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| <!DOCTYPE html> | |
| <html lang="en"> | |
| <head> | |
| <meta charset="utf-8"> | |
| <meta http-equiv="X-UA-Compatible" content="IE=edge"> | |
| <meta name="viewport" content="width=device-width, initial-scale=1"> | |
| <!-- The above 3 meta tags *must* come first in the head; any other head content must come *after* these tags --> | |
| <meta name="description" content=""> | |
| <meta name="author" content=""> | |
| <link rel="icon" href="https://bigmech.s3.amazonaws.com/indra-db/favicon.ico"> | |
| <title>INDRA Results</title> | |
| <script src="https://code.jquery.com/jquery-3.3.1.min.js" | |
| integrity="sha256-FgpCb/KJQlLNfOu91ta32o/NMZxltwRo8QtmkMRdAu8=" | |
| crossorigin="anonymous"></script> | |
| <!-- Latest compiled and minified CSS --> | |
| <link rel="stylesheet" | |
| href="https://stackpath.bootstrapcdn.com/bootstrap/4.1.3/css/bootstrap.min.css" | |
| integrity="sha384-MCw98/SFnGE8fJT3GXwEOngsV7Zt27NXFoaoApmYm81iuXoPkFOJwJ8ERdknLPMO" | |
| crossorigin="anonymous"> | |
| <!-- Optional theme --> | |
| <link rel="stylesheet" | |
| href="https://use.fontawesome.com/releases/v5.5.0/css/all.css" | |
| integrity="sha384-B4dIYHKNBt8Bc12p+WXckhzcICo0wtJAoU8YZTY5qE0Id1GSseTk6S+L3BlXeVIU" | |
| crossorigin="anonymous"> | |
| <!-- Latest compiled and minified JavaScript --> | |
| <script src="https://stackpath.bootstrapcdn.com/bootstrap/4.1.3/js/bootstrap.min.js" | |
| integrity="sha384-ChfqqxuZUCnJSK3+MXmPNIyE6ZbWh2IMqE241rYiqJxyMiZ6OW/JmZQ5stwEULTy" | |
| crossorigin="anonymous"></script> | |
| <style> | |
| a { | |
| color: #256DC5; | |
| target-new: tab; | |
| } | |
| h1 { | |
| margin-bottom: 0; | |
| } | |
| .page-header { | |
| padding: 1em; | |
| } | |
| </style> | |
| <!-- Toggle a hidden element --> | |
| <script> | |
| const pubmed_fetch = "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi"; | |
| let ALL_COLLAPSED = true; | |
| function toggler(short_name_key) { | |
| $("#" + short_name_key + "_group").toggle(); | |
| let header = "#" + short_name_key + "_heading"; | |
| $(header).show(); | |
| } | |
| function getPubMedMETAxmlByPMID(pmid) { | |
| let params_dict = { | |
| 'db': 'pubmed', | |
| 'retmode': 'xml', | |
| 'rettype': 'docsum', | |
| 'id': pmid | |
| }; | |
| return $.ajax({ | |
| url: pubmed_fetch, | |
| type: "POST", | |
| dataType: "xml", | |
| data: params_dict, | |
| }); | |
| } | |
| function pmidXML2dict(XML) { | |
| let xml_dict = {}; | |
| for (let child of XML.children) { | |
| let name = child.getAttribute("Name"); | |
| let type = child.getAttribute("Type"); | |
| if (child.hasChildNodes() && type === "List") { | |
| let innerItems; | |
| // Javascript can't really do nice recursive functions... | |
| // special cases for "History" and "ArticleIds" which has unique inner Names | |
| if (name === "ArticleIds" || name === "History") { | |
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| innerDict[c.getAttribute("Name")] = c.textContent; | |
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| innerItems = innerDict; | |
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| } | |
| innerItems = innerList; | |
| } | |
| xml_dict[name] = innerItems | |
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| // Here just get the inner strings | |
| xml_dict[name] = child.textContent; | |
| } else if (child.tagName === "Id") { | |
| // Special case | |
| xml_dict["Id"] = child.textContent; | |
| } else { | |
| if (!xml_dict["no_key"]) { | |
| xml_dict["no_key"] = [child.textContent] | |
| } else { | |
| xml_dict["no_key"].push(child.textContent) | |
| } | |
| } | |
| } | |
| return xml_dict; | |
| } | |
| // Modify link hover text | |
| function setPMIDlinkTitle(pmid, link_tag) { | |
| let pubmed_xml_promise = getPubMedMETAxmlByPMID(pmid); | |
| pubmed_xml_promise.then(responseXML => { | |
| const docsum_xml = responseXML.getElementsByTagName('DocSum')[0]; | |
| const pmd = pmidXML2dict(docsum_xml); | |
| const nAuthors = pmd.AuthorList.length; | |
| let authorsStr; | |
| if (nAuthors > 3) | |
| authorsStr = `${pmd.AuthorList[0]}, ... ${pmd.AuthorList[nAuthors - 1]}`; | |
| else | |
| authorsStr = pmd.AuthorList.join(", "); | |
| // Shortened journal name is in .Source, while full name is in .FullJournalName | |
| link_tag.title = `${authorsStr}, "${pmd.Title}", ${pmd.Source}, ${pmd.SO}`; | |
| }) | |
| } | |
| // Loop all pmid link nodes and set title | |
| function populatePMIDlinkTitles() { | |
| let pmid_link_array = document.getElementsByClassName("pmid_link"); | |
| for (link_obj of pmid_link_array) { | |
| pmid = link_obj.textContent; | |
| setPMIDlinkTitle(pmid, link_obj) | |
| } | |
| } | |
| // Open journal in PubmedCentral | |
| function openPMCIDJournal(pmcid, html){ | |
| var span = document.createElement('span'); | |
| span.innerHTML = html; | |
| var text = span.innerText; | |
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| var secondLastWord = ""; | |
| if(words.length>7) | |
| secondLastWord = words[words.length - 2] + " "; | |
| var lastWord = words[words.length - 1]; | |
| if(lastWord.endsWith(".")) | |
| lastWord = lastWord.substring(0,lastWord.length-1) | |
| searchText += "," + encodeURIComponent(secondLastWord + lastWord); | |
| } | |
| window.open("https://www.ncbi.nlm.nih.gov/pmc/articles/"+pmcid+"#maincontent:~:text="+ searchText.trim()) | |
| } | |
| // Expand/collapse all | |
| function expandCollapseAll() { | |
| let expColBtn = document.getElementById('expand-collapse-all'); | |
| let setCss = ''; | |
| // Expand all; set ALL_COLLAPSED = false; | |
| if (ALL_COLLAPSED) { | |
| setCss = 'display: block;'; | |
| ALL_COLLAPSED = false; | |
| expColBtn.textContent = 'Collapse All'; | |
| // Collapse all; set ALL_COLLAPSED = true; | |
| } else { | |
| setCss = 'display: none;'; | |
| ALL_COLLAPSED = true; | |
| expColBtn.textContent = 'Expand All'; | |
| } | |
| // Loop all tags | |
| for (tag of document.getElementsByClassName('group')) { | |
| tag.style.cssText = setCss | |
| } | |
| } | |
| </script> | |
| <style> | |
| .source-phosphosite { | |
| background-color: #bc80bd; | |
| color: black; | |
| } | |
| .source-cbn { | |
| background-color: #fccde5; | |
| color: black; | |
| } | |
| .source-pc11 { | |
| background-color: #b3de69; | |
| color: black; | |
| } | |
| .source-biopax { | |
| background-color: #80b1d3; | |
| color: black; | |
| } | |
| .source-bel_lc { | |
| background-color: #fb8072; | |
| color: black; | |
| } | |
| .source-signor { | |
| background-color: #bebada; | |
| color: black; | |
| } | |
| .source-biogrid { | |
| background-color: #fdb462; | |
| color: black; | |
| } | |
| .source-tas { | |
| background-color: #8dd3c7; | |
| color: black; | |
| } | |
| .source-lincs_drug { | |
| background-color: #ffffb3; | |
| color: black; | |
| } | |
| .source-hprd { | |
| background-color: #d9d9d9; | |
| color: black; | |
| } | |
| .source-trrust { | |
| background-color: #ccebc5; | |
| color: black; | |
| } | |
| .source-geneways { | |
| background-color: #bc80bd; | |
| color: white; | |
| } | |
| .source-tees { | |
| background-color: #fccde5; | |
| color: white; | |
| } | |
| .source-isi { | |
| background-color: #b3de69; | |
| color: white; | |
| } | |
| .source-trips { | |
| background-color: #80b1d3; | |
| color: white; | |
| } | |
| .source-rlimsp { | |
| background-color: #fb8072; | |
| color: white; | |
| } | |
| .source-medscan { | |
| background-color: #bebada; | |
| color: white; | |
| } | |
| .source-sparser { | |
| background-color: #fdb462; | |
| color: white; | |
| } | |
| .source-reach { | |
| background-color: #8dd3c7; | |
| color: white; | |
| } | |
| .badge-source { | |
| font-size: 8pt; | |
| margin: 0; | |
| } | |
| .statements-header { | |
| position: -webkit-sticky; | |
| position: sticky; | |
| top: 0; | |
| background-color: white; | |
| z-index: 10; | |
| padding-top: 5px; | |
| } | |
| .nvp { | |
| padding-left: 0; | |
| padding-right: 0; | |
| } | |
| .src-api { | |
| overflow-x: hidden; | |
| } | |
| .group, .group-shown { | |
| padding: 5px; | |
| margin: 5px; | |
| } | |
| .group { | |
| display: none; | |
| border-left: #0d5aa7 solid 1px; | |
| border-right: #0d5aa7 solid 1px; | |
| } | |
| .super_group_heading, .group_heading, .statement, .evidence { | |
| padding: 2px; | |
| padding-left: 5px; | |
| margin: 2px; | |
| position: sticky; | |
| border-radius: 2px; | |
| } | |
| .evidence, .evidence-text { | |
| margin-bottom: 10px; | |
| } | |
| .evidence-text { | |
| border-top: #cfcfcf solid 1px; | |
| padding-top: 0.5em; | |
| } | |
| .super_group_heading, .group_heading { | |
| cursor: pointer; | |
| } | |
| .super_group_heading:hover, .group_heading:hover { | |
| background-color: #f2f2f2; | |
| } | |
| .badge-subject { | |
| background-color: #4a36aa; | |
| color: #FFFFFF; | |
| } | |
| .badge-object { | |
| background-color: #2d8e4c; | |
| color: #FFFFFF; | |
| } | |
| .badge-other { | |
| background-color: #606060; | |
| color: #FFFFFF; | |
| } | |
| .curation-row { | |
| overflow-y: hidden; | |
| } | |
| .curation_toggle { | |
| cursor: pointer; | |
| } | |
| .pmid_link, .pmcid_link, .doi_link { | |
| display: block; | |
| } | |
| .full_text_search:hover { | |
| text-decoration: underline; | |
| } | |
| </style> | |
| </head> | |
| <body> | |
| <div class="container"> | |
| <!-- Page Header --> | |
| <div class="page-header"> | |
| <h1>INDRA Results</h1> | |
| </div> | |
| This page allows you to curate the loaded statements. For more information | |
| please see the | |
| <a href="https://indra.readthedocs.io/en/latest/tutorials/html_curation.html" | |
| target="_blank">manual</a>. | |
| <hr> | |
| <div class="statements-header"> | |
| <div class="row"> | |
| <div class="col"> | |
| <h3 > | |
| Statements | |
| </h3> | |
| </div> | |
| <div class="col text-right"> | |
| <button id="expand-collapse-all" type="button" | |
| class="btn btn-primary" | |
| onclick="expandCollapseAll()"> | |
| Expand All | |
| </button> | |
| </div> | |
| </div> | |
| <hr> | |
| </div> | |
| <div class="group-shown" id="tl-7721e296-f530-452d-8af4-0a4da72dc20d_group"> | |
| <div class="container nvp"> | |
| <div class="row group-shown" id="all-statements-sub-group_group"> | |
| <div class="container nvp"> | |
| <a name="18090019861218668"></a> | |
| <div class="row statement"> | |
| <div class="col text-left nvp"> | |
| <h5 class="align-middle"> | |
| OleB gene activates β-lactone natural products. | |
| <a href="#" | |
| > | |
| <small class="badge badge-secondary badge-pill">1</small> | |
| </a> | |
| </h5> | |
| </div> | |
| <div class="col text-right nvp"> | |
| </div> | |
| </div> | |
| <div class="row evidence"> | |
| <div class="container" id="stmt-0-0-0" | |
| data-stmt_hash="18090019861218668"> | |
| <div class="row evidence-text" data-source_hash="1035630220624888133" | |
| style="border-bottom: 1px solid #FFFFFF;" | |
| id="ev-0-0-0-0"> | |
| <div class="col-1"> | |
| <div class="row"> | |
| <div class="col-3 nvp curation_toggle" | |
| id="ev-0-0-0-0-click" | |
| data-parent_id="ev-0-0-0-0"> | |
| <a href="#" | |
| > | |
| ➶ | |
| </a> | |
| </div> | |
| <div class="col-9 nvp src-api" | |
| title="reach"> | |
| reach | |
| </div> | |
| </div> | |
| </div> | |
| <div class="col-9"> | |
| "Indeed, other Actinobacteria, such as Streptomyces toxytricini and Nocardia brasiliensis that have oleACD biosynthetic gene clusters but lack an <span class="badge badge-subject">oleB gene</span> produce <span class="badge badge-object">β-lactone natural products</span> (XREF_BIBR, XREF_BIBR)." | |
| </div> | |
| <div class="col-2 text-right"> | |
| <a class="pmid_link" | |
| title="Hover again to see info" | |
| onmouseover="setPMIDlinkTitle(this.textContent, this); this.onmouseover=null;" | |
| href='https://www.ncbi.nlm.nih.gov/pubmed/32156808' | |
| target="_blank"> | |
| 32156808</a> | |
| | <a class="pmcid_link full_text_search" | |
| onclick='openPMCIDJournal(`PMC7064751`, `Indeed, other Actinobacteria, such as Streptomyces toxytricini and Nocardia brasiliensis that have oleACD biosynthetic gene clusters but lack an <span class="badge badge-subject">oleB gene</span> produce <span class="badge badge-object">β-lactone natural products</span> (XREF_BIBR, XREF_BIBR).` );' | |
| href="javascript:;">Full-Text Search: PMC7064751</a> | |
| </div> | |
| </div> | |
| </div> <!-- container --> | |
| </div> <!-- row evidence --> | |
| <a name="-12371255862782732"></a> | |
| <div class="row statement"> | |
| <div class="col text-left nvp"> | |
| <h5 class="align-middle"> | |
| OleA genes activates OleA proteins. | |
| <a href="#" | |
| > | |
| <small class="badge badge-secondary badge-pill">1</small> | |
| </a> | |
| </h5> | |
| </div> | |
| <div class="col text-right nvp"> | |
| </div> | |
| </div> | |
| <div class="row evidence"> | |
| <div class="container" id="stmt-0-0-1" | |
| data-stmt_hash="-12371255862782732"> | |
| <div class="row evidence-text" data-source_hash="-5060015897982332429" | |
| style="border-bottom: 1px solid #FFFFFF;" | |
| id="ev-0-0-1-0"> | |
| <div class="col-1"> | |
| <div class="row"> | |
| <div class="col-3 nvp curation_toggle" | |
| id="ev-0-0-1-0-click" | |
| data-parent_id="ev-0-0-1-0"> | |
| <a href="#" | |
| > | |
| ➶ | |
| </a> | |
| </div> | |
| <div class="col-9 nvp src-api" | |
| title="reach"> | |
| reach | |
| </div> | |
| </div> | |
| </div> | |
| <div class="col-9"> | |
| "In this context, genome sequences were analyzed here to identify divergent <span class="badge badge-subject">oleA genes</span> that might produce stable and active <span class="badge badge-object">OleA proteins</span> when expressed heterologously in Escherichia coli." | |
| </div> | |
| <div class="col-2 text-right"> | |
| <a class="pmid_link" | |
| title="Hover again to see info" | |
| onmouseover="setPMIDlinkTitle(this.textContent, this); this.onmouseover=null;" | |
| href='https://www.ncbi.nlm.nih.gov/pubmed/32156808' | |
| target="_blank"> | |
| 32156808</a> | |
| | <a class="pmcid_link full_text_search" | |
| onclick='openPMCIDJournal(`PMC7064751`, `In this context, genome sequences were analyzed here to identify divergent <span class="badge badge-subject">oleA genes</span> that might produce stable and active <span class="badge badge-object">OleA proteins</span> when expressed heterologously in Escherichia coli.` );' | |
| href="javascript:;">Full-Text Search: PMC7064751</a> | |
| </div> | |
| </div> | |
| </div> <!-- container --> | |
| </div> <!-- row evidence --> | |
| <a name="1688310692637109"></a> | |
| <div class="row statement"> | |
| <div class="col text-left nvp"> | |
| <h5 class="align-middle"> | |
| <a href='https://identifiers.org/chebi/CHEBI:89919' target='_blank'>Sialyllacto-N-tetraose a</a> binds <a href='https://identifiers.org/chebi/CHEBI:88450' target='_blank'>Sialyllacto-N-tetraose b</a>. | |
| <a href="#" | |
| > | |
| <small class="badge badge-secondary badge-pill">1</small> | |
| </a> | |
| </h5> | |
| </div> | |
| <div class="col text-right nvp"> | |
| </div> | |
| </div> | |
| <div class="row evidence"> | |
| <div class="container" id="stmt-0-0-2" | |
| data-stmt_hash="1688310692637109"> | |
| <div class="row evidence-text" data-source_hash="1698484995511814354" | |
| style="border-bottom: 1px solid #FFFFFF;" | |
| id="ev-0-0-2-0"> | |
| <div class="col-1"> | |
| <div class="row"> | |
| <div class="col-3 nvp curation_toggle" | |
| id="ev-0-0-2-0-click" | |
| data-parent_id="ev-0-0-2-0"> | |
| <a href="#" | |
| > | |
| ➶ | |
| </a> | |
| </div> | |
| <div class="col-9 nvp src-api" | |
| title="reach"> | |
| reach | |
| </div> | |
| </div> | |
| </div> | |
| <div class="col-9"> | |
| "Two distant homologs of OleA are <span class="badge badge-other">LstA</span> and <span class="badge badge-other">LstB</span> that together form a heterodimer in solution and catalyze the condensation of (3S,5 Z,8 Z)-3-hydroxytetradeca-5,8-dienoyl-CoA and octyl-CoA to produce the backbone of the β-lactone natural product, lipstatin (XREF_BIBR)." | |
| </div> | |
| <div class="col-2 text-right"> | |
| <a class="pmid_link" | |
| title="Hover again to see info" | |
| onmouseover="setPMIDlinkTitle(this.textContent, this); this.onmouseover=null;" | |
| href='https://www.ncbi.nlm.nih.gov/pubmed/32156808' | |
| target="_blank"> | |
| 32156808</a> | |
| | <a class="pmcid_link full_text_search" | |
| onclick='openPMCIDJournal(`PMC7064751`, `Two distant homologs of OleA are <span class="badge badge-other">LstA</span> and <span class="badge badge-other">LstB</span> that together form a heterodimer in solution and catalyze the condensation of (3S,5 Z,8 Z)-3-hydroxytetradeca-5,8-dienoyl-CoA and octyl-CoA to produce the backbone of the β-lactone natural product, lipstatin (XREF_BIBR).` );' | |
| href="javascript:;">Full-Text Search: PMC7064751</a> | |
| </div> | |
| </div> | |
| </div> <!-- container --> | |
| </div> <!-- row evidence --> | |
| <a name="-30852087796738834"></a> | |
| <div class="row statement"> | |
| <div class="col text-left nvp"> | |
| <h5 class="align-middle"> | |
| <a href='https://identifiers.org/chebi/CHEBI:89919' target='_blank'>Sialyllacto-N-tetraose a</a> bound to Sialyllacto-N-tetraose b activates <a href='https://identifiers.org/pfam/PF00668' target='_blank'>condensation</a>. | |
| <a href="#" | |
| > | |
| <small class="badge badge-secondary badge-pill">1</small> | |
| </a> | |
| </h5> | |
| </div> | |
| <div class="col text-right nvp"> | |
| </div> | |
| </div> | |
| <div class="row evidence"> | |
| <div class="container" id="stmt-0-0-3" | |
| data-stmt_hash="-30852087796738834"> | |
| <div class="row evidence-text" data-source_hash="1698484995511814354" | |
| style="border-bottom: 1px solid #FFFFFF;" | |
| id="ev-0-0-3-0"> | |
| <div class="col-1"> | |
| <div class="row"> | |
| <div class="col-3 nvp curation_toggle" | |
| id="ev-0-0-3-0-click" | |
| data-parent_id="ev-0-0-3-0"> | |
| <a href="#" | |
| > | |
| ➶ | |
| </a> | |
| </div> | |
| <div class="col-9 nvp src-api" | |
| title="reach"> | |
| reach | |
| </div> | |
| </div> | |
| </div> | |
| <div class="col-9"> | |
| "Two distant homologs of OleA are <span class="badge badge-subject">LstA</span> and LstB that together form a heterodimer in solution and catalyze the <span class="badge badge-object">condensation</span> of (3S,5 Z,8 Z)-3-hydroxytetradeca-5,8-dienoyl-CoA and octyl-CoA to produce the backbone of the β-lactone natural product, lipstatin (XREF_BIBR)." | |
| </div> | |
| <div class="col-2 text-right"> | |
| <a class="pmid_link" | |
| title="Hover again to see info" | |
| onmouseover="setPMIDlinkTitle(this.textContent, this); this.onmouseover=null;" | |
| href='https://www.ncbi.nlm.nih.gov/pubmed/32156808' | |
| target="_blank"> | |
| 32156808</a> | |
| | <a class="pmcid_link full_text_search" | |
| onclick='openPMCIDJournal(`PMC7064751`, `Two distant homologs of OleA are <span class="badge badge-subject">LstA</span> and LstB that together form a heterodimer in solution and catalyze the <span class="badge badge-object">condensation</span> of (3S,5 Z,8 Z)-3-hydroxytetradeca-5,8-dienoyl-CoA and octyl-CoA to produce the backbone of the β-lactone natural product, lipstatin (XREF_BIBR).` );' | |
| href="javascript:;">Full-Text Search: PMC7064751</a> | |
| </div> | |
| </div> | |
| </div> <!-- container --> | |
| </div> <!-- row evidence --> | |
| <a name="1688310692637109"></a> | |
| <div class="row statement"> | |
| <div class="col text-left nvp"> | |
| <h5 class="align-middle"> | |
| <a href='https://identifiers.org/chebi/CHEBI:89919' target='_blank'>Sialyllacto-N-tetraose a</a> binds <a href='https://identifiers.org/chebi/CHEBI:88450' target='_blank'>Sialyllacto-N-tetraose b</a>. | |
| <a href="#" | |
| > | |
| <small class="badge badge-secondary badge-pill">1</small> | |
| </a> | |
| </h5> | |
| </div> | |
| <div class="col text-right nvp"> | |
| </div> | |
| </div> | |
| <div class="row evidence"> | |
| <div class="container" id="stmt-0-0-4" | |
| data-stmt_hash="1688310692637109"> | |
| <div class="row evidence-text" data-source_hash="1698484995511814354" | |
| style="border-bottom: 1px solid #FFFFFF;" | |
| id="ev-0-0-4-0"> | |
| <div class="col-1"> | |
| <div class="row"> | |
| <div class="col-3 nvp curation_toggle" | |
| id="ev-0-0-4-0-click" | |
| data-parent_id="ev-0-0-4-0"> | |
| <a href="#" | |
| > | |
| ➶ | |
| </a> | |
| </div> | |
| <div class="col-9 nvp src-api" | |
| title="reach"> | |
| reach | |
| </div> | |
| </div> | |
| </div> | |
| <div class="col-9"> | |
| "Two distant homologs of OleA are <span class="badge badge-other">LstA</span> and <span class="badge badge-other">LstB</span> that together form a heterodimer in solution and catalyze the condensation of (3S,5 Z,8 Z)-3-hydroxytetradeca-5,8-dienoyl-CoA and octyl-CoA to produce the backbone of the β-lactone natural product, lipstatin (XREF_BIBR)." | |
| </div> | |
| <div class="col-2 text-right"> | |
| <a class="pmid_link" | |
| title="Hover again to see info" | |
| onmouseover="setPMIDlinkTitle(this.textContent, this); this.onmouseover=null;" | |
| href='https://www.ncbi.nlm.nih.gov/pubmed/32156808' | |
| target="_blank"> | |
| 32156808</a> | |
| | <a class="pmcid_link full_text_search" | |
| onclick='openPMCIDJournal(`PMC7064751`, `Two distant homologs of OleA are <span class="badge badge-other">LstA</span> and <span class="badge badge-other">LstB</span> that together form a heterodimer in solution and catalyze the condensation of (3S,5 Z,8 Z)-3-hydroxytetradeca-5,8-dienoyl-CoA and octyl-CoA to produce the backbone of the β-lactone natural product, lipstatin (XREF_BIBR).` );' | |
| href="javascript:;">Full-Text Search: PMC7064751</a> | |
| </div> | |
| </div> | |
| </div> <!-- container --> | |
| </div> <!-- row evidence --> | |
| <a name="-34761742586364869"></a> | |
| <div class="row statement"> | |
| <div class="col text-left nvp"> | |
| <h5 class="align-middle"> | |
| OleA enzymes activates <a href='https://identifiers.org/go/GO:0009058' target='_blank'>biosynthetic process</a>. | |
| <a href="#" | |
| > | |
| <small class="badge badge-secondary badge-pill">1</small> | |
| </a> | |
| </h5> | |
| </div> | |
| <div class="col text-right nvp"> | |
| </div> | |
| </div> | |
| <div class="row evidence"> | |
| <div class="container" id="stmt-0-0-5" | |
| data-stmt_hash="-34761742586364869"> | |
| <div class="row evidence-text" data-source_hash="-1160084477400697116" | |
| style="border-bottom: 1px solid #FFFFFF;" | |
| id="ev-0-0-5-0"> | |
| <div class="col-1"> | |
| <div class="row"> | |
| <div class="col-3 nvp curation_toggle" | |
| id="ev-0-0-5-0-click" | |
| data-parent_id="ev-0-0-5-0"> | |
| <a href="#" | |
| > | |
| ➶ | |
| </a> | |
| </div> | |
| <div class="col-9 nvp src-api" | |
| title="reach"> | |
| reach | |
| </div> | |
| </div> | |
| </div> | |
| <div class="col-9"> | |
| "Both β-lactone and olefin <span class="badge badge-object">biosynthesis</span> pathways are initiated by <span class="badge badge-subject">OleA enzymes</span> that define the overall structure of the final product." | |
| </div> | |
| <div class="col-2 text-right"> | |
| <a class="pmid_link" | |
| title="Hover again to see info" | |
| onmouseover="setPMIDlinkTitle(this.textContent, this); this.onmouseover=null;" | |
| href='https://www.ncbi.nlm.nih.gov/pubmed/32156808' | |
| target="_blank"> | |
| 32156808</a> | |
| | <a class="pmcid_link full_text_search" | |
| onclick='openPMCIDJournal(`PMC7064751`, `Both β-lactone and olefin <span class="badge badge-object">biosynthesis</span> pathways are initiated by <span class="badge badge-subject">OleA enzymes</span> that define the overall structure of the final product.` );' | |
| href="javascript:;">Full-Text Search: PMC7064751</a> | |
| </div> | |
| </div> | |
| </div> <!-- container --> | |
| </div> <!-- row evidence --> | |
| <a name="9236011087742973"></a> | |
| <div class="row statement"> | |
| <div class="col text-left nvp"> | |
| <h5 class="align-middle"> | |
| OleA activates <a href='https://identifiers.org/chebi/CHEBI:32806' target='_blank'>trans-aconitic acid</a>. | |
| <a href="#" | |
| > | |
| <small class="badge badge-secondary badge-pill">1</small> | |
| </a> | |
| </h5> | |
| </div> | |
| <div class="col text-right nvp"> | |
| </div> | |
| </div> | |
| <div class="row evidence"> | |
| <div class="container" id="stmt-0-0-6" | |
| data-stmt_hash="9236011087742973"> | |
| <div class="row evidence-text" data-source_hash="-1900691400893357833" | |
| style="border-bottom: 1px solid #FFFFFF;" | |
| id="ev-0-0-6-0"> | |
| <div class="col-1"> | |
| <div class="row"> | |
| <div class="col-3 nvp curation_toggle" | |
| id="ev-0-0-6-0-click" | |
| data-parent_id="ev-0-0-6-0"> | |
| <a href="#" | |
| > | |
| ➶ | |
| </a> | |
| </div> | |
| <div class="col-9 nvp src-api" | |
| title="reach"> | |
| reach | |
| </div> | |
| </div> | |
| </div> | |
| <div class="col-9"> | |
| "<span class="badge badge-subject">OleA</span> was shown to produce p-nitrophenol and a fatty <span class="badge badge-object">acid</span> via UV-visible (UV-Vis) spectroscopy and gas chromatography (see XREF_SUPPLEMENTARY in the supplemental material)." | |
| </div> | |
| <div class="col-2 text-right"> | |
| <a class="pmid_link" | |
| title="Hover again to see info" | |
| onmouseover="setPMIDlinkTitle(this.textContent, this); this.onmouseover=null;" | |
| href='https://www.ncbi.nlm.nih.gov/pubmed/32156808' | |
| target="_blank"> | |
| 32156808</a> | |
| | <a class="pmcid_link full_text_search" | |
| onclick='openPMCIDJournal(`PMC7064751`, `<span class="badge badge-subject">OleA</span> was shown to produce p-nitrophenol and a fatty <span class="badge badge-object">acid</span> via UV-visible (UV-Vis) spectroscopy and gas chromatography (see XREF_SUPPLEMENTARY in the supplemental material).` );' | |
| href="javascript:;">Full-Text Search: PMC7064751</a> | |
| </div> | |
| </div> | |
| </div> <!-- container --> | |
| </div> <!-- row evidence --> | |
| <a name="12662859413003999"></a> | |
| <div class="row statement"> | |
| <div class="col text-left nvp"> | |
| <h5 class="align-middle"> | |
| OleA activates OleA proteins. | |
| <a href="#" | |
| > | |
| <small class="badge badge-secondary badge-pill">1</small> | |
| </a> | |
| </h5> | |
| </div> | |
| <div class="col text-right nvp"> | |
| </div> | |
| </div> | |
| <div class="row evidence"> | |
| <div class="container" id="stmt-0-0-7" | |
| data-stmt_hash="12662859413003999"> | |
| <div class="row evidence-text" data-source_hash="-96681937166224759" | |
| style="border-bottom: 1px solid #FFFFFF;" | |
| id="ev-0-0-7-0"> | |
| <div class="col-1"> | |
| <div class="row"> | |
| <div class="col-3 nvp curation_toggle" | |
| id="ev-0-0-7-0-click" | |
| data-parent_id="ev-0-0-7-0"> | |
| <a href="#" | |
| > | |
| ➶ | |
| </a> | |
| </div> | |
| <div class="col-9 nvp src-api" | |
| title="reach"> | |
| reach | |
| </div> | |
| </div> | |
| </div> | |
| <div class="col-9"> | |
| "The high rate of <span class="badge badge-subject">OleA</span> in hydrolyzing p-nitrophenyl hexanoate versus other E. coli proteins allowed for a rapid assay to screen a wide range of putative <span class="badge badge-object">OleA proteins</span> that could be identified by bioinformatics." | |
| </div> | |
| <div class="col-2 text-right"> | |
| <a class="pmid_link" | |
| title="Hover again to see info" | |
| onmouseover="setPMIDlinkTitle(this.textContent, this); this.onmouseover=null;" | |
| href='https://www.ncbi.nlm.nih.gov/pubmed/32156808' | |
| target="_blank"> | |
| 32156808</a> | |
| | <a class="pmcid_link full_text_search" | |
| onclick='openPMCIDJournal(`PMC7064751`, `The high rate of <span class="badge badge-subject">OleA</span> in hydrolyzing p-nitrophenyl hexanoate versus other E. coli proteins allowed for a rapid assay to screen a wide range of putative <span class="badge badge-object">OleA proteins</span> that could be identified by bioinformatics.` );' | |
| href="javascript:;">Full-Text Search: PMC7064751</a> | |
| </div> | |
| </div> | |
| </div> <!-- container --> | |
| </div> <!-- row evidence --> | |
| <a name="13467664496267322"></a> | |
| <div class="row statement"> | |
| <div class="col text-left nvp"> | |
| <h5 class="align-middle"> | |
| OleA activates Claisen. | |
| <a href="#" | |
| > | |
| <small class="badge badge-secondary badge-pill">1</small> | |
| </a> | |
| </h5> | |
| </div> | |
| <div class="col text-right nvp"> | |
| </div> | |
| </div> | |
| <div class="row evidence"> | |
| <div class="container" id="stmt-0-0-8" | |
| data-stmt_hash="13467664496267322"> | |
| <div class="row evidence-text" data-source_hash="-7508905441933400527" | |
| style="border-bottom: 1px solid #FFFFFF;" | |
| id="ev-0-0-8-0"> | |
| <div class="col-1"> | |
| <div class="row"> | |
| <div class="col-3 nvp curation_toggle" | |
| id="ev-0-0-8-0-click" | |
| data-parent_id="ev-0-0-8-0"> | |
| <a href="#" | |
| > | |
| ➶ | |
| </a> | |
| </div> | |
| <div class="col-9 nvp src-api" | |
| title="reach"> | |
| reach | |
| </div> | |
| </div> | |
| </div> | |
| <div class="col-9"> | |
| "Studies investigating the potential <span class="badge badge-subject">OleA</span> catalyzed <span class="badge badge-object">Claisen</span> condensation of p-nitrophenyl alkanoates are under way." | |
| </div> | |
| <div class="col-2 text-right"> | |
| <a class="pmid_link" | |
| title="Hover again to see info" | |
| onmouseover="setPMIDlinkTitle(this.textContent, this); this.onmouseover=null;" | |
| href='https://www.ncbi.nlm.nih.gov/pubmed/32156808' | |
| target="_blank"> | |
| 32156808</a> | |
| | <a class="pmcid_link full_text_search" | |
| onclick='openPMCIDJournal(`PMC7064751`, `Studies investigating the potential <span class="badge badge-subject">OleA</span> catalyzed <span class="badge badge-object">Claisen</span> condensation of p-nitrophenyl alkanoates are under way.` );' | |
| href="javascript:;">Full-Text Search: PMC7064751</a> | |
| </div> | |
| </div> | |
| </div> <!-- container --> | |
| </div> <!-- row evidence --> | |
| <a name="-23221469944594960"></a> | |
| <div class="row statement"> | |
| <div class="col text-left nvp"> | |
| <h5 class="align-middle"> | |
| <a href='https://identifiers.org/chebi/CHEBI:84834' target='_blank'>O-hexanoyl-L-carnitine</a> activates OleA proteins. | |
| <a href="#" | |
| > | |
| <small class="badge badge-secondary badge-pill">1</small> | |
| </a> | |
| </h5> | |
| </div> | |
| <div class="col text-right nvp"> | |
| </div> | |
| </div> | |
| <div class="row evidence"> | |
| <div class="container" id="stmt-0-0-9" | |
| data-stmt_hash="-23221469944594960"> | |
| <div class="row evidence-text" data-source_hash="-96681937166224759" | |
| style="border-bottom: 1px solid #FFFFFF;" | |
| id="ev-0-0-9-0"> | |
| <div class="col-1"> | |
| <div class="row"> | |
| <div class="col-3 nvp curation_toggle" | |
| id="ev-0-0-9-0-click" | |
| data-parent_id="ev-0-0-9-0"> | |
| <a href="#" | |
| > | |
| ➶ | |
| </a> | |
| </div> | |
| <div class="col-9 nvp src-api" | |
| title="reach"> | |
| reach | |
| </div> | |
| </div> | |
| </div> | |
| <div class="col-9"> | |
| "The high rate of OleA in hydrolyzing p-nitrophenyl <span class="badge badge-subject">hexanoate</span> versus other E. coli proteins allowed for a rapid assay to screen a wide range of putative <span class="badge badge-object">OleA proteins</span> that could be identified by bioinformatics." | |
| </div> | |
| <div class="col-2 text-right"> | |
| <a class="pmid_link" | |
| title="Hover again to see info" | |
| onmouseover="setPMIDlinkTitle(this.textContent, this); this.onmouseover=null;" | |
| href='https://www.ncbi.nlm.nih.gov/pubmed/32156808' | |
| target="_blank"> | |
| 32156808</a> | |
| | <a class="pmcid_link full_text_search" | |
| onclick='openPMCIDJournal(`PMC7064751`, `The high rate of OleA in hydrolyzing p-nitrophenyl <span class="badge badge-subject">hexanoate</span> versus other E. coli proteins allowed for a rapid assay to screen a wide range of putative <span class="badge badge-object">OleA proteins</span> that could be identified by bioinformatics.` );' | |
| href="javascript:;">Full-Text Search: PMC7064751</a> | |
| </div> | |
| </div> | |
| </div> <!-- container --> | |
| </div> <!-- row evidence --> | |
| <a name="8799868811599853"></a> | |
| <div class="row statement"> | |
| <div class="col text-left nvp"> | |
| <h5 class="align-middle"> | |
| <a href='https://identifiers.org/hgnc/HGNC:13203' target='_blank'>AICDA</a> activates OleA proteins. | |
| <a href="#" | |
| > | |
| <small class="badge badge-secondary badge-pill">1</small> | |
| </a> | |
| </h5> | |
| </div> | |
| <div class="col text-right nvp"> | |
| </div> | |
| </div> | |
| <div class="row evidence"> | |
| <div class="container" id="stmt-0-0-10" | |
| data-stmt_hash="8799868811599853"> | |
| <div class="row evidence-text" data-source_hash="-795292031187857700" | |
| style="border-bottom: 1px solid #FFFFFF;" | |
| id="ev-0-0-10-0"> | |
| <div class="col-1"> | |
| <div class="row"> | |
| <div class="col-3 nvp curation_toggle" | |
| id="ev-0-0-10-0-click" | |
| data-parent_id="ev-0-0-10-0"> | |
| <a href="#" | |
| > | |
| ➶ | |
| </a> | |
| </div> | |
| <div class="col-9 nvp src-api" | |
| title="reach"> | |
| reach | |
| </div> | |
| </div> | |
| </div> | |
| <div class="col-9"> | |
| "Sequence cluster representatives belonging to 74 different organisms were selected as described in Materials and Methods to do the following : (i) define the sequence signature of true <span class="badge badge-object">OleA proteins</span> within the thiolase superfamily, (ii) screen for <span class="badge badge-object">OleA proteins</span> likely to express in active form in E. coli, and (iii) identify new <span class="badge badge-object">OleA proteins</span> that <span class="badge badge-subject">aid</span> in determining the structural diversity of products made by OleA initiated metabolic pathways." | |
| </div> | |
| <div class="col-2 text-right"> | |
| <a class="pmid_link" | |
| title="Hover again to see info" | |
| onmouseover="setPMIDlinkTitle(this.textContent, this); this.onmouseover=null;" | |
| href='https://www.ncbi.nlm.nih.gov/pubmed/32156808' | |
| target="_blank"> | |
| 32156808</a> | |
| | <a class="pmcid_link full_text_search" | |
| onclick='openPMCIDJournal(`PMC7064751`, `Sequence cluster representatives belonging to 74 different organisms were selected as described in Materials and Methods to do the following : (i) define the sequence signature of true <span class="badge badge-object">OleA proteins</span> within the thiolase superfamily, (ii) screen for <span class="badge badge-object">OleA proteins</span> likely to express in active form in E. coli, and (iii) identify new <span class="badge badge-object">OleA proteins</span> that <span class="badge badge-subject">aid</span> in determining the structural diversity of products made by OleA initiated metabolic pathways.` );' | |
| href="javascript:;">Full-Text Search: PMC7064751</a> | |
| </div> | |
| </div> | |
| </div> <!-- container --> | |
| </div> <!-- row evidence --> | |
| </div> <!-- PA Statement container --> | |
| </div> <!-- PA Statement group --> | |
| </div> <!-- container --> | |
| </div> <!-- type groups --> | |
| <hr> | |
| <!-- Footer --> | |
| <footer class="footer text-muted" id="about"> | |
| <h5 class="my-0 mr-md-auto font-weight-normal">About</h5> | |
| INDRA is developed by <a href="https://indralab.github.io/">indralabs</a>, | |
| a part of the Harvard Medical School Laboratory of Systems Pharmacology. | |
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