Demo for workaround on writing tsx file without React but with Hyperscript.

global.d.ts

declare module '__globals' {
  type DomElement = Element;
  type DeepPartial<T> = {
    [K in keyof T]?: T[K] | DeepPartial<T[K]>;
  };
  type FreePartialProperties<T> = {
    [K in keyof T]: DeepPartial<T[K]> & {
      [key: string]: any;
    };
  };

  global {
    namespace JSX {
      interface Element extends DomElement {}
      interface IntrinsicElements extends
        FreePartialProperties<HTMLElementTagNameMap>,
        FreePartialProperties<SVGElementTagNameMap> {
        [tagName: string]: any;
      }
    }
  }
}

index.tsx

import h from 'hyperscript';

document.body.appendChild(<div className="root">
  <h1>Hello Hyperscript!</h1>
  <div onclick={(e: MouseEvent) => alert(`Clicked at ${e.clientX},${e.clientY}`)} style={{
    width: '100%',
    height: '90%',
    border: 'solid 1px black'
  }}>Click ME!!</div>
</div>);

tsconfig.json

{
  "compilerOptions": {
    "target": "es5",
    "module": "commonjs",
    "lib": ["dom", "es2015", "es5"],  
    "jsx": "react",
    "jsxFactory": "h",
    "sourceMap": true,
    "strict": true,
    "noImplicitAny": true,
    "moduleResolution": "node",
    "esModuleInterop": true
  }
}