Published May 17, 2011 based on experiences building GS Research for iPad. Updates will be additive as the original article will be kept intact for posterity.
UPDATE (9/22/2012): Facebook developer Tobie Langel has posted some interesting feedback to a W3C mailing list in the aftermath of rewriting Facebook's failed web-based iOS application.
UPDATE 2 (11/28/2012): And now my app (Tumblr) is fully native as well.
Interested in building a mobile application but not sure where to start? There are a dizzying number of frameworks and platforms all currently vying to be your answer. In order to decide which is right for you, it’s important to understand the pros and cons of the different mobile development and deployment strategies available today.