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@PritiShaw
Last active June 18, 2020 20:14
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<!DOCTYPE html>
<html lang="en">
<head>
<meta charset="utf-8">
<meta http-equiv="X-UA-Compatible" content="IE=edge">
<meta name="viewport" content="width=device-width, initial-scale=1">
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<meta name="description" content="">
<meta name="author" content="">
<link rel="icon" href="https://bigmech.s3.amazonaws.com/indra-db/favicon.ico">
<title>INDRA Results</title>
<script src="https://code.jquery.com/jquery-3.3.1.min.js"
integrity="sha256-FgpCb/KJQlLNfOu91ta32o/NMZxltwRo8QtmkMRdAu8="
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href="https://stackpath.bootstrapcdn.com/bootstrap/4.1.3/css/bootstrap.min.css"
integrity="sha384-MCw98/SFnGE8fJT3GXwEOngsV7Zt27NXFoaoApmYm81iuXoPkFOJwJ8ERdknLPMO"
crossorigin="anonymous">
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<link rel="stylesheet"
href="https://use.fontawesome.com/releases/v5.5.0/css/all.css"
integrity="sha384-B4dIYHKNBt8Bc12p+WXckhzcICo0wtJAoU8YZTY5qE0Id1GSseTk6S+L3BlXeVIU"
crossorigin="anonymous">
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<script src="https://stackpath.bootstrapcdn.com/bootstrap/4.1.3/js/bootstrap.min.js"
integrity="sha384-ChfqqxuZUCnJSK3+MXmPNIyE6ZbWh2IMqE241rYiqJxyMiZ6OW/JmZQ5stwEULTy"
crossorigin="anonymous"></script>
<style>
a {
color: #256DC5;
target-new: tab;
}
h1 {
margin-bottom: 0;
}
.page-header {
padding: 1em;
}
</style>
<!-- Toggle a hidden element -->
<script>
const pubmed_fetch = "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi";
let ALL_COLLAPSED = true;
function toggler(short_name_key) {
$("#" + short_name_key + "_group").toggle();
let header = "#" + short_name_key + "_heading";
$(header).show();
}
function getPubMedMETAxmlByPMID(pmid) {
let params_dict = {
'db': 'pubmed',
'retmode': 'xml',
'rettype': 'docsum',
'id': pmid
};
return $.ajax({
url: pubmed_fetch,
type: "POST",
dataType: "xml",
data: params_dict,
});
}
function pmidXML2dict(XML) {
let xml_dict = {};
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let innerItems;
// Javascript can't really do nice recursive functions...
// special cases for "History" and "ArticleIds" which has unique inner Names
if (name === "ArticleIds" || name === "History") {
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innerDict[c.getAttribute("Name")] = c.textContent;
}
innerItems = innerDict;
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innerList.push(c.textContent);
}
innerItems = innerList;
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xml_dict[name] = innerItems
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// Here just get the inner strings
xml_dict[name] = child.textContent;
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// Special case
xml_dict["Id"] = child.textContent;
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if (!xml_dict["no_key"]) {
xml_dict["no_key"] = [child.textContent]
} else {
xml_dict["no_key"].push(child.textContent)
}
}
}
return xml_dict;
}
// Modify link hover text
function setPMIDlinkTitle(pmid, link_tag) {
let pubmed_xml_promise = getPubMedMETAxmlByPMID(pmid);
pubmed_xml_promise.then(responseXML => {
const docsum_xml = responseXML.getElementsByTagName('DocSum')[0];
const pmd = pmidXML2dict(docsum_xml);
const nAuthors = pmd.AuthorList.length;
let authorsStr;
if (nAuthors > 3)
authorsStr = `${pmd.AuthorList[0]}, ... ${pmd.AuthorList[nAuthors - 1]}`;
else
authorsStr = pmd.AuthorList.join(", ");
// Shortened journal name is in .Source, while full name is in .FullJournalName
link_tag.title = `${authorsStr}, "${pmd.Title}", ${pmd.Source}, ${pmd.SO}`;
})
}
// Loop all pmid link nodes and set title
function populatePMIDlinkTitles() {
let pmid_link_array = document.getElementsByClassName("pmid_link");
for (link_obj of pmid_link_array) {
pmid = link_obj.textContent;
setPMIDlinkTitle(pmid, link_obj)
}
}
// Open journal in PubmedCentral
function openPMCIDJournal(pmcid, html){
var span = document.createElement('span');
span.innerHTML = html;
var text = span.innerText;
window.open("https://www.ncbi.nlm.nih.gov/pmc/articles/"+pmcid+"?text="+ encodeURIComponent(text))
}
// Expand/collapse all
function expandCollapseAll() {
let expColBtn = document.getElementById('expand-collapse-all');
let setCss = '';
// Expand all; set ALL_COLLAPSED = false;
if (ALL_COLLAPSED) {
setCss = 'display: block;';
ALL_COLLAPSED = false;
expColBtn.textContent = 'Collapse All';
// Collapse all; set ALL_COLLAPSED = true;
} else {
setCss = 'display: none;';
ALL_COLLAPSED = true;
expColBtn.textContent = 'Expand All';
}
// Loop all tags
for (tag of document.getElementsByClassName('group')) {
tag.style.cssText = setCss
}
}
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<style>
.source-phosphosite {
background-color: #bc80bd;
color: black;
}
.source-cbn {
background-color: #fccde5;
color: black;
}
.source-pc11 {
background-color: #b3de69;
color: black;
}
.source-biopax {
background-color: #80b1d3;
color: black;
}
.source-bel_lc {
background-color: #fb8072;
color: black;
}
.source-signor {
background-color: #bebada;
color: black;
}
.source-biogrid {
background-color: #fdb462;
color: black;
}
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background-color: #8dd3c7;
color: black;
}
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background-color: #ffffb3;
color: black;
}
.source-hprd {
background-color: #d9d9d9;
color: black;
}
.source-trrust {
background-color: #ccebc5;
color: black;
}
.source-geneways {
background-color: #bc80bd;
color: white;
}
.source-tees {
background-color: #fccde5;
color: white;
}
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background-color: #b3de69;
color: white;
}
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background-color: #80b1d3;
color: white;
}
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background-color: #fb8072;
color: white;
}
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background-color: #bebada;
color: white;
}
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background-color: #fdb462;
color: white;
}
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background-color: #8dd3c7;
color: white;
}
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font-size: 8pt;
margin: 0;
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position: -webkit-sticky;
position: sticky;
top: 0;
background-color: white;
z-index: 10;
padding-top: 5px;
}
.nvp {
padding-left: 0;
padding-right: 0;
}
.src-api {
overflow-x: hidden;
}
.group, .group-shown {
padding: 5px;
margin: 5px;
}
.group {
display: none;
border-left: #0d5aa7 solid 1px;
border-right: #0d5aa7 solid 1px;
}
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padding: 2px;
padding-left: 5px;
margin: 2px;
position: sticky;
border-radius: 2px;
}
.evidence, .evidence-text {
margin-bottom: 10px;
}
.evidence-text {
border-top: #cfcfcf solid 1px;
padding-top: 0.5em;
}
.super_group_heading, .group_heading {
cursor: pointer;
}
.super_group_heading:hover, .group_heading:hover {
background-color: #f2f2f2;
}
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background-color: #4a36aa;
color: #FFFFFF;
}
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background-color: #2d8e4c;
color: #FFFFFF;
}
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background-color: #606060;
color: #FFFFFF;
}
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overflow-y: hidden;
}
.curation_toggle {
cursor: pointer;
}
.pmid_link, .pmcid_link, .doi_link {
display: block;
}
.full_text_search:hover {
text-decoration: underline;
}
</style>
</head>
<body>
<div class="container">
<!-- Page Header -->
<div class="page-header">
<h1>INDRA Results</h1>
</div>
This page allows you to curate the loaded statements. For more information
please see the
<a href="https://indra.readthedocs.io/en/latest/tutorials/html_curation.html"
target="_blank">manual</a>.
<hr>
<div class="statements-header">
<div class="row">
<div class="col">
<h3 >
Statements
</h3>
</div>
<div class="col text-right">
<button id="expand-collapse-all" type="button"
class="btn btn-primary"
onclick="expandCollapseAll()">
Expand All
</button>
</div>
</div>
<hr>
</div>
<div class="row super_group_heading"
id="tl-37647242-7e59-4309-880d-9f6cc39714f4"
onclick="toggler('tl-37647242-7e59-4309-880d-9f6cc39714f4')">
<div class="col nvp">
<h5 class="align-middle">
<a href='https://identifiers.org/chebi/CHEBI:49470' target='_blank'>Aluminium(3+)</a> affects <a href='https://identifiers.org/go/GO:0006955' target='_blank'>immune response</a>
</h5>
</div>
<div class="col text-right nvp">
</div>
</div>
<div class="group" id="tl-37647242-7e59-4309-880d-9f6cc39714f4_group">
<div class="container nvp">
<div class="row group-shown" id="904d9c54-4ef4-4b7b-a2d0-b01804bd240b_group">
<div class="container nvp">
<a name="-10301112258491834"></a>
<div class="row statement">
<div class="col text-left nvp">
<h5 class="align-middle">
<a href='https://identifiers.org/chebi/CHEBI:49470' target='_blank'>Aluminium(3+)</a> activates <a href='https://identifiers.org/go/GO:0006955' target='_blank'>immune response</a>.
<a href="#"
>
<small class="badge badge-secondary badge-pill">1</small>
</a>
</h5>
</div>
<div class="col text-right nvp">
</div>
</div>
<div class="row evidence">
<div class="container" id="stmt-0-0-0"
data-stmt_hash="-10301112258491834">
<div class="row evidence-text" data-source_hash="8490993238778999406"
style="border-bottom: 1px solid #FFFFFF;"
id="ev-0-0-0-0">
<div class="col-1">
<div class="row">
<div class="col-3 nvp curation_toggle"
id="ev-0-0-0-0-click"
data-parent_id="ev-0-0-0-0">
<a href="#"
>
&#10166;
</a>
</div>
<div class="col-9 nvp src-api"
title="reach">
reach
</div>
</div>
</div>
<div class="col-9">
"We further characterized the <span class="badge badge-object">immune response</span> induced by the formulation that provided the highest protection against invasive lethal challenge and compared it to the <span class="badge badge-object">immune response</span> induced by Combo5 / <span class="badge badge-subject">alum</span> and M1/<span class="badge badge-subject">alum</span>."
</div>
<div class="col-2 text-right">
<a class="pmid_link"
title="Hover again to see info"
onmouseover="setPMIDlinkTitle(this.textContent, this); this.onmouseover=null;"
href='https://www.ncbi.nlm.nih.gov/pubmed/32156809'
target="_blank">
32156809</a>
| <a class="pmcid_link full_text_search"
onclick='openPMCIDJournal(`PMC7064752`, `We further characterized the <span class="badge badge-object">immune response</span> induced by the formulation that provided the highest protection against invasive lethal challenge and compared it to the <span class="badge badge-object">immune response</span> induced by Combo5 / <span class="badge badge-subject">alum</span> and M1/<span class="badge badge-subject">alum</span>.` );'
href="javascript:;">Full-Text Search: PMC7064752</a>
</div>
</div>
</div> <!-- container -->
</div> <!-- row evidence -->
</div> <!-- PA Statement container -->
</div> <!-- PA Statement group -->
</div> <!-- container -->
</div> <!-- type groups -->
<div class="row super_group_heading"
id="tl-fe24ee06-4f41-4b6d-918a-6a0d37516186"
onclick="toggler('tl-fe24ee06-4f41-4b6d-918a-6a0d37516186')">
<div class="col nvp">
<h5 class="align-middle">
SMQ affects TNF-α
</h5>
</div>
<div class="col text-right nvp">
</div>
</div>
<div class="group" id="tl-fe24ee06-4f41-4b6d-918a-6a0d37516186_group">
<div class="container nvp">
<div class="row group-shown" id="3260a5fc-2f9c-4b8b-85d3-37da286b05bd_group">
<div class="container nvp">
<a name="-25651963520341412"></a>
<div class="row statement">
<div class="col text-left nvp">
<h5 class="align-middle">
SMQ activates TNF-α.
<a href="#"
>
<small class="badge badge-secondary badge-pill">1</small>
</a>
</h5>
</div>
<div class="col text-right nvp">
</div>
</div>
<div class="row evidence">
<div class="container" id="stmt-1-0-0"
data-stmt_hash="-25651963520341412">
<div class="row evidence-text" data-source_hash="4155885927386739680"
style="border-bottom: 1px solid #FFFFFF;"
id="ev-1-0-0-0">
<div class="col-1">
<div class="row">
<div class="col-3 nvp curation_toggle"
id="ev-1-0-0-0-click"
data-parent_id="ev-1-0-0-0">
<a href="#"
>
&#10166;
</a>
</div>
<div class="col-9 nvp src-api"
title="reach">
reach
</div>
</div>
</div>
<div class="col-9">
"A comparison between the cytokine concentrations secreted by splenocytes from Combo5 / alum and Combo5 / <span class="badge badge-subject">SMQ</span> immune mice showed that the <span class="badge badge-subject">SMQ</span> adjuvanted formulation induced significantly higher secretion of IL-6, IL-10, IFN-γ, and <span class="badge badge-object">TNF-α</span> than the alum adjuvanted formulation."
</div>
<div class="col-2 text-right">
<a class="pmid_link"
title="Hover again to see info"
onmouseover="setPMIDlinkTitle(this.textContent, this); this.onmouseover=null;"
href='https://www.ncbi.nlm.nih.gov/pubmed/32156809'
target="_blank">
32156809</a>
| <a class="pmcid_link full_text_search"
onclick='openPMCIDJournal(`PMC7064752`, `A comparison between the cytokine concentrations secreted by splenocytes from Combo5 / alum and Combo5 / <span class="badge badge-subject">SMQ</span> immune mice showed that the <span class="badge badge-subject">SMQ</span> adjuvanted formulation induced significantly higher secretion of IL-6, IL-10, IFN-γ, and <span class="badge badge-object">TNF-α</span> than the alum adjuvanted formulation.` );'
href="javascript:;">Full-Text Search: PMC7064752</a>
</div>
</div>
</div> <!-- container -->
</div> <!-- row evidence -->
</div> <!-- PA Statement container -->
</div> <!-- PA Statement group -->
</div> <!-- container -->
</div> <!-- type groups -->
<div class="row super_group_heading"
id="tl-d5196a9b-4c5e-4d13-813b-2a262c6a1801"
onclick="toggler('tl-d5196a9b-4c5e-4d13-813b-2a262c6a1801')">
<div class="col nvp">
<h5 class="align-middle">
SMQ affects <a href='https://identifiers.org/hgnc/HGNC:6018' target='_blank'>IL6</a>
</h5>
</div>
<div class="col text-right nvp">
</div>
</div>
<div class="group" id="tl-d5196a9b-4c5e-4d13-813b-2a262c6a1801_group">
<div class="container nvp">
<div class="row group-shown" id="d2e4c2d0-edea-4418-83dc-3bb7349d6622_group">
<div class="container nvp">
<a name="-17919606370707517"></a>
<div class="row statement">
<div class="col text-left nvp">
<h5 class="align-middle">
SMQ activates <a href='https://identifiers.org/hgnc/HGNC:6018' target='_blank'>IL6</a>.
<a href="#"
>
<small class="badge badge-secondary badge-pill">1</small>
</a>
</h5>
</div>
<div class="col text-right nvp">
</div>
</div>
<div class="row evidence">
<div class="container" id="stmt-2-0-0"
data-stmt_hash="-17919606370707517">
<div class="row evidence-text" data-source_hash="4155885927386739680"
style="border-bottom: 1px solid #FFFFFF;"
id="ev-2-0-0-0">
<div class="col-1">
<div class="row">
<div class="col-3 nvp curation_toggle"
id="ev-2-0-0-0-click"
data-parent_id="ev-2-0-0-0">
<a href="#"
>
&#10166;
</a>
</div>
<div class="col-9 nvp src-api"
title="reach">
reach
</div>
</div>
</div>
<div class="col-9">
"A comparison between the cytokine concentrations secreted by splenocytes from Combo5 / alum and Combo5 / <span class="badge badge-subject">SMQ</span> immune mice showed that the <span class="badge badge-subject">SMQ</span> adjuvanted formulation induced significantly higher secretion of <span class="badge badge-object">IL-6</span>, IL-10, IFN-γ, and TNF-α than the alum adjuvanted formulation."
</div>
<div class="col-2 text-right">
<a class="pmid_link"
title="Hover again to see info"
onmouseover="setPMIDlinkTitle(this.textContent, this); this.onmouseover=null;"
href='https://www.ncbi.nlm.nih.gov/pubmed/32156809'
target="_blank">
32156809</a>
| <a class="pmcid_link full_text_search"
onclick='openPMCIDJournal(`PMC7064752`, `A comparison between the cytokine concentrations secreted by splenocytes from Combo5 / alum and Combo5 / <span class="badge badge-subject">SMQ</span> immune mice showed that the <span class="badge badge-subject">SMQ</span> adjuvanted formulation induced significantly higher secretion of <span class="badge badge-object">IL-6</span>, IL-10, IFN-γ, and TNF-α than the alum adjuvanted formulation.` );'
href="javascript:;">Full-Text Search: PMC7064752</a>
</div>
</div>
</div> <!-- container -->
</div> <!-- row evidence -->
</div> <!-- PA Statement container -->
</div> <!-- PA Statement group -->
</div> <!-- container -->
</div> <!-- type groups -->
<div class="row super_group_heading"
id="tl-3c759c4a-d031-42b0-9f67-5f9fe8fe0827"
onclick="toggler('tl-3c759c4a-d031-42b0-9f67-5f9fe8fe0827')">
<div class="col nvp">
<h5 class="align-middle">
SMQ affects <a href='https://identifiers.org/hgnc/HGNC:5962' target='_blank'>IL10</a>
</h5>
</div>
<div class="col text-right nvp">
</div>
</div>
<div class="group" id="tl-3c759c4a-d031-42b0-9f67-5f9fe8fe0827_group">
<div class="container nvp">
<div class="row group-shown" id="ba1a9b42-32e5-4069-95c4-599248fb18fc_group">
<div class="container nvp">
<a name="30554384213470801"></a>
<div class="row statement">
<div class="col text-left nvp">
<h5 class="align-middle">
SMQ activates <a href='https://identifiers.org/hgnc/HGNC:5962' target='_blank'>IL10</a>.
<a href="#"
>
<small class="badge badge-secondary badge-pill">1</small>
</a>
</h5>
</div>
<div class="col text-right nvp">
</div>
</div>
<div class="row evidence">
<div class="container" id="stmt-3-0-0"
data-stmt_hash="30554384213470801">
<div class="row evidence-text" data-source_hash="4155885927386739680"
style="border-bottom: 1px solid #FFFFFF;"
id="ev-3-0-0-0">
<div class="col-1">
<div class="row">
<div class="col-3 nvp curation_toggle"
id="ev-3-0-0-0-click"
data-parent_id="ev-3-0-0-0">
<a href="#"
>
&#10166;
</a>
</div>
<div class="col-9 nvp src-api"
title="reach">
reach
</div>
</div>
</div>
<div class="col-9">
"A comparison between the cytokine concentrations secreted by splenocytes from Combo5 / alum and Combo5 / <span class="badge badge-subject">SMQ</span> immune mice showed that the <span class="badge badge-subject">SMQ</span> adjuvanted formulation induced significantly higher secretion of IL-6, <span class="badge badge-object">IL-10</span>, IFN-γ, and TNF-α than the alum adjuvanted formulation."
</div>
<div class="col-2 text-right">
<a class="pmid_link"
title="Hover again to see info"
onmouseover="setPMIDlinkTitle(this.textContent, this); this.onmouseover=null;"
href='https://www.ncbi.nlm.nih.gov/pubmed/32156809'
target="_blank">
32156809</a>
| <a class="pmcid_link full_text_search"
onclick='openPMCIDJournal(`PMC7064752`, `A comparison between the cytokine concentrations secreted by splenocytes from Combo5 / alum and Combo5 / <span class="badge badge-subject">SMQ</span> immune mice showed that the <span class="badge badge-subject">SMQ</span> adjuvanted formulation induced significantly higher secretion of IL-6, <span class="badge badge-object">IL-10</span>, IFN-γ, and TNF-α than the alum adjuvanted formulation.` );'
href="javascript:;">Full-Text Search: PMC7064752</a>
</div>
</div>
</div> <!-- container -->
</div> <!-- row evidence -->
</div> <!-- PA Statement container -->
</div> <!-- PA Statement group -->
</div> <!-- container -->
</div> <!-- type groups -->
<div class="row super_group_heading"
id="tl-9f6196e4-7d73-4e47-826b-1d2649d1fd03"
onclick="toggler('tl-9f6196e4-7d73-4e47-826b-1d2649d1fd03')">
<div class="col nvp">
<h5 class="align-middle">
SMQ affects IFN-γ
</h5>
</div>
<div class="col text-right nvp">
</div>
</div>
<div class="group" id="tl-9f6196e4-7d73-4e47-826b-1d2649d1fd03_group">
<div class="container nvp">
<div class="row group-shown" id="3b9e1ee8-2a64-4acb-9407-0081f84a656a_group">
<div class="container nvp">
<a name="13465087121692280"></a>
<div class="row statement">
<div class="col text-left nvp">
<h5 class="align-middle">
SMQ activates IFN-γ.
<a href="#"
>
<small class="badge badge-secondary badge-pill">1</small>
</a>
</h5>
</div>
<div class="col text-right nvp">
</div>
</div>
<div class="row evidence">
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"A comparison between the cytokine concentrations secreted by splenocytes from Combo5 / alum and Combo5 / <span class="badge badge-subject">SMQ</span> immune mice showed that the <span class="badge badge-subject">SMQ</span> adjuvanted formulation induced significantly higher secretion of IL-6, IL-10, <span class="badge badge-object">IFN-γ</span>, and TNF-α than the alum adjuvanted formulation."
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32156809</a>
| <a class="pmcid_link full_text_search"
onclick='openPMCIDJournal(`PMC7064752`, `A comparison between the cytokine concentrations secreted by splenocytes from Combo5 / alum and Combo5 / <span class="badge badge-subject">SMQ</span> immune mice showed that the <span class="badge badge-subject">SMQ</span> adjuvanted formulation induced significantly higher secretion of IL-6, IL-10, <span class="badge badge-object">IFN-γ</span>, and TNF-α than the alum adjuvanted formulation.` );'
href="javascript:;">Full-Text Search: PMC7064752</a>
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<a href='https://identifiers.org/chebi/CHEBI:51079' target='_blank'>GS26575</a> affects <a href='https://identifiers.org/hgnc/HGNC:4164' target='_blank'>GAST</a>
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<a href='https://identifiers.org/chebi/CHEBI:51079' target='_blank'>GS26575</a> activates <a href='https://identifiers.org/hgnc/HGNC:4164' target='_blank'>GAST</a>.
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<small class="badge badge-secondary badge-pill">1</small>
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"Only <span class="badge badge-subject">M1</span> immune sera was able to promote opsonophagocytic killing of <span class="badge badge-object">GAS</span> (XREF_FIG) with an opsonic index significantly higher than that measured for naive mice."
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onclick='openPMCIDJournal(`PMC7064752`, `Only <span class="badge badge-subject">M1</span> immune sera was able to promote opsonophagocytic killing of <span class="badge badge-object">GAS</span> (XREF_FIG) with an opsonic index significantly higher than that measured for naive mice.` );'
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Combo5 affects <a href='https://identifiers.org/go/GO:0006955' target='_blank'>immune response</a>
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Combo5 activates <a href='https://identifiers.org/go/GO:0006955' target='_blank'>immune response</a>.
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"We further characterized the protective <span class="badge badge-object">immune response</span> elicited by <span class="badge badge-subject">Combo5</span> formulated with SMQ adjuvant and compared this to the nonprotective response elicited by <span class="badge badge-subject">Combo5</span> / alum and to the protective response elicited by the “ gold standard ” homologous M1 protein formulated with alum."
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target="_blank">
32156809</a>
| <a class="pmcid_link full_text_search"
onclick='openPMCIDJournal(`PMC7064752`, `We further characterized the protective <span class="badge badge-object">immune response</span> elicited by <span class="badge badge-subject">Combo5</span> formulated with SMQ adjuvant and compared this to the nonprotective response elicited by <span class="badge badge-subject">Combo5</span> / alum and to the protective response elicited by the “ gold standard ” homologous M1 protein formulated with alum.` );'
href="javascript:;">Full-Text Search: PMC7064752</a>
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<a href='https://identifiers.org/chebi/CHEBI:49470' target='_blank'>Aluminium(3+)</a> affects <a href='https://identifiers.org/go/GO:0006955' target='_blank'>immune response</a>
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<a href='https://identifiers.org/chebi/CHEBI:49470' target='_blank'>Aluminium(3+)</a> activates <a href='https://identifiers.org/go/GO:0006955' target='_blank'>immune response</a>.
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"We further characterized the <span class="badge badge-object">immune response</span> induced by the formulation that provided the highest protection against invasive lethal challenge and compared it to the <span class="badge badge-object">immune response</span> induced by Combo5 / <span class="badge badge-subject">alum</span> and M1/<span class="badge badge-subject">alum</span>."
</div>
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<a class="pmid_link"
title="Hover again to see info"
onmouseover="setPMIDlinkTitle(this.textContent, this); this.onmouseover=null;"
href='https://www.ncbi.nlm.nih.gov/pubmed/32156809'
target="_blank">
32156809</a>
| <a class="pmcid_link full_text_search"
onclick='openPMCIDJournal(`PMC7064752`, `We further characterized the <span class="badge badge-object">immune response</span> induced by the formulation that provided the highest protection against invasive lethal challenge and compared it to the <span class="badge badge-object">immune response</span> induced by Combo5 / <span class="badge badge-subject">alum</span> and M1/<span class="badge badge-subject">alum</span>.` );'
href="javascript:;">Full-Text Search: PMC7064752</a>
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SMQ affects TNF-α
</h5>
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SMQ activates TNF-α.
<a href="#"
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<small class="badge badge-secondary badge-pill">1</small>
</a>
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"A comparison between the cytokine concentrations secreted by splenocytes from Combo5 / alum and Combo5 / <span class="badge badge-subject">SMQ</span> immune mice showed that the <span class="badge badge-subject">SMQ</span> adjuvanted formulation induced significantly higher secretion of IL-6, IL-10, IFN-γ, and <span class="badge badge-object">TNF-α</span> than the alum adjuvanted formulation."
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title="Hover again to see info"
onmouseover="setPMIDlinkTitle(this.textContent, this); this.onmouseover=null;"
href='https://www.ncbi.nlm.nih.gov/pubmed/32156809'
target="_blank">
32156809</a>
| <a class="pmcid_link full_text_search"
onclick='openPMCIDJournal(`PMC7064752`, `A comparison between the cytokine concentrations secreted by splenocytes from Combo5 / alum and Combo5 / <span class="badge badge-subject">SMQ</span> immune mice showed that the <span class="badge badge-subject">SMQ</span> adjuvanted formulation induced significantly higher secretion of IL-6, IL-10, IFN-γ, and <span class="badge badge-object">TNF-α</span> than the alum adjuvanted formulation.` );'
href="javascript:;">Full-Text Search: PMC7064752</a>
</div>
</div>
</div> <!-- container -->
</div> <!-- row evidence -->
</div> <!-- PA Statement container -->
</div> <!-- PA Statement group -->
</div> <!-- container -->
</div> <!-- type groups -->
<div class="row super_group_heading"
id="tl-d5196a9b-4c5e-4d13-813b-2a262c6a1801"
onclick="toggler('tl-d5196a9b-4c5e-4d13-813b-2a262c6a1801')">
<div class="col nvp">
<h5 class="align-middle">
SMQ affects <a href='https://identifiers.org/hgnc/HGNC:6018' target='_blank'>IL6</a>
</h5>
</div>
<div class="col text-right nvp">
</div>
</div>
<div class="group" id="tl-d5196a9b-4c5e-4d13-813b-2a262c6a1801_group">
<div class="container nvp">
<div class="row group-shown" id="d2e4c2d0-edea-4418-83dc-3bb7349d6622_group">
<div class="container nvp">
<a name="-17919606370707517"></a>
<div class="row statement">
<div class="col text-left nvp">
<h5 class="align-middle">
SMQ activates <a href='https://identifiers.org/hgnc/HGNC:6018' target='_blank'>IL6</a>.
<a href="#"
>
<small class="badge badge-secondary badge-pill">1</small>
</a>
</h5>
</div>
<div class="col text-right nvp">
</div>
</div>
<div class="row evidence">
<div class="container" id="stmt-2-0-0"
data-stmt_hash="-17919606370707517">
<div class="row evidence-text" data-source_hash="4155885927386739680"
style="border-bottom: 1px solid #FFFFFF;"
id="ev-2-0-0-0">
<div class="col-1">
<div class="row">
<div class="col-3 nvp curation_toggle"
id="ev-2-0-0-0-click"
data-parent_id="ev-2-0-0-0">
<a href="#"
>
&#10166;
</a>
</div>
<div class="col-9 nvp src-api"
title="reach">
reach
</div>
</div>
</div>
<div class="col-9">
"A comparison between the cytokine concentrations secreted by splenocytes from Combo5 / alum and Combo5 / <span class="badge badge-subject">SMQ</span> immune mice showed that the <span class="badge badge-subject">SMQ</span> adjuvanted formulation induced significantly higher secretion of <span class="badge badge-object">IL-6</span>, IL-10, IFN-γ, and TNF-α than the alum adjuvanted formulation."
</div>
<div class="col-2 text-right">
<a class="pmid_link"
title="Hover again to see info"
onmouseover="setPMIDlinkTitle(this.textContent, this); this.onmouseover=null;"
href='https://www.ncbi.nlm.nih.gov/pubmed/32156809'
target="_blank">
32156809</a>
| <a class="pmcid_link full_text_search"
onclick='openPMCIDJournal(`PMC7064752`, `A comparison between the cytokine concentrations secreted by splenocytes from Combo5 / alum and Combo5 / <span class="badge badge-subject">SMQ</span> immune mice showed that the <span class="badge badge-subject">SMQ</span> adjuvanted formulation induced significantly higher secretion of <span class="badge badge-object">IL-6</span>, IL-10, IFN-γ, and TNF-α than the alum adjuvanted formulation.` );'
href="javascript:;">Full-Text Search: PMC7064752</a>
</div>
</div>
</div> <!-- container -->
</div> <!-- row evidence -->
</div> <!-- PA Statement container -->
</div> <!-- PA Statement group -->
</div> <!-- container -->
</div> <!-- type groups -->
<div class="row super_group_heading"
id="tl-3c759c4a-d031-42b0-9f67-5f9fe8fe0827"
onclick="toggler('tl-3c759c4a-d031-42b0-9f67-5f9fe8fe0827')">
<div class="col nvp">
<h5 class="align-middle">
SMQ affects <a href='https://identifiers.org/hgnc/HGNC:5962' target='_blank'>IL10</a>
</h5>
</div>
<div class="col text-right nvp">
</div>
</div>
<div class="group" id="tl-3c759c4a-d031-42b0-9f67-5f9fe8fe0827_group">
<div class="container nvp">
<div class="row group-shown" id="ba1a9b42-32e5-4069-95c4-599248fb18fc_group">
<div class="container nvp">
<a name="30554384213470801"></a>
<div class="row statement">
<div class="col text-left nvp">
<h5 class="align-middle">
SMQ activates <a href='https://identifiers.org/hgnc/HGNC:5962' target='_blank'>IL10</a>.
<a href="#"
>
<small class="badge badge-secondary badge-pill">1</small>
</a>
</h5>
</div>
<div class="col text-right nvp">
</div>
</div>
<div class="row evidence">
<div class="container" id="stmt-3-0-0"
data-stmt_hash="30554384213470801">
<div class="row evidence-text" data-source_hash="4155885927386739680"
style="border-bottom: 1px solid #FFFFFF;"
id="ev-3-0-0-0">
<div class="col-1">
<div class="row">
<div class="col-3 nvp curation_toggle"
id="ev-3-0-0-0-click"
data-parent_id="ev-3-0-0-0">
<a href="#"
>
&#10166;
</a>
</div>
<div class="col-9 nvp src-api"
title="reach">
reach
</div>
</div>
</div>
<div class="col-9">
"A comparison between the cytokine concentrations secreted by splenocytes from Combo5 / alum and Combo5 / <span class="badge badge-subject">SMQ</span> immune mice showed that the <span class="badge badge-subject">SMQ</span> adjuvanted formulation induced significantly higher secretion of IL-6, <span class="badge badge-object">IL-10</span>, IFN-γ, and TNF-α than the alum adjuvanted formulation."
</div>
<div class="col-2 text-right">
<a class="pmid_link"
title="Hover again to see info"
onmouseover="setPMIDlinkTitle(this.textContent, this); this.onmouseover=null;"
href='https://www.ncbi.nlm.nih.gov/pubmed/32156809'
target="_blank">
32156809</a>
| <a class="pmcid_link full_text_search"
onclick='openPMCIDJournal(`PMC7064752`, `A comparison between the cytokine concentrations secreted by splenocytes from Combo5 / alum and Combo5 / <span class="badge badge-subject">SMQ</span> immune mice showed that the <span class="badge badge-subject">SMQ</span> adjuvanted formulation induced significantly higher secretion of IL-6, <span class="badge badge-object">IL-10</span>, IFN-γ, and TNF-α than the alum adjuvanted formulation.` );'
href="javascript:;">Full-Text Search: PMC7064752</a>
</div>
</div>
</div> <!-- container -->
</div> <!-- row evidence -->
</div> <!-- PA Statement container -->
</div> <!-- PA Statement group -->
</div> <!-- container -->
</div> <!-- type groups -->
<div class="row super_group_heading"
id="tl-9f6196e4-7d73-4e47-826b-1d2649d1fd03"
onclick="toggler('tl-9f6196e4-7d73-4e47-826b-1d2649d1fd03')">
<div class="col nvp">
<h5 class="align-middle">
SMQ affects IFN-γ
</h5>
</div>
<div class="col text-right nvp">
</div>
</div>
<div class="group" id="tl-9f6196e4-7d73-4e47-826b-1d2649d1fd03_group">
<div class="container nvp">
<div class="row group-shown" id="3b9e1ee8-2a64-4acb-9407-0081f84a656a_group">
<div class="container nvp">
<a name="13465087121692280"></a>
<div class="row statement">
<div class="col text-left nvp">
<h5 class="align-middle">
SMQ activates IFN-γ.
<a href="#"
>
<small class="badge badge-secondary badge-pill">1</small>
</a>
</h5>
</div>
<div class="col text-right nvp">
</div>
</div>
<div class="row evidence">
<div class="container" id="stmt-4-0-0"
data-stmt_hash="13465087121692280">
<div class="row evidence-text" data-source_hash="4155885927386739680"
style="border-bottom: 1px solid #FFFFFF;"
id="ev-4-0-0-0">
<div class="col-1">
<div class="row">
<div class="col-3 nvp curation_toggle"
id="ev-4-0-0-0-click"
data-parent_id="ev-4-0-0-0">
<a href="#"
>
&#10166;
</a>
</div>
<div class="col-9 nvp src-api"
title="reach">
reach
</div>
</div>
</div>
<div class="col-9">
"A comparison between the cytokine concentrations secreted by splenocytes from Combo5 / alum and Combo5 / <span class="badge badge-subject">SMQ</span> immune mice showed that the <span class="badge badge-subject">SMQ</span> adjuvanted formulation induced significantly higher secretion of IL-6, IL-10, <span class="badge badge-object">IFN-γ</span>, and TNF-α than the alum adjuvanted formulation."
</div>
<div class="col-2 text-right">
<a class="pmid_link"
title="Hover again to see info"
onmouseover="setPMIDlinkTitle(this.textContent, this); this.onmouseover=null;"
href='https://www.ncbi.nlm.nih.gov/pubmed/32156809'
target="_blank">
32156809</a>
| <a class="pmcid_link full_text_search"
onclick='openPMCIDJournal(`PMC7064752`, `A comparison between the cytokine concentrations secreted by splenocytes from Combo5 / alum and Combo5 / <span class="badge badge-subject">SMQ</span> immune mice showed that the <span class="badge badge-subject">SMQ</span> adjuvanted formulation induced significantly higher secretion of IL-6, IL-10, <span class="badge badge-object">IFN-γ</span>, and TNF-α than the alum adjuvanted formulation.` );'
href="javascript:;">Full-Text Search: PMC7064752</a>
</div>
</div>
</div> <!-- container -->
</div> <!-- row evidence -->
</div> <!-- PA Statement container -->
</div> <!-- PA Statement group -->
</div> <!-- container -->
</div> <!-- type groups -->
<div class="row super_group_heading"
id="tl-e7c84fd6-4341-4cdf-af52-4d53ea2cd73f"
onclick="toggler('tl-e7c84fd6-4341-4cdf-af52-4d53ea2cd73f')">
<div class="col nvp">
<h5 class="align-middle">
<a href='https://identifiers.org/chebi/CHEBI:51079' target='_blank'>GS26575</a> affects <a href='https://identifiers.org/hgnc/HGNC:4164' target='_blank'>GAST</a>
</h5>
</div>
<div class="col text-right nvp">
</div>
</div>
<div class="group" id="tl-e7c84fd6-4341-4cdf-af52-4d53ea2cd73f_group">
<div class="container nvp">
<div class="row group-shown" id="9cf74aef-9073-41b0-895d-51655ee916f8_group">
<div class="container nvp">
<a name="-31029788656818151"></a>
<div class="row statement">
<div class="col text-left nvp">
<h5 class="align-middle">
<a href='https://identifiers.org/chebi/CHEBI:51079' target='_blank'>GS26575</a> activates <a href='https://identifiers.org/hgnc/HGNC:4164' target='_blank'>GAST</a>.
<a href="#"
>
<small class="badge badge-secondary badge-pill">1</small>
</a>
</h5>
</div>
<div class="col text-right nvp">
</div>
</div>
<div class="row evidence">
<div class="container" id="stmt-5-0-0"
data-stmt_hash="-31029788656818151">
<div class="row evidence-text" data-source_hash="-5164385967986893407"
style="border-bottom: 1px solid #FFFFFF;"
id="ev-5-0-0-0">
<div class="col-1">
<div class="row">
<div class="col-3 nvp curation_toggle"
id="ev-5-0-0-0-click"
data-parent_id="ev-5-0-0-0">
<a href="#"
>
&#10166;
</a>
</div>
<div class="col-9 nvp src-api"
title="reach">
reach
</div>
</div>
</div>
<div class="col-9">
"Only <span class="badge badge-subject">M1</span> immune sera was able to promote opsonophagocytic killing of <span class="badge badge-object">GAS</span> (XREF_FIG) with an opsonic index significantly higher than that measured for naive mice."
</div>
<div class="col-2 text-right">
<a class="pmid_link"
title="Hover again to see info"
onmouseover="setPMIDlinkTitle(this.textContent, this); this.onmouseover=null;"
href='https://www.ncbi.nlm.nih.gov/pubmed/32156809'
target="_blank">
32156809</a>
| <a class="pmcid_link full_text_search"
onclick='openPMCIDJournal(`PMC7064752`, `Only <span class="badge badge-subject">M1</span> immune sera was able to promote opsonophagocytic killing of <span class="badge badge-object">GAS</span> (XREF_FIG) with an opsonic index significantly higher than that measured for naive mice.` );'
href="javascript:;">Full-Text Search: PMC7064752</a>
</div>
</div>
</div> <!-- container -->
</div> <!-- row evidence -->
</div> <!-- PA Statement container -->
</div> <!-- PA Statement group -->
</div> <!-- container -->
</div> <!-- type groups -->
<div class="row super_group_heading"
id="tl-764b485b-d8f0-4df9-b48b-16e5cdf28b55"
onclick="toggler('tl-764b485b-d8f0-4df9-b48b-16e5cdf28b55')">
<div class="col nvp">
<h5 class="align-middle">
Combo5 affects <a href='https://identifiers.org/go/GO:0006955' target='_blank'>immune response</a>
</h5>
</div>
<div class="col text-right nvp">
</div>
</div>
<div class="group" id="tl-764b485b-d8f0-4df9-b48b-16e5cdf28b55_group">
<div class="container nvp">
<div class="row group-shown" id="471570d0-b7a7-4a22-9bd4-f931d4f1afbe_group">
<div class="container nvp">
<a name="-12695682573761343"></a>
<div class="row statement">
<div class="col text-left nvp">
<h5 class="align-middle">
Combo5 activates <a href='https://identifiers.org/go/GO:0006955' target='_blank'>immune response</a>.
<a href="#"
>
<small class="badge badge-secondary badge-pill">1</small>
</a>
</h5>
</div>
<div class="col text-right nvp">
</div>
</div>
<div class="row evidence">
<div class="container" id="stmt-6-0-0"
data-stmt_hash="-12695682573761343">
<div class="row evidence-text" data-source_hash="597975201937205239"
style="border-bottom: 1px solid #FFFFFF;"
id="ev-6-0-0-0">
<div class="col-1">
<div class="row">
<div class="col-3 nvp curation_toggle"
id="ev-6-0-0-0-click"
data-parent_id="ev-6-0-0-0">
<a href="#"
>
&#10166;
</a>
</div>
<div class="col-9 nvp src-api"
title="reach">
reach
</div>
</div>
</div>
<div class="col-9">
"We further characterized the protective <span class="badge badge-object">immune response</span> elicited by <span class="badge badge-subject">Combo5</span> formulated with SMQ adjuvant and compared this to the nonprotective response elicited by <span class="badge badge-subject">Combo5</span> / alum and to the protective response elicited by the “ gold standard ” homologous M1 protein formulated with alum."
</div>
<div class="col-2 text-right">
<a class="pmid_link"
title="Hover again to see info"
onmouseover="setPMIDlinkTitle(this.textContent, this); this.onmouseover=null;"
href='https://www.ncbi.nlm.nih.gov/pubmed/32156809'
target="_blank">
32156809</a>
| <a class="pmcid_link full_text_search"
onclick='openPMCIDJournal(`PMC7064752`, `We further characterized the protective <span class="badge badge-object">immune response</span> elicited by <span class="badge badge-subject">Combo5</span> formulated with SMQ adjuvant and compared this to the nonprotective response elicited by <span class="badge badge-subject">Combo5</span> / alum and to the protective response elicited by the “ gold standard ” homologous M1 protein formulated with alum.` );'
href="javascript:;">Full-Text Search: PMC7064752</a>
</div>
</div>
</div> <!-- container -->
</div> <!-- row evidence -->
</div> <!-- PA Statement container -->
</div> <!-- PA Statement group -->
</div> <!-- container -->
</div> <!-- type groups -->
<hr>
<!-- Footer -->
<footer class="footer text-muted" id="about">
<h5 class="my-0 mr-md-auto font-weight-normal">About</h5>
INDRA is developed by <a href="https://indralab.github.io/">indralabs</a>,
a part of the Harvard Medical School Laboratory of Systems Pharmacology.
</footer>
</div>
</body>
</html>
import json
from indra.sources import reach, trips
from indra.statements.statements import stmts_to_json
from indra.assemblers.html.assembler import HtmlAssembler
from indra.assemblers.english.assembler import EnglishAssembler
from indra.assemblers.tsv.assembler import TsvAssembler
ha = HtmlAssembler()
reach_processor_2 = reach.api.process_pmc("7064752")
stmts = reach_processor_2.statements
ha.add_statements(stmts)
html = ha.make_model(template=None, with_grouping=True, add_full_text_search_link=True)
ha.save_model('output.html')
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