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Ohara_Rudy_2011.cellml
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<?xml version="1.0" encoding="utf-8"?> | |
<model name="MyModel1" cmeta:id="MyModel1" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#"> | |
<units name="millisecond"> | |
<unit units="second" prefix="milli"/> | |
</units> | |
<units name="per_millisecond"> | |
<unit units="millisecond" exponent="-1"/> | |
</units> | |
<units name="millivolt"> | |
<unit units="volt" prefix="milli"/> | |
</units> | |
<units name="millivolt_per_millimole"> | |
<unit units="volt" prefix="milli"/> | |
<unit units="millimolar" exponent="-1"/> | |
</units> | |
<units name="per_millivolt"> | |
<unit units="millivolt" exponent="-1"/> | |
</units> | |
<units name="per_millivolt_millisecond"> | |
<unit units="millivolt" exponent="-1"/> | |
<unit units="millisecond" exponent="-1"/> | |
</units> | |
<units name="millimolar"> | |
<unit units="mole" prefix="milli"/> | |
<unit units="litre" exponent="-1"/> | |
</units> | |
<units name="per_millimolar"> | |
<unit units="millimolar" exponent="-1"/> | |
</units> | |
<units name="millimolar_per_millisecond"> | |
<unit units="millimolar"/> | |
<unit units="millisecond" exponent="-1"/> | |
</units> | |
<units name="per_millimolar_per_millisecond"> | |
<unit units="millimolar" exponent="-1"/> | |
<unit units="millisecond" exponent="-1"/> | |
</units> | |
<units name="millisecond_per_millimolar"> | |
<unit units="millisecond"/> | |
<unit units="millimolar" exponent="-1"/> | |
</units> | |
<units name="picoA"> | |
<unit units="ampere" prefix="pico"/> | |
</units> | |
<units name="microA_per_microF"> | |
<unit units="ampere" prefix="micro"/> | |
<unit units="farad" prefix="micro" exponent="-1"/> | |
</units> | |
<units name="milliS_per_microF"> | |
<unit units="siemens" prefix="milli"/> | |
<unit units="farad" prefix="micro" exponent="-1"/> | |
</units> | |
<units name="microF"> | |
<unit units="farad" prefix="micro"/> | |
</units> | |
<units name="micrometre_3"> | |
<unit units="metre" prefix="micro" exponent="3"/> | |
</units> | |
<units name="per_micrometre_3"> | |
<unit units="metre" prefix="micro" exponent="-3"/> | |
</units> | |
<units name="mm2"> | |
<unit units="metre" prefix="milli" exponent="2"/> | |
</units> | |
<units name="centimeter"> | |
<unit units="metre" prefix="centi"/> | |
</units> | |
<units name="centimeter_squared"> | |
<unit units="centimeter" exponent="2"/> | |
</units> | |
<units name="microliter_per_centimeter_cubed"> | |
<unit units="microliter"/> | |
<unit units="centimeter" exponent="-3"/> | |
</units> | |
<units name="microF_per_centimeter_squared"> | |
<unit units="microF"/> | |
<unit units="centimeter_squared" exponent="-1"/> | |
</units> | |
<units name="microliter"> | |
<unit units="liter" prefix="micro"/> | |
</units> | |
<units name="joule_per_kilomole_kelvin"> | |
<unit units="joule"/> | |
<unit units="mole" prefix="kilo" exponent="-1"/> | |
<unit units="kelvin" exponent="-1"/> | |
</units> | |
<units name="coulomb_per_mole"> | |
<unit units="coulomb"/> | |
<unit units="mole" exponent="-1"/> | |
</units> | |
<component name="environment"> | |
<variable name="time" units="millisecond" public_interface="out"/> | |
<variable name="celltype" units="dimensionless" initial_value="0" public_interface="out"/> | |
</component> | |
<component name="extracellular"> | |
<variable name="nao" units="millimolar" initial_value="140" public_interface="out"/> | |
<variable name="cao" units="millimolar" initial_value="1.8" public_interface="out"/> | |
<variable name="ko" units="millimolar" initial_value="5.4" public_interface="out"/> | |
</component> | |
<component name="physical_constants"> | |
<variable name="R" units="joule_per_kilomole_kelvin" initial_value="8314" public_interface="out"/> | |
<variable name="T" units="kelvin" initial_value="310" public_interface="out"/> | |
<variable name="F" units="coulomb_per_mole" initial_value="96485" public_interface="out"/> | |
<variable name="zna" units="dimensionless" initial_value="1" public_interface="out"/> | |
<variable name="zca" units="dimensionless" initial_value="2" public_interface="out"/> | |
<variable name="zk" units="dimensionless" initial_value="1" public_interface="out"/> | |
</component> | |
<component name="cell_geometry"> | |
<variable name="L" units="centimeter" initial_value="0.01"/> | |
<variable name="rad" units="centimeter" initial_value="0.0011"/> | |
<variable name="vcell" units="microliter" public_interface="out"/> | |
<variable name="Ageo" units="centimeter_squared" public_interface="out"/> | |
<variable name="Acap" units="centimeter_squared" public_interface="out"/> | |
<variable name="vmyo" units="microliter" public_interface="out"/> | |
<variable name="vnsr" units="microliter" public_interface="out"/> | |
<variable name="vjsr" units="microliter" public_interface="out"/> | |
<variable name="vss" units="microliter" public_interface="out"/> | |
<math xmlns="http://www.w3.org/1998/Math/MathML"> | |
<apply> | |
<eq/> | |
<ci>vcell</ci> | |
<apply> | |
<times/> | |
<cn cellml:units="microliter_per_centimeter_cubed">1000</cn> | |
<cn cellml:units="dimensionless">3.14</cn> | |
<ci>rad</ci> | |
<ci>rad</ci> | |
<ci>L</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>Ageo</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">2</cn> | |
<cn cellml:units="dimensionless">3.14</cn> | |
<ci>rad</ci> | |
<ci>rad</ci> | |
</apply> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">2</cn> | |
<cn cellml:units="dimensionless">3.14</cn> | |
<ci>rad</ci> | |
<ci>L</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>Acap</ci> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">2</cn> | |
<ci>Ageo</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>vmyo</ci> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.68</cn> | |
<ci>vcell</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>vnsr</ci> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.0552</cn> | |
<ci>vcell</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>vjsr</ci> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.0048</cn> | |
<ci>vcell</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>vss</ci> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.02</cn> | |
<ci>vcell</ci> | |
</apply> | |
</apply> | |
</math> | |
</component> | |
<component name="membrane"> | |
<variable name="v" units="millivolt" initial_value="-87" public_interface="out"/> | |
<variable name="time" units="millisecond" public_interface="in"/> | |
<variable name="R" units="joule_per_kilomole_kelvin" public_interface="in"/> | |
<variable name="T" units="kelvin" public_interface="in"/> | |
<variable name="F" units="coulomb_per_mole" public_interface="in"/> | |
<variable name="vffrt" units="coulomb_per_mole" public_interface="out"/> | |
<variable name="vfrt" units="dimensionless" public_interface="out"/> | |
<variable name="INa" units="microA_per_microF" public_interface="in"/> | |
<variable name="INaL" units="microA_per_microF" public_interface="in"/> | |
<variable name="Ito" units="microA_per_microF" public_interface="in"/> | |
<variable name="ICaL" units="microA_per_microF" public_interface="in"/> | |
<variable name="ICaNa" units="microA_per_microF" public_interface="in"/> | |
<variable name="ICaK" units="microA_per_microF" public_interface="in"/> | |
<variable name="IKr" units="microA_per_microF" public_interface="in"/> | |
<variable name="IKs" units="microA_per_microF" public_interface="in"/> | |
<variable name="IK1" units="microA_per_microF" public_interface="in"/> | |
<variable name="INaCa_i" units="microA_per_microF" public_interface="in"/> | |
<variable name="INaCa_ss" units="microA_per_microF" public_interface="in"/> | |
<variable name="INaK" units="microA_per_microF" public_interface="in"/> | |
<variable name="INab" units="microA_per_microF" public_interface="in"/> | |
<variable name="IKb" units="microA_per_microF" public_interface="in"/> | |
<variable name="IpCa" units="microA_per_microF" public_interface="in"/> | |
<variable name="ICab" units="microA_per_microF" public_interface="in"/> | |
<variable name="Istim" units="microA_per_microF" public_interface="out"/> | |
<variable name="amp" units="microA_per_microF" initial_value="-80"/> | |
<variable name="duration" units="millisecond" initial_value="0.5"/> | |
<math xmlns="http://www.w3.org/1998/Math/MathML"> | |
<apply> | |
<eq/> | |
<ci>Istim</ci> | |
<piecewise> | |
<piece> | |
<ci>amp</ci> | |
<apply> | |
<leq/> | |
<ci>time</ci> | |
<ci>duration</ci> | |
</apply> | |
</piece> | |
<otherwise> | |
<cn cellml:units="microA_per_microF">0</cn> | |
</otherwise> | |
</piecewise> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>vffrt</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>v</ci> | |
<ci>F</ci> | |
<ci>F</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>R</ci> | |
<ci>T</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>vfrt</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>v</ci> | |
<ci>F</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>R</ci> | |
<ci>T</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<apply> | |
<diff/> | |
<bvar> | |
<ci>time</ci> | |
</bvar> | |
<ci>v</ci> | |
</apply> | |
<apply> | |
<minus/> | |
<apply> | |
<plus/> | |
<ci>INa</ci> | |
<ci>INaL</ci> | |
<ci>Ito</ci> | |
<ci>ICaL</ci> | |
<ci>ICaNa</ci> | |
<ci>ICaK</ci> | |
<ci>IKr</ci> | |
<ci>IKs</ci> | |
<ci>IK1</ci> | |
<ci>INaCa_i</ci> | |
<ci>INaCa_ss</ci> | |
<ci>INaK</ci> | |
<ci>INab</ci> | |
<ci>IKb</ci> | |
<ci>IpCa</ci> | |
<ci>ICab</ci> | |
<ci>Istim</ci> | |
</apply> | |
</apply> | |
</apply> | |
</math> | |
</component> | |
<component name="CaMK"> | |
<variable name="KmCaMK" units="millimolar" initial_value="0.15" public_interface="out"/> | |
<variable name="aCaMK" units="per_millimolar_per_millisecond" initial_value="0.05"/> | |
<variable name="bCaMK" units="per_millisecond" initial_value="0.00068"/> | |
<variable name="CaMKo" units="dimensionless" initial_value="0.05"/> | |
<variable name="KmCaM" units="millimolar" initial_value="0.0015"/> | |
<variable name="CaMKb" units="millimolar" public_interface="out"/> | |
<variable name="CaMKa" units="millimolar" public_interface="out"/> | |
<variable name="CaMKt" units="millimolar" initial_value="0"/> | |
<variable name="cass" units="millimolar" public_interface="in"/> | |
<variable name="time" units="millisecond" public_interface="in"/> | |
<math xmlns="http://www.w3.org/1998/Math/MathML"> | |
<apply> | |
<eq/> | |
<ci>CaMKb</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>CaMKo</ci> | |
<apply> | |
<minus/> | |
<cn cellml:units="millimolar">1</cn> | |
<ci>CaMKt</ci> | |
</apply> | |
</apply> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<ci>KmCaM</ci> | |
<ci>cass</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>CaMKa</ci> | |
<apply> | |
<plus/> | |
<ci>CaMKb</ci> | |
<ci>CaMKt</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<apply> | |
<diff/> | |
<bvar> | |
<ci>time</ci> | |
</bvar> | |
<ci>CaMKt</ci> | |
</apply> | |
<apply> | |
<minus/> | |
<apply> | |
<times/> | |
<ci>aCaMK</ci> | |
<ci>CaMKb</ci> | |
<apply> | |
<plus/> | |
<ci>CaMKb</ci> | |
<ci>CaMKt</ci> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<ci>bCaMK</ci> | |
<ci>CaMKt</ci> | |
</apply> | |
</apply> | |
</apply> | |
</math> | |
</component> | |
<component name="intracellular_ions"> | |
<variable name="cmdnmax_b" units="millimolar" initial_value="0.05"/> | |
<variable name="cmdnmax" units="millimolar"/> | |
<variable name="kmcmdn" units="millimolar" initial_value="0.00238"/> | |
<variable name="trpnmax" units="millimolar" initial_value="0.07"/> | |
<variable name="kmtrpn" units="millimolar" initial_value="0.0005"/> | |
<variable name="BSRmax" units="millimolar" initial_value="0.047"/> | |
<variable name="KmBSR" units="millimolar" initial_value="0.00087"/> | |
<variable name="BSLmax" units="millimolar" initial_value="1.124"/> | |
<variable name="KmBSL" units="millimolar" initial_value="0.0087"/> | |
<variable name="csqnmax" units="millimolar" initial_value="10"/> | |
<variable name="kmcsqn" units="millimolar" initial_value="0.8"/> | |
<variable name="nai" units="millimolar" initial_value="7" public_interface="out"/> | |
<variable name="nass" units="millimolar" initial_value="7" public_interface="out"/> | |
<variable name="ki" units="millimolar" initial_value="145" public_interface="out"/> | |
<variable name="kss" units="millimolar" initial_value="145" public_interface="out"/> | |
<variable name="cass" units="millimolar" initial_value="1e-4" public_interface="out"/> | |
<variable name="cansr" units="millimolar" initial_value="1.2" public_interface="out"/> | |
<variable name="cajsr" units="millimolar" initial_value="1.2" public_interface="out"/> | |
<variable name="cai" units="millimolar" initial_value="1e-4" public_interface="out"/> | |
<variable name="celltype" units="dimensionless" public_interface="in"/> | |
<variable name="Acap" units="centimeter_squared" public_interface="in"/> | |
<variable name="R" units="joule_per_kilomole_kelvin" public_interface="in"/> | |
<variable name="T" units="kelvin" public_interface="in"/> | |
<variable name="F" units="coulomb_per_mole" public_interface="in"/> | |
<variable name="INa" units="microA_per_microF" public_interface="in"/> | |
<variable name="INaL" units="microA_per_microF" public_interface="in"/> | |
<variable name="INaCa_i" units="microA_per_microF" public_interface="in"/> | |
<variable name="INaCa_ss" units="microA_per_microF" public_interface="in"/> | |
<variable name="ICaNa" units="microA_per_microF" public_interface="in"/> | |
<variable name="INaK" units="microA_per_microF" public_interface="in"/> | |
<variable name="INab" units="microA_per_microF" public_interface="in"/> | |
<variable name="IK1" units="microA_per_microF" public_interface="in"/> | |
<variable name="IKb" units="microA_per_microF" public_interface="in"/> | |
<variable name="IKr" units="microA_per_microF" public_interface="in"/> | |
<variable name="IKs" units="microA_per_microF" public_interface="in"/> | |
<variable name="Istim" units="microA_per_microF" public_interface="in"/> | |
<variable name="Ito" units="microA_per_microF" public_interface="in"/> | |
<variable name="ICab" units="microA_per_microF" public_interface="in"/> | |
<variable name="IpCa" units="microA_per_microF" public_interface="in"/> | |
<variable name="ICaL" units="microA_per_microF" public_interface="in"/> | |
<variable name="JdiffNa" units="millimolar_per_millisecond" public_interface="in"/> | |
<variable name="Jdiff" units="millimolar_per_millisecond" public_interface="in"/> | |
<variable name="Jup" units="millimolar_per_millisecond" public_interface="in"/> | |
<variable name="JdiffK" units="millimolar_per_millisecond" public_interface="in"/> | |
<variable name="Jrel" units="millimolar_per_millisecond" public_interface="in"/> | |
<variable name="Jtr" units="millimolar_per_millisecond" public_interface="in"/> | |
<variable name="ICaK" units="microA_per_microF" public_interface="in"/> | |
<variable name="time" units="millisecond" public_interface="in"/> | |
<variable name="vmyo" units="microliter" public_interface="in"/> | |
<variable name="vnsr" units="microliter" public_interface="in"/> | |
<variable name="vss" units="microliter" public_interface="in"/> | |
<variable name="vjsr" units="microliter" public_interface="in"/> | |
<variable name="Bcai" units="dimensionless"/> | |
<variable name="Bcajsr" units="dimensionless"/> | |
<variable name="Bcass" units="dimensionless"/> | |
<variable name="cm" units="microF_per_centimeter_squared" initial_value="1" public_interface="out"/> | |
<math xmlns="http://www.w3.org/1998/Math/MathML"> | |
<apply> | |
<eq/> | |
<ci>cmdnmax</ci> | |
<piecewise> | |
<piece> | |
<apply> | |
<times/> | |
<ci>cmdnmax_b</ci> | |
<cn cellml:units="dimensionless">1.3</cn> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>celltype</ci> | |
<cn cellml:units="dimensionless">1</cn> | |
</apply> | |
</piece> | |
<otherwise> | |
<ci>cmdnmax_b</ci> | |
</otherwise> | |
</piecewise> | |
</apply> | |
<apply> | |
<eq/> | |
<apply> | |
<diff/> | |
<bvar> | |
<ci>time</ci> | |
</bvar> | |
<ci>nai</ci> | |
</apply> | |
<apply> | |
<plus/> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<apply> | |
<minus/> | |
<apply> | |
<plus/> | |
<ci>INa</ci> | |
<ci>INaL</ci> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">3</cn> | |
<ci>INaCa_i</ci> | |
</apply> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">3</cn> | |
<ci>INaK</ci> | |
</apply> | |
<ci>INab</ci> | |
</apply> | |
</apply> | |
<ci>Acap</ci> | |
<ci>cm</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>F</ci> | |
<ci>vmyo</ci> | |
</apply> | |
</apply> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>JdiffNa</ci> | |
<ci>vss</ci> | |
</apply> | |
<ci>vmyo</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<apply> | |
<diff/> | |
<bvar> | |
<ci>time</ci> | |
</bvar> | |
<ci>nass</ci> | |
</apply> | |
<apply> | |
<minus/> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<apply> | |
<minus/> | |
<apply> | |
<plus/> | |
<ci>ICaNa</ci> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">3</cn> | |
<ci>INaCa_ss</ci> | |
</apply> | |
</apply> | |
</apply> | |
<ci>cm</ci> | |
<ci>Acap</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>F</ci> | |
<ci>vss</ci> | |
</apply> | |
</apply> | |
<ci>JdiffNa</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<apply> | |
<diff/> | |
<bvar> | |
<ci>time</ci> | |
</bvar> | |
<ci>ki</ci> | |
</apply> | |
<apply> | |
<plus/> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<apply> | |
<minus/> | |
<apply> | |
<minus/> | |
<apply> | |
<plus/> | |
<ci>Ito</ci> | |
<ci>IKr</ci> | |
<ci>IKs</ci> | |
<ci>IK1</ci> | |
<ci>IKb</ci> | |
<ci>Istim</ci> | |
</apply> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">2</cn> | |
<ci>INaK</ci> | |
</apply> | |
</apply> | |
</apply> | |
<ci>cm</ci> | |
<ci>Acap</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>F</ci> | |
<ci>vmyo</ci> | |
</apply> | |
</apply> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>JdiffK</ci> | |
<ci>vss</ci> | |
</apply> | |
<ci>vmyo</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
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<ci>Acap</ci> | |
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<ci>vss</ci> | |
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<apply> | |
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<cn cellml:units="dimensionless">2</cn> | |
<ci>INaCa_ss</ci> | |
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<ci>Acap</ci> | |
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<cn cellml:units="dimensionless">2</cn> | |
<ci>F</ci> | |
<ci>vss</ci> | |
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<apply> | |
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<apply> | |
<times/> | |
<ci>Jrel</ci> | |
<ci>vjsr</ci> | |
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<ci>vss</ci> | |
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<ci>Jdiff</ci> | |
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<ci>cansr</ci> | |
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<apply> | |
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<ci>vjsr</ci> | |
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<cn cellml:units="dimensionless">1</cn> | |
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<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
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<apply> | |
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<ci>csqnmax</ci> | |
<ci>kmcsqn</ci> | |
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<ci>kmcsqn</ci> | |
<ci>cajsr</ci> | |
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<apply> | |
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<ci>time</ci> | |
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<ci>cajsr</ci> | |
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<ci>Bcajsr</ci> | |
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<minus/> | |
<ci>Jtr</ci> | |
<ci>Jrel</ci> | |
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<component name="reversal_potentials"> | |
<variable name="PKNa" units="dimensionless" initial_value="0.01833"/> | |
<variable name="ENa" units="millivolt" public_interface="out"/> | |
<variable name="EK" units="millivolt" public_interface="out"/> | |
<variable name="EKs" units="millivolt" public_interface="out"/> | |
<variable name="nao" units="millimolar" public_interface="in"/> | |
<variable name="ko" units="millimolar" public_interface="in"/> | |
<variable name="nai" units="millimolar" public_interface="in"/> | |
<variable name="ki" units="millimolar" public_interface="in"/> | |
<variable name="R" units="joule_per_kilomole_kelvin" public_interface="in"/> | |
<variable name="T" units="kelvin" public_interface="in"/> | |
<variable name="F" units="coulomb_per_mole" public_interface="in"/> | |
<math xmlns="http://www.w3.org/1998/Math/MathML"> | |
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<ci>ENa</ci> | |
<apply> | |
<times/> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>R</ci> | |
<ci>T</ci> | |
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<ci>F</ci> | |
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<ln/> | |
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<ci>nai</ci> | |
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<times/> | |
<ci>R</ci> | |
<ci>T</ci> | |
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<ci>F</ci> | |
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<ci>ki</ci> | |
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<times/> | |
<apply> | |
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<apply> | |
<times/> | |
<ci>R</ci> | |
<ci>T</ci> | |
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<ln/> | |
<apply> | |
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<apply> | |
<times/> | |
<ci>PKNa</ci> | |
<ci>nao</ci> | |
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<apply> | |
<times/> | |
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<ci>nai</ci> | |
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</apply> | |
</apply> | |
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<component name="INa"> | |
<variable name="mss" units="dimensionless"/> | |
<variable name="tm" units="millisecond" public_interface="out"/> | |
<variable name="mssV1" units="millivolt" initial_value="39.57"/> | |
<variable name="mssV2" units="millivolt" initial_value="9.871"/> | |
<variable name="mtV1" units="millivolt" initial_value="11.64"/> | |
<variable name="mtV2" units="millivolt" initial_value="34.77"/> | |
<variable name="mtD1" units="dimensionless" initial_value="6.765"/> | |
<variable name="mtD2" units="dimensionless" initial_value="8.552"/> | |
<variable name="mtV3" units="millivolt" initial_value="77.42"/> | |
<variable name="mtV4" units="millivolt" initial_value="5.955"/> | |
<variable name="m" units="dimensionless" initial_value="0"/> | |
<variable name="time" units="millisecond" public_interface="in"/> | |
<variable name="hss" units="dimensionless"/> | |
<variable name="thf" units="millisecond"/> | |
<variable name="ths" units="millisecond"/> | |
<variable name="hssV1" units="millivolt" initial_value="82.9"/> | |
<variable name="hssV2" units="millivolt" initial_value="6.086"/> | |
<variable name="Ahs" units="dimensionless"/> | |
<variable name="Ahf" units="dimensionless" initial_value="0.99"/> | |
<variable name="hf" units="dimensionless" initial_value="1"/> | |
<variable name="hs" units="dimensionless" initial_value="1"/> | |
<variable name="h" units="dimensionless"/> | |
<variable name="GNa" units="milliS_per_microF" initial_value="75"/> | |
<variable name="jss" units="dimensionless"/> | |
<variable name="tj" units="millisecond"/> | |
<variable name="j" units="dimensionless" initial_value="1"/> | |
<variable name="hssp" units="dimensionless"/> | |
<variable name="thsp" units="millisecond"/> | |
<variable name="hsp" units="dimensionless" initial_value="1"/> | |
<variable name="hp" units="dimensionless"/> | |
<variable name="tjp" units="millisecond"/> | |
<variable name="jp" units="dimensionless" initial_value="1"/> | |
<variable name="fINap" units="dimensionless"/> | |
<variable name="INa" units="microA_per_microF" public_interface="out"/> | |
<variable name="v" units="millivolt" public_interface="in"/> | |
<variable name="KmCaMK" units="millimolar" public_interface="in"/> | |
<variable name="CaMKa" units="millimolar" public_interface="in"/> | |
<variable name="ENa" units="millivolt" public_interface="in"/> | |
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<ci>m</ci> | |
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<cn cellml:units="dimensionless">1</cn> | |
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</apply> | |
</apply> | |
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<ci>hf</ci> | |
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<ci>hs</ci> | |
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<ci>hss</ci> | |
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<cn cellml:units="millivolt">0.9941</cn> | |
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<cn cellml:units="millivolt">38.45</cn> | |
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<ci>j</ci> | |
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<ci>j</ci> | |
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<cn cellml:units="millivolt">6.086</cn> | |
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<ci>thsp</ci> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">3</cn> | |
<ci>ths</ci> | |
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<ci>time</ci> | |
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<cn cellml:units="millivolt">167.4</cn> | |
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<cn cellml:units="millivolt">15.89</cn> | |
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</apply> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<apply> | |
<minus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">12.23</cn> | |
</apply> | |
</apply> | |
<cn cellml:units="millivolt">0.2154</cn> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>dti_recover</ci> | |
<apply> | |
<minus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">0.5</cn> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<plus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">70</cn> | |
</apply> | |
<cn cellml:units="millivolt">20</cn> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>tiFp</ci> | |
<apply> | |
<times/> | |
<ci>dti_develop</ci> | |
<ci>dti_recover</ci> | |
<ci>tiF</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>tiSp</ci> | |
<apply> | |
<times/> | |
<ci>dti_develop</ci> | |
<ci>dti_recover</ci> | |
<ci>tiS</ci> | |
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</apply> | |
<apply> | |
<eq/> | |
<apply> | |
<diff/> | |
<bvar> | |
<ci>time</ci> | |
</bvar> | |
<ci>iFp</ci> | |
</apply> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>iss</ci> | |
<ci>iFp</ci> | |
</apply> | |
<ci>tiFp</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<apply> | |
<diff/> | |
<bvar> | |
<ci>time</ci> | |
</bvar> | |
<ci>iSp</ci> | |
</apply> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>iss</ci> | |
<ci>iSp</ci> | |
</apply> | |
<ci>tiSp</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>ip</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>AiF</ci> | |
<ci>iFp</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>AiS</ci> | |
<ci>iSp</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>Gto</ci> | |
<piecewise> | |
<piece> | |
<apply> | |
<times/> | |
<ci>Gto_b</ci> | |
<cn cellml:units="dimensionless">4</cn> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>celltype</ci> | |
<cn cellml:units="dimensionless">1</cn> | |
</apply> | |
</piece> | |
<piece> | |
<apply> | |
<times/> | |
<ci>Gto_b</ci> | |
<cn cellml:units="dimensionless">4</cn> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>celltype</ci> | |
<cn cellml:units="dimensionless">2</cn> | |
</apply> | |
</piece> | |
<otherwise> | |
<ci>Gto_b</ci> | |
</otherwise> | |
</piecewise> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>fItop</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<ci>KmCaMK</ci> | |
<ci>CaMKa</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>Ito</ci> | |
<apply> | |
<times/> | |
<ci>Gto</ci> | |
<apply> | |
<minus/> | |
<ci>v</ci> | |
<ci>EK</ci> | |
</apply> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<apply> | |
<minus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>fItop</ci> | |
</apply> | |
<ci>a</ci> | |
<ci>i</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>fItop</ci> | |
<ci>ap</ci> | |
<ci>ip</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</math> | |
</component> | |
<component name="ICaL"> | |
<variable name="Kmn" units="millimolar" initial_value="0.002"/> | |
<variable name="k2n" units="per_millisecond" initial_value="1000"/> | |
<variable name="PCa_b" units="dimensionless" initial_value="0.0001"/> | |
<variable name="dss" units="dimensionless"/> | |
<variable name="d" units="dimensionless" initial_value="0"/> | |
<variable name="fss" units="dimensionless"/> | |
<variable name="Aff" units="dimensionless"/> | |
<variable name="Afs" units="dimensionless"/> | |
<variable name="ff" units="dimensionless" initial_value="1"/> | |
<variable name="fs" units="dimensionless" initial_value="1"/> | |
<variable name="f" units="dimensionless"/> | |
<variable name="fcass" units="dimensionless"/> | |
<variable name="Afcaf" units="dimensionless"/> | |
<variable name="Afcas" units="dimensionless"/> | |
<variable name="fcaf" units="dimensionless" initial_value="1"/> | |
<variable name="fcas" units="dimensionless" initial_value="1"/> | |
<variable name="fca" units="dimensionless"/> | |
<variable name="jca" units="dimensionless" initial_value="1"/> | |
<variable name="ffp" units="dimensionless" initial_value="1"/> | |
<variable name="fp" units="dimensionless"/> | |
<variable name="fcafp" units="dimensionless" initial_value="1"/> | |
<variable name="fcap" units="dimensionless"/> | |
<variable name="km2n" units="per_millisecond"/> | |
<variable name="anca" units="dimensionless"/> | |
<variable name="nca" units="dimensionless" initial_value="0"/> | |
<variable name="PhiCaL" units="dimensionless"/> | |
<variable name="PhiCaNa" units="dimensionless"/> | |
<variable name="PhiCaK" units="dimensionless"/> | |
<variable name="PCa" units="dimensionless"/> | |
<variable name="celltype" units="dimensionless" public_interface="in"/> | |
<variable name="PCap" units="dimensionless"/> | |
<variable name="PCaNa" units="dimensionless"/> | |
<variable name="PCaK" units="dimensionless"/> | |
<variable name="PCaNap" units="dimensionless"/> | |
<variable name="PCaKp" units="dimensionless"/> | |
<variable name="fICaLp" units="dimensionless"/> | |
<variable name="td" units="millisecond"/> | |
<variable name="tff" units="millisecond"/> | |
<variable name="tfs" units="millisecond"/> | |
<variable name="tfcaf" units="millisecond"/> | |
<variable name="tfcas" units="millisecond"/> | |
<variable name="tjca" units="millisecond"/> | |
<variable name="tffp" units="millisecond"/> | |
<variable name="tfcafp" units="millisecond"/> | |
<variable name="ICaL" units="microA_per_microF" public_interface="out"/> | |
<variable name="ICaNa" units="microA_per_microF" public_interface="out"/> | |
<variable name="ICaK" units="microA_per_microF" public_interface="out"/> | |
<variable name="v" units="millivolt" public_interface="in"/> | |
<variable name="time" units="millisecond" public_interface="in"/> | |
<variable name="cass" units="millimolar" public_interface="in"/> | |
<variable name="cao" units="millimolar" public_interface="in"/> | |
<variable name="vffrt" units="coulomb_per_mole" public_interface="in"/> | |
<variable name="vfrt" units="dimensionless" public_interface="in"/> | |
<variable name="nao" units="millimolar" public_interface="in"/> | |
<variable name="nass" units="millimolar" public_interface="in"/> | |
<variable name="ko" units="millimolar" public_interface="in"/> | |
<variable name="kss" units="millimolar" public_interface="in"/> | |
<variable name="KmCaMK" units="millimolar" public_interface="in"/> | |
<variable name="CaMKa" units="millimolar" public_interface="in"/> | |
<variable name="R" units="joule_per_kilomole_kelvin" public_interface="in"/> | |
<variable name="T" units="kelvin" public_interface="in"/> | |
<variable name="F" units="coulomb_per_mole" public_interface="in"/> | |
<math xmlns="http://www.w3.org/1998/Math/MathML"> | |
<apply> | |
<eq/> | |
<ci>dss</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<apply> | |
<plus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">3.94</cn> | |
</apply> | |
</apply> | |
<cn cellml:units="millivolt">4.23</cn> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>td</ci> | |
<apply> | |
<plus/> | |
<cn cellml:units="millisecond">0.6</cn> | |
<apply> | |
<divide/> | |
<cn cellml:units="millisecond">1</cn> | |
<apply> | |
<plus/> | |
<apply> | |
<exp/> | |
<apply> | |
<times/> | |
<apply> | |
<minus/> | |
<cn cellml:units="per_millivolt">0.05</cn> | |
</apply> | |
<apply> | |
<plus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">6</cn> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<exp/> | |
<apply> | |
<times/> | |
<cn cellml:units="per_millivolt">0.09</cn> | |
<apply> | |
<plus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">14</cn> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<apply> | |
<diff/> | |
<bvar> | |
<ci>time</ci> | |
</bvar> | |
<ci>d</ci> | |
</apply> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>dss</ci> | |
<ci>d</ci> | |
</apply> | |
<ci>td</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>fss</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<plus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">19.58</cn> | |
</apply> | |
<cn cellml:units="millivolt">3.696</cn> | |
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</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>tff</ci> | |
<apply> | |
<plus/> | |
<cn cellml:units="millisecond">7</cn> | |
<apply> | |
<divide/> | |
<cn cellml:units="millisecond">1</cn> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.0045</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<apply> | |
<plus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">20</cn> | |
</apply> | |
</apply> | |
<cn cellml:units="millivolt">10</cn> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.0045</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<plus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">20</cn> | |
</apply> | |
<cn cellml:units="millivolt">10</cn> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>tfs</ci> | |
<apply> | |
<plus/> | |
<cn cellml:units="millisecond">1000</cn> | |
<apply> | |
<divide/> | |
<cn cellml:units="millisecond">1</cn> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.000035</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<apply> | |
<plus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">5</cn> | |
</apply> | |
</apply> | |
<cn cellml:units="millivolt">4</cn> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.000035</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<plus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">5</cn> | |
</apply> | |
<cn cellml:units="millivolt">6</cn> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>Aff</ci> | |
<cn cellml:units="dimensionless">0.6</cn> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>Afs</ci> | |
<apply> | |
<minus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>Aff</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<apply> | |
<diff/> | |
<bvar> | |
<ci>time</ci> | |
</bvar> | |
<ci>ff</ci> | |
</apply> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>fss</ci> | |
<ci>ff</ci> | |
</apply> | |
<ci>tff</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<apply> | |
<diff/> | |
<bvar> | |
<ci>time</ci> | |
</bvar> | |
<ci>fs</ci> | |
</apply> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>fss</ci> | |
<ci>fs</ci> | |
</apply> | |
<ci>tfs</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>f</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>Aff</ci> | |
<ci>ff</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>Afs</ci> | |
<ci>fs</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>fcass</ci> | |
<ci>fss</ci> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>tfcaf</ci> | |
<apply> | |
<plus/> | |
<cn cellml:units="millisecond">7</cn> | |
<apply> | |
<divide/> | |
<cn cellml:units="millisecond">1</cn> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.04</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<apply> | |
<minus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">4</cn> | |
</apply> | |
</apply> | |
<cn cellml:units="millivolt">7</cn> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.04</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">4</cn> | |
</apply> | |
<cn cellml:units="millivolt">7</cn> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>tfcas</ci> | |
<apply> | |
<plus/> | |
<cn cellml:units="millisecond">100</cn> | |
<apply> | |
<divide/> | |
<cn cellml:units="millisecond">1</cn> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.00012</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>v</ci> | |
</apply> | |
<cn cellml:units="millivolt">3</cn> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.00012</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">7</cn> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>Afcaf</ci> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">0.3</cn> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">0.6</cn> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">10</cn> | |
</apply> | |
<cn cellml:units="millivolt">10</cn> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>Afcas</ci> | |
<apply> | |
<minus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>Afcaf</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<apply> | |
<diff/> | |
<bvar> | |
<ci>time</ci> | |
</bvar> | |
<ci>fcaf</ci> | |
</apply> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>fcass</ci> | |
<ci>fcaf</ci> | |
</apply> | |
<ci>tfcaf</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<apply> | |
<diff/> | |
<bvar> | |
<ci>time</ci> | |
</bvar> | |
<ci>fcas</ci> | |
</apply> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>fcass</ci> | |
<ci>fcas</ci> | |
</apply> | |
<ci>tfcas</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>fca</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>Afcaf</ci> | |
<ci>fcaf</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>Afcas</ci> | |
<ci>fcas</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>tjca</ci> | |
<cn cellml:units="millisecond">75</cn> | |
</apply> | |
<apply> | |
<eq/> | |
<apply> | |
<diff/> | |
<bvar> | |
<ci>time</ci> | |
</bvar> | |
<ci>jca</ci> | |
</apply> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>fcass</ci> | |
<ci>jca</ci> | |
</apply> | |
<ci>tjca</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>tffp</ci> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">2.5</cn> | |
<ci>tff</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<apply> | |
<diff/> | |
<bvar> | |
<ci>time</ci> | |
</bvar> | |
<ci>ffp</ci> | |
</apply> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>fss</ci> | |
<ci>ffp</ci> | |
</apply> | |
<ci>tffp</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>fp</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>Aff</ci> | |
<ci>ffp</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>Afs</ci> | |
<ci>fs</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>tfcafp</ci> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">2.5</cn> | |
<ci>tfcaf</ci> | |
</apply> | |
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<apply> | |
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<bvar> | |
<ci>time</ci> | |
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<ci>fcafp</ci> | |
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<minus/> | |
<ci>fcass</ci> | |
<ci>fcafp</ci> | |
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<ci>tfcafp</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>fcap</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>Afcaf</ci> | |
<ci>fcafp</ci> | |
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<apply> | |
<times/> | |
<ci>Afcas</ci> | |
<ci>fcas</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>km2n</ci> | |
<apply> | |
<times/> | |
<ci>jca</ci> | |
<cn cellml:units="per_millisecond">1</cn> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>anca</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
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<plus/> | |
<apply> | |
<divide/> | |
<ci>k2n</ci> | |
<ci>km2n</ci> | |
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<apply> | |
<power/> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<ci>Kmn</ci> | |
<ci>cass</ci> | |
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</apply> | |
<cn cellml:units="dimensionless">4</cn> | |
</apply> | |
</apply> | |
</apply> | |
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<apply> | |
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<bvar> | |
<ci>time</ci> | |
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<ci>nca</ci> | |
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<ci>k2n</ci> | |
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<times/> | |
<ci>nca</ci> | |
<ci>km2n</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>PhiCaL</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<cn cellml:units="per_millivolt">4</cn> | |
<ci>vffrt</ci> | |
<apply> | |
<minus/> | |
<apply> | |
<times/> | |
<ci>cass</ci> | |
<apply> | |
<exp/> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">2</cn> | |
<ci>vfrt</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<cn cellml:units="per_millimolar">0.341</cn> | |
<ci>cao</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<minus/> | |
<apply> | |
<exp/> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">2</cn> | |
<ci>vfrt</ci> | |
</apply> | |
</apply> | |
<cn cellml:units="dimensionless">1</cn> | |
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</apply> | |
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<apply> | |
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<ci>PhiCaNa</ci> | |
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<apply> | |
<times/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>vffrt</ci> | |
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<times/> | |
<cn cellml:units="dimensionless">0.75</cn> | |
<ci>nass</ci> | |
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<apply> | |
<times/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>vfrt</ci> | |
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</apply> | |
</apply> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.75</cn> | |
<ci>nao</ci> | |
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</apply> | |
</apply> | |
<apply> | |
<minus/> | |
<apply> | |
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<apply> | |
<times/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>vfrt</ci> | |
</apply> | |
</apply> | |
<cn cellml:units="dimensionless">1</cn> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
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<ci>PhiCaK</ci> | |
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<divide/> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>vffrt</ci> | |
<apply> | |
<minus/> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.75</cn> | |
<ci>kss</ci> | |
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<apply> | |
<times/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>vfrt</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.75</cn> | |
<ci>ko</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<minus/> | |
<apply> | |
<exp/> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>vfrt</ci> | |
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</apply> | |
<cn cellml:units="dimensionless">1</cn> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>PCa</ci> | |
<piecewise> | |
<piece> | |
<apply> | |
<times/> | |
<ci>PCa_b</ci> | |
<cn cellml:units="dimensionless">1.2</cn> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>celltype</ci> | |
<cn cellml:units="dimensionless">1</cn> | |
</apply> | |
</piece> | |
<piece> | |
<apply> | |
<times/> | |
<ci>PCa_b</ci> | |
<cn cellml:units="dimensionless">2.5</cn> | |
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<apply> | |
<eq/> | |
<ci>celltype</ci> | |
<cn cellml:units="dimensionless">2</cn> | |
</apply> | |
</piece> | |
<otherwise> | |
<ci>PCa_b</ci> | |
</otherwise> | |
</piecewise> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>PCap</ci> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">1.1</cn> | |
<ci>PCa</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>PCaNa</ci> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.00125</cn> | |
<ci>PCa</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>PCaK</ci> | |
<apply> | |
<times/> | |
<cn type="e-notation" cellml:units="dimensionless">3.574 <sep/> | |
-4</cn> | |
<ci>PCa</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>PCaNap</ci> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.00125</cn> | |
<ci>PCap</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>PCaKp</ci> | |
<apply> | |
<times/> | |
<cn type="e-notation" cellml:units="dimensionless">3.574 <sep/> | |
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<ci>PCap</ci> | |
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<apply> | |
<eq/> | |
<ci>fICaLp</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
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<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
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<ci>KmCaMK</ci> | |
<ci>CaMKa</ci> | |
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</apply> | |
</apply> | |
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<apply> | |
<eq/> | |
<ci>ICaL</ci> | |
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<plus/> | |
<apply> | |
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<apply> | |
<minus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>fICaLp</ci> | |
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<ci>PCa</ci> | |
<ci>PhiCaL</ci> | |
<ci>d</ci> | |
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<ci>f</ci> | |
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<cn cellml:units="dimensionless">1</cn> | |
<ci>nca</ci> | |
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<apply> | |
<times/> | |
<ci>jca</ci> | |
<ci>fca</ci> | |
<ci>nca</ci> | |
</apply> | |
</apply> | |
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<apply> | |
<times/> | |
<ci>fICaLp</ci> | |
<ci>PCap</ci> | |
<ci>PhiCaL</ci> | |
<ci>d</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>fp</ci> | |
<apply> | |
<minus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>nca</ci> | |
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<apply> | |
<times/> | |
<ci>jca</ci> | |
<ci>fcap</ci> | |
<ci>nca</ci> | |
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</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>ICaNa</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<apply> | |
<minus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>fICaLp</ci> | |
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<ci>PCaNa</ci> | |
<ci>PhiCaNa</ci> | |
<ci>d</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>f</ci> | |
<apply> | |
<minus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>nca</ci> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<ci>jca</ci> | |
<ci>fca</ci> | |
<ci>nca</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<ci>fICaLp</ci> | |
<ci>PCaNap</ci> | |
<ci>PhiCaNa</ci> | |
<ci>d</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>fp</ci> | |
<apply> | |
<minus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>nca</ci> | |
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</apply> | |
<apply> | |
<times/> | |
<ci>jca</ci> | |
<ci>fcap</ci> | |
<ci>nca</ci> | |
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</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>ICaK</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<apply> | |
<minus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>fICaLp</ci> | |
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<ci>PCaK</ci> | |
<ci>PhiCaK</ci> | |
<ci>d</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>f</ci> | |
<apply> | |
<minus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>nca</ci> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<ci>jca</ci> | |
<ci>fca</ci> | |
<ci>nca</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<ci>fICaLp</ci> | |
<ci>PCaKp</ci> | |
<ci>PhiCaK</ci> | |
<ci>d</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>fp</ci> | |
<apply> | |
<minus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>nca</ci> | |
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</apply> | |
<apply> | |
<times/> | |
<ci>jca</ci> | |
<ci>fcap</ci> | |
<ci>nca</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</math> | |
</component> | |
<component name="IKr"> | |
<variable name="GKr_b" units="milliS_per_microF" initial_value="0.046"/> | |
<variable name="GKr" units="milliS_per_microF"/> | |
<variable name="xrss" units="dimensionless"/> | |
<variable name="txrf" units="millisecond"/> | |
<variable name="txrs" units="millisecond"/> | |
<variable name="Axrf" units="dimensionless"/> | |
<variable name="Axrs" units="dimensionless"/> | |
<variable name="xrf" units="dimensionless" initial_value="0"/> | |
<variable name="xrs" units="dimensionless" initial_value="0"/> | |
<variable name="xr" units="dimensionless"/> | |
<variable name="rkr" units="dimensionless"/> | |
<variable name="v" units="millivolt" public_interface="in"/> | |
<variable name="time" units="millisecond" public_interface="in"/> | |
<variable name="celltype" units="dimensionless" public_interface="in"/> | |
<variable name="EK" units="millivolt" public_interface="in"/> | |
<variable name="ko" units="millimolar" public_interface="in"/> | |
<variable name="IKr" units="microA_per_microF" public_interface="out"/> | |
<math xmlns="http://www.w3.org/1998/Math/MathML"> | |
<apply> | |
<eq/> | |
<ci>xrss</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<exp/> | |
<apply> | |
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<apply> | |
<minus/> | |
<apply> | |
<plus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">8.337</cn> | |
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</apply> | |
<cn cellml:units="millivolt">6.789</cn> | |
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</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>txrf</ci> | |
<apply> | |
<plus/> | |
<cn cellml:units="millisecond">12.98</cn> | |
<apply> | |
<divide/> | |
<cn cellml:units="millisecond">1</cn> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.3652</cn> | |
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<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">31.66</cn> | |
</apply> | |
<cn cellml:units="millivolt">3.869</cn> | |
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</apply> | |
</apply> | |
<apply> | |
<times/> | |
<cn type="e-notation" cellml:units="dimensionless">4.123 <sep/> | |
-5</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<apply> | |
<minus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">47.78</cn> | |
</apply> | |
</apply> | |
<cn cellml:units="millivolt">20.38</cn> | |
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</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>txrs</ci> | |
<apply> | |
<plus/> | |
<cn cellml:units="millisecond">1.865</cn> | |
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<divide/> | |
<cn cellml:units="millisecond">1</cn> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.06629</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">34.7</cn> | |
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<cn cellml:units="millivolt">7.355</cn> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<cn type="e-notation" cellml:units="dimensionless">1.128 <sep/> | |
-5</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<apply> | |
<minus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">29.74</cn> | |
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</apply> | |
<cn cellml:units="millivolt">25.94</cn> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>Axrf</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<plus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">54.81</cn> | |
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<cn cellml:units="millivolt">38.21</cn> | |
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</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>Axrs</ci> | |
<apply> | |
<minus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>Axrf</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<apply> | |
<diff/> | |
<bvar> | |
<ci>time</ci> | |
</bvar> | |
<ci>xrf</ci> | |
</apply> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>xrss</ci> | |
<ci>xrf</ci> | |
</apply> | |
<ci>txrf</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<apply> | |
<diff/> | |
<bvar> | |
<ci>time</ci> | |
</bvar> | |
<ci>xrs</ci> | |
</apply> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>xrss</ci> | |
<ci>xrs</ci> | |
</apply> | |
<ci>txrs</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>xr</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>Axrf</ci> | |
<ci>xrf</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>Axrs</ci> | |
<ci>xrs</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>rkr</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<plus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">55</cn> | |
</apply> | |
<cn cellml:units="millivolt">75</cn> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<cn cellml:units="dimensionless">1</cn> | |
</apply> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">10</cn> | |
</apply> | |
<cn cellml:units="millivolt">30</cn> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>GKr</ci> | |
<piecewise> | |
<piece> | |
<apply> | |
<times/> | |
<ci>GKr_b</ci> | |
<cn cellml:units="dimensionless">1.3</cn> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>celltype</ci> | |
<cn cellml:units="dimensionless">1</cn> | |
</apply> | |
</piece> | |
<piece> | |
<apply> | |
<times/> | |
<ci>GKr_b</ci> | |
<cn cellml:units="dimensionless">0.8</cn> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>celltype</ci> | |
<cn cellml:units="dimensionless">2</cn> | |
</apply> | |
</piece> | |
<otherwise> | |
<ci>GKr_b</ci> | |
</otherwise> | |
</piecewise> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>IKr</ci> | |
<apply> | |
<times/> | |
<ci>GKr</ci> | |
<apply> | |
<root/> | |
<apply> | |
<divide/> | |
<ci>ko</ci> | |
<cn cellml:units="millimolar">5.4</cn> | |
</apply> | |
</apply> | |
<ci>xr</ci> | |
<ci>rkr</ci> | |
<apply> | |
<minus/> | |
<ci>v</ci> | |
<ci>EK</ci> | |
</apply> | |
</apply> | |
</apply> | |
</math> | |
</component> | |
<component name="IKs"> | |
<variable name="GKs_b" units="milliS_per_microF" initial_value="0.0034"/> | |
<variable name="GKs" units="milliS_per_microF"/> | |
<variable name="xs1ss" units="dimensionless"/> | |
<variable name="xs2ss" units="dimensionless"/> | |
<variable name="txs1" units="millisecond"/> | |
<variable name="xs1" units="dimensionless" initial_value="0"/> | |
<variable name="xs2" units="dimensionless" initial_value="0"/> | |
<variable name="KsCa" units="dimensionless"/> | |
<variable name="v" units="millivolt" public_interface="in"/> | |
<variable name="time" units="millisecond" public_interface="in"/> | |
<variable name="celltype" units="dimensionless" public_interface="in"/> | |
<variable name="EKs" units="millivolt" public_interface="in"/> | |
<variable name="IKs" units="microA_per_microF" public_interface="out"/> | |
<variable name="txs2" units="millisecond"/> | |
<variable name="cai" units="millimolar" public_interface="in"/> | |
<math xmlns="http://www.w3.org/1998/Math/MathML"> | |
<apply> | |
<eq/> | |
<ci>xs1ss</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<apply> | |
<plus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">11.6</cn> | |
</apply> | |
</apply> | |
<cn cellml:units="millivolt">8.932</cn> | |
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</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>txs1</ci> | |
<apply> | |
<plus/> | |
<cn cellml:units="millisecond">817.3</cn> | |
<apply> | |
<divide/> | |
<cn cellml:units="millisecond">1</cn> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<cn type="e-notation" cellml:units="dimensionless">2.326 <sep/> | |
-4</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<plus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">48.28</cn> | |
</apply> | |
<cn cellml:units="millivolt">17.8</cn> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.001292</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<apply> | |
<plus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">210</cn> | |
</apply> | |
</apply> | |
<cn cellml:units="millivolt">230</cn> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<apply> | |
<diff/> | |
<bvar> | |
<ci>time</ci> | |
</bvar> | |
<ci>xs1</ci> | |
</apply> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>xs1ss</ci> | |
<ci>xs1</ci> | |
</apply> | |
<ci>txs1</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>xs2ss</ci> | |
<ci>xs1ss</ci> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>txs2</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="millisecond">1</cn> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.01</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">50</cn> | |
</apply> | |
<cn cellml:units="millivolt">20</cn> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.0193</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<apply> | |
<plus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">66.54</cn> | |
</apply> | |
</apply> | |
<cn cellml:units="millivolt">31</cn> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<apply> | |
<diff/> | |
<bvar> | |
<ci>time</ci> | |
</bvar> | |
<ci>xs2</ci> | |
</apply> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>xs2ss</ci> | |
<ci>xs2</ci> | |
</apply> | |
<ci>txs2</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>KsCa</ci> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">0.6</cn> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<power/> | |
<apply> | |
<divide/> | |
<cn type="e-notation" cellml:units="millimolar">3.8 <sep/> | |
-5</cn> | |
<ci>cai</ci> | |
</apply> | |
<cn cellml:units="dimensionless">1.4</cn> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>GKs</ci> | |
<piecewise> | |
<piece> | |
<apply> | |
<times/> | |
<ci>GKs_b</ci> | |
<cn cellml:units="dimensionless">1.4</cn> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>celltype</ci> | |
<cn cellml:units="dimensionless">1</cn> | |
</apply> | |
</piece> | |
<otherwise> | |
<ci>GKs_b</ci> | |
</otherwise> | |
</piecewise> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>IKs</ci> | |
<apply> | |
<times/> | |
<ci>GKs</ci> | |
<ci>KsCa</ci> | |
<ci>xs1</ci> | |
<ci>xs2</ci> | |
<apply> | |
<minus/> | |
<ci>v</ci> | |
<ci>EKs</ci> | |
</apply> | |
</apply> | |
</apply> | |
</math> | |
</component> | |
<component name="IK1"> | |
<variable name="GK1" units="milliS_per_microF"/> | |
<variable name="GK1_b" units="milliS_per_microF" initial_value="0.1908"/> | |
<variable name="xk1ss" units="dimensionless"/> | |
<variable name="txk1" units="millisecond"/> | |
<variable name="xk1" units="dimensionless" initial_value="1"/> | |
<variable name="rk1" units="millisecond"/> | |
<variable name="v" units="millivolt" public_interface="in"/> | |
<variable name="time" units="millisecond" public_interface="in"/> | |
<variable name="celltype" units="dimensionless" public_interface="in"/> | |
<variable name="EK" units="millivolt" public_interface="in"/> | |
<variable name="ko" units="millimolar" public_interface="in"/> | |
<variable name="IK1" units="microA_per_microF" public_interface="out"/> | |
<math xmlns="http://www.w3.org/1998/Math/MathML"> | |
<apply> | |
<eq/> | |
<ci>xk1ss</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<apply> | |
<plus/> | |
<ci>v</ci> | |
<apply> | |
<times/> | |
<cn cellml:units="millivolt_per_millimole">2.5538</cn> | |
<ci>ko</ci> | |
</apply> | |
<cn cellml:units="millivolt">144.59</cn> | |
</apply> | |
</apply> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<cn cellml:units="millivolt_per_millimole">1.5692</cn> | |
<ci>ko</ci> | |
</apply> | |
<cn cellml:units="millivolt">3.8115</cn> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>txk1</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="millisecond">122.2</cn> | |
<apply> | |
<plus/> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<apply> | |
<plus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">127.2</cn> | |
</apply> | |
</apply> | |
<cn cellml:units="millivolt">20.36</cn> | |
</apply> | |
</apply> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<plus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">236.8</cn> | |
</apply> | |
<cn cellml:units="millivolt">69.33</cn> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<apply> | |
<diff/> | |
<bvar> | |
<ci>time</ci> | |
</bvar> | |
<ci>xk1</ci> | |
</apply> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>xk1ss</ci> | |
<ci>xk1</ci> | |
</apply> | |
<ci>txk1</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>rk1</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<apply> | |
<plus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">105.8</cn> | |
</apply> | |
<apply> | |
<times/> | |
<cn cellml:units="millivolt_per_millimole">2.6</cn> | |
<ci>ko</ci> | |
</apply> | |
</apply> | |
<cn cellml:units="millivolt">9.493</cn> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>GK1</ci> | |
<piecewise> | |
<piece> | |
<apply> | |
<times/> | |
<ci>GK1_b</ci> | |
<cn cellml:units="dimensionless">1.2</cn> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>celltype</ci> | |
<cn cellml:units="dimensionless">1</cn> | |
</apply> | |
</piece> | |
<piece> | |
<apply> | |
<times/> | |
<ci>GK1_b</ci> | |
<cn cellml:units="dimensionless">1.3</cn> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>celltype</ci> | |
<cn cellml:units="dimensionless">2</cn> | |
</apply> | |
</piece> | |
<otherwise> | |
<ci>GK1_b</ci> | |
</otherwise> | |
</piecewise> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>IK1</ci> | |
<apply> | |
<times/> | |
<ci>GK1</ci> | |
<apply> | |
<root/> | |
<ci>ko</ci> | |
</apply> | |
<ci>rk1</ci> | |
<ci>xk1</ci> | |
<apply> | |
<minus/> | |
<ci>v</ci> | |
<ci>EK</ci> | |
</apply> | |
</apply> | |
</apply> | |
</math> | |
</component> | |
<component name="INaCa_i"> | |
<variable name="kna1" units="per_millisecond" initial_value="15"/> | |
<variable name="kna2" units="per_millisecond" initial_value="5"/> | |
<variable name="kna3" units="per_millisecond" initial_value="88.12"/> | |
<variable name="kasymm" units="dimensionless" initial_value="12.5"/> | |
<variable name="wna" units="dimensionless" initial_value="6e4"/> | |
<variable name="wca" units="dimensionless" initial_value="6e4"/> | |
<variable name="wnaca" units="dimensionless" initial_value="5e3"/> | |
<variable name="kcaon" units="per_millisecond" initial_value="1.5e6"/> | |
<variable name="kcaoff" units="per_millisecond" initial_value="5e3"/> | |
<variable name="qna" units="dimensionless" initial_value="0.5224"/> | |
<variable name="qca" units="dimensionless" initial_value="0.167"/> | |
<variable name="hna" units="dimensionless"/> | |
<variable name="hca" units="dimensionless"/> | |
<variable name="zca" units="dimensionless" public_interface="in"/> | |
<variable name="KmCaAct" units="millimolar" initial_value="150e-6"/> | |
<variable name="zna" units="dimensionless" public_interface="in"/> | |
<variable name="Gncx_b" units="milliS_per_microF" initial_value="0.0008"/> | |
<variable name="Gncx" units="milliS_per_microF"/> | |
<variable name="R" units="joule_per_kilomole_kelvin" public_interface="in"/> | |
<variable name="T" units="kelvin" public_interface="in"/> | |
<variable name="F" units="coulomb_per_mole" public_interface="in"/> | |
<variable name="v" units="millivolt" public_interface="in"/> | |
<variable name="nai" units="millimolar" public_interface="in"/> | |
<variable name="nass" units="millimolar" public_interface="in"/> | |
<variable name="cass" units="millimolar" public_interface="in"/> | |
<variable name="nao" units="millimolar" public_interface="in"/> | |
<variable name="cai" units="millimolar" public_interface="in"/> | |
<variable name="cao" units="millimolar" public_interface="in"/> | |
<variable name="h1_i" units="dimensionless"/> | |
<variable name="h2_i" units="dimensionless"/> | |
<variable name="h3_i" units="dimensionless"/> | |
<variable name="h4_i" units="dimensionless"/> | |
<variable name="h5_i" units="dimensionless"/> | |
<variable name="h6_i" units="dimensionless"/> | |
<variable name="h7_i" units="dimensionless"/> | |
<variable name="h8_i" units="dimensionless"/> | |
<variable name="h9_i" units="dimensionless"/> | |
<variable name="h10_i" units="dimensionless"/> | |
<variable name="h11_i" units="dimensionless"/> | |
<variable name="h12_i" units="dimensionless"/> | |
<variable name="k1_i" units="dimensionless"/> | |
<variable name="k2_i" units="dimensionless"/> | |
<variable name="k3p_i" units="dimensionless"/> | |
<variable name="k3pp_i" units="dimensionless"/> | |
<variable name="k3_i" units="dimensionless"/> | |
<variable name="k4_i" units="dimensionless"/> | |
<variable name="k4p_i" units="dimensionless"/> | |
<variable name="k4pp_i" units="dimensionless"/> | |
<variable name="k5_i" units="dimensionless"/> | |
<variable name="k6_i" units="dimensionless"/> | |
<variable name="k7_i" units="dimensionless"/> | |
<variable name="k8_i" units="dimensionless"/> | |
<variable name="x1_i" units="dimensionless"/> | |
<variable name="x2_i" units="dimensionless"/> | |
<variable name="x3_i" units="dimensionless"/> | |
<variable name="x4_i" units="dimensionless"/> | |
<variable name="E1_i" units="dimensionless"/> | |
<variable name="E2_i" units="dimensionless"/> | |
<variable name="E3_i" units="dimensionless"/> | |
<variable name="E4_i" units="dimensionless"/> | |
<variable name="allo_i" units="dimensionless"/> | |
<variable name="JncxNa_i" units="millimolar_per_millisecond"/> | |
<variable name="JncxCa_i" units="millimolar_per_millisecond"/> | |
<variable name="celltype" units="dimensionless" public_interface="in"/> | |
<variable name="INaCa_i" units="microA_per_microF" public_interface="out"/> | |
<variable name="INaCa_ss" units="microA_per_microF" public_interface="out"/> | |
<variable name="h1_ss" units="dimensionless"/> | |
<variable name="h2_ss" units="dimensionless"/> | |
<variable name="h3_ss" units="dimensionless"/> | |
<variable name="h4_ss" units="dimensionless"/> | |
<variable name="h5_ss" units="dimensionless"/> | |
<variable name="h6_ss" units="dimensionless"/> | |
<variable name="h7_ss" units="dimensionless"/> | |
<variable name="h8_ss" units="dimensionless"/> | |
<variable name="h9_ss" units="dimensionless"/> | |
<variable name="h10_ss" units="dimensionless"/> | |
<variable name="h11_ss" units="dimensionless"/> | |
<variable name="h12_ss" units="dimensionless"/> | |
<variable name="k1_ss" units="dimensionless"/> | |
<variable name="k2_ss" units="dimensionless"/> | |
<variable name="k3p_ss" units="dimensionless"/> | |
<variable name="k3pp_ss" units="dimensionless"/> | |
<variable name="k3_ss" units="dimensionless"/> | |
<variable name="k4_ss" units="dimensionless"/> | |
<variable name="k4p_ss" units="dimensionless"/> | |
<variable name="k4pp_ss" units="dimensionless"/> | |
<variable name="k5_ss" units="dimensionless"/> | |
<variable name="k6_ss" units="dimensionless"/> | |
<variable name="k7_ss" units="dimensionless"/> | |
<variable name="k8_ss" units="dimensionless"/> | |
<variable name="x1_ss" units="dimensionless"/> | |
<variable name="x2_ss" units="dimensionless"/> | |
<variable name="x3_ss" units="dimensionless"/> | |
<variable name="x4_ss" units="dimensionless"/> | |
<variable name="E1_ss" units="dimensionless"/> | |
<variable name="E2_ss" units="dimensionless"/> | |
<variable name="E3_ss" units="dimensionless"/> | |
<variable name="E4_ss" units="dimensionless"/> | |
<variable name="allo_ss" units="dimensionless"/> | |
<variable name="JncxNa_ss" units="millimolar_per_millisecond"/> | |
<variable name="JncxCa_ss" units="millimolar_per_millisecond"/> | |
<math xmlns="http://www.w3.org/1998/Math/MathML"> | |
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<eq/> | |
<ci>hca</ci> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>qca</ci> | |
<ci>v</ci> | |
<ci>F</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>R</ci> | |
<ci>T</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>hna</ci> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>qna</ci> | |
<ci>v</ci> | |
<ci>F</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>R</ci> | |
<ci>T</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h1_i</ci> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<times/> | |
<apply> | |
<divide/> | |
<ci>nai</ci> | |
<ci>kna3</ci> | |
</apply> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>hna</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h2_i</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>nai</ci> | |
<ci>hna</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>kna3</ci> | |
<ci>h1_i</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h3_i</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>h1_i</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h4_i</ci> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<times/> | |
<apply> | |
<divide/> | |
<ci>nai</ci> | |
<ci>kna1</ci> | |
</apply> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<ci>nai</ci> | |
<ci>kna2</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h5_i</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>nai</ci> | |
<ci>nai</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>h4_i</ci> | |
<ci>kna1</ci> | |
<ci>kna2</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h6_i</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>h4_i</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h7_i</ci> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<times/> | |
<apply> | |
<divide/> | |
<ci>nao</ci> | |
<ci>kna3</ci> | |
</apply> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>hna</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h8_i</ci> | |
<apply> | |
<divide/> | |
<ci>nao</ci> | |
<apply> | |
<times/> | |
<ci>kna3</ci> | |
<ci>hna</ci> | |
<ci>h7_i</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h9_i</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>h7_i</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h10_i</ci> | |
<apply> | |
<plus/> | |
<ci>kasymm</ci> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<times/> | |
<apply> | |
<divide/> | |
<ci>nao</ci> | |
<ci>kna1</ci> | |
</apply> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<ci>nao</ci> | |
<ci>kna2</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h11_i</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>nao</ci> | |
<ci>nao</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>h10_i</ci> | |
<ci>kna1</ci> | |
<ci>kna2</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h12_i</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>h10_i</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k1_i</ci> | |
<apply> | |
<times/> | |
<ci>h12_i</ci> | |
<ci>cao</ci> | |
<ci>kcaon</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k2_i</ci> | |
<ci>kcaoff</ci> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k3p_i</ci> | |
<apply> | |
<times/> | |
<ci>h9_i</ci> | |
<ci>wca</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k3pp_i</ci> | |
<apply> | |
<times/> | |
<ci>h8_i</ci> | |
<ci>wnaca</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k3_i</ci> | |
<apply> | |
<plus/> | |
<ci>k3p_i</ci> | |
<ci>k3pp_i</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k4p_i</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>h3_i</ci> | |
<ci>wca</ci> | |
</apply> | |
<ci>hca</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k4pp_i</ci> | |
<apply> | |
<times/> | |
<ci>h2_i</ci> | |
<ci>wnaca</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k4_i</ci> | |
<apply> | |
<plus/> | |
<ci>k4p_i</ci> | |
<ci>k4pp_i</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k5_i</ci> | |
<ci>kcaoff</ci> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k6_i</ci> | |
<apply> | |
<times/> | |
<ci>h6_i</ci> | |
<ci>cai</ci> | |
<ci>kcaon</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k7_i</ci> | |
<apply> | |
<times/> | |
<ci>h5_i</ci> | |
<ci>h2_i</ci> | |
<ci>wna</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k8_i</ci> | |
<apply> | |
<times/> | |
<ci>h8_i</ci> | |
<ci>h11_i</ci> | |
<ci>wna</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>x1_i</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>k2_i</ci> | |
<ci>k4_i</ci> | |
<apply> | |
<plus/> | |
<ci>k7_i</ci> | |
<ci>k6_i</ci> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<ci>k5_i</ci> | |
<ci>k7_i</ci> | |
<apply> | |
<plus/> | |
<ci>k2_i</ci> | |
<ci>k3_i</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>x2_i</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>k1_i</ci> | |
<ci>k7_i</ci> | |
<apply> | |
<plus/> | |
<ci>k4_i</ci> | |
<ci>k5_i</ci> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<ci>k4_i</ci> | |
<ci>k6_i</ci> | |
<apply> | |
<plus/> | |
<ci>k1_i</ci> | |
<ci>k8_i</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>x3_i</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>k1_i</ci> | |
<ci>k3_i</ci> | |
<apply> | |
<plus/> | |
<ci>k7_i</ci> | |
<ci>k6_i</ci> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<ci>k8_i</ci> | |
<ci>k6_i</ci> | |
<apply> | |
<plus/> | |
<ci>k2_i</ci> | |
<ci>k3_i</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>x4_i</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>k2_i</ci> | |
<ci>k8_i</ci> | |
<apply> | |
<plus/> | |
<ci>k4_i</ci> | |
<ci>k5_i</ci> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<ci>k3_i</ci> | |
<ci>k5_i</ci> | |
<apply> | |
<plus/> | |
<ci>k1_i</ci> | |
<ci>k8_i</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>E1_i</ci> | |
<apply> | |
<divide/> | |
<ci>x1_i</ci> | |
<apply> | |
<plus/> | |
<ci>x1_i</ci> | |
<ci>x2_i</ci> | |
<ci>x3_i</ci> | |
<ci>x4_i</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>E2_i</ci> | |
<apply> | |
<divide/> | |
<ci>x2_i</ci> | |
<apply> | |
<plus/> | |
<ci>x1_i</ci> | |
<ci>x2_i</ci> | |
<ci>x3_i</ci> | |
<ci>x4_i</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>E3_i</ci> | |
<apply> | |
<divide/> | |
<ci>x3_i</ci> | |
<apply> | |
<plus/> | |
<ci>x1_i</ci> | |
<ci>x2_i</ci> | |
<ci>x3_i</ci> | |
<ci>x4_i</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>E4_i</ci> | |
<apply> | |
<divide/> | |
<ci>x4_i</ci> | |
<apply> | |
<plus/> | |
<ci>x1_i</ci> | |
<ci>x2_i</ci> | |
<ci>x3_i</ci> | |
<ci>x4_i</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>allo_i</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<power/> | |
<apply> | |
<divide/> | |
<ci>KmCaAct</ci> | |
<ci>cai</ci> | |
</apply> | |
<cn cellml:units="dimensionless">2</cn> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>JncxNa_i</ci> | |
<apply> | |
<minus/> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">3</cn> | |
<apply> | |
<minus/> | |
<apply> | |
<times/> | |
<ci>E4_i</ci> | |
<ci>k7_i</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>E1_i</ci> | |
<ci>k8_i</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<ci>E3_i</ci> | |
<ci>k4pp_i</ci> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<ci>E2_i</ci> | |
<ci>k3pp_i</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>JncxCa_i</ci> | |
<apply> | |
<minus/> | |
<apply> | |
<times/> | |
<ci>E2_i</ci> | |
<ci>k2_i</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>E1_i</ci> | |
<ci>k1_i</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>Gncx</ci> | |
<piecewise> | |
<piece> | |
<apply> | |
<times/> | |
<ci>Gncx_b</ci> | |
<cn cellml:units="dimensionless">1.1</cn> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>celltype</ci> | |
<cn cellml:units="dimensionless">1</cn> | |
</apply> | |
</piece> | |
<piece> | |
<apply> | |
<times/> | |
<ci>Gncx_b</ci> | |
<cn cellml:units="dimensionless">1.4</cn> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>celltype</ci> | |
<cn cellml:units="dimensionless">2</cn> | |
</apply> | |
</piece> | |
<otherwise> | |
<ci>Gncx_b</ci> | |
</otherwise> | |
</piecewise> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>INaCa_i</ci> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.8</cn> | |
<ci>Gncx</ci> | |
<ci>allo_i</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>zna</ci> | |
<ci>JncxNa_i</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>zca</ci> | |
<ci>JncxCa_i</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h1_ss</ci> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<times/> | |
<apply> | |
<divide/> | |
<ci>nass</ci> | |
<ci>kna3</ci> | |
</apply> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>hna</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h2_ss</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>nass</ci> | |
<ci>hna</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>kna3</ci> | |
<ci>h1_ss</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h3_ss</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>h1_ss</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h4_ss</ci> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<times/> | |
<apply> | |
<divide/> | |
<ci>nass</ci> | |
<ci>kna1</ci> | |
</apply> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<ci>nass</ci> | |
<ci>kna2</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h5_ss</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>nass</ci> | |
<ci>nass</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>h4_ss</ci> | |
<ci>kna1</ci> | |
<ci>kna2</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h6_ss</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>h4_ss</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h7_ss</ci> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<times/> | |
<apply> | |
<divide/> | |
<ci>nao</ci> | |
<ci>kna3</ci> | |
</apply> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>hna</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h8_ss</ci> | |
<apply> | |
<divide/> | |
<ci>nao</ci> | |
<apply> | |
<times/> | |
<ci>kna3</ci> | |
<ci>hna</ci> | |
<ci>h7_ss</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h9_ss</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>h7_ss</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h10_ss</ci> | |
<apply> | |
<plus/> | |
<ci>kasymm</ci> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<times/> | |
<apply> | |
<divide/> | |
<ci>nao</ci> | |
<ci>kna1</ci> | |
</apply> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<ci>nao</ci> | |
<ci>kna2</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h11_ss</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>nao</ci> | |
<ci>nao</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>h10_ss</ci> | |
<ci>kna1</ci> | |
<ci>kna2</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>h12_ss</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>h10_ss</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k1_ss</ci> | |
<apply> | |
<times/> | |
<ci>h12_ss</ci> | |
<ci>cao</ci> | |
<ci>kcaon</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k2_ss</ci> | |
<ci>kcaoff</ci> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k3p_ss</ci> | |
<apply> | |
<times/> | |
<ci>h9_ss</ci> | |
<ci>wca</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k3pp_ss</ci> | |
<apply> | |
<times/> | |
<ci>h8_ss</ci> | |
<ci>wnaca</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k3_ss</ci> | |
<apply> | |
<plus/> | |
<ci>k3p_ss</ci> | |
<ci>k3pp_ss</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k4p_ss</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>h3_ss</ci> | |
<ci>wca</ci> | |
</apply> | |
<ci>hca</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k4pp_ss</ci> | |
<apply> | |
<times/> | |
<ci>h2_ss</ci> | |
<ci>wnaca</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k4_ss</ci> | |
<apply> | |
<plus/> | |
<ci>k4p_ss</ci> | |
<ci>k4pp_ss</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k5_ss</ci> | |
<ci>kcaoff</ci> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k6_ss</ci> | |
<apply> | |
<times/> | |
<ci>h6_ss</ci> | |
<ci>cass</ci> | |
<ci>kcaon</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k7_ss</ci> | |
<apply> | |
<times/> | |
<ci>h5_ss</ci> | |
<ci>h2_ss</ci> | |
<ci>wna</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>k8_ss</ci> | |
<apply> | |
<times/> | |
<ci>h8_ss</ci> | |
<ci>h11_ss</ci> | |
<ci>wna</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>x1_ss</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>k2_ss</ci> | |
<ci>k4_ss</ci> | |
<apply> | |
<plus/> | |
<ci>k7_ss</ci> | |
<ci>k6_ss</ci> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<ci>k5_ss</ci> | |
<ci>k7_ss</ci> | |
<apply> | |
<plus/> | |
<ci>k2_ss</ci> | |
<ci>k3_ss</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>x2_ss</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>k1_ss</ci> | |
<ci>k7_ss</ci> | |
<apply> | |
<plus/> | |
<ci>k4_ss</ci> | |
<ci>k5_ss</ci> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<ci>k4_ss</ci> | |
<ci>k6_ss</ci> | |
<apply> | |
<plus/> | |
<ci>k1_ss</ci> | |
<ci>k8_ss</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>x3_ss</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>k1_ss</ci> | |
<ci>k3_ss</ci> | |
<apply> | |
<plus/> | |
<ci>k7_ss</ci> | |
<ci>k6_ss</ci> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<ci>k8_ss</ci> | |
<ci>k6_ss</ci> | |
<apply> | |
<plus/> | |
<ci>k2_ss</ci> | |
<ci>k3_ss</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>x4_ss</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>k2_ss</ci> | |
<ci>k8_ss</ci> | |
<apply> | |
<plus/> | |
<ci>k4_ss</ci> | |
<ci>k5_ss</ci> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<ci>k3_ss</ci> | |
<ci>k5_ss</ci> | |
<apply> | |
<plus/> | |
<ci>k1_ss</ci> | |
<ci>k8_ss</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>E1_ss</ci> | |
<apply> | |
<divide/> | |
<ci>x1_ss</ci> | |
<apply> | |
<plus/> | |
<ci>x1_ss</ci> | |
<ci>x2_ss</ci> | |
<ci>x3_ss</ci> | |
<ci>x4_ss</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>E2_ss</ci> | |
<apply> | |
<divide/> | |
<ci>x2_ss</ci> | |
<apply> | |
<plus/> | |
<ci>x1_ss</ci> | |
<ci>x2_ss</ci> | |
<ci>x3_ss</ci> | |
<ci>x4_ss</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>E3_ss</ci> | |
<apply> | |
<divide/> | |
<ci>x3_ss</ci> | |
<apply> | |
<plus/> | |
<ci>x1_ss</ci> | |
<ci>x2_ss</ci> | |
<ci>x3_ss</ci> | |
<ci>x4_ss</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>E4_ss</ci> | |
<apply> | |
<divide/> | |
<ci>x4_ss</ci> | |
<apply> | |
<plus/> | |
<ci>x1_ss</ci> | |
<ci>x2_ss</ci> | |
<ci>x3_ss</ci> | |
<ci>x4_ss</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>allo_ss</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<power/> | |
<apply> | |
<divide/> | |
<ci>KmCaAct</ci> | |
<ci>cass</ci> | |
</apply> | |
<cn cellml:units="dimensionless">2</cn> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>JncxNa_ss</ci> | |
<apply> | |
<minus/> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">3</cn> | |
<apply> | |
<minus/> | |
<apply> | |
<times/> | |
<ci>E4_ss</ci> | |
<ci>k7_ss</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>E1_ss</ci> | |
<ci>k8_ss</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<ci>E3_ss</ci> | |
<ci>k4pp_ss</ci> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<ci>E2_ss</ci> | |
<ci>k3pp_ss</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>JncxCa_ss</ci> | |
<apply> | |
<minus/> | |
<apply> | |
<times/> | |
<ci>E2_ss</ci> | |
<ci>k2_ss</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>E1_ss</ci> | |
<ci>k1_ss</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>INaCa_ss</ci> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.2</cn> | |
<ci>Gncx</ci> | |
<ci>allo_ss</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>zna</ci> | |
<ci>JncxNa_ss</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>zca</ci> | |
<ci>JncxCa_ss</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</math> | |
</component> | |
<component name="INaK"> | |
<variable name="k1p" units="per_millisecond" initial_value="949.5"/> | |
<variable name="k1m" units="per_millisecond" initial_value="182.4"/> | |
<variable name="k2p" units="per_millisecond" initial_value="687.2"/> | |
<variable name="k2m" units="per_millisecond" initial_value="39.4"/> | |
<variable name="k3p" units="per_millisecond" initial_value="1899"/> | |
<variable name="k3m" units="per_millisecond" initial_value="79300"/> | |
<variable name="k4p" units="per_millisecond" initial_value="639"/> | |
<variable name="k4m" units="per_millisecond" initial_value="40"/> | |
<variable name="Knai0" units="millimolar" initial_value="9.073"/> | |
<variable name="Knao0" units="millimolar" initial_value="27.78"/> | |
<variable name="delta" units="millivolt" initial_value="-0.155"/> | |
<variable name="Kki" units="per_millisecond" initial_value="0.5"/> | |
<variable name="Kko" units="per_millisecond" initial_value="0.3582"/> | |
<variable name="MgADP" units="millimolar" initial_value="0.05"/> | |
<variable name="MgATP" units="millimolar" initial_value="9.8"/> | |
<variable name="Kmgatp" units="millimolar" initial_value="1.698e-7"/> | |
<variable name="H" units="millimolar" initial_value="1e-7"/> | |
<variable name="eP" units="dimensionless" initial_value="4.2"/> | |
<variable name="Khp" units="millimolar" initial_value="1.698e-7"/> | |
<variable name="Knap" units="millimolar" initial_value="224"/> | |
<variable name="Kxkur" units="millimolar" initial_value="292"/> | |
<variable name="zk" units="dimensionless" public_interface="in"/> | |
<variable name="zna" units="dimensionless" public_interface="in"/> | |
<variable name="Pnak_b" units="milliS_per_microF" initial_value="30"/> | |
<variable name="Pnak" units="milliS_per_microF"/> | |
<variable name="celltype" units="dimensionless" public_interface="in"/> | |
<variable name="R" units="joule_per_kilomole_kelvin" public_interface="in"/> | |
<variable name="T" units="kelvin" public_interface="in"/> | |
<variable name="F" units="coulomb_per_mole" public_interface="in"/> | |
<variable name="v" units="millivolt" public_interface="in"/> | |
<variable name="nai" units="millimolar" public_interface="in"/> | |
<variable name="ki" units="millimolar" public_interface="in"/> | |
<variable name="nao" units="millimolar" public_interface="in"/> | |
<variable name="ko" units="millimolar" public_interface="in"/> | |
<variable name="Knai" units="millimolar"/> | |
<variable name="Knao" units="millimolar"/> | |
<variable name="P" units="dimensionless"/> | |
<variable name="a1" units="dimensionless"/> | |
<variable name="b1" units="dimensionless"/> | |
<variable name="a2" units="dimensionless"/> | |
<variable name="b2" units="dimensionless"/> | |
<variable name="a3" units="dimensionless"/> | |
<variable name="b3" units="dimensionless"/> | |
<variable name="a4" units="dimensionless"/> | |
<variable name="b4" units="dimensionless"/> | |
<variable name="x1" units="dimensionless"/> | |
<variable name="x2" units="dimensionless"/> | |
<variable name="x3" units="dimensionless"/> | |
<variable name="x4" units="dimensionless"/> | |
<variable name="E1" units="dimensionless"/> | |
<variable name="E2" units="dimensionless"/> | |
<variable name="E3" units="dimensionless"/> | |
<variable name="E4" units="dimensionless"/> | |
<variable name="JnakNa" units="millimolar_per_millisecond"/> | |
<variable name="JnakK" units="millimolar_per_millisecond"/> | |
<variable name="INaK" units="microA_per_microF" public_interface="out"/> | |
<math xmlns="http://www.w3.org/1998/Math/MathML"> | |
<apply> | |
<eq/> | |
<ci>Knai</ci> | |
<apply> | |
<times/> | |
<ci>Knai0</ci> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>delta</ci> | |
<ci>v</ci> | |
<ci>F</ci> | |
</apply> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">3</cn> | |
<ci>R</ci> | |
<ci>T</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>Knao</ci> | |
<apply> | |
<times/> | |
<ci>Knao0</ci> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<apply> | |
<minus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>delta</ci> | |
</apply> | |
<ci>v</ci> | |
<ci>F</ci> | |
</apply> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">3</cn> | |
<ci>R</ci> | |
<ci>T</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>P</ci> | |
<apply> | |
<divide/> | |
<ci>eP</ci> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<ci>H</ci> | |
<ci>Khp</ci> | |
</apply> | |
<apply> | |
<divide/> | |
<ci>nai</ci> | |
<ci>Knap</ci> | |
</apply> | |
<apply> | |
<divide/> | |
<ci>ki</ci> | |
<ci>Kxkur</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>a1</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>k1p</ci> | |
<apply> | |
<power/> | |
<apply> | |
<divide/> | |
<ci>nai</ci> | |
<ci>Knai</ci> | |
</apply> | |
<cn cellml:units="dimensionless">3</cn> | |
</apply> | |
</apply> | |
<apply> | |
<minus/> | |
<apply> | |
<plus/> | |
<apply> | |
<power/> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<ci>nai</ci> | |
<ci>Knai</ci> | |
</apply> | |
</apply> | |
<cn cellml:units="dimensionless">3</cn> | |
</apply> | |
<apply> | |
<power/> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<ci>ki</ci> | |
<ci>Kki</ci> | |
</apply> | |
</apply> | |
<cn cellml:units="dimensionless">2</cn> | |
</apply> | |
</apply> | |
<cn cellml:units="dimensionless">1</cn> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>b1</ci> | |
<apply> | |
<times/> | |
<ci>k1m</ci> | |
<ci>MgADP</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>a2</ci> | |
<ci>k2p</ci> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>b2</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>k2m</ci> | |
<apply> | |
<power/> | |
<apply> | |
<divide/> | |
<ci>nao</ci> | |
<ci>Knao</ci> | |
</apply> | |
<cn cellml:units="dimensionless">3</cn> | |
</apply> | |
</apply> | |
<apply> | |
<minus/> | |
<apply> | |
<plus/> | |
<apply> | |
<power/> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<ci>nao</ci> | |
<ci>Knao</ci> | |
</apply> | |
</apply> | |
<cn cellml:units="dimensionless">3</cn> | |
</apply> | |
<apply> | |
<power/> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<ci>ko</ci> | |
<ci>Kko</ci> | |
</apply> | |
</apply> | |
<cn cellml:units="dimensionless">2</cn> | |
</apply> | |
</apply> | |
<cn cellml:units="dimensionless">1</cn> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>a3</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>k3p</ci> | |
<apply> | |
<power/> | |
<apply> | |
<divide/> | |
<ci>ko</ci> | |
<ci>Kko</ci> | |
</apply> | |
<cn cellml:units="dimensionless">2</cn> | |
</apply> | |
</apply> | |
<apply> | |
<minus/> | |
<apply> | |
<plus/> | |
<apply> | |
<power/> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<ci>nao</ci> | |
<ci>Knao</ci> | |
</apply> | |
</apply> | |
<cn cellml:units="dimensionless">3</cn> | |
</apply> | |
<apply> | |
<power/> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<ci>ko</ci> | |
<ci>Kko</ci> | |
</apply> | |
</apply> | |
<cn cellml:units="dimensionless">2</cn> | |
</apply> | |
</apply> | |
<cn cellml:units="dimensionless">1</cn> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>b3</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>k3m</ci> | |
<ci>P</ci> | |
<ci>H</ci> | |
</apply> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<ci>MgATP</ci> | |
<ci>Kmgatp</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>a4</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>k4p</ci> | |
<ci>MgATP</ci> | |
</apply> | |
<ci>Kmgatp</ci> | |
</apply> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<ci>MgATP</ci> | |
<ci>Kmgatp</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>b4</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>k4m</ci> | |
<apply> | |
<power/> | |
<apply> | |
<divide/> | |
<ci>ki</ci> | |
<ci>Kki</ci> | |
</apply> | |
<cn cellml:units="dimensionless">2</cn> | |
</apply> | |
</apply> | |
<apply> | |
<minus/> | |
<apply> | |
<plus/> | |
<apply> | |
<power/> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<ci>nai</ci> | |
<ci>Knai</ci> | |
</apply> | |
</apply> | |
<cn cellml:units="dimensionless">3</cn> | |
</apply> | |
<apply> | |
<power/> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<ci>ki</ci> | |
<ci>Kki</ci> | |
</apply> | |
</apply> | |
<cn cellml:units="dimensionless">2</cn> | |
</apply> | |
</apply> | |
<cn cellml:units="dimensionless">1</cn> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>x1</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>a4</ci> | |
<ci>a1</ci> | |
<ci>a2</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>b2</ci> | |
<ci>b4</ci> | |
<ci>b3</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>a2</ci> | |
<ci>b4</ci> | |
<ci>b3</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>b3</ci> | |
<ci>a1</ci> | |
<ci>a2</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>x2</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>b2</ci> | |
<ci>b1</ci> | |
<ci>b4</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>a1</ci> | |
<ci>a2</ci> | |
<ci>a3</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>a3</ci> | |
<ci>b1</ci> | |
<ci>b4</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>a2</ci> | |
<ci>a3</ci> | |
<ci>b4</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>x3</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>a2</ci> | |
<ci>a3</ci> | |
<ci>a4</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>b3</ci> | |
<ci>b2</ci> | |
<ci>b1</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>b2</ci> | |
<ci>b1</ci> | |
<ci>a4</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>a3</ci> | |
<ci>a4</ci> | |
<ci>b1</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>x4</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>b4</ci> | |
<ci>b3</ci> | |
<ci>b2</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>a3</ci> | |
<ci>a4</ci> | |
<ci>a1</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>b2</ci> | |
<ci>a4</ci> | |
<ci>a1</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>b3</ci> | |
<ci>b2</ci> | |
<ci>a1</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>E1</ci> | |
<apply> | |
<divide/> | |
<ci>x1</ci> | |
<apply> | |
<plus/> | |
<ci>x1</ci> | |
<ci>x2</ci> | |
<ci>x3</ci> | |
<ci>x4</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>E2</ci> | |
<apply> | |
<divide/> | |
<ci>x2</ci> | |
<apply> | |
<plus/> | |
<ci>x1</ci> | |
<ci>x2</ci> | |
<ci>x3</ci> | |
<ci>x4</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>E3</ci> | |
<apply> | |
<divide/> | |
<ci>x3</ci> | |
<apply> | |
<plus/> | |
<ci>x1</ci> | |
<ci>x2</ci> | |
<ci>x3</ci> | |
<ci>x4</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>E4</ci> | |
<apply> | |
<divide/> | |
<ci>x4</ci> | |
<apply> | |
<plus/> | |
<ci>x1</ci> | |
<ci>x2</ci> | |
<ci>x3</ci> | |
<ci>x4</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>JnakNa</ci> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">3</cn> | |
<apply> | |
<minus/> | |
<apply> | |
<times/> | |
<ci>E1</ci> | |
<ci>a3</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>E2</ci> | |
<ci>b3</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>JnakK</ci> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">2</cn> | |
<apply> | |
<minus/> | |
<apply> | |
<times/> | |
<ci>E4</ci> | |
<ci>b1</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>E3</ci> | |
<ci>a1</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>Pnak</ci> | |
<piecewise> | |
<piece> | |
<apply> | |
<times/> | |
<ci>Pnak_b</ci> | |
<cn cellml:units="dimensionless">0.9</cn> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>celltype</ci> | |
<cn cellml:units="dimensionless">1</cn> | |
</apply> | |
</piece> | |
<piece> | |
<apply> | |
<times/> | |
<ci>Pnak_b</ci> | |
<cn cellml:units="dimensionless">0.7</cn> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>celltype</ci> | |
<cn cellml:units="dimensionless">2</cn> | |
</apply> | |
</piece> | |
<otherwise> | |
<ci>Pnak_b</ci> | |
</otherwise> | |
</piecewise> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>INaK</ci> | |
<apply> | |
<times/> | |
<ci>Pnak</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<ci>zna</ci> | |
<ci>JnakNa</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>zk</ci> | |
<ci>JnakK</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</math> | |
</component> | |
<component name="IKb"> | |
<variable name="xkb" units="dimensionless"/> | |
<variable name="GKb_b" units="milliS_per_microF" initial_value="0.003"/> | |
<variable name="GKb" units="milliS_per_microF"/> | |
<variable name="v" units="millivolt" public_interface="in"/> | |
<variable name="EK" units="millivolt" public_interface="in"/> | |
<variable name="celltype" units="dimensionless" public_interface="in"/> | |
<variable name="IKb" units="microA_per_microF" public_interface="out"/> | |
<math xmlns="http://www.w3.org/1998/Math/MathML"> | |
<apply> | |
<eq/> | |
<ci>xkb</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<exp/> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<apply> | |
<minus/> | |
<ci>v</ci> | |
<cn cellml:units="millivolt">14.48</cn> | |
</apply> | |
</apply> | |
<cn cellml:units="millivolt">18.34</cn> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>GKb</ci> | |
<piecewise> | |
<piece> | |
<apply> | |
<times/> | |
<ci>GKb_b</ci> | |
<cn cellml:units="dimensionless">0.6</cn> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>celltype</ci> | |
<cn cellml:units="dimensionless">1</cn> | |
</apply> | |
</piece> | |
<otherwise> | |
<ci>GKb_b</ci> | |
</otherwise> | |
</piecewise> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>IKb</ci> | |
<apply> | |
<times/> | |
<ci>GKb</ci> | |
<ci>xkb</ci> | |
<apply> | |
<minus/> | |
<ci>v</ci> | |
<ci>EK</ci> | |
</apply> | |
</apply> | |
</apply> | |
</math> | |
</component> | |
<component name="INab"> | |
<variable name="PNab" units="milliS_per_microF" initial_value="3.75e-10"/> | |
<variable name="INab" units="microA_per_microF" public_interface="out"/> | |
<variable name="nai" units="millimolar" public_interface="in"/> | |
<variable name="nao" units="millimolar" public_interface="in"/> | |
<variable name="vffrt" units="coulomb_per_mole" public_interface="in"/> | |
<variable name="vfrt" units="dimensionless" public_interface="in"/> | |
<math xmlns="http://www.w3.org/1998/Math/MathML"> | |
<apply> | |
<eq/> | |
<ci>INab</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>PNab</ci> | |
<ci>vffrt</ci> | |
<apply> | |
<minus/> | |
<apply> | |
<times/> | |
<ci>nai</ci> | |
<apply> | |
<exp/> | |
<ci>vfrt</ci> | |
</apply> | |
</apply> | |
<ci>nao</ci> | |
</apply> | |
</apply> | |
<apply> | |
<minus/> | |
<apply> | |
<exp/> | |
<ci>vfrt</ci> | |
</apply> | |
<cn cellml:units="dimensionless">1</cn> | |
</apply> | |
</apply> | |
</apply> | |
</math> | |
</component> | |
<component name="ICab"> | |
<variable name="PCab" units="milliS_per_microF" initial_value="2.5e-8"/> | |
<variable name="ICab" units="microA_per_microF" public_interface="out"/> | |
<variable name="cai" units="millimolar" public_interface="in"/> | |
<variable name="cao" units="millimolar" public_interface="in"/> | |
<variable name="vffrt" units="coulomb_per_mole" public_interface="in"/> | |
<variable name="vfrt" units="dimensionless" public_interface="in"/> | |
<math xmlns="http://www.w3.org/1998/Math/MathML"> | |
<apply> | |
<eq/> | |
<ci>ICab</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>PCab</ci> | |
<cn cellml:units="dimensionless">4</cn> | |
<ci>vffrt</ci> | |
<apply> | |
<minus/> | |
<apply> | |
<times/> | |
<ci>cai</ci> | |
<apply> | |
<exp/> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">2</cn> | |
<ci>vfrt</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.341</cn> | |
<ci>cao</ci> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<minus/> | |
<apply> | |
<exp/> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">2</cn> | |
<ci>vfrt</ci> | |
</apply> | |
</apply> | |
<cn cellml:units="dimensionless">1</cn> | |
</apply> | |
</apply> | |
</apply> | |
</math> | |
</component> | |
<component name="IpCa"> | |
<variable name="GpCa" units="milliS_per_microF" initial_value="0.0005"/> | |
<variable name="KmCap" units="millimolar" initial_value="0.0005"/> | |
<variable name="IpCa" units="microA_per_microF" public_interface="out"/> | |
<variable name="cai" units="millimolar" public_interface="in"/> | |
<math xmlns="http://www.w3.org/1998/Math/MathML"> | |
<apply> | |
<eq/> | |
<ci>IpCa</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>GpCa</ci> | |
<ci>cai</ci> | |
</apply> | |
<apply> | |
<plus/> | |
<ci>KmCap</ci> | |
<ci>cai</ci> | |
</apply> | |
</apply> | |
</apply> | |
</math> | |
</component> | |
<component name="diff"> | |
<variable name="cai" units="millimolar" public_interface="in"/> | |
<variable name="cass" units="millimolar" public_interface="in"/> | |
<variable name="nai" units="millimolar" public_interface="in"/> | |
<variable name="nass" units="millimolar" public_interface="in"/> | |
<variable name="ki" units="millimolar" public_interface="in"/> | |
<variable name="kss" units="millimolar" public_interface="in"/> | |
<variable name="JdiffNa" units="millimolar_per_millisecond" public_interface="out"/> | |
<variable name="Jdiff" units="millimolar_per_millisecond" public_interface="out"/> | |
<variable name="JdiffK" units="millimolar_per_millisecond" public_interface="out"/> | |
<math xmlns="http://www.w3.org/1998/Math/MathML"> | |
<apply> | |
<eq/> | |
<ci>JdiffNa</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>nass</ci> | |
<ci>nai</ci> | |
</apply> | |
<cn cellml:units="dimensionless">2</cn> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>JdiffK</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>kss</ci> | |
<ci>ki</ci> | |
</apply> | |
<cn cellml:units="dimensionless">2</cn> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>Jdiff</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>cass</ci> | |
<ci>cai</ci> | |
</apply> | |
<cn cellml:units="dimensionless">0.2</cn> | |
</apply> | |
</apply> | |
</math> | |
</component> | |
<component name="ryr"> | |
<variable name="bt" units="millisecond" initial_value="4.75"/> | |
<variable name="a_rel" units="millisecond"/> | |
<variable name="Jrel_inf" units="dimensionless"/> | |
<variable name="tau_rel" units="millisecond"/> | |
<variable name="celltype" units="dimensionless" public_interface="in"/> | |
<variable name="ICaL" units="microA_per_microF" public_interface="in"/> | |
<variable name="cajsr" units="millimolar" public_interface="in"/> | |
<variable name="Jrel_infp" units="dimensionless"/> | |
<variable name="Jrel_temp" units="dimensionless"/> | |
<variable name="tau_relp" units="millisecond"/> | |
<variable name="Jrelnp" units="dimensionless" initial_value="0"/> | |
<variable name="Jrelp" units="dimensionless" initial_value="0"/> | |
<variable name="time" units="millisecond" public_interface="in"/> | |
<variable name="btp" units="millisecond"/> | |
<variable name="a_relp" units="millisecond"/> | |
<variable name="KmCaMK" units="millimolar" public_interface="in"/> | |
<variable name="CaMKa" units="millimolar" public_interface="in"/> | |
<variable name="Jrel_inf_temp" units="dimensionless"/> | |
<variable name="fJrelp" units="dimensionless"/> | |
<variable name="Jrel" units="millimolar_per_millisecond" public_interface="out"/> | |
<variable name="tau_rel_temp" units="millisecond"/> | |
<variable name="tau_relp_temp" units="millisecond"/> | |
<math xmlns="http://www.w3.org/1998/Math/MathML"> | |
<apply> | |
<eq/> | |
<ci>a_rel</ci> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.5</cn> | |
<ci>bt</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>Jrel_inf_temp</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>a_rel</ci> | |
<apply> | |
<minus/> | |
<ci>ICaL</ci> | |
</apply> | |
</apply> | |
<apply> | |
<plus/> | |
<cn cellml:units="microA_per_microF">1</cn> | |
<apply> | |
<times/> | |
<cn cellml:units="microA_per_microF">1</cn> | |
<apply> | |
<power/> | |
<apply> | |
<divide/> | |
<cn cellml:units="millimolar">1.5</cn> | |
<ci>cajsr</ci> | |
</apply> | |
<cn cellml:units="dimensionless">8</cn> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>Jrel_inf</ci> | |
<piecewise> | |
<piece> | |
<apply> | |
<times/> | |
<ci>Jrel_inf_temp</ci> | |
<cn cellml:units="dimensionless">1.7</cn> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>celltype</ci> | |
<cn cellml:units="dimensionless">2</cn> | |
</apply> | |
</piece> | |
<otherwise> | |
<ci>Jrel_inf_temp</ci> | |
</otherwise> | |
</piecewise> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>tau_rel_temp</ci> | |
<apply> | |
<divide/> | |
<ci>bt</ci> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<cn cellml:units="millimolar">0.0123</cn> | |
<ci>cajsr</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>tau_rel</ci> | |
<piecewise> | |
<piece> | |
<cn cellml:units="millisecond">0.001</cn> | |
<apply> | |
<lt/> | |
<ci>tau_rel_temp</ci> | |
<cn cellml:units="millisecond">0.001</cn> | |
</apply> | |
</piece> | |
<otherwise> | |
<ci>tau_rel_temp</ci> | |
</otherwise> | |
</piecewise> | |
</apply> | |
<apply> | |
<eq/> | |
<apply> | |
<diff/> | |
<bvar> | |
<ci>time</ci> | |
</bvar> | |
<ci>Jrelnp</ci> | |
</apply> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>Jrel_inf</ci> | |
<ci>Jrelnp</ci> | |
</apply> | |
<ci>tau_rel</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>btp</ci> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">1.25</cn> | |
<ci>bt</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>a_relp</ci> | |
<apply> | |
<times/> | |
<cn cellml:units="dimensionless">0.5</cn> | |
<ci>btp</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>Jrel_temp</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>a_relp</ci> | |
<apply> | |
<minus/> | |
<ci>ICaL</ci> | |
</apply> | |
</apply> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<power/> | |
<apply> | |
<divide/> | |
<cn cellml:units="millimolar">1.5</cn> | |
<ci>cajsr</ci> | |
</apply> | |
<cn cellml:units="dimensionless">8</cn> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>Jrel_infp</ci> | |
<piecewise> | |
<piece> | |
<apply> | |
<times/> | |
<ci>Jrel_temp</ci> | |
<cn cellml:units="dimensionless">1.7</cn> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>celltype</ci> | |
<cn cellml:units="dimensionless">2</cn> | |
</apply> | |
</piece> | |
<otherwise> | |
<ci>Jrel_temp</ci> | |
</otherwise> | |
</piecewise> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>tau_relp_temp</ci> | |
<apply> | |
<divide/> | |
<ci>btp</ci> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<cn cellml:units="millimolar">0.0123</cn> | |
<ci>cajsr</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>tau_relp</ci> | |
<piecewise> | |
<piece> | |
<cn cellml:units="millisecond">0.001</cn> | |
<apply> | |
<lt/> | |
<ci>tau_relp_temp</ci> | |
<cn cellml:units="millisecond">0.001</cn> | |
</apply> | |
</piece> | |
<otherwise> | |
<ci>tau_relp_temp</ci> | |
</otherwise> | |
</piecewise> | |
</apply> | |
<apply> | |
<eq/> | |
<apply> | |
<diff/> | |
<bvar> | |
<ci>time</ci> | |
</bvar> | |
<ci>Jrelp</ci> | |
</apply> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>Jrel_infp</ci> | |
<ci>Jrelp</ci> | |
</apply> | |
<ci>tau_relp</ci> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>fJrelp</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<ci>KmCaMK</ci> | |
<ci>CaMKa</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>Jrel</ci> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<apply> | |
<minus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>fJrelp</ci> | |
</apply> | |
<ci>Jrelnp</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>fJrelp</ci> | |
<ci>Jrelp</ci> | |
</apply> | |
</apply> | |
</apply> | |
</math> | |
</component> | |
<component name="SERCA"> | |
<variable name="upScale" units="dimensionless"/> | |
<variable name="Jupnp" units="millimolar_per_millisecond"/> | |
<variable name="Jupp" units="millimolar_per_millisecond"/> | |
<variable name="KmCaMK" units="millimolar" public_interface="in"/> | |
<variable name="CaMKa" units="millimolar" public_interface="in"/> | |
<variable name="celltype" units="dimensionless" public_interface="in"/> | |
<variable name="cai" units="millimolar" public_interface="in"/> | |
<variable name="cansr" units="millimolar" public_interface="in"/> | |
<variable name="fJupp" units="dimensionless"/> | |
<variable name="Jleak" units="millimolar_per_millisecond"/> | |
<variable name="Jup" units="millimolar_per_millisecond" public_interface="out"/> | |
<math xmlns="http://www.w3.org/1998/Math/MathML"> | |
<apply> | |
<eq/> | |
<ci>upScale</ci> | |
<piecewise> | |
<piece> | |
<cn cellml:units="dimensionless">1.3</cn> | |
<apply> | |
<eq/> | |
<ci>celltype</ci> | |
<cn cellml:units="dimensionless">1</cn> | |
</apply> | |
</piece> | |
<otherwise> | |
<cn cellml:units="dimensionless">1</cn> | |
</otherwise> | |
</piecewise> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>Jupnp</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>upScale</ci> | |
<cn cellml:units="dimensionless">0.004375</cn> | |
<ci>cai</ci> | |
</apply> | |
<apply> | |
<plus/> | |
<ci>cai</ci> | |
<cn cellml:units="millimolar">0.00092</cn> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>Jupp</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<ci>upScale</ci> | |
<cn cellml:units="dimensionless">2.75</cn> | |
<cn cellml:units="dimensionless">0.004375</cn> | |
<ci>cai</ci> | |
</apply> | |
<apply> | |
<minus/> | |
<apply> | |
<plus/> | |
<ci>cai</ci> | |
<cn cellml:units="millimolar">0.00092</cn> | |
</apply> | |
<cn cellml:units="millimolar">0.00017</cn> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>fJupp</ci> | |
<apply> | |
<divide/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<plus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<apply> | |
<divide/> | |
<ci>KmCaMK</ci> | |
<ci>CaMKa</ci> | |
</apply> | |
</apply> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>Jleak</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<times/> | |
<cn cellml:units="millimolar_per_millisecond">0.0039375</cn> | |
<ci>cansr</ci> | |
</apply> | |
<cn cellml:units="millimolar">15</cn> | |
</apply> | |
</apply> | |
<apply> | |
<eq/> | |
<ci>Jup</ci> | |
<apply> | |
<minus/> | |
<apply> | |
<plus/> | |
<apply> | |
<times/> | |
<apply> | |
<minus/> | |
<cn cellml:units="dimensionless">1</cn> | |
<ci>fJupp</ci> | |
</apply> | |
<ci>Jupnp</ci> | |
</apply> | |
<apply> | |
<times/> | |
<ci>fJupp</ci> | |
<ci>Jupp</ci> | |
</apply> | |
</apply> | |
<ci>Jleak</ci> | |
</apply> | |
</apply> | |
</math> | |
</component> | |
<component name="trans_flux"> | |
<variable name="cansr" units="millimolar" public_interface="in"/> | |
<variable name="cajsr" units="millimolar" public_interface="in"/> | |
<variable name="Jtr" units="millimolar_per_millisecond" public_interface="out"/> | |
<math xmlns="http://www.w3.org/1998/Math/MathML"> | |
<apply> | |
<eq/> | |
<ci>Jtr</ci> | |
<apply> | |
<divide/> | |
<apply> | |
<minus/> | |
<ci>cansr</ci> | |
<ci>cajsr</ci> | |
</apply> | |
<cn cellml:units="millisecond">100</cn> | |
</apply> | |
</apply> | |
</math> | |
</component> | |
<connection> | |
<map_components component_1="intracellular_ions" component_2="INaL"/> | |
<map_variables variable_1="INaL" variable_2="INaL"/> | |
</connection> | |
<connection> | |
<map_components component_1="intracellular_ions" component_2="membrane"/> | |
<map_variables variable_1="Istim" variable_2="Istim"/> | |
</connection> | |
<connection> | |
<map_components component_1="intracellular_ions" component_2="trans_flux"/> | |
<map_variables variable_1="cajsr" variable_2="cajsr"/> | |
<map_variables variable_1="cansr" variable_2="cansr"/> | |
<map_variables variable_1="Jtr" variable_2="Jtr"/> | |
</connection> | |
<connection> | |
<map_components component_1="intracellular_ions" component_2="SERCA"/> | |
<map_variables variable_1="cai" variable_2="cai"/> | |
<map_variables variable_1="cansr" variable_2="cansr"/> | |
<map_variables variable_1="Jup" variable_2="Jup"/> | |
</connection> | |
<connection> | |
<map_components component_1="SERCA" component_2="environment"/> | |
<map_variables variable_1="celltype" variable_2="celltype"/> | |
</connection> | |
<connection> | |
<map_components component_1="SERCA" component_2="CaMK"/> | |
<map_variables variable_1="KmCaMK" variable_2="KmCaMK"/> | |
<map_variables variable_1="CaMKa" variable_2="CaMKa"/> | |
</connection> | |
<connection> | |
<map_components component_1="intracellular_ions" component_2="ryr"/> | |
<map_variables variable_1="cajsr" variable_2="cajsr"/> | |
<map_variables variable_1="Jrel" variable_2="Jrel"/> | |
</connection> | |
<connection> | |
<map_components component_1="ICaL" component_2="ryr"/> | |
<map_variables variable_1="ICaL" variable_2="ICaL"/> | |
</connection> | |
<connection> | |
<map_components component_1="ryr" component_2="CaMK"/> | |
<map_variables variable_1="KmCaMK" variable_2="KmCaMK"/> | |
<map_variables variable_1="CaMKa" variable_2="CaMKa"/> | |
</connection> | |
<connection> | |
<map_components component_1="ryr" component_2="environment"/> | |
<map_variables variable_1="celltype" variable_2="celltype"/> | |
<map_variables variable_1="time" variable_2="time"/> | |
</connection> | |
<connection> | |
<map_components component_1="intracellular_ions" component_2="diff"/> | |
<map_variables variable_1="cai" variable_2="cai"/> | |
<map_variables variable_1="cass" variable_2="cass"/> | |
<map_variables variable_1="nai" variable_2="nai"/> | |
<map_variables variable_1="nass" variable_2="nass"/> | |
<map_variables variable_1="ki" variable_2="ki"/> | |
<map_variables variable_1="kss" variable_2="kss"/> | |
<map_variables variable_1="JdiffK" variable_2="JdiffK"/> | |
<map_variables variable_1="Jdiff" variable_2="Jdiff"/> | |
<map_variables variable_1="JdiffNa" variable_2="JdiffNa"/> | |
</connection> | |
<connection> | |
<map_components component_1="IpCa" component_2="membrane"/> | |
<map_variables variable_1="IpCa" variable_2="IpCa"/> | |
</connection> | |
<connection> | |
<map_components component_1="intracellular_ions" component_2="IpCa"/> | |
<map_variables variable_1="cai" variable_2="cai"/> | |
<map_variables variable_1="IpCa" variable_2="IpCa"/> | |
</connection> | |
<connection> | |
<map_components component_1="extracellular" component_2="ICab"/> | |
<map_variables variable_1="cao" variable_2="cao"/> | |
</connection> | |
<connection> | |
<map_components component_1="intracellular_ions" component_2="ICab"/> | |
<map_variables variable_1="cai" variable_2="cai"/> | |
<map_variables variable_1="ICab" variable_2="ICab"/> | |
</connection> | |
<connection> | |
<map_components component_1="ICab" component_2="membrane"/> | |
<map_variables variable_1="vffrt" variable_2="vffrt"/> | |
<map_variables variable_1="vfrt" variable_2="vfrt"/> | |
<map_variables variable_1="ICab" variable_2="ICab"/> | |
</connection> | |
<connection> | |
<map_components component_1="extracellular" component_2="INab"/> | |
<map_variables variable_1="nao" variable_2="nao"/> | |
</connection> | |
<connection> | |
<map_components component_1="intracellular_ions" component_2="INab"/> | |
<map_variables variable_1="nai" variable_2="nai"/> | |
<map_variables variable_1="INab" variable_2="INab"/> | |
</connection> | |
<connection> | |
<map_components component_1="INab" component_2="membrane"/> | |
<map_variables variable_1="vffrt" variable_2="vffrt"/> | |
<map_variables variable_1="vfrt" variable_2="vfrt"/> | |
<map_variables variable_1="INab" variable_2="INab"/> | |
</connection> | |
<connection> | |
<map_components component_1="IKb" component_2="membrane"/> | |
<map_variables variable_1="v" variable_2="v"/> | |
<map_variables variable_1="IKb" variable_2="IKb"/> | |
</connection> | |
<connection> | |
<map_components component_1="IKb" component_2="environment"/> | |
<map_variables variable_1="celltype" variable_2="celltype"/> | |
</connection> | |
<connection> | |
<map_components component_1="IKb" component_2="reversal_potentials"/> | |
<map_variables variable_1="EK" variable_2="EK"/> | |
</connection> | |
<connection> | |
<map_components component_1="intracellular_ions" component_2="IKb"/> | |
<map_variables variable_1="IKb" variable_2="IKb"/> | |
</connection> | |
<connection> | |
<map_components component_1="intracellular_ions" component_2="INaK"/> | |
<map_variables variable_1="ki" variable_2="ki"/> | |
<map_variables variable_1="nai" variable_2="nai"/> | |
<map_variables variable_1="INaK" variable_2="INaK"/> | |
</connection> | |
<connection> | |
<map_components component_1="INaK" component_2="membrane"/> | |
<map_variables variable_1="v" variable_2="v"/> | |
<map_variables variable_1="INaK" variable_2="INaK"/> | |
</connection> | |
<connection> | |
<map_components component_1="INaK" component_2="environment"/> | |
<map_variables variable_1="celltype" variable_2="celltype"/> | |
</connection> | |
<connection> | |
<map_components component_1="INaK" component_2="physical_constants"/> | |
<map_variables variable_1="R" variable_2="R"/> | |
<map_variables variable_1="T" variable_2="T"/> | |
<map_variables variable_1="F" variable_2="F"/> | |
<map_variables variable_1="zna" variable_2="zna"/> | |
<map_variables variable_1="zk" variable_2="zk"/> | |
</connection> | |
<connection> | |
<map_components component_1="extracellular" component_2="INaK"/> | |
<map_variables variable_1="nao" variable_2="nao"/> | |
<map_variables variable_1="ko" variable_2="ko"/> | |
</connection> | |
<connection> | |
<map_components component_1="intracellular_ions" component_2="INaCa_i"/> | |
<map_variables variable_1="cai" variable_2="cai"/> | |
<map_variables variable_1="nai" variable_2="nai"/> | |
<map_variables variable_1="nass" variable_2="nass"/> | |
<map_variables variable_1="cass" variable_2="cass"/> | |
<map_variables variable_1="INaCa_i" variable_2="INaCa_i"/> | |
<map_variables variable_1="INaCa_ss" variable_2="INaCa_ss"/> | |
</connection> | |
<connection> | |
<map_components component_1="INaCa_i" component_2="membrane"/> | |
<map_variables variable_1="v" variable_2="v"/> | |
<map_variables variable_1="INaCa_i" variable_2="INaCa_i"/> | |
<map_variables variable_1="INaCa_ss" variable_2="INaCa_ss"/> | |
</connection> | |
<connection> | |
<map_components component_1="INaCa_i" component_2="environment"/> | |
<map_variables variable_1="celltype" variable_2="celltype"/> | |
</connection> | |
<connection> | |
<map_components component_1="INaCa_i" component_2="physical_constants"/> | |
<map_variables variable_1="R" variable_2="R"/> | |
<map_variables variable_1="T" variable_2="T"/> | |
<map_variables variable_1="F" variable_2="F"/> | |
<map_variables variable_1="zna" variable_2="zna"/> | |
<map_variables variable_1="zca" variable_2="zca"/> | |
</connection> | |
<connection> | |
<map_components component_1="extracellular" component_2="INaCa_i"/> | |
<map_variables variable_1="nao" variable_2="nao"/> | |
<map_variables variable_1="cao" variable_2="cao"/> | |
</connection> | |
<connection> | |
<map_components component_1="intracellular_ions" component_2="IKs"/> | |
<map_variables variable_1="cai" variable_2="cai"/> | |
<map_variables variable_1="IKs" variable_2="IKs"/> | |
</connection> | |
<connection> | |
<map_components component_1="IK1" component_2="membrane"/> | |
<map_variables variable_1="v" variable_2="v"/> | |
<map_variables variable_1="IK1" variable_2="IK1"/> | |
</connection> | |
<connection> | |
<map_components component_1="IK1" component_2="environment"/> | |
<map_variables variable_1="celltype" variable_2="celltype"/> | |
<map_variables variable_1="time" variable_2="time"/> | |
</connection> | |
<connection> | |
<map_components component_1="IKs" component_2="membrane"/> | |
<map_variables variable_1="v" variable_2="v"/> | |
<map_variables variable_1="IKs" variable_2="IKs"/> | |
</connection> | |
<connection> | |
<map_components component_1="IKs" component_2="environment"/> | |
<map_variables variable_1="celltype" variable_2="celltype"/> | |
<map_variables variable_1="time" variable_2="time"/> | |
</connection> | |
<connection> | |
<map_components component_1="IK1" component_2="reversal_potentials"/> | |
<map_variables variable_1="EK" variable_2="EK"/> | |
</connection> | |
<connection> | |
<map_components component_1="IKs" component_2="reversal_potentials"/> | |
<map_variables variable_1="EKs" variable_2="EKs"/> | |
</connection> | |
<connection> | |
<map_components component_1="Ito" component_2="membrane"/> | |
<map_variables variable_1="v" variable_2="v"/> | |
<map_variables variable_1="Ito" variable_2="Ito"/> | |
</connection> | |
<connection> | |
<map_components component_1="INaL" component_2="membrane"/> | |
<map_variables variable_1="v" variable_2="v"/> | |
<map_variables variable_1="INaL" variable_2="INaL"/> | |
</connection> | |
<connection> | |
<map_components component_1="IKr" component_2="membrane"/> | |
<map_variables variable_1="v" variable_2="v"/> | |
<map_variables variable_1="IKr" variable_2="IKr"/> | |
</connection> | |
<connection> | |
<map_components component_1="IKr" component_2="environment"/> | |
<map_variables variable_1="celltype" variable_2="celltype"/> | |
<map_variables variable_1="time" variable_2="time"/> | |
</connection> | |
<connection> | |
<map_components component_1="INaL" component_2="reversal_potentials"/> | |
<map_variables variable_1="ENa" variable_2="ENa"/> | |
</connection> | |
<connection> | |
<map_components component_1="Ito" component_2="reversal_potentials"/> | |
<map_variables variable_1="EK" variable_2="EK"/> | |
</connection> | |
<connection> | |
<map_components component_1="INaL" component_2="CaMK"/> | |
<map_variables variable_1="KmCaMK" variable_2="KmCaMK"/> | |
<map_variables variable_1="CaMKa" variable_2="CaMKa"/> | |
</connection> | |
<connection> | |
<map_components component_1="Ito" component_2="CaMK"/> | |
<map_variables variable_1="KmCaMK" variable_2="KmCaMK"/> | |
<map_variables variable_1="CaMKa" variable_2="CaMKa"/> | |
</connection> | |
<connection> | |
<map_components component_1="INaL" component_2="INa"/> | |
<map_variables variable_1="tm" variable_2="tm"/> | |
</connection> | |
<connection> | |
<map_components component_1="INaL" component_2="environment"/> | |
<map_variables variable_1="celltype" variable_2="celltype"/> | |
<map_variables variable_1="time" variable_2="time"/> | |
</connection> | |
<connection> | |
<map_components component_1="ICaL" component_2="environment"/> | |
<map_variables variable_1="celltype" variable_2="celltype"/> | |
<map_variables variable_1="time" variable_2="time"/> | |
</connection> | |
<connection> | |
<map_components component_1="ICaL" component_2="CaMK"/> | |
<map_variables variable_1="KmCaMK" variable_2="KmCaMK"/> | |
<map_variables variable_1="CaMKa" variable_2="CaMKa"/> | |
</connection> | |
<connection> | |
<map_components component_1="CaMK" component_2="environment"/> | |
<map_variables variable_1="time" variable_2="time"/> | |
</connection> | |
<connection> | |
<map_components component_1="membrane" component_2="environment"/> | |
<map_variables variable_1="time" variable_2="time"/> | |
</connection> | |
<connection> | |
<map_components component_1="ICaL" component_2="physical_constants"/> | |
<map_variables variable_1="R" variable_2="R"/> | |
<map_variables variable_1="T" variable_2="T"/> | |
<map_variables variable_1="F" variable_2="F"/> | |
</connection> | |
<connection> | |
<map_components component_1="membrane" component_2="ICaL"/> | |
<map_variables variable_1="v" variable_2="v"/> | |
<map_variables variable_1="vffrt" variable_2="vffrt"/> | |
<map_variables variable_1="vfrt" variable_2="vfrt"/> | |
<map_variables variable_1="ICaL" variable_2="ICaL"/> | |
<map_variables variable_1="ICaNa" variable_2="ICaNa"/> | |
<map_variables variable_1="ICaK" variable_2="ICaK"/> | |
</connection> | |
<connection> | |
<map_components component_1="membrane" component_2="physical_constants"/> | |
<map_variables variable_1="R" variable_2="R"/> | |
<map_variables variable_1="T" variable_2="T"/> | |
<map_variables variable_1="F" variable_2="F"/> | |
</connection> | |
<connection> | |
<map_components component_1="intracellular_ions" component_2="physical_constants"/> | |
<map_variables variable_1="R" variable_2="R"/> | |
<map_variables variable_1="T" variable_2="T"/> | |
<map_variables variable_1="F" variable_2="F"/> | |
</connection> | |
<connection> | |
<map_components component_1="intracellular_ions" component_2="ICaL"/> | |
<map_variables variable_1="cass" variable_2="cass"/> | |
<map_variables variable_1="nass" variable_2="nass"/> | |
<map_variables variable_1="kss" variable_2="kss"/> | |
<map_variables variable_1="ICaNa" variable_2="ICaNa"/> | |
<map_variables variable_1="ICaK" variable_2="ICaK"/> | |
<map_variables variable_1="ICaL" variable_2="ICaL"/> | |
</connection> | |
<connection> | |
<map_components component_1="extracellular" component_2="IK1"/> | |
<map_variables variable_1="ko" variable_2="ko"/> | |
</connection> | |
<connection> | |
<map_components component_1="intracellular_ions" component_2="IK1"/> | |
<map_variables variable_1="IK1" variable_2="IK1"/> | |
</connection> | |
<connection> | |
<map_components component_1="extracellular" component_2="ICaL"/> | |
<map_variables variable_1="nao" variable_2="nao"/> | |
<map_variables variable_1="ko" variable_2="ko"/> | |
<map_variables variable_1="cao" variable_2="cao"/> | |
</connection> | |
<connection> | |
<map_components component_1="extracellular" component_2="IKr"/> | |
<map_variables variable_1="ko" variable_2="ko"/> | |
</connection> | |
<connection> | |
<map_components component_1="intracellular_ions" component_2="IKr"/> | |
<map_variables variable_1="IKr" variable_2="IKr"/> | |
</connection> | |
<connection> | |
<map_components component_1="reversal_potentials" component_2="physical_constants"/> | |
<map_variables variable_1="R" variable_2="R"/> | |
<map_variables variable_1="T" variable_2="T"/> | |
<map_variables variable_1="F" variable_2="F"/> | |
</connection> | |
<connection> | |
<map_components component_1="reversal_potentials" component_2="IKr"/> | |
<map_variables variable_1="EK" variable_2="EK"/> | |
</connection> | |
<connection> | |
<map_components component_1="reversal_potentials" component_2="INa"/> | |
<map_variables variable_1="ENa" variable_2="ENa"/> | |
</connection> | |
<connection> | |
<map_components component_1="intracellular_ions" component_2="INa"/> | |
<map_variables variable_1="INa" variable_2="INa"/> | |
</connection> | |
<connection> | |
<map_components component_1="intracellular_ions" component_2="Ito"/> | |
<map_variables variable_1="Ito" variable_2="Ito"/> | |
</connection> | |
<connection> | |
<map_components component_1="membrane" component_2="INa"/> | |
<map_variables variable_1="v" variable_2="v"/> | |
<map_variables variable_1="INa" variable_2="INa"/> | |
</connection> | |
<connection> | |
<map_components component_1="CaMK" component_2="INa"/> | |
<map_variables variable_1="KmCaMK" variable_2="KmCaMK"/> | |
<map_variables variable_1="CaMKa" variable_2="CaMKa"/> | |
</connection> | |
<connection> | |
<map_components component_1="Ito" component_2="environment"/> | |
<map_variables variable_1="time" variable_2="time"/> | |
<map_variables variable_1="celltype" variable_2="celltype"/> | |
</connection> | |
<connection> | |
<map_components component_1="INa" component_2="environment"/> | |
<map_variables variable_1="time" variable_2="time"/> | |
</connection> | |
<connection> | |
<map_components component_1="intracellular_ions" component_2="CaMK"/> | |
<map_variables variable_1="cass" variable_2="cass"/> | |
</connection> | |
<connection> | |
<map_components component_1="intracellular_ions" component_2="cell_geometry"/> | |
<map_variables variable_1="Acap" variable_2="Acap"/> | |
<map_variables variable_1="vmyo" variable_2="vmyo"/> | |
<map_variables variable_1="vss" variable_2="vss"/> | |
<map_variables variable_1="vnsr" variable_2="vnsr"/> | |
<map_variables variable_1="vjsr" variable_2="vjsr"/> | |
</connection> | |
<connection> | |
<map_components component_1="intracellular_ions" component_2="environment"/> | |
<map_variables variable_1="time" variable_2="time"/> | |
<map_variables variable_1="celltype" variable_2="celltype"/> | |
</connection> | |
<connection> | |
<map_components component_1="intracellular_ions" component_2="reversal_potentials"/> | |
<map_variables variable_1="nai" variable_2="nai"/> | |
<map_variables variable_1="ki" variable_2="ki"/> | |
</connection> | |
<connection> | |
<map_components component_1="extracellular" component_2="reversal_potentials"/> | |
<map_variables variable_1="nao" variable_2="nao"/> | |
<map_variables variable_1="ko" variable_2="ko"/> | |
</connection> | |
</model> |
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