Add paths of sources and classes of your program, compile and execute it. Do them all at runtime.

dce.clj

(ns dce.core
  (:import java.net.URL clojure.lang.DynamicClassLoader)
  (:gen-class))

(defn -main [abs-path target-ns & args]
  (let [ccl (.getContextClassLoader (Thread/currentThread))
        dcl (if (instance? DynamicClassLoader ccl) ccl
                (let [l (DynamicClassLoader. ccl)]
                  (.setContextClassLoader (Thread/currentThread) l)
                  l))]
    (.addURL dcl (URL. (str "file://" abs-path "/src/")))
    (.addURL dcl (URL. (str "file://" abs-path "/classes/")))
    (binding [*compile-path* (str abs-path "/classes")]
      (compile (symbol target-ns)))
    (def f (future (apply (resolve (symbol (str target-ns "/-main"))) args)))
    (Thread/sleep 5000)
    (future-cancel f)))