I have moved this over to the Tech Interview Cheat Sheet Repo and has been expanded and even has code challenges you can run and practice against!
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This post also appears on lisper.in.
Reader macros are perhaps not as famous as ordinary macros. While macros are a great way to create your own DSL, reader macros provide even greater flexibility by allowing you to create entirely new syntax on top of Lisp.
Paul Graham explains them very well in [On Lisp][] (Chapter 17, Read-Macros):
The three big moments in a Lisp expression's life are read-time, compile-time, and runtime. Functions are in control at runtime. Macros give us a chance to perform transformations on programs at compile-time. ...read-macros... do their work at read-time.