I have successfully run a dedicated server (~1840 MB RAM, ~8 GB virtual, ~110ms CPU time on a Ryzen 5 3500U) on Fedora 35:
- ext4 filesystem (I've had issues with other ones -- ntfs3 seems to work most of the time, but I've had tf2 complain about corrupted files a few times; overlayfs has the same issue unless it's backed by ext4)
- Titanfall 2 (copied game files, not even fully installed, no origin)
- Northstar v1.1.2
- Mesa 21.3.2 (distro packages)
- Wine 7.0.0-rc2 (distro packages)