields = iterateArray\\$1;\n",
" } else if ((n = immutableName(object))) {\n",
" tag = \\`Immutable.\\${n.name}\\${n.name === 'Record' ? '' : \\`(\\${object.size})\\`}\\`;\n",
" arrayish = n.arrayish;\n",
" fields = n.arrayish ? iterateImArray\\$1 : n.setish ? iterateImSet\\$1 : iterateImObject\\$1;\n",
" } else {\n",
" tag = tagof(object);\n",
" fields = iterateObject\\$1;\n",
" }\n",
"\n",
" if (shallow) {\n",
" const span = document.createElement(\"span\");\n",
" span.className = \"observablehq--shallow\";\n",
" if (name) {\n",
" span.appendChild(inspectName(name));\n",
" }\n",
" span.appendChild(document.createTextNode(tag));\n",
" span.addEventListener(\"mouseup\", function(event) {\n",
" if (hasSelection(span)) return;\n",
" event.stopPropagation();\n",
" replace(span, inspectCollapsed(object));\n",
" });\n",
" return span;\n",
" }\n",
"\n",
" const span = document.createElement(\"span\");\n",
" span.className = \"observablehq--collapsed\";\n",
" if (name) {\n",
" span.appendChild(inspectName(name));\n",
" }\n",
" const a = span.appendChild(document.createElement(\"a\"));\n",
" a.innerHTML = \\`<svg width=8 height=8 class='observablehq--caret'>\n",
" <path d='M7 4L1 8V0z' fill='currentColor' />\n",
" </svg>\\`;\n",
" a.appendChild(document.createTextNode(\\`\\${tag}\\${arrayish ? \" [\" : \" {\"}\\`));\n",
" span.addEventListener(\"mouseup\", function(event) {\n",
" if (hasSelection(span)) return;\n",
" event.stopPropagation();\n",
" replace(span, inspectExpanded(object, null, name, proto));\n",
" }, true);\n",
"\n",
" fields = fields(object);\n",
" for (let i = 0; !(next = fields.next()).done && i < 20; ++i) {\n",
" if (i > 0) span.appendChild(document.createTextNode(\", \"));\n",
" span.appendChild(next.value);\n",
" }\n",
"\n",
" if (!next.done) span.appendChild(document.createTextNode(\", …\"));\n",
" span.appendChild(document.createTextNode(arrayish ? \"]\" : \"}\"));\n",
"\n",
" return span;\n",
" }\n",
"\n",
" function* iterateMap\\$1(map) {\n",
" for (const [key, value] of map) {\n",
" yield formatMapField\\$1(key, value);\n",
" }\n",
" yield* iterateObject\\$1(map);\n",
" }\n",
"\n",
" function* iterateSet\\$1(set) {\n",
" for (const value of set) {\n",
" yield inspect(value, true);\n",
" }\n",
" yield* iterateObject\\$1(set);\n",
" }\n",
"\n",
" function* iterateImSet\\$1(set) {\n",
" for (const value of set) {\n",
" yield inspect(value, true);\n",
" }\n",
" }\n",
"\n",
" function* iterateImArray\\$1(array) {\n",
" let i0 = -1, i1 = 0;\n",
" for (const n = array.size; i1 < n; ++i1) {\n",
" if (i1 > i0 + 1) yield formatEmpty(i1 - i0 - 1);\n",
" yield inspect(array.get(i1), true);\n",
" i0 = i1;\n",
" }\n",
" if (i1 > i0 + 1) yield formatEmpty(i1 - i0 - 1);\n",
" }\n",
"\n",
" function* iterateArray\\$1(array) {\n",
" let i0 = -1, i1 = 0;\n",
" for (const n = array.length; i1 < n; ++i1) {\n",
" if (i1 in array) {\n",
" if (i1 > i0 + 1) yield formatEmpty(i1 - i0 - 1);\n",
" yield inspect(valueof(array, i1), true);\n",
" i0 = i1;\n",
" }\n",
" }\n",
" if (i1 > i0 + 1) yield formatEmpty(i1 - i0 - 1);\n",
" for (const key in array) {\n",
" if (!isindex(key) && isown(array, key)) {\n",
" yield formatField\\$1(key, valueof(array, key), \"observablehq--key\");\n",
" }\n",
" }\n",
" for (const symbol of symbolsof(array)) {\n",
" yield formatField\\$1(formatSymbol(symbol), valueof(array, symbol), \"observablehq--symbol\");\n",
" }\n",
" }\n",
"\n",
" function* iterateObject\\$1(object) {\n",
" for (const key in object) {\n",
" if (isown(object, key)) {\n",
" yield formatField\\$1(key, valueof(object, key), \"observablehq--key\");\n",
" }\n",
" }\n",
" for (const symbol of symbolsof(object)) {\n",
" yield formatField\\$1(formatSymbol(symbol), valueof(object, symbol), \"observablehq--symbol\");\n",
" }\n",
" }\n",
"\n",
" function* iterateImObject\\$1(object) {\n",
" for (const [key, value] of object) {\n",
" yield formatField\\$1(key, value, \"observablehq--key\");\n",
" }\n",
" }\n",
"\n",
" function formatEmpty(e) {\n",
" const span = document.createElement(\"span\");\n",
" span.className = \"observablehq--empty\";\n",
" span.textContent = e === 1 ? \"empty\" : \\`empty × \\${e}\\`;\n",
" return span;\n",
" }\n",
"\n",
" function formatField\\$1(key, value, className) {\n",
" const fragment = document.createDocumentFragment();\n",
" const span = fragment.appendChild(document.createElement(\"span\"));\n",
" span.className = className;\n",
" span.textContent = key;\n",
" fragment.appendChild(document.createTextNode(\": \"));\n",
" fragment.appendChild(inspect(value, true));\n",
" return fragment;\n",
" }\n",
"\n",
" function formatMapField\\$1(key, value) {\n",
" const fragment = document.createDocumentFragment();\n",
" fragment.appendChild(inspect(key, true));\n",
" fragment.appendChild(document.createTextNode(\" => \"));\n",
" fragment.appendChild(inspect(value, true));\n",
" return fragment;\n",
" }\n",
"\n",
" function pad(value, width) {\n",
" var s = value + \"\", length = s.length;\n",
" return length < width ? new Array(width - length + 1).join(0) + s : s;\n",
" }\n",
"\n",
" function isUTCMidnight(date) {\n",
" return date.getUTCMilliseconds() === 0\n",
" && date.getUTCSeconds() === 0\n",
" && date.getUTCMinutes() === 0\n",
" && date.getUTCHours() === 0;\n",
" }\n",
"\n",
" function formatYear(year) {\n",
" return year < 0 ? \"-\" + pad(-year, 6)\n",
" : year > 9999 ? \"+\" + pad(year, 6)\n",
" : pad(year, 4);\n",
" }\n",
"\n",
" function formatDate(date) {\n",
" return isNaN(date)\n",
" ? \"Invalid Date\"\n",
" : isUTCMidnight(date)\n",
" ? formatYear(date.getUTCFullYear()) + \"-\" + pad(date.getUTCMonth() + 1, 2) + \"-\" + pad(date.getUTCDate(), 2)\n",
" : formatYear(date.getFullYear()) + \"-\" + pad(date.getMonth() + 1, 2) + \"-\" + pad(date.getDate(), 2)\n",
" + \"T\" + pad(date.getHours(), 2) + \":\" + pad(date.getMinutes(), 2)\n",
" + (date.getMilliseconds() ? \":\" + pad(date.getSeconds(), 2) + \".\" + pad(date.getMilliseconds(), 3)\n",
" : date.getSeconds() ? \":\" + pad(date.getSeconds(), 2)\n",
" : \"\");\n",
" }\n",
"\n",
" var errorToString = Error.prototype.toString;\n",
"\n",
" function formatError(value) {\n",
" return value.stack || errorToString.call(value);\n",
" }\n",
"\n",
" var regExpToString = RegExp.prototype.toString;\n",
"\n",
" function formatRegExp(value) {\n",
" return regExpToString.call(value);\n",
" }\n",
"\n",
" /* eslint-disable no-control-regex */\n",
" const NEWLINE_LIMIT = 20;\n",
"\n",
" function formatString(string, shallow, expanded, name) {\n",
" if (shallow === false) {\n",
" // String has fewer escapes displayed with double quotes\n",
" if (count(string, /[\"\\\\n]/g) <= count(string, /\\`|\\\\\\${/g)) {\n",
" const span = document.createElement(\"span\");\n",
" if (name) span.appendChild(inspectName(name));\n",
" const textValue = span.appendChild(document.createElement(\"span\"));\n",
" textValue.className = \"observablehq--string\";\n",
" textValue.textContent = JSON.stringify(string);\n",
" return span;\n",
" }\n",
" const lines = string.split(\"\\\\n\");\n",
" if (lines.length > NEWLINE_LIMIT && !expanded) {\n",
" const div = document.createElement(\"div\");\n",
" if (name) div.appendChild(inspectName(name));\n",
" const textValue = div.appendChild(document.createElement(\"span\"));\n",
" textValue.className = \"observablehq--string\";\n",
" textValue.textContent = \"\\`\" + templatify(lines.slice(0, NEWLINE_LIMIT).join(\"\\\\n\"));\n",
" const splitter = div.appendChild(document.createElement(\"span\"));\n",
" const truncatedCount = lines.length - NEWLINE_LIMIT;\n",
" splitter.textContent = \\`Show \\${truncatedCount} truncated line\\${truncatedCount > 1 ? \"s\": \"\"}\\`; splitter.className = \"observablehq--string-expand\";\n",
" splitter.addEventListener(\"mouseup\", function (event) {\n",
" event.stopPropagation();\n",
" replace(div, inspect(string, shallow, true, name));\n",
" });\n",
" return div;\n",
" }\n",
" const span = document.createElement(\"span\");\n",
" if (name) span.appendChild(inspectName(name));\n",
" const textValue = span.appendChild(document.createElement(\"span\"));\n",
" textValue.className = \\`observablehq--string\\${expanded ? \" observablehq--expanded\" : \"\"}\\`;\n",
" textValue.textContent = \"\\`\" + templatify(string) + \"\\`\";\n",
" return span;\n",
" }\n",
"\n",
" const span = document.createElement(\"span\");\n",
" if (name) span.appendChild(inspectName(name));\n",
" const textValue = span.appendChild(document.createElement(\"span\"));\n",
" textValue.className = \"observablehq--string\";\n",
" textValue.textContent = JSON.stringify(string.length > 100 ?\n",
" \\`\\${string.slice(0, 50)}…\\${string.slice(-49)}\\` : string);\n",
" return span;\n",
" }\n",
"\n",
" function templatify(string) {\n",
" return string.replace(/[\\\\\\\\\\`\\\\x00-\\\\x09\\\\x0b-\\\\x19]|\\\\\\${/g, templatifyChar);\n",
" }\n",
"\n",
" function templatifyChar(char) {\n",
" var code = char.charCodeAt(0);\n",
" switch (code) {\n",
" case 0x8: return \"\\\\\\\\b\";\n",
" case 0x9: return \"\\\\\\\\t\";\n",
" case 0xb: return \"\\\\\\\\v\";\n",
" case 0xc: return \"\\\\\\\\f\";\n",
" case 0xd: return \"\\\\\\\\r\";\n",
" }\n",
" return code < 0x10 ? \"\\\\\\\\x0\" + code.toString(16)\n",
" : code < 0x20 ? \"\\\\\\\\x\" + code.toString(16)\n",
" : \"\\\\\\\\\" + char;\n",
" }\n",
"\n",
" function count(string, re) {\n",
" var n = 0;\n",
" while (re.exec(string)) ++n;\n",
" return n;\n",
" }\n",
"\n",
" var toString = Function.prototype.toString,\n",
" TYPE_ASYNC = {prefix: \"async ƒ\"},\n",
" TYPE_ASYNC_GENERATOR = {prefix: \"async ƒ*\"},\n",
" TYPE_CLASS = {prefix: \"class\"},\n",
" TYPE_FUNCTION = {prefix: \"ƒ\"},\n",
" TYPE_GENERATOR = {prefix: \"ƒ*\"};\n",
"\n",
" function inspectFunction(f, name) {\n",
" var type, m, t = toString.call(f);\n",
"\n",
" switch (f.constructor && f.constructor.name) {\n",
" case \"AsyncFunction\": type = TYPE_ASYNC; break;\n",
" case \"AsyncGeneratorFunction\": type = TYPE_ASYNC_GENERATOR; break;\n",
" case \"GeneratorFunction\": type = TYPE_GENERATOR; break;\n",
" default: type = /^class\\\\b/.test(t) ? TYPE_CLASS : TYPE_FUNCTION; break;\n",
" }\n",
"\n",
" // A class, possibly named.\n",
" // class Name\n",
" if (type === TYPE_CLASS) {\n",
" return formatFunction(type, \"\", name);\n",
" }\n",
"\n",
" // An arrow function with a single argument.\n",
" // foo =>\n",
" // async foo =>\n",
" if ((m = /^(?:async\\\\s*)?(\\\\w+)\\\\s*=>/.exec(t))) {\n",
" return formatFunction(type, \"(\" + m[1] + \")\", name);\n",
" }\n",
"\n",
" // An arrow function with parenthesized arguments.\n",
" // (…)\n",
" // async (…)\n",
" if ((m = /^(?:async\\\\s*)?\\\\(\\\\s*(\\\\w+(?:\\\\s*,\\\\s*\\\\w+)*)?\\\\s*\\\\)/.exec(t))) {\n",
" return formatFunction(type, m[1] ? \"(\" + m[1].replace(/\\\\s*,\\\\s*/g, \", \") + \")\" : \"()\", name);\n",
" }\n",
"\n",
" // A function, possibly: async, generator, anonymous, simply arguments.\n",
" // function name(…)\n",
" // function* name(…)\n",
" // async function name(…)\n",
" // async function* name(…)\n",
" if ((m = /^(?:async\\\\s*)?function(?:\\\\s*\\\\*)?(?:\\\\s*\\\\w+)?\\\\s*\\\\(\\\\s*(\\\\w+(?:\\\\s*,\\\\s*\\\\w+)*)?\\\\s*\\\\)/.exec(t))) {\n",
" return formatFunction(type, m[1] ? \"(\" + m[1].replace(/\\\\s*,\\\\s*/g, \", \") + \")\" : \"()\", name);\n",
" }\n",
"\n",
" // Something else, like destructuring, comments or default values.\n",
" return formatFunction(type, \"(…)\", name);\n",
" }\n",
"\n",
" function formatFunction(type, args, cellname) {\n",
" var span = document.createElement(\"span\");\n",
" span.className = \"observablehq--function\";\n",
" if (cellname) {\n",
" span.appendChild(inspectName(cellname));\n",
" }\n",
" var spanType = span.appendChild(document.createElement(\"span\"));\n",
" spanType.className = \"observablehq--keyword\";\n",
" spanType.textContent = type.prefix;\n",
" span.appendChild(document.createTextNode(args));\n",
" return span;\n",
" }\n",
"\n",
" const {prototype: {toString: toString\\$1}} = Object;\n",
"\n",
" function inspect(value, shallow, expand, name, proto) {\n",
" let type = typeof value;\n",
" switch (type) {\n",
" case \"boolean\":\n",
" case \"undefined\": { value += \"\"; break; }\n",
" case \"number\": { value = value === 0 && 1 / value < 0 ? \"-0\" : value + \"\"; break; }\n",
" case \"bigint\": { value = value + \"n\"; break; }\n",
" case \"symbol\": { value = formatSymbol(value); break; }\n",
" case \"function\": { return inspectFunction(value, name); }\n",
" case \"string\": { return formatString(value, shallow, expand, name); }\n",
" default: {\n",
" if (value === null) { type = null, value = \"null\"; break; }\n",
" if (value instanceof Date) { type = \"date\", value = formatDate(value); break; }\n",
" if (value === FORBIDDEN) { type = \"forbidden\", value = \"[forbidden]\"; break; }\n",
" switch (toString\\$1.call(value)) {\n",
" case \"[object RegExp]\": { type = \"regexp\", value = formatRegExp(value); break; }\n",
" case \"[object Error]\": // https://github.com/lodash/lodash/blob/master/isError.js#L26\n",
" case \"[object DOMException]\": { type = \"error\", value = formatError(value); break; }\n",
" default: return (expand ? inspectExpanded : inspectCollapsed)(value, shallow, name, proto);\n",
" }\n",
" break;\n",
" }\n",
" }\n",
" const span = document.createElement(\"span\");\n",
" if (name) span.appendChild(inspectName(name));\n",
" const n = span.appendChild(document.createElement(\"span\"));\n",
" n.className = \\`observablehq--\\${type}\\`;\n",
" n.textContent = value;\n",
" return span;\n",
" }\n",
"\n",
" function replace(spanOld, spanNew) {\n",
" if (spanOld.classList.contains(\"observablehq--inspect\")) spanNew.classList.add(\"observablehq--inspect\");\n",
" spanOld.parentNode.replaceChild(spanNew, spanOld);\n",
" dispatch(spanNew, \"load\");\n",
" }\n",
"\n",
" const LOCATION_MATCH = /\\\\s+\\\\(\\\\d+:\\\\d+\\\\)\\$/m;\n",
"\n",
" class Inspector {\n",
" constructor(node) {\n",
" if (!node) throw new Error(\"invalid node\");\n",
" this._node = node;\n",
" node.classList.add(\"observablehq\");\n",
" }\n",
" pending() {\n",
" const {_node} = this;\n",
" _node.classList.remove(\"observablehq--error\");\n",
" _node.classList.add(\"observablehq--running\");\n",
" }\n",
" fulfilled(value, name) {\n",
" const {_node} = this;\n",
" if (!(value instanceof Element || value instanceof Text) || (value.parentNode && value.parentNode !== _node)) {\n",
" value = inspect(value, false, _node.firstChild // TODO Do this better.\n",
" && _node.firstChild.classList\n",
" && _node.firstChild.classList.contains(\"observablehq--expanded\"), name);\n",
" value.classList.add(\"observablehq--inspect\");\n",
" }\n",
" _node.classList.remove(\"observablehq--running\", \"observablehq--error\");\n",
" if (_node.firstChild !== value) {\n",
" if (_node.firstChild) {\n",
" while (_node.lastChild !== _node.firstChild) _node.removeChild(_node.lastChild);\n",
" _node.replaceChild(value, _node.firstChild);\n",
" } else {\n",
" _node.appendChild(value);\n",
" }\n",
" }\n",
" dispatch(_node, \"update\");\n",
" }\n",
" rejected(error, name) {\n",
" const {_node} = this;\n",
" _node.classList.remove(\"observablehq--running\");\n",
" _node.classList.add(\"observablehq--error\");\n",
" while (_node.lastChild) _node.removeChild(_node.lastChild);\n",
" var div = document.createElement(\"div\");\n",
" div.className = \"observablehq--inspect\";\n",
" if (name) div.appendChild(inspectName(name));\n",
" div.appendChild(document.createTextNode((error + \"\").replace(LOCATION_MATCH, \"\")));\n",
" _node.appendChild(div);\n",
" dispatch(_node, \"error\", {error: error});\n",
" }\n",
" }\n",
"\n",
" Inspector.into = function(container) {\n",
" if (typeof container === \"string\") {\n",
" container = document.querySelector(container);\n",
" if (container == null) throw new Error(\"container not found\");\n",
" }\n",
" return function() {\n",
" return new Inspector(container.appendChild(document.createElement(\"div\")));\n",
" };\n",
" };\n",
"\n",
" async function remote_fetch(file) {\n",
" const response = await fetch(await file.url());\n",
" if (!response.ok) throw new Error(\\`Unable to load file: \\${file.name}\\`);\n",
" return response;\n",
" }\n",
"\n",
" class FileAttachment {\n",
" constructor(url, name) {\n",
" Object.defineProperties(this, {\n",
" _url: {value: url},\n",
" name: {value: name, enumerable: true}\n",
" });\n",
" }\n",
" async url() {\n",
" return this._url;\n",
" }\n",
" async blob() {\n",
" return (await remote_fetch(this)).blob();\n",
" }\n",
" async arrayBuffer() {\n",
" return (await remote_fetch(this)).arrayBuffer();\n",
" }\n",
" async text() {\n",
" return (await remote_fetch(this)).text();\n",
" }\n",
" async json() {\n",
" return (await remote_fetch(this)).json();\n",
" }\n",
" async stream() {\n",
" return (await remote_fetch(this)).body;\n",
" }\n",
" async image() {\n",
" const url = await this.url();\n",
" return new Promise((resolve, reject) => {\n",
" const i = new Image;\n",
" if (new URL(url, document.baseURI).origin !== new URL(location).origin) {\n",
" i.crossOrigin = \"anonymous\";\n",
" }\n",
" i.onload = () => resolve(i);\n",
" i.onerror = () => reject(new Error(\\`Unable to load file: \\${this.name}\\`));\n",
" i.src = url;\n",
" });\n",
" }\n",
" }\n",
"\n",
" function NoFileAttachments(name) {\n",
" throw new Error(\\`File not found: \\${name}\\`);\n",
" }\n",
"\n",
" function FileAttachments(resolve) {\n",
" return name => {\n",
" const url = resolve(name += \"\"); // Returns a Promise, string, or null.\n",
" if (url == null) throw new Error(\\`File not found: \\${name}\\`);\n",
" return new FileAttachment(url, name);\n",
" };\n",
" }\n",
"\n",
" const metas = new Map;\n",
" const queue = [];\n",
" const map = queue.map;\n",
" const some = queue.some;\n",
" const hasOwnProperty\\$1 = queue.hasOwnProperty;\n",
" const origin = \"https://cdn.jsdelivr.net/npm/\";\n",
" const identifierRe = /^((?:@[^/@]+\\\\/)?[^/@]+)(?:@([^/]+))?(?:\\\\/(.*))?\\$/;\n",
" const versionRe = /^\\\\d+\\\\.\\\\d+\\\\.\\\\d+(-[\\\\w-.+]+)?\\$/;\n",
" const extensionRe = /\\\\.[^/]*\\$/;\n",
" const mains = [\"unpkg\", \"jsdelivr\", \"browser\", \"main\"];\n",
"\n",
" class RequireError extends Error {\n",
" constructor(message) {\n",
" super(message);\n",
" }\n",
" }\n",
"\n",
" RequireError.prototype.name = RequireError.name;\n",
"\n",
" function main(meta) {\n",
" for (const key of mains) {\n",
" const value = meta[key];\n",
" if (typeof value === \"string\") {\n",
" return extensionRe.test(value) ? value : \\`\\${value}.js\\`;\n",
" }\n",
" }\n",
" }\n",
"\n",
" function parseIdentifier(identifier) {\n",
" const match = identifierRe.exec(identifier);\n",
" return match && {\n",
" name: match[1],\n",
" version: match[2],\n",
" path: match[3]\n",
" };\n",
" }\n",
"\n",
" function resolveMeta(target) {\n",
" const url = \\`\\${origin}\\${target.name}\\${target.version ? \\`@\\${target.version}\\` : \"\"}/package.json\\`;\n",
" let meta = metas.get(url);\n",
" if (!meta) metas.set(url, meta = fetch(url).then(response => {\n",
" if (!response.ok) throw new RequireError(\"unable to load package.json\");\n",
" if (response.redirected && !metas.has(response.url)) metas.set(response.url, meta);\n",
" return response.json();\n",
" }));\n",
" return meta;\n",
" }\n",
"\n",
" async function resolve(name, base) {\n",
" if (name.startsWith(origin)) name = name.substring(origin.length);\n",
" if (/^(\\\\w+:)|\\\\/\\\\//i.test(name)) return name;\n",
" if (/^[.]{0,2}\\\\//i.test(name)) return new URL(name, base == null ? location : base).href;\n",
" if (!name.length || /^[\\\\s._]/.test(name) || /\\\\s\\$/.test(name)) throw new RequireError(\"illegal name\");\n",
" const target = parseIdentifier(name);\n",
" if (!target) return \\`\\${origin}\\${name}\\`;\n",
" if (!target.version && base != null && base.startsWith(origin)) {\n",
" const meta = await resolveMeta(parseIdentifier(base.substring(origin.length)));\n",
" target.version = meta.dependencies && meta.dependencies[target.name] || meta.peerDependencies && meta.peerDependencies[target.name];\n",
" }\n",
" if (target.path && !extensionRe.test(target.path)) target.path += \".js\";\n",
" if (target.path && target.version && versionRe.test(target.version)) return \\`\\${origin}\\${target.name}@\\${target.version}/\\${target.path}\\`;\n",
" const meta = await resolveMeta(target);\n",
" return \\`\\${origin}\\${meta.name}@\\${meta.version}/\\${target.path || main(meta) || \"index.js\"}\\`;\n",
" }\n",
"\n",
" var require = requireFrom(resolve);\n",
"\n",
" function requireFrom(resolver) {\n",
" const cache = new Map;\n",
" const requireBase = requireRelative(null);\n",
"\n",
" function requireAbsolute(url) {\n",
" if (typeof url !== \"string\") return url;\n",
" let module = cache.get(url);\n",
" if (!module) cache.set(url, module = new Promise((resolve, reject) => {\n",
" const script = document.createElement(\"script\");\n",
" script.onload = () => {\n",
" try { resolve(queue.pop()(requireRelative(url))); }\n",
" catch (error) { reject(new RequireError(\"invalid module\")); }\n",
" script.remove();\n",
" };\n",
" script.onerror = () => {\n",
" reject(new RequireError(\"unable to load module\"));\n",
" script.remove();\n",
" };\n",
" script.async = true;\n",
" script.src = url;\n",
" window.define = define;\n",
" document.head.appendChild(script);\n",
" }));\n",
" return module;\n",
" }\n",
"\n",
" function requireRelative(base) {\n",
" return name => Promise.resolve(resolver(name, base)).then(requireAbsolute);\n",
" }\n",
"\n",
" function requireAlias(aliases) {\n",
" return requireFrom((name, base) => {\n",
" if (name in aliases) {\n",
" name = aliases[name], base = null;\n",
" if (typeof name !== \"string\") return name;\n",
" }\n",
" return resolver(name, base);\n",
" });\n",
" }\n",
"\n",
" function require(name) {\n",
" return arguments.length > 1\n",
" ? Promise.all(map.call(arguments, requireBase)).then(merge)\n",
" : requireBase(name);\n",
" }\n",
"\n",
" require.alias = requireAlias;\n",
" require.resolve = resolver;\n",
"\n",
" return require;\n",
" }\n",
"\n",
" function merge(modules) {\n",
" const o = {};\n",
" for (const m of modules) {\n",
" for (const k in m) {\n",
" if (hasOwnProperty\\$1.call(m, k)) {\n",
" if (m[k] == null) Object.defineProperty(o, k, {get: getter(m, k)});\n",
" else o[k] = m[k];\n",
" }\n",
" }\n",
" }\n",
" return o;\n",
" }\n",
"\n",
" function getter(object, name) {\n",
" return () => object[name];\n",
" }\n",
"\n",
" function isbuiltin(name) {\n",
" name = name + \"\";\n",
" return name === \"exports\" || name === \"module\";\n",
" }\n",
"\n",
" function define(name, dependencies, factory) {\n",
" const n = arguments.length;\n",
" if (n < 2) factory = name, dependencies = [];\n",
" else if (n < 3) factory = dependencies, dependencies = typeof name === \"string\" ? [] : name;\n",
" queue.push(some.call(dependencies, isbuiltin) ? require => {\n",
" const exports = {};\n",
" const module = {exports};\n",
" return Promise.all(map.call(dependencies, name => {\n",
" name = name + \"\";\n",
" return name === \"exports\" ? exports : name === \"module\" ? module : require(name);\n",
" })).then(dependencies => {\n",
" factory.apply(null, dependencies);\n",
" return module.exports;\n",
" });\n",
" } : require => {\n",
" return Promise.all(map.call(dependencies, require)).then(dependencies => {\n",
" return typeof factory === \"function\" ? factory.apply(null, dependencies) : factory;\n",
" });\n",
" });\n",
" }\n",
"\n",
" define.amd = {};\n",
"\n",
" function constant(x) {\n",
" return function() {\n",
" return x;\n",
" };\n",
" }\n",
"\n",
" function canvas(width, height) {\n",
" var canvas = document.createElement(\"canvas\");\n",
" canvas.width = width;\n",
" canvas.height = height;\n",
" return canvas;\n",
" }\n",
"\n",
" function context2d(width, height, dpi) {\n",
" if (dpi == null) dpi = devicePixelRatio;\n",
" var canvas = document.createElement(\"canvas\");\n",
" canvas.width = width * dpi;\n",
" canvas.height = height * dpi;\n",
" canvas.style.width = width + \"px\";\n",
" var context = canvas.getContext(\"2d\");\n",
" context.scale(dpi, dpi);\n",
" return context;\n",
" }\n",
"\n",
" function download(value, name = \"untitled\", label = \"Save\") {\n",
" const a = document.createElement(\"a\");\n",
" const b = a.appendChild(document.createElement(\"button\"));\n",
" b.textContent = label;\n",
" a.download = name;\n",
"\n",
" async function reset() {\n",
" await new Promise(requestAnimationFrame);\n",
" URL.revokeObjectURL(a.href);\n",
" a.removeAttribute(\"href\");\n",
" b.textContent = label;\n",
" b.disabled = false;\n",
" }\n",
"\n",
" a.onclick = async event => {\n",
" b.disabled = true;\n",
" if (a.href) return reset(); // Already saved.\n",
" b.textContent = \"Saving…\";\n",
" try {\n",
" const object = await (typeof value === \"function\" ? value() : value);\n",
" b.textContent = \"Download\";\n",
" a.href = URL.createObjectURL(object); // eslint-disable-line require-atomic-updates\n",
" } catch (ignore) {\n",
" b.textContent = label;\n",
" }\n",
" if (event.eventPhase) return reset(); // Already downloaded.\n",
" b.disabled = false;\n",
" };\n",
"\n",
" return a;\n",
" }\n",
"\n",
" var namespaces = {\n",
" math: \"http://www.w3.org/1998/Math/MathML\",\n",
" svg: \"http://www.w3.org/2000/svg\",\n",
" xhtml: \"http://www.w3.org/1999/xhtml\",\n",
" xlink: \"http://www.w3.org/1999/xlink\",\n",
" xml: \"http://www.w3.org/XML/1998/namespace\",\n",
" xmlns: \"http://www.w3.org/2000/xmlns/\"\n",
" };\n",
"\n",
" function element(name, attributes) {\n",
" var prefix = name += \"\", i = prefix.indexOf(\":\"), value;\n",
" if (i >= 0 && (prefix = name.slice(0, i)) !== \"xmlns\") name = name.slice(i + 1);\n",
" var element = namespaces.hasOwnProperty(prefix) // eslint-disable-line no-prototype-builtins\n",
" ? document.createElementNS(namespaces[prefix], name)\n",
" : document.createElement(name);\n",
" if (attributes) for (var key in attributes) {\n",
" prefix = key, i = prefix.indexOf(\":\"), value = attributes[key];\n",
" if (i >= 0 && (prefix = key.slice(0, i)) !== \"xmlns\") key = key.slice(i + 1);\n",
" if (namespaces.hasOwnProperty(prefix)) element.setAttributeNS(namespaces[prefix], key, value); // eslint-disable-line no-prototype-builtins\n",
" else element.setAttribute(key, value);\n",
" }\n",
" return element;\n",
" }\n",
"\n",
" function input(type) {\n",
" var input = document.createElement(\"input\");\n",
" if (type != null) input.type = type;\n",
" return input;\n",
" }\n",
"\n",
" function range(min, max, step) {\n",
" if (arguments.length === 1) max = min, min = null;\n",
" var input = document.createElement(\"input\");\n",
" input.min = min = min == null ? 0 : +min;\n",
" input.max = max = max == null ? 1 : +max;\n",
" input.step = step == null ? \"any\" : step = +step;\n",
" input.type = \"range\";\n",
" return input;\n",
" }\n",
"\n",
" function select(values) {\n",
" var select = document.createElement(\"select\");\n",
" Array.prototype.forEach.call(values, function(value) {\n",
" var option = document.createElement(\"option\");\n",
" option.value = option.textContent = value;\n",
" select.appendChild(option);\n",
" });\n",
" return select;\n",
" }\n",
"\n",
" function svg(width, height) {\n",
" var svg = document.createElementNS(\"http://www.w3.org/2000/svg\", \"svg\");\n",
" svg.setAttribute(\"viewBox\", [0, 0, width, height]);\n",
" svg.setAttribute(\"width\", width);\n",
" svg.setAttribute(\"height\", height);\n",
" return svg;\n",
" }\n",
"\n",
" function text(value) {\n",
" return document.createTextNode(value);\n",
" }\n",
"\n",
" var count\\$1 = 0;\n",
"\n",
" function uid(name) {\n",
" return new Id(\"O-\" + (name == null ? \"\" : name + \"-\") + ++count\\$1);\n",
" }\n",
"\n",
" function Id(id) {\n",
" this.id = id;\n",
" this.href = new URL(\\`#\\${id}\\`, location) + \"\";\n",
" }\n",
"\n",
" Id.prototype.toString = function() {\n",
" return \"url(\" + this.href + \")\";\n",
" };\n",
"\n",
" var DOM = {\n",
" canvas: canvas,\n",
" context2d: context2d,\n",
" download: download,\n",
" element: element,\n",
" input: input,\n",
" range: range,\n",
" select: select,\n",
" svg: svg,\n",
" text: text,\n",
" uid: uid\n",
" };\n",
"\n",
" function buffer(file) {\n",
" return new Promise(function(resolve, reject) {\n",
" var reader = new FileReader;\n",
" reader.onload = function() { resolve(reader.result); };\n",
" reader.onerror = reject;\n",
" reader.readAsArrayBuffer(file);\n",
" });\n",
" }\n",
"\n",
" function text\\$1(file) {\n",
" return new Promise(function(resolve, reject) {\n",
" var reader = new FileReader;\n",
" reader.onload = function() { resolve(reader.result); };\n",
" reader.onerror = reject;\n",
" reader.readAsText(file);\n",
" });\n",
" }\n",
"\n",
" function url(file) {\n",
" return new Promise(function(resolve, reject) {\n",
" var reader = new FileReader;\n",
" reader.onload = function() { resolve(reader.result); };\n",
" reader.onerror = reject;\n",
" reader.readAsDataURL(file);\n",
" });\n",
" }\n",
"\n",
" var Files = {\n",
" buffer: buffer,\n",
" text: text\\$1,\n",
" url: url\n",
" };\n",
"\n",
" function that() {\n",
" return this;\n",
" }\n",
"\n",
" function disposable(value, dispose) {\n",
" let done = false;\n",
" return {\n",
" [Symbol.iterator]: that,\n",
" next: () => done ? {done: true} : (done = true, {done: false, value}),\n",
" return: () => (done = true, dispose(value), {done: true}),\n",
" throw: () => ({done: done = true})\n",
" };\n",
" }\n",
"\n",
" function* filter(iterator, test) {\n",
" var result, index = -1;\n",
" while (!(result = iterator.next()).done) {\n",
" if (test(result.value, ++index)) {\n",
" yield result.value;\n",
" }\n",
" }\n",
" }\n",
"\n",
" function observe(initialize) {\n",
" let stale = false;\n",
" let value;\n",
" let resolve;\n",
" const dispose = initialize(change);\n",
"\n",
" function change(x) {\n",
" if (resolve) resolve(x), resolve = null;\n",
" else stale = true;\n",
" return value = x;\n",
" }\n",
"\n",
" function next() {\n",
" return {done: false, value: stale\n",
" ? (stale = false, Promise.resolve(value))\n",
" : new Promise(_ => (resolve = _))};\n",
" }\n",
"\n",
" return {\n",
" [Symbol.iterator]: that,\n",
" throw: () => ({done: true}),\n",
" return: () => (dispose != null && dispose(), {done: true}),\n",
" next\n",
" };\n",
" }\n",
"\n",
" function input\\$1(input) {\n",
" return observe(function(change) {\n",
" var event = eventof(input), value = valueof\\$1(input);\n",
" function inputted() { change(valueof\\$1(input)); }\n",
" input.addEventListener(event, inputted);\n",
" if (value !== undefined) change(value);\n",
" return function() { input.removeEventListener(event, inputted); };\n",
" });\n",
" }\n",
"\n",
" function valueof\\$1(input) {\n",
" switch (input.type) {\n",
" case \"range\":\n",
" case \"number\": return input.valueAsNumber;\n",
" case \"date\": return input.valueAsDate;\n",
" case \"checkbox\": return input.checked;\n",
" case \"file\": return input.multiple ? input.files : input.files[0];\n",
" default: return input.value;\n",
" }\n",
" }\n",
"\n",
" function eventof(input) {\n",
" switch (input.type) {\n",
" case \"button\":\n",
" case \"submit\":\n",
" case \"checkbox\": return \"click\";\n",
" case \"file\": return \"change\";\n",
" default: return \"input\";\n",
" }\n",
" }\n",
"\n",
" function* map\\$1(iterator, transform) {\n",
" var result, index = -1;\n",
" while (!(result = iterator.next()).done) {\n",
" yield transform(result.value, ++index);\n",
" }\n",
" }\n",
"\n",
" function queue\\$1(initialize) {\n",
" let resolve;\n",
" const queue = [];\n",
" const dispose = initialize(push);\n",
"\n",
" function push(x) {\n",
" queue.push(x);\n",
" if (resolve) resolve(queue.shift()), resolve = null;\n",
" return x;\n",
" }\n",
"\n",
" function next() {\n",
" return {done: false, value: queue.length\n",
" ? Promise.resolve(queue.shift())\n",
" : new Promise(_ => (resolve = _))};\n",
" }\n",
"\n",
" return {\n",
" [Symbol.iterator]: that,\n",
" throw: () => ({done: true}),\n",
" return: () => (dispose != null && dispose(), {done: true}),\n",
" next\n",
" };\n",
" }\n",
"\n",
" function* range\\$1(start, stop, step) {\n",
" start = +start;\n",
" stop = +stop;\n",
" step = (n = arguments.length) < 2 ? (stop = start, start = 0, 1) : n < 3 ? 1 : +step;\n",
" var i = -1, n = Math.max(0, Math.ceil((stop - start) / step)) | 0;\n",
" while (++i < n) {\n",
" yield start + i * step;\n",
" }\n",
" }\n",
"\n",
" function valueAt(iterator, i) {\n",
" if (!isFinite(i = +i) || i < 0 || i !== i | 0) return;\n",
" var result, index = -1;\n",
" while (!(result = iterator.next()).done) {\n",
" if (++index === i) {\n",
" return result.value;\n",
" }\n",
" }\n",
" }\n",
"\n",
" function worker(source) {\n",
" const url = URL.createObjectURL(new Blob([source], {type: \"text/javascript\"}));\n",
" const worker = new Worker(url);\n",
" return disposable(worker, () => {\n",
" worker.terminate();\n",
" URL.revokeObjectURL(url);\n",
" });\n",
" }\n",
"\n",
" var Generators = {\n",
" disposable: disposable,\n",
" filter: filter,\n",
" input: input\\$1,\n",
" map: map\\$1,\n",
" observe: observe,\n",
" queue: queue\\$1,\n",
" range: range\\$1,\n",
" valueAt: valueAt,\n",
" worker: worker\n",
" };\n",
"\n",
" function template(render, wrapper) {\n",
" return function(strings) {\n",
" var string = strings[0],\n",
" parts = [], part,\n",
" root = null,\n",
" node, nodes,\n",
" walker,\n",
" i, n, j, m, k = -1;\n",
"\n",
" // Concatenate the text using comments as placeholders.\n",
" for (i = 1, n = arguments.length; i < n; ++i) {\n",
" part = arguments[i];\n",
" if (part instanceof Node) {\n",
" parts[++k] = part;\n",
" string += \"<!--o:\" + k + \"-->\";\n",
" } else if (Array.isArray(part)) {\n",
" for (j = 0, m = part.length; j < m; ++j) {\n",
" node = part[j];\n",
" if (node instanceof Node) {\n",
" if (root === null) {\n",
" parts[++k] = root = document.createDocumentFragment();\n",
" string += \"<!--o:\" + k + \"-->\";\n",
" }\n",
" root.appendChild(node);\n",
" } else {\n",
" root = null;\n",
" string += node;\n",
" }\n",
" }\n",
" root = null;\n",
" } else {\n",
" string += part;\n",
" }\n",
" string += strings[i];\n",
" }\n",
"\n",
" // Render the text.\n",
" root = render(string);\n",
"\n",
" // Walk the rendered content to replace comment placeholders.\n",
" if (++k > 0) {\n",
" nodes = new Array(k);\n",
" walker = document.createTreeWalker(root, NodeFilter.SHOW_COMMENT, null, false);\n",
" while (walker.nextNode()) {\n",
" node = walker.currentNode;\n",
" if (/^o:/.test(node.nodeValue)) {\n",
" nodes[+node.nodeValue.slice(2)] = node;\n",
" }\n",
" }\n",
" for (i = 0; i < k; ++i) {\n",
" if (node = nodes[i]) {\n",
" node.parentNode.replaceChild(parts[i], node);\n",
" }\n",
" }\n",
" }\n",
"\n",
" // Is the rendered content\n",
" // … a parent of a single child? Detach and return the child.\n",
" // … a document fragment? Replace the fragment with an element.\n",
" // … some other node? Return it.\n",
" return root.childNodes.length === 1 ? root.removeChild(root.firstChild)\n",
" : root.nodeType === 11 ? ((node = wrapper()).appendChild(root), node)\n",
" : root;\n",
" };\n",
" }\n",
"\n",
" var html = template(function(string) {\n",
" var template = document.createElement(\"template\");\n",
" template.innerHTML = string.trim();\n",
" return document.importNode(template.content, true);\n",
" }, function() {\n",
" return document.createElement(\"span\");\n",
" });\n",
"\n",
" const HL_ROOT =\n",
" \"https://cdn.jsdelivr.net/npm/@observablehq/highlight.js@2.0.0/\";\n",
"\n",
" function md(require) {\n",
" return function() {\n",
" return require(\"marked@0.3.12/marked.min.js\").then(function(marked) {\n",
" return template(\n",
" function(string) {\n",
" var root = document.createElement(\"div\");\n",
" root.innerHTML = marked(string, {langPrefix: \"\"}).trim();\n",
" var code = root.querySelectorAll(\"pre code[class]\");\n",
" if (code.length > 0) {\n",
" require(HL_ROOT + \"highlight.min.js\").then(function(hl) {\n",
" code.forEach(function(block) {\n",
" function done() {\n",
" hl.highlightBlock(block);\n",
" block.parentNode.classList.add(\"observablehq--md-pre\");\n",
" }\n",
" if (hl.getLanguage(block.className)) {\n",
" done();\n",
" } else {\n",
" require(HL_ROOT + \"async-languages/index.js\")\n",
" .then(index => {\n",
" if (index.has(block.className)) {\n",
" return require(HL_ROOT +\n",
" \"async-languages/\" +\n",
" index.get(block.className)).then(language => {\n",
" hl.registerLanguage(block.className, language);\n",
" });\n",
" }\n",
" })\n",
" .then(done, done);\n",
" }\n",
" });\n",
" });\n",
" }\n",
" return root;\n",
" },\n",
" function() {\n",
" return document.createElement(\"div\");\n",
" }\n",
" );\n",
" });\n",
" };\n",
" }\n",
"\n",
" function Mutable(value) {\n",
" let change;\n",
" Object.defineProperties(this, {\n",
" generator: {value: observe(_ => void (change = _))},\n",
" value: {get: () => value, set: x => change(value = x)}\n",
" });\n",
" if (value !== undefined) change(value);\n",
" }\n",
"\n",
" function* now() {\n",
" while (true) {\n",
" yield Date.now();\n",
" }\n",
" }\n",
"\n",
" function delay(duration, value) {\n",
" return new Promise(function(resolve) {\n",
" setTimeout(function() {\n",
" resolve(value);\n",
" }, duration);\n",
" });\n",
" }\n",
"\n",
" var timeouts = new Map;\n",
"\n",
" function timeout(now, time) {\n",
" var t = new Promise(function(resolve) {\n",
" timeouts.delete(time);\n",
" var delay = time - now;\n",
" if (!(delay > 0)) throw new Error(\"invalid time\");\n",
" if (delay > 0x7fffffff) throw new Error(\"too long to wait\");\n",
" setTimeout(resolve, delay);\n",
" });\n",
" timeouts.set(time, t);\n",
" return t;\n",
" }\n",
"\n",
" function when(time, value) {\n",
" var now;\n",
" return (now = timeouts.get(time = +time)) ? now.then(constant(value))\n",
" : (now = Date.now()) >= time ? Promise.resolve(value)\n",
" : timeout(now, time).then(constant(value));\n",
" }\n",
"\n",
" function tick(duration, value) {\n",
" return when(Math.ceil((Date.now() + 1) / duration) * duration, value);\n",
" }\n",
"\n",
" var Promises = {\n",
" delay: delay,\n",
" tick: tick,\n",
" when: when\n",
" };\n",
"\n",
" function resolve\\$1(name, base) {\n",
" if (/^(\\\\w+:)|\\\\/\\\\//i.test(name)) return name;\n",
" if (/^[.]{0,2}\\\\//i.test(name)) return new URL(name, base == null ? location : base).href;\n",
" if (!name.length || /^[\\\\s._]/.test(name) || /\\\\s\\$/.test(name)) throw new Error(\"illegal name\");\n",
" return \"https://unpkg.com/\" + name;\n",
" }\n",
"\n",
" function requirer(resolve) {\n",
" return resolve == null ? require : requireFrom(resolve);\n",
" }\n",
"\n",
" var svg\\$1 = template(function(string) {\n",
" var root = document.createElementNS(\"http://www.w3.org/2000/svg\", \"g\");\n",
" root.innerHTML = string.trim();\n",
" return root;\n",
" }, function() {\n",
" return document.createElementNS(\"http://www.w3.org/2000/svg\", \"g\");\n",
" });\n",
"\n",
" var raw = String.raw;\n",
"\n",
" function style(href) {\n",
" return new Promise(function(resolve, reject) {\n",
" var link = document.createElement(\"link\");\n",
" link.rel = \"stylesheet\";\n",
" link.href = href;\n",
" link.onerror = reject;\n",
" link.onload = resolve;\n",
" document.head.appendChild(link);\n",
" });\n",
" }\n",
"\n",
" function tex(require) {\n",
" return function() {\n",
" return Promise.all([\n",
" require(\"@observablehq/katex@0.11.1/dist/katex.min.js\"),\n",
" require.resolve(\"@observablehq/katex@0.11.1/dist/katex.min.css\").then(style)\n",
" ]).then(function(values) {\n",
" var katex = values[0], tex = renderer();\n",
"\n",
" function renderer(options) {\n",
" return function() {\n",
" var root = document.createElement(\"div\");\n",
" katex.render(raw.apply(String, arguments), root, options);\n",
" return root.removeChild(root.firstChild);\n",
" };\n",
" }\n",
"\n",
" tex.options = renderer;\n",
" tex.block = renderer({displayMode: true});\n",
" return tex;\n",
" });\n",
" };\n",
" }\n",
"\n",
" function width() {\n",
" return observe(function(change) {\n",
" var width = change(document.body.clientWidth);\n",
" function resized() {\n",
" var w = document.body.clientWidth;\n",
" if (w !== width) change(width = w);\n",
" }\n",
" window.addEventListener(\"resize\", resized);\n",
" return function() {\n",
" window.removeEventListener(\"resize\", resized);\n",
" };\n",
" });\n",
" }\n",
"\n",
" var Library = Object.assign(function Library(resolver) {\n",
" const require = requirer(resolver);\n",
" Object.defineProperties(this, {\n",
" DOM: {value: DOM, writable: true, enumerable: true},\n",
" FileAttachment: {value: constant(NoFileAttachments), writable: true, enumerable: true},\n",
" Files: {value: Files, writable: true, enumerable: true},\n",
" Generators: {value: Generators, writable: true, enumerable: true},\n",
" html: {value: constant(html), writable: true, enumerable: true},\n",
" md: {value: md(require), writable: true, enumerable: true},\n",
" Mutable: {value: constant(Mutable), writable: true, enumerable: true},\n",
" now: {value: now, writable: true, enumerable: true},\n",
" Promises: {value: Promises, writable: true, enumerable: true},\n",
" require: {value: constant(require), writable: true, enumerable: true},\n",
" resolve: {value: constant(resolve\\$1), writable: true, enumerable: true},\n",
" svg: {value: constant(svg\\$1), writable: true, enumerable: true},\n",
" tex: {value: tex(require), writable: true, enumerable: true},\n",
" width: {value: width, writable: true, enumerable: true}\n",
" });\n",
" }, {resolve: require.resolve});\n",
"\n",
" function RuntimeError(message, input) {\n",
" this.message = message + \"\";\n",
" this.input = input;\n",
" }\n",
"\n",
" RuntimeError.prototype = Object.create(Error.prototype);\n",
" RuntimeError.prototype.name = \"RuntimeError\";\n",
" RuntimeError.prototype.constructor = RuntimeError;\n",
"\n",
" function generatorish(value) {\n",
" return value\n",
" && typeof value.next === \"function\"\n",
" && typeof value.return === \"function\";\n",
" }\n",
"\n",
" function load(notebook, library, observer) {\n",
" if (typeof library == \"function\") observer = library, library = null;\n",
" if (typeof observer !== \"function\") throw new Error(\"invalid observer\");\n",
" if (library == null) library = new Library();\n",
"\n",
" const {modules, id} = notebook;\n",
" const map = new Map;\n",
" const runtime = new Runtime(library);\n",
" const main = runtime_module(id);\n",
"\n",
" function runtime_module(id) {\n",
" let module = map.get(id);\n",
" if (!module) map.set(id, module = runtime.module());\n",
" return module;\n",
" }\n",
"\n",
" for (const m of modules) {\n",
" const module = runtime_module(m.id);\n",
" let i = 0;\n",
" for (const v of m.variables) {\n",
" if (v.from) module.import(v.remote, v.name, runtime_module(v.from));\n",
" else if (module === main) module.variable(observer(v, i, m.variables)).define(v.name, v.inputs, v.value);\n",
" else module.define(v.name, v.inputs, v.value);\n",
" ++i;\n",
" }\n",
" }\n",
"\n",
" return runtime;\n",
" }\n",
"\n",
" var prototype = Array.prototype;\n",
" var map\\$2 = prototype.map;\n",
" var forEach = prototype.forEach;\n",
"\n",
" function constant\\$1(x) {\n",
" return function() {\n",
" return x;\n",
" };\n",
" }\n",
"\n",
" function identity(x) {\n",
" return x;\n",
" }\n",
"\n",
" function rethrow(e) {\n",
" return function() {\n",
" throw e;\n",
" };\n",
" }\n",
"\n",
" function noop() {}\n",
"\n",
" var TYPE_NORMAL = 1; // a normal variable\n",
" var TYPE_IMPLICIT = 2; // created on reference\n",
" var TYPE_DUPLICATE = 3; // created on duplicate definition\n",
"\n",
" var no_observer = {};\n",
"\n",
" function Variable(type, module, observer) {\n",
" if (observer == null) observer = no_observer;\n",
" Object.defineProperties(this, {\n",
" _observer: {value: observer, writable: true},\n",
" _definition: {value: variable_undefined, writable: true},\n",
" _duplicate: {value: undefined, writable: true},\n",
" _duplicates: {value: undefined, writable: true},\n",
" _indegree: {value: NaN, writable: true}, // The number of computing inputs.\n",
" _inputs: {value: [], writable: true},\n",
" _invalidate: {value: noop, writable: true},\n",
" _module: {value: module},\n",
" _name: {value: null, writable: true},\n",
" _outputs: {value: new Set, writable: true},\n",
" _promise: {value: Promise.resolve(undefined), writable: true},\n",
" _reachable: {value: observer !== no_observer, writable: true}, // Is this variable transitively visible?\n",
" _rejector: {value: variable_rejector(this)},\n",
" _type: {value: type},\n",
" _value: {value: undefined, writable: true},\n",
" _version: {value: 0, writable: true}\n",
" });\n",
" }\n",
"\n",
" Object.defineProperties(Variable.prototype, {\n",
" _pending: {value: variable_pending, writable: true, configurable: true},\n",
" _fulfilled: {value: variable_fulfilled, writable: true, configurable: true},\n",
" _rejected: {value: variable_rejected, writable: true, configurable: true},\n",
" define: {value: variable_define, writable: true, configurable: true},\n",
" delete: {value: variable_delete, writable: true, configurable: true},\n",
" import: {value: variable_import, writable: true, configurable: true}\n",
" });\n",
"\n",
" function variable_attach(variable) {\n",
" variable._module._runtime._dirty.add(variable);\n",
" variable._outputs.add(this);\n",
" }\n",
"\n",
" function variable_detach(variable) {\n",
" variable._module._runtime._dirty.add(variable);\n",
" variable._outputs.delete(this);\n",
" }\n",
"\n",
" function variable_undefined() {\n",
" throw variable_undefined;\n",
" }\n",
"\n",
" function variable_rejector(variable) {\n",
" return function(error) {\n",
" if (error === variable_undefined) throw new RuntimeError(variable._name + \" is not defined\", variable._name);\n",
" throw new RuntimeError(variable._name + \" could not be resolved\", variable._name);\n",
" };\n",
" }\n",
"\n",
" function variable_duplicate(name) {\n",
" return function() {\n",
" throw new RuntimeError(name + \" is defined more than once\");\n",
" };\n",
" }\n",
"\n",
" function variable_define(name, inputs, definition) {\n",
" switch (arguments.length) {\n",
" case 1: {\n",
" definition = name, name = inputs = null;\n",
" break;\n",
" }\n",
" case 2: {\n",
" definition = inputs;\n",
" if (typeof name === \"string\") inputs = null;\n",
" else inputs = name, name = null;\n",
" break;\n",
" }\n",
" }\n",
" return variable_defineImpl.call(this,\n",
" name == null ? null : name + \"\",\n",
" inputs == null ? [] : map\\$2.call(inputs, this._module._resolve, this._module),\n",
" typeof definition === \"function\" ? definition : constant\\$1(definition)\n",
" );\n",
" }\n",
"\n",
" function variable_defineImpl(name, inputs, definition) {\n",
" var scope = this._module._scope, runtime = this._module._runtime;\n",
"\n",
" this._inputs.forEach(variable_detach, this);\n",
" inputs.forEach(variable_attach, this);\n",
" this._inputs = inputs;\n",
" this._definition = definition;\n",
" this._value = undefined;\n",
"\n",
" // Is this an active variable (that may require disposal)?\n",
" if (definition === noop) runtime._variables.delete(this);\n",
" else runtime._variables.add(this);\n",
"\n",
" // Did the variable’s name change? Time to patch references!\n",
" if (name == this._name && scope.get(name) === this) {\n",
" this._outputs.forEach(runtime._updates.add, runtime._updates);\n",
" } else {\n",
" var error, found;\n",
"\n",
" if (this._name) { // Did this variable previously have a name?\n",
" if (this._outputs.size) { // And did other variables reference this variable?\n",
" scope.delete(this._name);\n",
" found = this._module._resolve(this._name);\n",
" found._outputs = this._outputs, this._outputs = new Set;\n",
" found._outputs.forEach(function(output) { output._inputs[output._inputs.indexOf(this)] = found; }, this);\n",
" found._outputs.forEach(runtime._updates.add, runtime._updates);\n",
" runtime._dirty.add(found).add(this);\n",
" scope.set(this._name, found);\n",
" } else if ((found = scope.get(this._name)) === this) { // Do no other variables reference this variable?\n",
" scope.delete(this._name); // It’s safe to delete!\n",
" } else if (found._type === TYPE_DUPLICATE) { // Do other variables assign this name?\n",
" found._duplicates.delete(this); // This variable no longer assigns this name.\n",
" this._duplicate = undefined;\n",
" if (found._duplicates.size === 1) { // Is there now only one variable assigning this name?\n",
" found = found._duplicates.keys().next().value; // Any references are now fixed!\n",
" error = scope.get(this._name);\n",
" found._outputs = error._outputs, error._outputs = new Set;\n",
" found._outputs.forEach(function(output) { output._inputs[output._inputs.indexOf(error)] = found; });\n",
" found._definition = found._duplicate, found._duplicate = undefined;\n",
" runtime._dirty.add(error).add(found);\n",
" runtime._updates.add(found);\n",
" scope.set(this._name, found);\n",
" }\n",
" } else {\n",
" throw new Error;\n",
" }\n",
" }\n",
"\n",
" if (this._outputs.size) throw new Error;\n",
"\n",
" if (name) { // Does this variable have a new name?\n",
" if (found = scope.get(name)) { // Do other variables reference or assign this name?\n",
" if (found._type === TYPE_DUPLICATE) { // Do multiple other variables already define this name?\n",
" this._definition = variable_duplicate(name), this._duplicate = definition;\n",
" found._duplicates.add(this);\n",
" } else if (found._type === TYPE_IMPLICIT) { // Are the variable references broken?\n",
" this._outputs = found._outputs, found._outputs = new Set; // Now they’re fixed!\n",
" this._outputs.forEach(function(output) { output._inputs[output._inputs.indexOf(found)] = this; }, this);\n",
" runtime._dirty.add(found).add(this);\n",
" scope.set(name, this);\n",
" } else { // Does another variable define this name?\n",
" found._duplicate = found._definition, this._duplicate = definition; // Now they’re duplicates.\n",
" error = new Variable(TYPE_DUPLICATE, this._module);\n",
" error._name = name;\n",
" error._definition = this._definition = found._definition = variable_duplicate(name);\n",
" error._outputs = found._outputs, found._outputs = new Set;\n",
" error._outputs.forEach(function(output) { output._inputs[output._inputs.indexOf(found)] = error; });\n",
" error._duplicates = new Set([this, found]);\n",
" runtime._dirty.add(found).add(error);\n",
" runtime._updates.add(found).add(error);\n",
" scope.set(name, error);\n",
" }\n",
" } else {\n",
" scope.set(name, this);\n",
" }\n",
" }\n",
"\n",
" this._name = name;\n",
" }\n",
"\n",
" runtime._updates.add(this);\n",
" runtime._compute();\n",
" return this;\n",
" }\n",
"\n",
" function variable_import(remote, name, module) {\n",
" if (arguments.length < 3) module = name, name = remote;\n",
" return variable_defineImpl.call(this, name + \"\", [module._resolve(remote + \"\")], identity);\n",
" }\n",
"\n",
" function variable_delete() {\n",
" return variable_defineImpl.call(this, null, [], noop);\n",
" }\n",
"\n",
" function variable_pending() {\n",
" if (this._observer.pending) this._observer.pending();\n",
" }\n",
"\n",
" function variable_fulfilled(value) {\n",
" if (this._observer.fulfilled) this._observer.fulfilled(value, this._name);\n",
" }\n",
"\n",
" function variable_rejected(error) {\n",
" if (this._observer.rejected) this._observer.rejected(error, this._name);\n",
" }\n",
"\n",
" function Module(runtime, builtins = []) {\n",
" Object.defineProperties(this, {\n",
" _runtime: {value: runtime},\n",
" _scope: {value: new Map},\n",
" _builtins: {value: new Map([\n",
" [\"invalidation\", variable_invalidation],\n",
" [\"visibility\", variable_visibility],\n",
" ...builtins\n",
" ])},\n",
" _source: {value: null, writable: true}\n",
" });\n",
" }\n",
"\n",
" Object.defineProperties(Module.prototype, {\n",
" _copy: {value: module_copy, writable: true, configurable: true},\n",
" _resolve: {value: module_resolve, writable: true, configurable: true},\n",
" redefine: {value: module_redefine, writable: true, configurable: true},\n",
" define: {value: module_define, writable: true, configurable: true},\n",
" derive: {value: module_derive, writable: true, configurable: true},\n",
" import: {value: module_import, writable: true, configurable: true},\n",
" value: {value: module_value, writable: true, configurable: true},\n",
" variable: {value: module_variable, writable: true, configurable: true},\n",
" builtin: {value: module_builtin, writable: true, configurable: true}\n",
" });\n",
"\n",
" function module_redefine(name) {\n",
" var v = this._scope.get(name);\n",
" if (!v) throw new RuntimeError(name + \" is not defined\");\n",
" if (v._type === TYPE_DUPLICATE) throw new RuntimeError(name + \" is defined more than once\");\n",
" return v.define.apply(v, arguments);\n",
" }\n",
"\n",
" function module_define() {\n",
" var v = new Variable(TYPE_NORMAL, this);\n",
" return v.define.apply(v, arguments);\n",
" }\n",
"\n",
" function module_import() {\n",
" var v = new Variable(TYPE_NORMAL, this);\n",
" return v.import.apply(v, arguments);\n",
" }\n",
"\n",
" function module_variable(observer) {\n",
" return new Variable(TYPE_NORMAL, this, observer);\n",
" }\n",
"\n",
" async function module_value(name) {\n",
" var v = this._scope.get(name);\n",
" if (!v) throw new RuntimeError(name + \" is not defined\");\n",
" if (v._observer === no_observer) {\n",
" v._observer = true;\n",
" this._runtime._dirty.add(v);\n",
" }\n",
" await this._runtime._compute();\n",
" return v._promise;\n",
" }\n",
"\n",
" function module_derive(injects, injectModule) {\n",
" var copy = new Module(this._runtime, this._builtins);\n",
" copy._source = this;\n",
" forEach.call(injects, function(inject) {\n",
" if (typeof inject !== \"object\") inject = {name: inject + \"\"};\n",
" if (inject.alias == null) inject.alias = inject.name;\n",
" copy.import(inject.name, inject.alias, injectModule);\n",
" });\n",
" Promise.resolve().then(() => {\n",
" const modules = new Set([this]);\n",
" for (const module of modules) {\n",
" for (const variable of module._scope.values()) {\n",
" if (variable._definition === identity) { // import\n",
" const module = variable._inputs[0]._module;\n",
" const source = module._source || module;\n",
" if (source === this) { // circular import-with!\n",
" console.warn(\"circular module definition; ignoring\"); // eslint-disable-line no-console\n",
" return;\n",
" }\n",
" modules.add(source);\n",
" }\n",
" }\n",
" }\n",
" this._copy(copy, new Map);\n",
" });\n",
" return copy;\n",
" }\n",
"\n",
" function module_copy(copy, map) {\n",
" copy._source = this;\n",
" map.set(this, copy);\n",
" for (const [name, source] of this._scope) {\n",
" var target = copy._scope.get(name);\n",
" if (target && target._type === TYPE_NORMAL) continue; // injection\n",
" if (source._definition === identity) { // import\n",
" var sourceInput = source._inputs[0],\n",
" sourceModule = sourceInput._module;\n",
" copy.import(sourceInput._name, name, map.get(sourceModule)\n",
" || (sourceModule._source\n",
" ? sourceModule._copy(new Module(copy._runtime, copy._builtins), map) // import-with\n",
" : sourceModule));\n",
" } else {\n",
" copy.define(name, source._inputs.map(variable_name), source._definition);\n",
" }\n",
" }\n",
" return copy;\n",
" }\n",
"\n",
" function module_resolve(name) {\n",
" var variable = this._scope.get(name), value;\n",
" if (!variable) {\n",
" variable = new Variable(TYPE_IMPLICIT, this);\n",
" if (this._builtins.has(name)) {\n",
" variable.define(name, constant\\$1(this._builtins.get(name)));\n",
" } else if (this._runtime._builtin._scope.has(name)) {\n",
" variable.import(name, this._runtime._builtin);\n",
" } else {\n",
" try {\n",
" value = this._runtime._global(name);\n",
" } catch (error) {\n",
" return variable.define(name, rethrow(error));\n",
" }\n",
" if (value === undefined) {\n",
" this._scope.set(variable._name = name, variable);\n",
" } else {\n",
" variable.define(name, constant\\$1(value));\n",
" }\n",
" }\n",
" }\n",
" return variable;\n",
" }\n",
"\n",
" function module_builtin(name, value) {\n",
" this._builtins.set(name, value);\n",
" }\n",
"\n",
" function variable_name(variable) {\n",
" return variable._name;\n",
" }\n",
"\n",
" const frame = typeof requestAnimationFrame === \"function\" ? requestAnimationFrame : setImmediate;\n",
"\n",
" var variable_invalidation = {};\n",
" var variable_visibility = {};\n",
"\n",
" function Runtime(builtins = new Library, global = window_global) {\n",
" var builtin = this.module();\n",
" Object.defineProperties(this, {\n",
" _dirty: {value: new Set},\n",
" _updates: {value: new Set},\n",
" _computing: {value: null, writable: true},\n",
" _init: {value: null, writable: true},\n",
" _modules: {value: new Map},\n",
" _variables: {value: new Set},\n",
" _disposed: {value: false, writable: true},\n",
" _builtin: {value: builtin},\n",
" _global: {value: global}\n",
" });\n",
" if (builtins) for (var name in builtins) {\n",
" (new Variable(TYPE_IMPLICIT, builtin)).define(name, [], builtins[name]);\n",
" }\n",
" }\n",
"\n",
" Object.defineProperties(Runtime, {\n",
" load: {value: load, writable: true, configurable: true}\n",
" });\n",
"\n",
" Object.defineProperties(Runtime.prototype, {\n",
" _compute: {value: runtime_compute, writable: true, configurable: true},\n",
" _computeSoon: {value: runtime_computeSoon, writable: true, configurable: true},\n",
" _computeNow: {value: runtime_computeNow, writable: true, configurable: true},\n",
" dispose: {value: runtime_dispose, writable: true, configurable: true},\n",
" module: {value: runtime_module, writable: true, configurable: true},\n",
" fileAttachments: {value: FileAttachments, writable: true, configurable: true}\n",
" });\n",
"\n",
" function runtime_dispose() {\n",
" this._computing = Promise.resolve();\n",
" this._disposed = true;\n",
" this._variables.forEach(v => {\n",
" v._invalidate();\n",
" v._version = NaN;\n",
" });\n",
" }\n",
"\n",
" function runtime_module(define, observer = noop) {\n",
" let module;\n",
" if (define === undefined) {\n",
" if (module = this._init) {\n",
" this._init = null;\n",
" return module;\n",
" }\n",
" return new Module(this);\n",
" }\n",
" module = this._modules.get(define);\n",
" if (module) return module;\n",
" this._init = module = new Module(this);\n",
" this._modules.set(define, module);\n",
" try {\n",
" define(this, observer);\n",
" } finally {\n",
" this._init = null;\n",
" }\n",
" return module;\n",
" }\n",
"\n",
" function runtime_compute() {\n",
" return this._computing || (this._computing = this._computeSoon());\n",
" }\n",
"\n",
" function runtime_computeSoon() {\n",
" var runtime = this;\n",
" return new Promise(function(resolve) {\n",
" frame(function() {\n",
" resolve();\n",
" runtime._disposed || runtime._computeNow();\n",
" });\n",
" });\n",
" }\n",
"\n",
" function runtime_computeNow() {\n",
" var queue = [],\n",
" variables,\n",
" variable;\n",
"\n",
" // Compute the reachability of the transitive closure of dirty variables.\n",
" // Any newly-reachable variable must also be recomputed.\n",
" // Any no-longer-reachable variable must be terminated.\n",
" variables = new Set(this._dirty);\n",
" variables.forEach(function(variable) {\n",
" variable._inputs.forEach(variables.add, variables);\n",
" const reachable = variable_reachable(variable);\n",
" if (reachable > variable._reachable) {\n",
" this._updates.add(variable);\n",
" } else if (reachable < variable._reachable) {\n",
" variable._invalidate();\n",
" }\n",
" variable._reachable = reachable;\n",
" }, this);\n",
"\n",
" // Compute the transitive closure of updating, reachable variables.\n",
" variables = new Set(this._updates);\n",
" variables.forEach(function(variable) {\n",
" if (variable._reachable) {\n",
" variable._indegree = 0;\n",
" variable._outputs.forEach(variables.add, variables);\n",
" } else {\n",
" variable._indegree = NaN;\n",
" variables.delete(variable);\n",
" }\n",
" });\n",
"\n",
" this._computing = null;\n",
" this._updates.clear();\n",
" this._dirty.clear();\n",
"\n",
" // Compute the indegree of updating variables.\n",
" variables.forEach(function(variable) {\n",
" variable._outputs.forEach(variable_increment);\n",
" });\n",
"\n",
" do {\n",
" // Identify the root variables (those with no updating inputs).\n",
" variables.forEach(function(variable) {\n",
" if (variable._indegree === 0) {\n",
" queue.push(variable);\n",
" }\n",
" });\n",
"\n",
" // Compute the variables in topological order.\n",
" while (variable = queue.pop()) {\n",
" variable_compute(variable);\n",
" variable._outputs.forEach(postqueue);\n",
" variables.delete(variable);\n",
" }\n",
"\n",
" // Any remaining variables are circular, or depend on them.\n",
" variables.forEach(function(variable) {\n",
" if (variable_circular(variable)) {\n",
" variable_error(variable, new RuntimeError(\"circular definition\"));\n",
" variable._outputs.forEach(variable_decrement);\n",
" variables.delete(variable);\n",
" }\n",
" });\n",
" } while (variables.size);\n",
"\n",
" function postqueue(variable) {\n",
" if (--variable._indegree === 0) {\n",
" queue.push(variable);\n",
" }\n",
" }\n",
" }\n",
"\n",
" function variable_circular(variable) {\n",
" const inputs = new Set(variable._inputs);\n",
" for (const i of inputs) {\n",
" if (i === variable) return true;\n",
" i._inputs.forEach(inputs.add, inputs);\n",
" }\n",
" return false;\n",
" }\n",
"\n",
" function variable_increment(variable) {\n",
" ++variable._indegree;\n",
" }\n",
"\n",
" function variable_decrement(variable) {\n",
" --variable._indegree;\n",
" }\n",
"\n",
" function variable_value(variable) {\n",
" return variable._promise.catch(variable._rejector);\n",
" }\n",
"\n",
" function variable_invalidator(variable) {\n",
" return new Promise(function(resolve) {\n",
" variable._invalidate = resolve;\n",
" });\n",
" }\n",
"\n",
" function variable_intersector(invalidation, variable) {\n",
" let node = typeof IntersectionObserver === \"function\" && variable._observer && variable._observer._node;\n",
" let visible = !node, resolve = noop, reject = noop, promise, observer;\n",
" if (node) {\n",
" observer = new IntersectionObserver(([entry]) => (visible = entry.isIntersecting) && (promise = null, resolve()));\n",
" observer.observe(node);\n",
" invalidation.then(() => (observer.disconnect(), observer = null, reject()));\n",
" }\n",
" return function(value) {\n",
" if (visible) return Promise.resolve(value);\n",
" if (!observer) return Promise.reject();\n",
" if (!promise) promise = new Promise((y, n) => (resolve = y, reject = n));\n",
" return promise.then(() => value);\n",
" };\n",
" }\n",
"\n",
" function variable_compute(variable) {\n",
" variable._invalidate();\n",
" variable._invalidate = noop;\n",
" variable._pending();\n",
" var value0 = variable._value,\n",
" version = ++variable._version,\n",
" invalidation = null,\n",
" promise = variable._promise = Promise.all(variable._inputs.map(variable_value)).then(function(inputs) {\n",
" if (variable._version !== version) return;\n",
"\n",
" // Replace any reference to invalidation with the promise, lazily.\n",
" for (var i = 0, n = inputs.length; i < n; ++i) {\n",
" switch (inputs[i]) {\n",
" case variable_invalidation: {\n",
" inputs[i] = invalidation = variable_invalidator(variable);\n",
" break;\n",
" }\n",
" case variable_visibility: {\n",
" if (!invalidation) invalidation = variable_invalidator(variable);\n",
" inputs[i] = variable_intersector(invalidation, variable);\n",
" break;\n",
" }\n",
" }\n",
" }\n",
"\n",
" // Compute the initial value of the variable.\n",
" return variable._definition.apply(value0, inputs);\n",
" }).then(function(value) {\n",
" // If the value is a generator, then retrieve its first value,\n",
" // and dispose of the generator if the variable is invalidated.\n",
" // Note that the cell may already have been invalidated here,\n",
" // in which case we need to terminate the generator immediately!\n",
" if (generatorish(value)) {\n",
" if (variable._version !== version) return void value.return();\n",
" (invalidation || variable_invalidator(variable)).then(variable_return(value));\n",
" return variable_precompute(variable, version, promise, value);\n",
" }\n",
" return value;\n",
" });\n",
" promise.then(function(value) {\n",
" if (variable._version !== version) return;\n",
" variable._value = value;\n",
" variable._fulfilled(value);\n",
" }, function(error) {\n",
" if (variable._version !== version) return;\n",
" variable._value = undefined;\n",
" variable._rejected(error);\n",
" });\n",
" }\n",
"\n",
" function variable_precompute(variable, version, promise, generator) {\n",
" function recompute() {\n",
" var promise = new Promise(function(resolve) {\n",
" resolve(generator.next());\n",
" }).then(function(next) {\n",
" return next.done ? undefined : Promise.resolve(next.value).then(function(value) {\n",
" if (variable._version !== version) return;\n",
" variable_postrecompute(variable, value, promise).then(recompute);\n",
" variable._fulfilled(value);\n",
" return value;\n",
" });\n",
" });\n",
" promise.catch(function(error) {\n",
" if (variable._version !== version) return;\n",
" variable_postrecompute(variable, undefined, promise);\n",
" variable._rejected(error);\n",
" });\n",
" }\n",
" return new Promise(function(resolve) {\n",
" resolve(generator.next());\n",
" }).then(function(next) {\n",
" if (next.done) return;\n",
" promise.then(recompute);\n",
" return next.value;\n",
" });\n",
" }\n",
"\n",
" function variable_postrecompute(variable, value, promise) {\n",
" var runtime = variable._module._runtime;\n",
" variable._value = value;\n",
" variable._promise = promise;\n",
" variable._outputs.forEach(runtime._updates.add, runtime._updates); // TODO Cleaner?\n",
" return runtime._compute();\n",
" }\n",
"\n",
" function variable_error(variable, error) {\n",
" variable._invalidate();\n",
" variable._invalidate = noop;\n",
" variable._pending();\n",
" ++variable._version;\n",
" variable._indegree = NaN;\n",
" (variable._promise = Promise.reject(error)).catch(noop);\n",
" variable._value = undefined;\n",
" variable._rejected(error);\n",
" }\n",
"\n",
" function variable_return(generator) {\n",
" return function() {\n",
" generator.return();\n",
" };\n",
" }\n",
"\n",
" function variable_reachable(variable) {\n",
" if (variable._observer !== no_observer) return true; // Directly reachable.\n",
" var outputs = new Set(variable._outputs);\n",
" for (const output of outputs) {\n",
" if (output._observer !== no_observer) return true;\n",
" output._outputs.forEach(outputs.add, outputs);\n",
" }\n",
" return false;\n",
" }\n",
"\n",
" function window_global(name) {\n",
" return window[name];\n",
" }\n",
"\n",
" const MONITOR_INTERVAL = 200;\n",
"\n",
" class DocumentBodyDimensionsMutationObserverMonitor {\n",
" constructor() {\n",
" this.lastHeight = -1;\n",
"\n",
" this.onMutation = entries => {\n",
" const height = document.body.clientHeight;\n",
" if (height !== this.lastHeight) {\n",
" this.lastHeight = height;\n",
" postHeight(this.lastHeight);\n",
" }\n",
" };\n",
" }\n",
"\n",
" start() {\n",
" this.observer = new MutationObserver(this.onMutation);\n",
" this.observer.observe(document.body, {\n",
" childList: true,\n",
" attributes: true,\n",
" subtree: true\n",
" });\n",
" }\n",
" }\n",
"\n",
" class DocumentBodyDimensionsResizeObserverMonitor {\n",
" constructor() {\n",
" if (typeof window.ResizeObserver === \"undefined\") {\n",
" throw Error(\"ResizeObserver is not supported\");\n",
" }\n",
" this.lastHeight = -1;\n",
"\n",
" this.onResize = entries => {\n",
" for (let entry of entries) {\n",
" const height = entry.contentRect.height;\n",
" if (height !== this.lastHeight) {\n",
" this.lastHeight = height;\n",
" postHeight(this.lastHeight);\n",
" }\n",
" }\n",
" };\n",
" }\n",
"\n",
" start() {\n",
" this.observer = new ResizeObserver(this.onResize);\n",
" this.observer.observe(document.body);\n",
" }\n",
" }\n",
"\n",
" class DocumentBodyDimensionsPollingMonitor {\n",
" constructor() {\n",
" this.lastHeight = -1;\n",
" this.timer = undefined;\n",
"\n",
" this.checkAndSchedule = () => {\n",
" if (!this.monitoring) return;\n",
" this.check();\n",
" this.monitoring = setTimeout(this.checkAndSchedule, MONITOR_INTERVAL);\n",
" };\n",
"\n",
" this.onMessage = event => {\n",
" if (window.parent !== event.source) {\n",
" return;\n",
" }\n",
" if (msg.data.type === \"cleanup\") {\n",
" this.cleanup();\n",
" }\n",
" };\n",
" }\n",
"\n",
" start() {\n",
" if (!this.monitoring) {\n",
" this.monitoring = true;\n",
" this.checkAndSchedule();\n",
" }\n",
" }\n",
"\n",
" stop() {\n",
" if (this.monitoring) {\n",
" clearTimeout(this.monitoring);\n",
" }\n",
" this.monitoring = undefined;\n",
" }\n",
"\n",
" check() {\n",
" const height = document.body.clientHeight;\n",
" if (height !== this.lastHeight) {\n",
" this.lastHeight = height;\n",
" postHeight(this.lastHeight);\n",
" }\n",
" }\n",
"\n",
" /* Never used in the normal iframe embedding since everything stops\n",
" * when the iframe gets unmounted */\n",
" cleanup() {\n",
" this.stop();\n",
" this.main.dispose();\n",
" }\n",
" }\n",
"\n",
" function postHeight(height) {\n",
" window.parent.postMessage(\n",
" {\n",
" type: \"iframeSize\",\n",
" height\n",
" },\n",
" \"*\"\n",
" );\n",
" }\n",
"\n",
" const monitor = () => {\n",
" if (typeof window.ResizeObserver !== \"undefined\") {\n",
" new DocumentBodyDimensionsResizeObserverMonitor().start();\n",
" } else {\n",
" new DocumentBodyDimensionsMutationObserverMonitor().start();\n",
" }\n",
" };\n",
"\n",
" const embed = async (slug, into, cells, inputs = {}) => {\n",
" const moduleUrl = \"https://api.observablehq.com/\" + slug + \".js?v=3\";\n",
" const define = (await import(moduleUrl)).default;\n",
" const inspect = Inspector.into(into);\n",
" const filter = cells ? name => cells.includes(name) : name => true;\n",
" const main = new Runtime().module(define, name => filter(name) && inspect());\n",
" for (let name of Object.keys(inputs)) {\n",
" main.redefine(name, inputs[name]);\n",
" }\n",
" return main;\n",
" };\n",
"\n",
" exports.DocumentBodyDimensionsMutationObserverMonitor = DocumentBodyDimensionsMutationObserverMonitor;\n",
" exports.DocumentBodyDimensionsPollingMonitor = DocumentBodyDimensionsPollingMonitor;\n",
" exports.DocumentBodyDimensionsResizeObserverMonitor = DocumentBodyDimensionsResizeObserverMonitor;\n",
" exports.embed = embed;\n",
" exports.monitor = monitor;\n",
"\n",
" return exports;\n",
"\n",
"}({}));\n",
"\n",
"CLOSESCRIPT\n",
"<div style=\"overflow: auto;\"></div>\n",
"<script type=\"module\">\n",
"const inputs = {\"network\": {\"row_nodes\": [{\"name\": \"KRT19\", \"ini\": 500, \"clust\": 133, \"rank\": 406, \"rankvar\": 499}, {\"name\": \"EPCAM\", \"ini\": 499, \"clust\": 151, \"rank\": 388, \"rankvar\": 498}, {\"name\": \"TACSTD2\", \"ini\": 498, \"clust\": 130, \"rank\": 280, \"rankvar\": 497}, {\"name\": \"MAL2\", \"ini\": 497, \"clust\": 152, \"rank\": 359, \"rankvar\": 496}, {\"name\": \"TGFBI\", \"ini\": 496, \"clust\": 369, \"rank\": 459, \"rankvar\": 495}, {\"name\": \"AGR2\", \"ini\": 495, \"clust\": 84, \"rank\": 182, \"rankvar\": 494}, {\"name\": \"VIM\", \"ini\": 494, \"clust\": 313, \"rank\": 487, \"rankvar\": 493}, {\"name\": \"GJA1\", \"ini\": 493, \"clust\": 169, \"rank\": 298, \"rankvar\": 492}, {\"name\": \"SRGN\", \"ini\": 492, \"clust\": 462, \"rank\": 285, \"rankvar\": 491}, {\"name\": \"IGFBP7\", \"ini\": 491, \"clust\": 234, \"rank\": 375, \"rankvar\": 490}, {\"name\": \"SPP1\", \"ini\": 490, \"clust\": 19, \"rank\": 230, \"rankvar\": 489}, {\"name\": 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