On windows if you see:
VBoxManage.exe: error: Failed to create the VirtualBox object!
VBoxManage.exe: error: Code CO_E_SERVER_EXEC_FAILURE (0x80080005) - Server execution failed (extended info not available)
VBoxManage.exe: error: Most likely, the VirtualBox COM server is not running or failed to start.
##Try starting VirtualBox as admin.