I'm now considering using deps.edn as a replacement for profiles.clj, especially because it seems easier for installing user scripts (without uberjars).

deps.edn

;; The deps.edn file describes the information needed to build a classpath.
;;
;; When using the `clojure` or `clj` script, there are several deps.edn files
;; that are combined:
;; - install-level
;; - user level (this file)
;; - project level (current directory when invoked)
;;
;; For all attributes other than :paths, these config files are merged left to right.
;; Only the last :paths is kept and others are dropped.

{
  ;; Paths
  ;;   Directories in the current project to include in the classpath

  ;; :paths ["src"]

  ;; External dependencies

  :deps {
         org.clojure/clojure {:mvn/version "1.8.0"}
         org.clojure/core.async {:mvn/version "0.3.465"}
         org.clojure/data.csv {:mvn/version "0.1.3"}
         org.clojure/data.priority-map {:mvn/version "0.0.7"}
         org.clojure/tools.cli {:mvn/version "0.3.5"}
         clojure.java-time {:mvn/version "0.3.1"}
         clj-http {:mvn/version "3.7.0"}
         clojurewerkz/money {:mvn/version "1.10.0"}
         cheshire {:mvn/version "5.8.0"}
         potemkin {:mvn/version "0.4.4"}
         me.raynes/fs {:mvn/version "1.4.6"}
         com.taoensso/timbre {:mvn/version "4.10.0"}
         com.draines/postal {:mvn/version "2.0.2"}
         com.rpl/specter {:mvn/version "1.0.5"}
         spyscope {:mvn/version "0.1.6"}}
  

  ;; Aliases
  ;;   resolve-deps aliases (-R) affect dependency resolution, options:
  ;;     :extra-deps - specifies extra deps to add to :deps
  ;;     :override-deps - specifies a coordinate to use instead of that in :deps
  ;;     :default-deps - specifies a coordinate to use for a lib if one isn't found
  ;;   make-classpath aliases (-C) affect the classpath generation, options:
  ;;     :extra-paths - vector of additional paths to add to the classpath
  ;;     :classpath-overrides - map of lib to path that overrides the result of resolving deps

  ;; :aliases {
  ;;   :deps {:extra-deps {org.clojure/tools.deps.alpha {:mvn/version "0.2.196"}}}
  ;;   :test {:extra-paths ["test"]}
  ;; }

  ;; Provider attributes

  :mvn/repos {
              "central" {:url "https://repo1.maven.org/maven2/"}
              "clojars" {:url "https://clojars.org/repo"}}}