One way to do bulk updates and deletes with Appcelerator Alloy Collections

app_snippet.js

// add all items to collection
Alloy.Collections.Fugitive.reset([{
        "name" : "Jeff Haynie"
}, {
        "name" : "Nolan Wright"
}, {
        "name" : "Don Thorp"
}, {
        "name" : "Marshall Culpepper"
}, {
        "name" : "Blain Hamon"
}]);

// save all the items
Alloy.Collections.Fugitive.saveAll();


// get the collection object
Alloy.Collections.instance("Fugitive");


// delete all items
Alloy.Collections.Fugitive.deleteAll();

model.js

exports.definition = {

  config : {
    "columns" : {
      "name" : "TEXT",
      "captured" : "integer",
      "url" : "TEXT",
      "capturedLat" : "real",
      "capturedLong" : "real"
    },
    "defaults" : {
      "name" : "",
      "captured" : 0,
      "url" : "",
      "capturedLat" : "",
      "capturedLong" : ""
    },
    "adapter" : {
      "type" : "sql",
      "collection_name" : "fugitives"
    }
  },

  extendModel : function(Model) {
    _.extend(Model.prototype, {

    });
    // end extend

    return Model;
  },

  extendCollection : function(Collection) {

    // helper functions
    function S4() {
      return (0 | 65536 * (1 + Math.random())).toString(16).substring(1);
    }

    function guid() {
      return S4() + S4() + "-" + S4() + "-" + S4() + "-" + S4() + "-" + S4() + S4() + S4();
    }


    _.extend(Collection.prototype, {

      deleteAll : function() {

        var collection = this;

        var sql = "DELETE FROM " + collection.config.adapter.collection_name;
        db = Ti.Database.open(collection.config.adapter.db_name);
        db.execute(sql);
        db.close();

        collection.trigger('sync');

      },

      saveAll : function() {
        var collection = this;

        var dbName = collection.config.adapter.db_name;
        var table = collection.config.adapter.collection_name;
        var columns = collection.config.columns;

        db = Ti.Database.open(dbName);
        db.execute("BEGIN;");

        collection.each(function(model) {

          if (!model.id) {
            model.id = guid();
            model.attributes[model.idAttribute] = model.id;
          }

          var names = [], values = [], q = [];
          for (var k in columns) {
            names.push(k);
            values.push(model.get(k));
            q.push("?");
          }
          var sqlInsert = "INSERT INTO " + table + " (" + names.join(",") + ") VALUES (" + q.join(",") + ");";

          db.execute(sqlInsert, values);

        });

        db.execute("COMMIT;");
        db.close();

        collection.trigger('sync');
      }
    });
    // end extend

    return Collection;
  }
}; 

Thank You! So useful

@aaronksaunders minor optimization: take the names.push(k) out of collection.each and create the names array in a separate one-time cycle.
On a 100 element insert you'll save (100*numcols)-1 .push() calls.

@aaronksaunders I'm using this SaveAll function in my model.
I have this config:
config: {
columns: {
"jobID": "INTEGER",
"jobTitle": "TEXT",
"joblastUpdated": "TEXT",
"jobLastDayOfService": "TEXT",
"jobInstructionReported": "INTEGER",
"jobInstructions": "TEXT",
"noReports": "INTEGER",
"instructionId": "INTEGER"
},
adapter: {
type: "sql",
collection_name: "jobs",
db_name: "DB",
idAttribute:'jobID'
}
},
jobID is unique and i'm receiving this id from the backed same as other values.

Insert is working fine but i can't make insert or replace to work:
var sqlInsert = "INSERT OR REPLACE INTO " + table + " (" + names.join(",") + ") VALUES (" + q.join(",") + ");";
db.execute(sqlInsert, values);