gistfile1.txt

- Bilateral Upper & lower limb weakness (Look at 5 signs: wasting, tone, reflexes, clonus, Babinski)
    - **Motor neurone?**
        - UMN signs
        - LMN signs
            - **Pattern of weakness?**
                - Proximal weakness
                    - **Sensation?**
                        - Sensation abnormal
                            - Beware cx myelopathy- "glove & socks" numbness
                            - GBS/CIDP
                                - 1) Lumbosacral plexo/radiculopathy-if UL N.
                                - 2) Kennedy's disease
                        - Sensation normal
                            - **Options:**
                                - Myopathy
                                - Myasthenia gravis
                                    - Fatigable. Bulbar, ocular weakness
                                - MND-SMA, MND-PMA, Polio
                                    - Fasiculations. Bulbar weakness
                - Distal weakness
                    - **Sensation? **
                        - Sensation abnormal
                            - **Defect type?**
                                - Glove and stocking numbness/weakness- in UL and LL
                                    - Note
                                        - Important to check that UL has "glove" pattern of deficits
                                    - Peripheral Neuropathy (Diffuse polyneuropathy)
                                - Patchy Numbness, weakness-Asymmetric. Not glove-stocking
                                    - **Options:**
                                        - In distribution of PN: Mononeuritis multiplex; Mono-neuropathies
                                        - Dermatomal: Radiculopathy
                        - Sensation normal
                            - **Options:**
                                - MND-PMA, Polio
                                - Pure motor peripheral neuropathy: MMN
                                - Distal myopathy inc. Myotonic Dystrophy
- [[roam/comments]]
    - [[July 2nd, 2021]]
        - **Pattern of weakness?** (< Replace with block ref)
            - At each step of the algorithm we just solve ^^one^^ problem
                - LMN
                - Distal weakness
                - Sensation abnormal
                - Patchy sensorimotor deficits VS Glove and stocking deficits
        - Sensation abnormal[*](((Second block))) (< Replace with block ref)
            - Since it is an important diagnostic "branch-point" remember to confirm abn sensation by checking 2-3 modalities.
            - Take care to be objective in your sensory exam... we demonstrated some techniques
        - In distribution of PN:
Mononeuritis multiplex; Mono-neuropathies[*](((Second block))) (< Replace with block ref)
            - If confined to 1–2 limbs... think of
                - Single/multiple mononeuropathy
                - Radiculopathy
            - To diff between radiculopathy and mononeuropathy—"Venn it"—PTO