Program.cs

using System;
using System.Runtime.Loader;
using System.Reflection;

class CustomLoadContext : AssemblyLoadContext
{
    protected override Assembly Load(AssemblyName assemblyName)
    {
        Console.WriteLine("loading {0}", assemblyName.Name);
        return LoadFromAssemblyPath(string.Format(@"E:\Desktop\test-corerun\program\{0}.dll", assemblyName.Name));
    }
}

public class Program
{
    public static void Main(string[] args)
    {
        LoadAssembly();
        Console.ReadLine();
    }
    
    public static void LoadAssembly()
    {
        var context = new CustomLoadContext();
        var asm = context.LoadFromAssemblyName(new AssemblyName("Test"));
        
        var type = asm.GetType("Test");
        var method = type.GetMethod("DoSomething", BindingFlags.Public | BindingFlags.Static);
        method.Invoke(null, null);
    }
}

Test.cs

using System;

public static class Test
{
    public static void DoSomething()
    {
        Console.WriteLine("hello world! {0}", TestDep.GetMessage());
    }
}

TestDep.cs

using System;

public static class TestDep
{
    public static string GetMessage()
    {
        return "snirt";
    }
}