These settings are designed to allow a user a better exxperience by removing annoyances. This works for Office 2016 and 2019

OfficeSettings.cmd

:: remove settings for individual and common apps
REG delete HKCU\Software\Microsoft\Office\16.0\Common\General /v "DisableBootToOfficeStart" /f
REG delete HKCU\Software\Microsoft\Office\16.0\Common\General /v "FirstRun" /f
REG delete HKCU\Software\Microsoft\Office\16.0\Common\General /v "AlertIfNotDefault" /f
REG delete HKCU\Software\Microsoft\Office\16.0\Excel\Options /v "AlertIfNotDefault" /f
REG delete HKCU\Software\Microsoft\Office\16.0\Excel\Options /v "DisableBootToOfficeStart" /f
REG delete HKCU\Software\Microsoft\Office\16.0\PowerPoint\Options /v "AlertIfNotDefault" /f
REG delete HKCU\Software\Microsoft\Office\16.0\PowerPoint\Options /v "DisableBootToOfficeStart" /f
REG delete HKCU\Software\Microsoft\Office\16.0\Word\Options /v "AlertIfNotDefault" /f
REG delete HKCU\Software\Microsoft\Office\16.0\Word\Options /v "DisableBootToOfficeStart" /f
ping 127.0.0.1 -n 1 -w 500> nul
:: Set all apps to not display the office startup Screen
REG ADD HKCU\Software\Microsoft\Office\16.0\Common\General /v "DisableBootToOfficeStart" /d 1 /t REG_DWORD /f
REG ADD HKCU\Software\Microsoft\Office\16.0\Common\General /v "FirstRun" /d 0 /t REG_DWORD /f

:: Hide Microsoft Office Upload icon systray display
REG ADD HKCU\Software\Microsoft\Office\16.0\Common\FileIO /v "DisableNotificationIcon" /d 1 /t REG_DWORD /f

:: set all apps to not allow an alert if the app is not the default extension handler
REG ADD HKCU\Software\Microsoft\Office\16.0\Common\General /v "AlertIfNotDefault" /d 0 /t REG_DWORD /f

:: Set .docx as the default document handler
REG ADD HKCU\Software\Microsoft\Office\16.0\Word\Options /v "DefaultFormat" /d "" /t REG_SZ /f

:: Power point do not extend displays
REG ADD HKCU\Software\Microsoft\Office\16.0\PowerPoint\Options /v "DisableSetTopology" /d 1 /t REG_DWORD /f

:: Change theme ( Dark Grey = 3, Black = 4, White = 5, colorful = 0 ) changes after second open
REG ADD "HKCU\Software\Microsoft\Office\16.0\Common\Roaming\Identities\Anonymous\Settings\1186\{00000000-0000-0000-0000-000000000000}\PendingChanges" /v "Data" /d "04000000" /t REG_BINARY /f
::REG delete "HKCU\Software\Microsoft\Office\16.0\Common\Roaming\Identities\Anonymous\Settings\1186\{00000000-0000-0000-0000-000000000000}\PendingChanges" /f
REG ADD "HKCU\Software\Microsoft\Office\16.0\Common\General" /v "UI Theme" /d 4 /t REG_DWORD /f



:: Per user settings for office tweaks you might have to change the path depending on your version of office
REG LOAD HKU\DefaultUser %SystemDrive%\Users\Default\NTUSER.DAT
:: remove settings for individual and common apps
REG delete HKU\DefaultUser\Software\Microsoft\Office\16.0\Common\General /v "DisableBootToOfficeStart" /f
REG delete HKU\DefaultUser\Software\Microsoft\Office\16.0\Common\General /v "FirstRun" /f
REG delete HKU\DefaultUser\Software\Microsoft\Office\16.0\Common\General /v "AlertIfNotDefault" /f
REG delete HKU\DefaultUser\Software\Microsoft\Office\16.0\Excel\Options /v "AlertIfNotDefault" /f
REG delete HKU\DefaultUser\Software\Microsoft\Office\16.0\Excel\Options /v "DisableBootToOfficeStart" /f
REG delete HKU\DefaultUser\Software\Microsoft\Office\16.0\PowerPoint\Options /v "AlertIfNotDefault" /f
REG delete HKU\DefaultUser\Software\Microsoft\Office\16.0\PowerPoint\Options /v "DisableBootToOfficeStart" /f
REG delete HKU\DefaultUser\Software\Microsoft\Office\16.0\Word\Options /v "AlertIfNotDefault" /f
REG delete HKU\DefaultUser\Software\Microsoft\Office\16.0\Word\Options /v "DisableBootToOfficeStart" /f
ping 127.0.0.1 -n 1 -w 500> nul
:: Set all apps to not display the office startup Screen
REG ADD HKU\DefaultUser\Software\Microsoft\Office\16.0\Common\General /v "DisableBootToOfficeStart" /d 1 /t REG_DWORD /f
REG ADD HKU\DefaultUser\Software\Microsoft\Office\16.0\Common\General /v "FirstRun" /d 0 /t REG_DWORD /f
:: Hide Microsoft Office Upload icon systray display
REG ADD HKU\DefaultUser\Software\Microsoft\Office\16.0\Common\FileIO /v "DisableNotificationIcon" /d 1 /t REG_DWORD /f
:: set all apps to not allow an alert if the app is not the default extension handler
REG ADD HKU\DefaultUser\Software\Microsoft\Office\16.0\Common\General /v "AlertIfNotDefault" /d 0 /t REG_DWORD /f

:: Set .docx as the default document handler
REG ADD HKU\DefaultUser\Software\Microsoft\Office\16.0\Word\Options /v "DefaultFormat" /d "" /t REG_SZ /f

:: Power point do not extend displays
REG ADD HKU\DefaultUser\Software\Microsoft\Office\16.0\PowerPoint\Options /v "DisableSetTopology" /d 1 /t REG_DWORD /f
REG UNLOAD HKU\DefaultUser