SQLite depends on native DLLs. In some cases, such as running xUnit tests in net48, those DLLs aren't copied to the execution folder. This hack will copy those files.

SQLitePCL.NativeLibraryHack.cs

using System;
using System.Diagnostics;
using System.IO;

namespace SQLitePCL
{
    public class NativeLibraryHack
    {
        public static bool Hacked { get; private set; }

        public static bool DoHack()
        {
            if (Hacked) return true;

            try
            {
                const string runtimeFolderName = "/runtimes";

                var destinationPath = typeof(SQLitePCL.raw).Assembly.Location
                    .Replace("\\", "/");
                var destinationLength = destinationPath.LastIndexOf("/", StringComparison.OrdinalIgnoreCase);
                var destinationDirectory = destinationPath.Substring(0, destinationLength) + runtimeFolderName;

                var sourcePath = new Uri(typeof(SQLitePCL.raw).Assembly.CodeBase)
                    .AbsolutePath;
                var sourceLength = sourcePath.LastIndexOf("/", StringComparison.OrdinalIgnoreCase);
                var sourceDirectory = sourcePath.Substring(0, sourceLength) + runtimeFolderName;

                if (Directory.Exists(sourceDirectory))
                    CopyFilesRecursively(new DirectoryInfo(sourceDirectory), new DirectoryInfo(destinationDirectory));
            }
            catch (Exception ex)
            {
                //Ignore Exception
                Debug.WriteLine(ex.Message);
                return false;
            }

            return (Hacked = true);
        }

        private static void CopyFilesRecursively(
            DirectoryInfo source,
            DirectoryInfo target
        )
        {
            foreach (var dir in source.GetDirectories())
                CopyFilesRecursively(dir, target.CreateSubdirectory(dir.Name));

            foreach (var file in source.GetFiles())
            {
                try
                {
                    var destinationFile = Path.Combine(target.FullName, file.Name);
                    if (!File.Exists(destinationFile))
                        file.CopyTo(destinationFile);
                }
                catch (Exception ex)
                {
                    //Ignore Exception
                    Debug.WriteLine(ex.Message);
                }
            }
        }
    }
}