There's been some discussion on #perl6
as to what's missing from Rakudo to make it 'production-ready'.
I recently started my first moderately-sized Perl6 project, which currently clocks in with 1021 lines of Perl6 code (without documentation).
This translates to a parsing stage of 11.5s, which makes it very painful to use without module precompilation.
As there's no automatic precompilation yet, it needs to be done manually, which is tricky as compilation needs to happen in dependency order.