a.rb

class Pilot < Pry::Autopilot
  on ->(frame) { frame.method_name == :bing } do
    input << "show-source"
    input << "ls"
    input << "next"
    input.interactive!
  end
  on ->(frame) { frame.var("x") > 10 } do
    output.puts "located a frame with x > 10"
    input << "whereami"
  end
end

# => #<NameError: uninitialized constant Pry::Autopilot>

So, for one I'd expect the frame method name would be a common case.

class Pilot < Pry::Autopilot
  on_method :bing do … end
end