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@aabiddanda
Created July 8, 2021 09:32
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Interpolating genetic map positions

Interpolating genetic maps

In order to run this script you would need to run:

python3 interp_genmap.py --snp test.snp --genmap test_chr20_22.txt --morgans True

the module requirements for this are:

  • pandas
  • numpy
  • tqdm
  • scipy
  • click

For any questions - please submit an issue on this gist.

#!/usr/local/bin/python3
'''
Perform linear interpolation of a genetic map
'''
import click
import numpy as np
import pandas as pd
from scipy.interpolate import interp1d
from tqdm import tqdm
@click.command()
@click.option('--snp', required=True, help='Eigenstrat SNP file.')
@click.option('--genmap', required=True, help='Genetic map')
@click.option('--extrapolate', default=True, help='Extrapolate the genetic distance outside of the defined map.')
@click.option('--morgans', default=False, help='Convert to morgans (assumes the map is in cM)')
def main(snp, genmap, extrapolate, morgans):
"""Interpolate genetic distances into a SNP dataset."""
map_interp_dict = {}
gen_map_df = pd.read_csv(genmap, sep='\s+', header=None, names=['chrom', 'phys_pos', 'gen_pos'])
for chrom in tqdm(np.unique(gen_map_df.chrom.values)):
cur_df = gen_map_df[gen_map_df.chrom == chrom]
if extrapolate:
map_interp_dict[chrom] = interp1d(cur_df['phys_pos'].values, cur_df['gen_pos'].values, fill_value='extrapolate')
else:
map_interp_dict[chrom] = interp1d(cur_df['phys_pos'].values, cur_df['gen_pos'].values, fill_value='NaN')
with open(snp, 'r') as snpfile:
for line in snpfile:
spltln = line.split()
cur_chrom = int(spltln[1])
cur_physpos = int(spltln[3])
# Run the interpolation operation
cur_genpos = map_interp_dict[cur_chrom](cur_physpos)
if morgans:
cur_genpos = cur_genpos / 100.
spltln[2] = str(cur_genpos)
print('\t'.join(spltln))
if __name__ =='__main__':
main()
This file has been truncated, but you can view the full file.
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rs605561
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(Sorry about that, but we can’t show files that are this big right now.)

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