When used with the Windows Multi-Keygen, this will render retail XP fully activated, and Microsoft sees it as genuine!

ActivateXP.py

import _winreg, os, sys
import win32api, win32con
import subprocess

from pywinauto import application

def deactivate():
    windir = os.getenv("windir", "C:\Windows")
    
    if os.path.exists(windir + "\system32\WPA.dbl"):
        if os.path.exists(windir + "\system32\wpa.old"):
            os.remove(windir + "\system32\wpa.old")

        os.rename(windir + "\system32\WPA.dbl", windir + "\system32\wpa.old")
    
    loc = "SOFTWARE\Microsoft\Windows NT\CurrentVersion\WPAEvents"
    key = _winreg.OpenKey(_winreg.HKEY_LOCAL_MACHINE, loc, 0, _winreg.KEY_ALL_ACCESS)

    value, type = _winreg.QueryValueEx(key, "OOBETimer")
    if value:
        end = value[-1:]
        
        if end == "\x00":
            end = "\x01"
        else:
            end = "\x00"
        
        value = value[:-1] + end
        _winreg.SetValueEx(key, "OOBETimer", 0, _winreg.REG_BINARY, value)
        
    sysroot = os.getenv("systemroot", "C:\Windows")
    if os.path.exists(r"{path}\system32\AntiWPA.dll".format(path=sysroot)):
        dehactivate()

def getProdKey(num=1):
    if not os.path.exists("%s\keygen\keygen.exe" % sys.path[0]):
        return False
    
    app = application.Application.start("%s\keygen\keygen.exe" % sys.path[0])
    window = app["Windows Keygen"]
    
    for i in range(0, num):
        window.Generate.Click()
        
    keys =  window.Edit5.WindowText()
    app.kill_()

    return list([x for x in keys.split("\r\n") if x])

def setProdKey(key):
    if isinstance(key, list):
        key = key[0]
    key = "".join(key.split("-")) # Remove hyphens
    
    import wmi
    c = wmi.WMI()
    activate = c.Win32_WindowsProductActivation()
    for item in activate:
        item.SetProductKey(key)

def patchHosts():
    file='c:\windows\system32\drivers\etc\hosts'
    win32api.SetFileAttributes(file, win32con.FILE_ATTRIBUTE_NORMAL)
    needpatch = True
    
    with open(file, "r") as f:
        for line in f:
            if "mpa.one.microsoft.com" in line:
                needpatch = False
                break
        
    if needpatch:
        win32api.SetFileAttributes(file, win32con.FILE_ATTRIBUTE_NORMAL)
        with open(file, "a") as f:
            f.write("\n127.0.0.1\tmpa.one.microsoft.com")
    
    return needpatch
        
def hactivate():
    arch = os.getenv("PROCESSOR_ARCHITECTURE", "X86")
    proc = subprocess.Popen(r'regsvr32 /s "{path}\hactivation\{arch}\antiwpa.dll"'.format(path=sys.path[0], arch=arch))
    proc.wait()
    
def dehactivate():
    arch = os.getenv("PROCESSOR_ARCHITECTURE", "X86")
    proc = subprocess.Popen(r'regsvr32 /s /u "{path}\hactivation\{arch}\antiwpa.dll"'.format(path=sys.path[0], arch=arch))
    proc.wait()
    sysroot = os.getenv("systemroot", "C:\Windows")
    if os.path.exists(r"{path}\system32\AntiWPA.dll".format(path=sysroot)):
        os.remove("%s\system32\AntiWPA.dll" % sysroot)
    
def genKeysFile(file, num=100, mode="a"):
    with open(file, mode) as f:
        lines = "\n".join(getProdKey(num))
        f.write(lines)

if __name__ == "__main__":
    print "Assuring that XP is deactivated."
    deactivate()
    print "Grabbing a key."
    key = getProdKey(1)
    if key:
        print "Using {key} for product key.".format(key=key[0])
        setProdKey(key)
        print "Patching HOSTS file."
        patchHosts()
        print "Hacktivating."
        hactivate()
        print "Done! Enjoy!"