MonoGame w/ IronPython Example

main.py

import os, clr
clr.AddReferenceToFile("MonoGame.Framework.dll")
clr.AddReferenceToFile("OpenTK.dll")

from Microsoft.Xna.Framework import *
from Microsoft.Xna.Framework.Graphics import *

class App(Game):
	def __init__(self):
		self.graphics = GraphicsDeviceManager(self)
		self.Content.RootDirectory = os.getcwd() + "/Content"
	
	def Initialize(self):
		""" Allows the game to perform any initialization it needs to before starting to run.  This is where it can query for any required 
		services and load any non-graphic related content.  Calling base.Initialize will enumerate through any components and initialize them as well. """
		# TODO: Add your initialization logic here
		self.Initialize()

	def LoadContent(self):
		""" LoadContent will be called once per game and is the place to load all of your content.	"""
		# Create a new SpriteBatch, which can be used to draw textures.
		self.spriteBatch = SpriteBatch(GraphicsDevice)

	#TODO: use this.Content to load your game content here 
	def Update(self, gameTime):
		""" Allows the game to run logic such as updating the world, checking for collisions, gathering input, and playing audio.		"""
		# For Mobile devices, this logic will close the Game when the Back button is pressed
		if GamePad.GetState(PlayerIndex.One).Buttons.Back == ButtonState.Pressed:
			self.Exit()
		# TODO: Add your update logic here			
		Game.Update(gameTime)

	def Draw(self, gameTime):
		"""  This is called when the game should draw itself.	"""
		self.graphics.GraphicsDevice.Clear(Color.CornflowerBlue)
		#TODO: Add your drawing code here
		Game.Draw(gameTime)

game = App()
game.Run()

@WillSams IronPython came back into the spotlight recently - they released a new version a couple of months ago, which is fantastic. Word is they're slowly progressing on IronPython 3 (Python 3), but 2.x (Python 2.7) seems quite stable/functional enough to actually build production things on it.