stackoverflow.com#57928364

test.py

# Comparing solutions for: https://stackoverflow.com/questions/57928364/pandas-and-tuple-check/57928434#57928434

import random
import string
import pandas as pd

def rnd_str(l):
    letters = string.ascii_lowercase
    return ''.join(random.choice(letters) for i in range(l))

unique_strings = set(rnd_str(3) for _ in range(20000))
cols = pd.Index(unique_strings)

tup = tuple(rnd_str(3) for _ in range(5000))

%timeit all(cols.get_indexer(tup)>-1)
# 714 µs ± 12.6 µs per loop (mean ± std. dev. of 7 runs, 1000 loops each)

%timeit all(e in cols for e in tup)
# 639 ns ± 0.988 ns per loop (mean ± std. dev. of 7 runs, 1000000 loops each)