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A small collection of R snippets that I found useful
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## | |
## Based on a trait name and the corresponding p-values, a QQ plot is generated with a | |
## marked genomic inflation factor. | |
## | |
QQ_plot = function(pvals, trait){ | |
mlogpv = -log10(pvals); # Observed data | |
mlogpv = mlogpv[! is.na(mlogpv)] # Remving Na-s | |
mlogexp = -log10(qunif(ppoints(length(pvals)))); # Generating expected data | |
# Initialize empty plot: | |
plot(-5,-5,xlim=c(0,max(mlogexp)),ylim=c(0,max(mlogpv)), | |
xlab=expression(paste('Theoretical ', -log[10], '(p)')), | |
ylab="", | |
main=trait, cex.lab = 1.3); | |
# equality line: | |
abline(a= 0, b =1 , col='firebrick'); | |
# Adding pvalues: | |
points(sort(mlogexp),sort(mlogpv),pch=19,cex=0.5,col='navy'); | |
# Adding y label: | |
title(ylab=expression(paste('Observed ', -log[10], '(p)')), | |
line=2, cex.lab=1.2) | |
# Calculating genomic infation factor: | |
chisq <- qchisq(1-pvals,1) | |
lambda = round(median(chisq)/qchisq(0.5,1), digits=3); | |
textColor = if(lambda <= 1.2 ) "black" else "red" | |
# Report lambda: | |
text(par('usr')[1] + diff(par('usr')[1:2])/10, | |
par('usr')[4] - diff(par('usr')[3:4])/10, | |
bquote(lambda*'='~.(lambda)), | |
cex = 2, pos = 4, col = textColor); | |
} |
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