This is pretty much off the top of my head right now. If it doesn't sound entirely crazy, please get back to me and I'll refine it!
"It's not the code, stupid!"
In all the businesses I've been involved in, as an employee, a consultant and even my own business, one thing I've consistently seen, which ... surprises the engineer in my heart: technical issues rarely cause show stopping problems. Most often, it boils down to people. I'd like to tell a few (true, but carefully sanitised) stories about start ups I've been involved in, some of the non-technical issues they've had and what I've learned from them. Then, hopefully, the folks listening to the talk don't have to make the same mistakes I've made. :-)
Couple of specific examples:
- If your management team doesn't get along, it's just not going to work. (This will be an interesting one to anonymise, but it's a fun story!)