Skip to content

Instantly share code, notes, and snippets.

@agarny

agarny/pandit_hinch_niederer.cellml

Created October 22, 2015 15:31
Show Gist options
  • Save agarny/adead841b09a061bf478 to your computer and use it in GitHub Desktop.
Save agarny/adead841b09a061bf478 to your computer and use it in GitHub Desktop.
Download ZIP
Raw
pandit_hinch_niederer.cellml
<?xml version="1.0" encoding="UTF-8"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:semsim="http://www.bhi.washington.edu/SemSim#" xmlns:dcterms="http://purl.org/dc/terms/" name="niederer_replace_units">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<section id="sec_status">
<title>Model Status</title>
<para>This model is known to run in OpenCell and COR to reproduce the output shown in the publication. The units have been checked and they are consistent.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>Abstract: The determinants of relaxation in cardiac muscle are poorly understood, yet compromised relaxation accompanies various pathologies and impaired pump function. In this study, we develop a model of active contraction to elucidate the relative importance of the [Ca2+]i transient magnitude, the unbinding of Ca2+ from troponin C (TnC), and the length-dependence of tension and Ca2+ sensitivity on relaxation. Using the framework proposed by one of our researchers, we extensively reviewed experimental literature, to quantitatively characterize the binding of Ca2+ to TnC, the kinetics of tropomyosin, the availability of binding sites, and the kinetics of crossbridge binding after perturbations in sarcomere length. Model parameters were determined from multiple experimental results and modalities (skinned and intact preparations) and model results were validated against data from length step, caged Ca2+, isometric twitches, and the half-time to relaxation with increasing sarcomere length experiments. A factorial analysis found that the [Ca2+]i transient and the unbinding of Ca2+ from TnC were the primary determinants of relaxation, with a fivefold greater effect than that of length-dependent maximum tension and twice the effect of tension-dependent binding of Ca2+ to TnC and length-dependent Ca2+ sensitivity. The affects of the [Ca2+]i transient and the unbinding rate of Ca2+ from TnC were tightly coupled with the effect of increasing either factor, depending on the reference [Ca2+]i transient and unbinding rate.</para>
<informalfigure float="0" id="fig_reaction_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>model diagram</title>
</objectinfo>
<imagedata fileref="niederer_2006.png" />
</imageobject>
</mediaobject>
<caption>Schematic diagram depicting the relationships of the active contraction framework proposed by Hunter et al. (11). The model is driven by SL and sarcomere velocity, and intracellular [Ca2+]i. Inputs are in bold, algebraic length dependencies are in italics, processes described by differential equations are standard font.</caption>
</informalfigure>
<para>The original publication reference is cited below:</para>
<para>
A Quantitative Analysis of Cardiac Myocyte Relaxation: A Simulation Study, Steven Niederer, Peter Hunter, Nicholas Smith, 2006
<emphasis>Biophysical Journal</emphasis>
, 90 1697-1722
<ulink url="http://www.ncbi.nlm.nih.gov/pubmed/16339881?ordinalpos=1&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">PubMed ID: 16339881</ulink>
</para>
</sect1>
</article>
</documentation>
<units name="per_mM_per_ms">
<unit exponent="-1.0" units="mM" />
<unit exponent="-1.0" prefix="milli" units="second" />
</units>
<units name="C_per_mole">
<unit units="coulomb" />
<unit exponent="-1.0" units="mole" />
</units>
<units name="coulomb" base_units="yes" />
<units name="nanoA">
<unit prefix="nano" units="ampere" />
</units>
<units name="uL">
<unit prefix="micro" units="litre" />
</units>
<units name="mJ_per_mole_K">
<unit exponent="-1.0" units="mole" />
<unit prefix="milli" units="joule" />
<unit exponent="-1.0" units="kelvin" />
</units>
<units name="per_ms">
<unit exponent="-1.0" prefix="milli" units="second" />
</units>
<units name="per_mM_ms">
<unit exponent="-1.0" prefix="milli" units="second" />
<unit exponent="-1.0" units="mM" />
</units>
<units name="um2">
<unit exponent="2.0" prefix="micro" units="meter" />
</units>
<units name="micro_litre">
<unit prefix="micro" units="litre" />
</units>
<units name="millijoule_per_mole_kelvin">
<unit exponent="-1.0" units="mole" />
<unit prefix="milli" units="joule" />
<unit exponent="-1.0" units="kelvin" />
</units>
<units name="millimolar_per_second">
<unit exponent="-1.0" units="second" />
<unit units="millimolar" />
</units>
<units name="coulomb_per_mole">
<unit exponent="-1.0" units="mole" />
<unit units="coulomb" />
</units>
<units name="per_ms3">
<unit exponent="-3.0" prefix="milli" units="second" />
</units>
<units name="millimolar">
<unit prefix="milli" units="mole" />
<unit exponent="-1.0" units="litre" />
</units>
<units name="mM">
<unit prefix="milli" units="mole" />
<unit exponent="-1.0" units="litre" />
</units>
<units name="mM_per_ms">
<unit exponent="-1.0" prefix="milli" units="second" />
<unit units="mM" />
</units>
<units name="uA">
<unit prefix="micro" units="ampere" />
</units>
<units name="mM_per_ms">
<unit exponent="-1.0" prefix="milli" units="second" />
<unit units="mM" />
</units>
<units name="per_millivolt">
<unit exponent="-1.0" prefix="milli" units="volt" />
</units>
<units name="millivolt">
<unit prefix="milli" units="volt" />
</units>
<units name="per_ms">
<unit exponent="-1.0" prefix="milli" units="second" />
</units>
<units name="microF">
<unit prefix="micro" units="farad" />
</units>
<units name="um3_mM_per_ms">
<unit exponent="-1.0" prefix="milli" units="second" />
<unit units="mM" />
<unit exponent="3.0" prefix="micro" units="meter" />
</units>
<units name="um3_per_ms">
<unit exponent="3.0" prefix="micro" units="meter" />
<unit exponent="-1.0" prefix="milli" units="second" />
</units>
<units name="nanoA_millimolar_4">
<unit units="nanoA" />
<unit exponent="-4.0" units="millimolar" />
</units>
<units name="mM_per_mV_ms">
<unit exponent="-1.0" prefix="milli" units="volt" />
<unit exponent="-1.0" prefix="milli" units="second" />
<unit units="mM" />
</units>
<units name="microS">
<unit prefix="micro" units="siemens" />
</units>
<units name="millimolar4_per_second">
<unit exponent="-4.0" units="millimolar" />
<unit exponent="-1.0" units="second" />
</units>
<units name="mM">
<unit prefix="milli" units="mole" />
<unit exponent="-1.0" units="litre" />
</units>
<units name="millimolar3_per_second">
<unit exponent="-1.0" units="second" />
<unit exponent="-3.0" units="millimolar" />
</units>
<units name="per_millimolar_per_second">
<unit exponent="-1.0" units="second" />
<unit exponent="-1.0" units="millimolar" />
</units>
<units name="N_per_mm2">
<unit units="newton" />
<unit exponent="-2.0" prefix="milli" units="metre" />
</units>
<units name="siemens" base_units="yes" />
<units name="per_second">
<unit exponent="-1.0" units="second" />
</units>
<units name="ms">
<unit prefix="milli" units="second" />
</units>
<units name="um3">
<unit exponent="3.0" prefix="micro" units="meter" />
</units>
<units name="mV">
<unit prefix="milli" units="volt" />
</units>
<units name="ms">
<unit prefix="milli" units="second" />
</units>
<units name="per_millivolt2">
<unit exponent="-2.0" prefix="milli" units="volt" />
</units>
<units name="millimolar_4">
<unit exponent="-4.0" units="millimolar" />
</units>
<component name="RyR_current" cmeta:id="">
<variable cmeta:id="v0" name="V_myo" public_interface="in" units="um3">
<rdf:RDF>
<rdf:Description rdf:ID="v0">
<dcterms:description>Volume of myoplasm</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v1" name="beta_pcc" public_interface="in" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v1">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor when both the L-type calcium channel and ryanodine receptor are closed</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v2" name="z_1" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v2">
<dcterms:description>State 1 of calcium release unit: z1 = ycc union yco union yoc union yoo</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v3" name="y_oc" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v3">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the open state and the ryanodine receptor is in the closed state</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v4" name="J_R3" public_interface="out" units="um3_mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v4">
<dcterms:description>Convenience term for expressing I_RyR equation?</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v5" name="y_oo" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v5">
<dcterms:description>The state of the calcium (2+) release unit when both the L-type calcium channel and the ryanodine receptor are in the open state</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v6" name="z_3" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v6">
<dcterms:description>State 3 of calcium release unit: z3 = yic union yio</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v7" name="N" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v7">
<dcterms:description>Number of calcium release units</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v8" name="J_R1" public_interface="out" units="um3_mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v8">
<dcterms:description>Convenience term for expressing I_RyR equation?</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v9" name="J_Rco" public_interface="in" units="um3_mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v9">
<dcterms:description>Current through the ryanodine receptor when L-type calcium channel state is closed and ryanodine receptor state is open</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v10" name="y_co" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v10">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the closed state and the ryanodine receptor is in the open state</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="RyR_current_I_RyR" name="I_RyR" public_interface="out" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="RyR_current_I_RyR">
<dcterms:description>Total whole-cell current through the ryanodine receptors</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v11" name="beta_m" public_interface="in" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v11">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v12" name="J_Roo" public_interface="in" units="um3_mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v12">
<dcterms:description>Current through the ryanodine receptor when both the L-type calcium channel and ryanodine receptor are in the open state</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>J_R1</ci>
<apply>
<plus />
<apply>
<times />
<ci>y_oo</ci>
<ci>J_Roo</ci>
</apply>
<apply>
<times />
<ci>J_Rco</ci>
<ci>y_co</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>J_R3</ci>
<apply>
<divide />
<apply>
<times />
<ci>J_Rco</ci>
<ci>beta_pcc</ci>
</apply>
<apply>
<plus />
<ci>beta_m</ci>
<ci>beta_pcc</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>I_RyR</ci>
<apply>
<divide />
<apply>
<times />
<apply>
<plus />
<apply>
<times />
<ci>z_1</ci>
<ci>J_R1</ci>
</apply>
<apply>
<times />
<ci>z_3</ci>
<ci>J_R3</ci>
</apply>
</apply>
<ci>N</ci>
</apply>
<ci>V_myo</ci>
</apply>
</apply>
</math>
</component>
<component name="tropomyosin" cmeta:id="">
<variable cmeta:id="v13" name="beta_0" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v13">
<dcterms:description>Scaling factor (slope) for the relationship between lambda and T_0</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v14" initial_value="0.85" name="z_p" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v14">
<dcterms:description>Point around which the non-linear component of equation 9 in the paper (solving for dz/dt) is linearized to maintain an explicit formulation for the model</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v15" initial_value="3" name="n_Hill" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v15">
<dcterms:description>Analogous to the Hill coefficient in the steady-state force-calcium (2+) curve (F-pCa) and provides a phenomenological rep- resentation of the high cooperativity, due to nearest-neighbor interactions between tropomyosin and/or crossbridges, seen in the activation of tension in cardiac muscle</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v16" initial_value="0.15" name="K_z" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v16">
<dcterms:description>Fast relaxation rate parameter for computing z</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v17" name="Ca_50" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v17">
<dcterms:description>Concentration of free calcium (2+) at half-activation of maximum tension</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v18" name="K_2" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v18">
<dcterms:description>Linearization term for computing z_max</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v19" name="Ca_b" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v19">
<dcterms:description>Concentration of calcium (2+) bound to troponin C</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v20" initial_value="3" name="n_Rel" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v20">
<dcterms:description>Fast relaxation rate parameter for computing z</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v21" name="Ca_TRPN_50" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v21">
<dcterms:description>Calcium (2+) bound to TnC at half-activation of maximum tension</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v22" name="K_1" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v22">
<dcterms:description>Linearization term for computing z_max</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v23" initial_value="-4" name="beta_1" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v23">
<dcterms:description>Scaling parameter for Ca_50 vs. lambda dependency</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v24" initial_value="2e-3" name="alpha_r1" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v24">
<dcterms:description>Slow relaxation rate parameter for computing z</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v25" name="z_max" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v25">
<dcterms:description>the maximum fraction of available actin sites at a given sarcomere length</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v26" initial_value="8e-3" name="alpha_0" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v26">
<dcterms:description>The monoexponential activation rate seen in caged calcium (2+) experiments. Used to compute z.</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v27" name="k_Ref_off" public_interface="in" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v27">
<dcterms:description>Rate of calcium (2+) unbinding from Troponin C in the absence of tension</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v28" name="time" public_interface="in" units="ms">
<rdf:RDF>
<rdf:Description rdf:ID="v28">
<dcterms:description>Temporal solution domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v29" name="Ca_TRPN_Max" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v29">
<dcterms:description>The maximum concentration of calcium ions that can bind to site II on troponin C</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v30" initial_value="1.05e-3" name="Ca_50ref" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v30">
<dcterms:description>Offset parameter for Ca_50 vs. lambda dependency</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v31" name="k_on" public_interface="in" units="per_mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v31">
<dcterms:description>The binding rate of calcium (2+) to troponin C site II</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v32" name="lambda" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v32">
<dcterms:description>Sarcomere strain?</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v33" name="beta_Tm" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v33">
<dcterms:description>Intermediate term for second component of variable z's ODE (equation 9 in reference paper)</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v34" initial_value="1.75e-3" name="alpha_r2" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v34">
<dcterms:description>Fast relaxation rate parameter for computing z</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v35" name="alpha_Tm" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v35">
<dcterms:description>Intermediate term for first component of varaible z's ODE (equation 9 in reference paper)</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v36" name="gamma_trpn" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v36">
<dcterms:description>A measure of the effect of tension on the unbinding rate of calcium (2+) from troponin C</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v37" initial_value="0.014417937837" name="z" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v37">
<dcterms:description>The fraction of actin sites available for crossbridge binding as determined by thin filament kinetics</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>K_2</ci>
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>alpha_r2</ci>
<apply>
<power />
<ci>z_p</ci>
<ci>n_Rel</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<power />
<ci>z_p</ci>
<ci>n_Rel</ci>
</apply>
<apply>
<power />
<ci>K_z</ci>
<ci>n_Rel</ci>
</apply>
</apply>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<apply>
<times />
<ci>n_Rel</ci>
<apply>
<power />
<ci>K_z</ci>
<ci>n_Rel</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<power />
<ci>z_p</ci>
<ci>n_Rel</ci>
</apply>
<apply>
<power />
<ci>K_z</ci>
<ci>n_Rel</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>K_1</ci>
<apply>
<divide />
<apply>
<times />
<ci>alpha_r2</ci>
<apply>
<power />
<ci>z_p</ci>
<apply>
<minus />
<ci>n_Rel</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
<ci>n_Rel</ci>
<apply>
<power />
<ci>K_z</ci>
<ci>n_Rel</ci>
</apply>
</apply>
<apply>
<power />
<apply>
<plus />
<apply>
<power />
<ci>z_p</ci>
<ci>n_Rel</ci>
</apply>
<apply>
<power />
<ci>K_z</ci>
<ci>n_Rel</ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>z_max</ci>
<apply>
<divide />
<apply>
<minus />
<apply>
<divide />
<ci>alpha_0</ci>
<apply>
<power />
<apply>
<divide />
<ci>Ca_TRPN_50</ci>
<ci>Ca_TRPN_Max</ci>
</apply>
<ci>n_Hill</ci>
</apply>
</apply>
<ci>K_2</ci>
</apply>
<apply>
<plus />
<ci>alpha_r1</ci>
<ci>K_1</ci>
<apply>
<divide />
<ci>alpha_0</ci>
<apply>
<power />
<apply>
<divide />
<ci>Ca_TRPN_50</ci>
<ci>Ca_TRPN_Max</ci>
</apply>
<ci>n_Hill</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>Ca_50</ci>
<apply>
<times />
<ci>Ca_50ref</ci>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times />
<ci>beta_1</ci>
<apply>
<minus />
<ci>lambda</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>Ca_TRPN_50</ci>
<apply>
<divide />
<apply>
<times />
<ci>Ca_50</ci>
<ci>Ca_TRPN_Max</ci>
</apply>
<apply>
<plus />
<ci>Ca_50</ci>
<apply>
<times />
<apply>
<divide />
<ci>k_Ref_off</ci>
<ci>k_on</ci>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<apply>
<times />
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times />
<ci>beta_0</ci>
<apply>
<minus />
<ci>lambda</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5</cn>
</apply>
<ci>gamma_trpn</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>alpha_Tm</ci>
<apply>
<times />
<ci>alpha_0</ci>
<apply>
<power />
<apply>
<divide />
<ci>Ca_b</ci>
<ci>Ca_TRPN_50</ci>
</apply>
<ci>n_Hill</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>beta_Tm</ci>
<apply>
<plus />
<ci>alpha_r1</ci>
<apply>
<divide />
<apply>
<times />
<ci>alpha_r2</ci>
<apply>
<power />
<ci>z</ci>
<apply>
<minus />
<ci>n_Rel</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<plus />
<apply>
<power />
<ci>z</ci>
<ci>n_Rel</ci>
</apply>
<apply>
<power />
<ci>K_z</ci>
<ci>n_Rel</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>z</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>alpha_Tm</ci>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>z</ci>
</apply>
</apply>
<apply>
<times />
<ci>beta_Tm</ci>
<ci>z</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Na_Ca_ion_exchanger_current" cmeta:id="">
<variable cmeta:id="v38" name="Na_i" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v38">
<dcterms:description>Concentration of sodium in bulk cytosol</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.5" name="gamma_NaCa" units="dimensionless" />
<variable cmeta:id="v39" name="i_NaCa" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v39">
<dcterms:description>Current through the sodium/calcium exchanger</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.0001" name="d_NaCa" units="millimolar_4" />
<variable cmeta:id="v40" name="Ca_i" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v40">
<dcterms:description>Concentration of calcium in bulk cytosol</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v41" name="Ca_o" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v41">
<dcterms:description>Concentration of calcium external to the cardiac myocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v42" name="time" public_interface="in" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v42">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.000009984" name="K_NaCa" units="nanoA_millimolar_4" />
<variable cmeta:id="v43" name="V" public_interface="in" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v43">
<dcterms:description>Voltage potential across the plasma membrane of the cardiomyocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v44" name="Na_o" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v44">
<dcterms:description>Concentration of sodium external to the cardiac myocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML" />
</component>
<component name="troponin" cmeta:id="">
<variable cmeta:id="v45" initial_value="2" name="gamma_trpn" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v45">
<dcterms:description>A measure of the effect of tension on the unbinding rate of calcium (2+) from troponin C</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v46" initial_value="100" name="k_on" public_interface="out" units="per_mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v46">
<dcterms:description>The binding rate of calcium (2+) to troponin C site II</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v47" name="Tension" public_interface="in" units="N_per_mm2">
<rdf:RDF>
<rdf:Description rdf:ID="v47">
<dcterms:description>Active tension of cardiac myocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v48" name="J_TRPN" public_interface="out" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v48">
<dcterms:description>Intracellular troponin flux</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v49" name="TRPN" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v49">
<dcterms:description>Intracellular troponin concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v50" name="Ca_i" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v50">
<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v51" initial_value="70e-3" name="Ca_TRPN_Max" public_interface="out" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v51">
<dcterms:description>The maximum concentration of calcium ions that can bind to site II on troponin C</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v52" initial_value="0.2" name="k_Ref_off" public_interface="out" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v52">
<dcterms:description>Rate of calcium (2+) unbinding from Troponin C in the absence of tension</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v53" name="k_off" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v53">
<dcterms:description>The unbinding rate of calcium (2+) from troponin C site II</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v54" name="T_ref" public_interface="in" units="N_per_mm2">
<rdf:RDF>
<rdf:Description rdf:ID="v54">
<dcterms:description>Maximum tension at resting sarcomere length</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>k_off</ci>
<piecewise>
<piece>
<apply>
<times />
<ci>k_Ref_off</ci>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<ci>Tension</ci>
<apply>
<times />
<ci>gamma_trpn</ci>
<ci>T_ref</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<gt />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<ci>Tension</ci>
<apply>
<times />
<ci>gamma_trpn</ci>
<ci>T_ref</ci>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
</apply>
</piece>
<otherwise>
<apply>
<times />
<ci>k_Ref_off</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq />
<ci>J_TRPN</ci>
<apply>
<minus />
<apply>
<times />
<apply>
<minus />
<ci>Ca_TRPN_Max</ci>
<ci>TRPN</ci>
</apply>
<ci>k_off</ci>
</apply>
<apply>
<times />
<ci>Ca_i</ci>
<ci>TRPN</ci>
<ci>k_on</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SERCA" cmeta:id="">
<variable cmeta:id="SERCA_I_SERCA" name="I_SERCA" public_interface="out" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="SERCA_I_SERCA">
<dcterms:description>Calcium (2+) resequestering into the sarcoplasmic reticulum via the sarco/endoplasmic reticulum Ca2+ -ATPase (SERCA) pump</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v55" initial_value="0.5e-3" name="K_SERCA" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v55">
<dcterms:description>Half saturation of sarco/endoplasmic reticulum Ca2+ -ATPase (SERCA) pump</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v56" initial_value="0.45e-3" name="g_SERCA" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v56">
<dcterms:description>Maximum pump rate of sarco/endoplasmic reticulum Ca2+ -ATPase (SERCA) pump</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v57" name="Ca_i" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v57">
<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>I_SERCA</ci>
<apply>
<divide />
<apply>
<times />
<ci>g_SERCA</ci>
<apply>
<power />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<plus />
<apply>
<power />
<ci>K_SERCA</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SR_Ca_leak_current" cmeta:id="">
<variable cmeta:id="SR_Ca_leak_current_I_SR" name="I_SR" public_interface="out" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="SR_Ca_leak_current_I_SR">
<dcterms:description>Calcium (2+) leak from the sarcoplasmic reticulum to the bulk myoplasm</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v58" name="Ca_i" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v58">
<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v59" initial_value="1.8951e-5" name="g_SRl" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v59">
<dcterms:description>Maximum pump rate of calcium (2+) leak current from the sarcoplasmic reticulum to the bulk myoplasm</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v60" name="Ca_SR" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v60">
<dcterms:description>Calcium (2+) concentration in sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>I_SR</ci>
<apply>
<times />
<ci>g_SRl</ci>
<apply>
<minus />
<ci>Ca_SR</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="env_hinch" cmeta:id="">
<variable cmeta:id="environment_time" name="time" public_interface="in" units="ms">
<rdf:RDF>
<rdf:Description rdf:ID="environment_time">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
</component>
<component name="sodium_current_h_gate" cmeta:id="">
<variable cmeta:id="v61" name="time" public_interface="in" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v61">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.6735613" name="h" public_interface="out" units="dimensionless" />
<variable name="tau_h" units="second" />
<variable name="h_infinity" units="dimensionless" />
<variable cmeta:id="v62" name="V" public_interface="in" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v62">
<dcterms:description>Voltage potential across the plasma membrane of the cardiomyocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>h_infinity</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">76.1</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.07</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>tau_h</ci>
<piecewise>
<piece>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.0004537</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<minus />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.66</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<geq />
<ci>V</ci>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.00349</cn>
<apply>
<plus />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.135</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<minus />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">80</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.8</cn>
</apply>
</apply>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.56</cn>
<apply>
<exp />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.079</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">310000</cn>
<apply>
<exp />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.35</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>h</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>h_infinity</ci>
<ci>h</ci>
</apply>
<ci>tau_h</ci>
</apply>
</apply>
</math>
</component>
<component name="Sarcolemmal_Ca_pump" cmeta:id="">
<variable cmeta:id="v63" initial_value="0.5e-3" name="K_mpCa" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v63">
<dcterms:description>Half saturation of sarcolemmal pump</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v64" initial_value="0.0035e-3" name="g_pCa" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v64">
<dcterms:description>Maximum pump rate of sarcolemmal pump</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="Sarcolemmal_Ca_pump_I_pCa" name="I_pCa" public_interface="out" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="Sarcolemmal_Ca_pump_I_pCa">
<dcterms:description>Sarcolemmal calcium-ATPase flow</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v65" name="Ca_i" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v65">
<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>I_pCa</ci>
<apply>
<divide />
<apply>
<times />
<ci>g_pCa</ci>
<ci>Ca_i</ci>
</apply>
<apply>
<plus />
<ci>K_mpCa</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_f_12_gate" cmeta:id="">
<variable cmeta:id="v66" name="time" public_interface="in" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v66">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="f_12_infinity" units="dimensionless" />
<variable name="tau_f_12" units="second" />
<variable cmeta:id="v67" name="V" public_interface="in" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v67">
<dcterms:description>Voltage potential across the plasma membrane of the cardiomyocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.9999529" name="f_12" public_interface="out" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>f_12_infinity</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">26.7</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.4</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>tau_f_12</ci>
<apply>
<plus />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.041</cn>
<apply>
<exp />
<apply>
<minus />
<apply>
<power />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">47</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">12</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.08</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">55</cn>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.015</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">75</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.0017</cn>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>f_12</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>f_12_infinity</ci>
<ci>f_12</ci>
</apply>
<ci>tau_f_12</ci>
</apply>
</apply>
</math>
</component>
<component name="env_niederer" cmeta:id="">
<variable cmeta:id="environment_time" name="time" public_interface="in" units="ms">
<rdf:RDF>
<rdf:Description rdf:ID="environment_time">
<dcterms:description>Temporal solution domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
</component>
<component name="iic_hinch" cmeta:id="">
<variable cmeta:id="intracellular_ion_concentrations_Ca_i" initial_value="0.0001" name="Ca_i" public_interface="out" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="intracellular_ion_concentrations_Ca_i">
<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v68" name="V_myo" public_interface="in" units="um3">
<rdf:RDF>
<rdf:Description rdf:ID="v68">
<dcterms:description>Volume of myoplasm</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v69" name="I_SERCA" public_interface="in" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v69">
<dcterms:description>Calcium (2+) resequestering into the sarcoplasmic reticulum via the sarco/endoplasmic reticulum Ca2+ -ATPase (SERCA) pump</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v70" name="I_LCC" public_interface="in" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v70">
<dcterms:description>Total whole-cell current through the L-type calcium channels</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v71" name="I_CaB" public_interface="in" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v71">
<dcterms:description>Sarcolemmal calcium leak current</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v72" name="TRPN" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v72">
<dcterms:description>Concentration of troponin in cytosol</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v73" name="I_TRPN" public_interface="in" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v73">
<dcterms:description>Rate of formation of calcium (2+)-bound troponin</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v74" name="I_pCa" public_interface="in" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v74">
<dcterms:description>Sarcolemmal calcium-ATPase flow</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v75" name="I_SR" public_interface="in" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v75">
<dcterms:description>Calcium (2+) leak from the sarcoplasmic reticulum to the bulk myoplasm</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="intracellular_ion_concentrations_CaSR_plot" name="CaSR_plot" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="intracellular_ion_concentrations_CaSR_plot">
<dcterms:description>Concentration of sarcoplasmic calcium normalized to cytosolic volume (presumably for comparing simulation results to Figure 7B of reference publication).</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v76" name="I_NaCa" public_interface="in" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v76">
<dcterms:description>Sodium-calcium exchange current</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v77" name="Na_i" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v77">
<dcterms:description>Intracellular sodium (1+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v78" name="I_RyR" public_interface="in" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v78">
<dcterms:description>Total whole-cell current through the ryanodine receptors</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v79" name="V_SR" public_interface="in" units="um3">
<rdf:RDF>
<rdf:Description rdf:ID="v79">
<dcterms:description>Volume of sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v80" initial_value="700e-3" name="Ca_SR" public_interface="out" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v80">
<dcterms:description>Calcium (2+) concentration in sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v81" name="beta_CMDN" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v81">
<dcterms:description>Rapid buffer coeffiecient in the cytoplasm</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v82" name="time" public_interface="in" units="ms">
<rdf:RDF>
<rdf:Description rdf:ID="v82">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_i</ci>
</apply>
<apply>
<times />
<ci>beta_CMDN</ci>
<apply>
<plus />
<apply>
<minus />
<apply>
<plus />
<apply>
<minus />
<apply>
<plus />
<ci>I_LCC</ci>
<ci>I_RyR</ci>
</apply>
<ci>I_SERCA</ci>
</apply>
<ci>I_SR</ci>
<ci>I_NaCa</ci>
</apply>
<ci>I_pCa</ci>
</apply>
<ci>I_CaB</ci>
<ci>I_TRPN</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_SR</ci>
</apply>
<apply>
<times />
<apply>
<divide />
<ci>V_myo</ci>
<ci>V_SR</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<minus />
<ci>I_RyR</ci>
</apply>
<ci>I_SERCA</ci>
</apply>
<ci>I_SR</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>CaSR_plot</ci>
<apply>
<divide />
<apply>
<times />
<ci>Ca_SR</ci>
<ci>V_SR</ci>
</apply>
<ci>V_myo</ci>
</apply>
</apply>
</math>
</component>
<component name="Ca_independent_transient_outward_K_current" cmeta:id="">
<variable cmeta:id="v83" name="K_i" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v83">
<dcterms:description>Concentration of potassium in bulk cytosol</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.035" name="g_t" units="microS" />
<variable cmeta:id="v84" name="T" public_interface="in" units="kelvin">
<rdf:RDF>
<rdf:Description rdf:ID="v84">
<dcterms:description>Temperature of the cardiac myocyte and its surrounding environment</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="s" private_interface="in" units="dimensionless" />
<variable cmeta:id="v85" name="V" public_interface="in" private_interface="out" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v85">
<dcterms:description>Voltage potential across the plasma membrane of the cardiomyocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v86" name="E_K" public_interface="out" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v86">
<dcterms:description>Nernst potential for sodium across the plasma membrane</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v87" name="R" public_interface="in" units="millijoule_per_mole_kelvin">
<rdf:RDF>
<rdf:Description rdf:ID="v87">
<dcterms:description>Universal gas constant</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00410" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.417" name="b_endo" units="dimensionless" />
<variable cmeta:id="v88" name="K_o" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v88">
<dcterms:description>Concentration of potassium external to the cardiac myocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.583" name="a_endo" units="dimensionless" />
<variable cmeta:id="v89" name="time" public_interface="in" private_interface="out" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v89">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="g_t_endo" units="microS" />
<variable cmeta:id="v90" name="i_t" public_interface="out" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v90">
<dcterms:description>Current through the transient outward potassium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v91" name="F" public_interface="in" units="coulomb_per_mole">
<rdf:RDF>
<rdf:Description rdf:ID="v91">
<dcterms:description>Faraday constant</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00089" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="s_slow" private_interface="in" units="dimensionless" />
<variable name="r" private_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>g_t_endo</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.4647</cn>
<ci>g_t</ci>
</apply>
</apply>
<apply>
<eq />
<ci>E_K</ci>
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln />
<apply>
<divide />
<ci>K_o</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>i_t</ci>
<apply>
<times />
<ci>g_t_endo</ci>
<ci>r</ci>
<apply>
<plus />
<apply>
<times />
<ci>a_endo</ci>
<ci>s</ci>
</apply>
<apply>
<times />
<ci>b_endo</ci>
<ci>s_slow</ci>
</apply>
</apply>
<apply>
<minus />
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Ca_independent_transient_outward_K_current_s_slow_gate" cmeta:id="">
<variable cmeta:id="v92" name="time" public_interface="in" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v92">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="s_slow_infinity" units="dimensionless" />
<variable name="tau_s_slow_endo" units="second" />
<variable cmeta:id="v93" name="V" public_interface="in" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v93">
<dcterms:description>Voltage potential across the plasma membrane of the cardiomyocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.6421196" name="s_slow" public_interface="out" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>s_slow_infinity</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">45.3</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.8841</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>tau_s_slow_endo</ci>
<apply>
<plus />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">3.3</cn>
<apply>
<exp />
<apply>
<minus />
<apply>
<power />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">70</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.049</cn>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>s_slow</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>s_slow_infinity</ci>
<ci>s_slow</ci>
</apply>
<ci>tau_s_slow_endo</ci>
</apply>
</apply>
</math>
</component>
<component name="sodium_current_j_gate" cmeta:id="">
<variable name="j_infinity" units="dimensionless" />
<variable cmeta:id="v94" name="time" public_interface="in" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v94">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="tau_j" units="second" />
<variable cmeta:id="v95" name="V" public_interface="in" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v95">
<dcterms:description>Voltage potential across the plasma membrane of the cardiomyocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.6729362" name="j" public_interface="out" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>j_infinity</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">76.1</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.07</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>tau_j</ci>
<piecewise>
<piece>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.01163</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
</apply>
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">32</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0000002535</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<geq />
<ci>V</ci>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.00349</cn>
<apply>
<plus />
<apply>
<times />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">37.78</cn>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.311</cn>
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">79.23</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">127140</cn>
</apply>
<apply>
<exp />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.2444</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.00003474</cn>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.04391</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1212</cn>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.01052</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1378</cn>
</apply>
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40.14</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>j</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>j_infinity</ci>
<ci>j</ci>
</apply>
<ci>tau_j</ci>
</apply>
</apply>
</math>
</component>
<component name="steady_state_outward_K_current" cmeta:id="">
<variable name="r_ss" private_interface="in" units="dimensionless" />
<variable initial_value="0.007" name="g_ss" units="microS" />
<variable name="s_ss" private_interface="in" units="dimensionless" />
<variable cmeta:id="v96" name="time" public_interface="in" private_interface="out" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v96">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v97" name="V" public_interface="in" private_interface="out" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v97">
<dcterms:description>Voltage potential across the plasma membrane of the cardiomyocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v98" name="i_ss" public_interface="out" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v98">
<dcterms:description>Current through the steady-state outward potassium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v99" name="E_K" public_interface="in" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v99">
<dcterms:description>Nernst potential for sodium across the plasma membrane</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>i_ss</ci>
<apply>
<times />
<ci>g_ss</ci>
<ci>r_ss</ci>
<ci>s_ss</ci>
<apply>
<minus />
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_current" cmeta:id="">
<variable cmeta:id="v100" name="V" public_interface="in" private_interface="out" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v100">
<dcterms:description>Voltage potential across the plasma membrane of the cardiomyocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v101" name="E_Na" public_interface="out" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v101">
<dcterms:description>Nernst potential for sodium across the plasma membrane</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v102" name="F" public_interface="in" units="coulomb_per_mole">
<rdf:RDF>
<rdf:Description rdf:ID="v102">
<dcterms:description>Faraday constant</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00089" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="g_Na_endo" units="microS" />
<variable cmeta:id="v103" name="Na_o" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v103">
<dcterms:description>Concentration of sodium external to the cardiac myocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v104" name="i_Na" public_interface="out" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v104">
<dcterms:description>Current through fast sodium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v105" name="R" public_interface="in" units="millijoule_per_mole_kelvin">
<rdf:RDF>
<rdf:Description rdf:ID="v105">
<dcterms:description>Universal gas constant</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00410" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v106" name="Na_i" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v106">
<dcterms:description>Concentration of sodium in bulk cytosol</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v107" name="time" public_interface="in" private_interface="out" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v107">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v108" name="T" public_interface="in" units="kelvin">
<rdf:RDF>
<rdf:Description rdf:ID="v108">
<dcterms:description>Temperature of the cardiac myocyte and its surrounding environment</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="h" private_interface="in" units="dimensionless" />
<variable name="m" private_interface="in" units="dimensionless" />
<variable initial_value="0.8" name="g_Na" units="microS" />
<variable name="j" private_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>g_Na_endo</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.33</cn>
<ci>g_Na</ci>
</apply>
</apply>
<apply>
<eq />
<ci>E_Na</ci>
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln />
<apply>
<divide />
<ci>Na_o</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>i_Na</ci>
<apply>
<times />
<ci>g_Na_endo</ci>
<apply>
<power />
<ci>m</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<ci>h</ci>
<ci>j</ci>
<apply>
<minus />
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_f_11_gate" cmeta:id="">
<variable cmeta:id="v109" name="V" public_interface="in" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v109">
<dcterms:description>Voltage potential across the plasma membrane of the cardiomyocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="f_11_infinity" units="dimensionless" />
<variable initial_value="0.9999529" name="f_11" public_interface="out" units="dimensionless" />
<variable name="tau_f_11" units="second" />
<variable cmeta:id="v110" name="time" public_interface="in" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v110">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>f_11_infinity</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">26.7</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.4</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>tau_f_11</ci>
<apply>
<plus />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.105</cn>
<apply>
<exp />
<apply>
<minus />
<apply>
<power />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">45</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">12</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.04</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<apply>
<minus />
<ci>V</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.015</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">75</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.0017</cn>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>f_11</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>f_11_infinity</ci>
<ci>f_11</ci>
</apply>
<ci>tau_f_11</ci>
</apply>
</apply>
</math>
</component>
<component name="CaRU_reduced_states" cmeta:id="">
<variable cmeta:id="v111" name="z_4" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v111">
<dcterms:description>State 4 of calcium release unit: z4 = yii</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v112" name="r_5" public_interface="out" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v112">
<dcterms:description>Rate constant for transition of calcium release unit from state 1 to state 3</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v113" name="epsilon_pcc" public_interface="in" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v113">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v114" name="mu_pcc" public_interface="in" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v114">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v115" name="y_oc" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v115">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the open state and the ryanodine receptor is in the closed state</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v116" name="mu_poc" public_interface="in" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v116">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v117" name="alpha_p" public_interface="in" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v117">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v118" name="epsilon_m" public_interface="in" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v118">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v119" name="beta_pcc" public_interface="in" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v119">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor when both the L-type calcium channel and ryanodine receptor are closed</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v120" name="y_co" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v120">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the closed state and the ryanodine receptor is in the open state</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v121" initial_value="0.0087302" name="z_2" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v121">
<dcterms:description>State 2 of calcium release channel: z2 = yoi union yci</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v122" name="r_3" public_interface="out" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v122">
<dcterms:description>Rate constant for transition of calcium release unit from state 3 to state 4</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v123" name="epsilon_pco" public_interface="in" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v123">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v124" name="r_2" public_interface="out" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v124">
<dcterms:description>Rate constant for transition of calcium release unit from state 2 to state 1</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v125" name="y_cc" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v125">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel and the ryanodine receptor are both in the closed state</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v126" name="time" public_interface="in" units="ms">
<rdf:RDF>
<rdf:Description rdf:ID="v126">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v127" name="mu_mcc" public_interface="in" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v127">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v128" name="r_7" public_interface="out" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v128">
<dcterms:description>Rate constant for transition of calcium release unit from state 2 to state 4</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v129" name="r_4" public_interface="out" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v129">
<dcterms:description>Rate constant for transition of calcium release unit from state 4 to state 3</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v130" initial_value="0.0026566" name="z_3" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v130">
<dcterms:description>State 3 of calcium release unit: z3 = yic union yio</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v131" name="r_8" public_interface="out" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v131">
<dcterms:description>Rate constant for transition of calcium release unit from state 4 to state 2</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v132" name="r_1" public_interface="out" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v132">
<dcterms:description>Rate constant for transition of calcium release unit from state 1 to state 2</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v133" name="beta_m" public_interface="in" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v133">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v134" name="alpha_m" public_interface="in" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v134">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v135" name="r_6" public_interface="out" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v135">
<dcterms:description>Rate constant for transition of calcium release unit from state 3 to state 1</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v136" initial_value="0.98859" name="z_1" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v136">
<dcterms:description>State 1 of calcium release unit: z1 = ycc union yco union yoc union yoo</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v137" name="mu_moc" public_interface="in" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v137">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>r_1</ci>
<apply>
<plus />
<apply>
<times />
<ci>y_oc</ci>
<ci>mu_poc</ci>
</apply>
<apply>
<times />
<ci>y_cc</ci>
<ci>mu_pcc</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>r_2</ci>
<apply>
<divide />
<apply>
<plus />
<apply>
<times />
<ci>alpha_p</ci>
<ci>mu_moc</ci>
</apply>
<apply>
<times />
<ci>alpha_m</ci>
<ci>mu_mcc</ci>
</apply>
</apply>
<apply>
<plus />
<ci>alpha_p</ci>
<ci>alpha_m</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>r_3</ci>
<apply>
<divide />
<apply>
<times />
<ci>beta_m</ci>
<ci>mu_pcc</ci>
</apply>
<apply>
<plus />
<ci>beta_m</ci>
<ci>beta_pcc</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>r_4</ci>
<ci>mu_mcc</ci>
</apply>
<apply>
<eq />
<ci>r_5</ci>
<apply>
<plus />
<apply>
<times />
<ci>y_co</ci>
<ci>epsilon_pco</ci>
</apply>
<apply>
<times />
<ci>y_cc</ci>
<ci>epsilon_pcc</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>r_6</ci>
<ci>epsilon_m</ci>
</apply>
<apply>
<eq />
<ci>r_7</ci>
<apply>
<divide />
<apply>
<times />
<ci>alpha_m</ci>
<ci>epsilon_pcc</ci>
</apply>
<apply>
<plus />
<ci>alpha_p</ci>
<ci>alpha_m</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>r_8</ci>
<ci>epsilon_m</ci>
</apply>
<apply>
<eq />
<ci>z_4</ci>
<apply>
<minus />
<apply>
<minus />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>z_1</ci>
</apply>
<ci>z_2</ci>
</apply>
<ci>z_3</ci>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>z_1</ci>
</apply>
<apply>
<plus />
<apply>
<times />
<apply>
<minus />
<apply>
<plus />
<ci>r_1</ci>
<ci>r_5</ci>
</apply>
</apply>
<ci>z_1</ci>
</apply>
<apply>
<times />
<ci>r_2</ci>
<ci>z_2</ci>
</apply>
<apply>
<times />
<ci>r_6</ci>
<ci>z_3</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>z_2</ci>
</apply>
<apply>
<plus />
<apply>
<minus />
<apply>
<times />
<ci>r_1</ci>
<ci>z_1</ci>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>r_2</ci>
<ci>r_7</ci>
</apply>
<ci>z_2</ci>
</apply>
</apply>
<apply>
<times />
<ci>r_8</ci>
<ci>z_4</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>z_3</ci>
</apply>
<apply>
<plus />
<apply>
<minus />
<apply>
<times />
<ci>r_5</ci>
<ci>z_1</ci>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>r_6</ci>
<ci>r_3</ci>
</apply>
<ci>z_3</ci>
</apply>
</apply>
<apply>
<times />
<ci>r_4</ci>
<ci>z_4</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Ca_independent_transient_outward_K_current_s_gate" cmeta:id="">
<variable name="s_infinity" units="dimensionless" />
<variable name="tau_s_endo" units="second" />
<variable initial_value="0.9842542" name="s" public_interface="out" units="dimensionless" />
<variable cmeta:id="v138" name="V" public_interface="in" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v138">
<dcterms:description>Voltage potential across the plasma membrane of the cardiomyocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v139" name="time" public_interface="in" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v139">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>s_infinity</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">45.3</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.8841</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>tau_s_endo</ci>
<apply>
<plus />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.55</cn>
<apply>
<exp />
<apply>
<minus />
<apply>
<power />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">70</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.049</cn>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>s</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>s_infinity</ci>
<ci>s</ci>
</apply>
<ci>tau_s_endo</ci>
</apply>
</apply>
</math>
</component>
<component name="inward_rectifier" cmeta:id="">
<variable cmeta:id="v140" name="F" public_interface="in" units="coulomb_per_mole">
<rdf:RDF>
<rdf:Description rdf:ID="v140">
<dcterms:description>Faraday constant</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00089" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v141" name="K_i" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v141">
<dcterms:description>Concentration of potassium in bulk cytosol</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.024" name="g_K1" units="microS" />
<variable cmeta:id="v142" name="time" public_interface="in" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v142">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v143" name="V" public_interface="in" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v143">
<dcterms:description>Voltage potential across the plasma membrane of the cardiomyocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v144" name="K_o" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v144">
<dcterms:description>Concentration of potassium external to the cardiac myocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v145" name="R" public_interface="in" units="millijoule_per_mole_kelvin">
<rdf:RDF>
<rdf:Description rdf:ID="v145">
<dcterms:description>Universal gas constant</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00410" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v146" name="i_K1" public_interface="out" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v146">
<dcterms:description>Current through the inward rectifier potassium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v147" name="T" public_interface="in" units="kelvin">
<rdf:RDF>
<rdf:Description rdf:ID="v147">
<dcterms:description>Temperature of the cardiac myocyte and its surrounding environment</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v148" name="E_K" public_interface="in" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v148">
<dcterms:description>Nernst potential for sodium across the plasma membrane</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>i_K1</ci>
<apply>
<plus />
<apply>
<divide />
<apply>
<times />
<apply>
<plus />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="nanoA">48</cn>
<apply>
<plus />
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">37</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
</apply>
</apply>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">37</cn>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="nanoA">10</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0001</cn>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<minus />
<ci>V</ci>
<apply>
<plus />
<ci>E_K</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">76.77</cn>
</apply>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">17</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>g_K1</ci>
<apply>
<minus />
<ci>V</ci>
<apply>
<plus />
<ci>E_K</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">1.73</cn>
</apply>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.613</cn>
<ci>F</ci>
<apply>
<minus />
<ci>V</ci>
<apply>
<plus />
<ci>E_K</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">1.73</cn>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<minus />
<ci>K_o</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.9988</cn>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.124</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Background_Ca_current" cmeta:id="">
<variable cmeta:id="v149" name="Ca_o" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v149">
<dcterms:description>Extracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v150" name="Ca_i" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v150">
<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v151" name="R" public_interface="in" units="mJ_per_mole_K">
<rdf:RDF>
<rdf:Description rdf:ID="v151">
<dcterms:description>Universal gas constant</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00410" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v152" name="T" public_interface="in" units="kelvin">
<rdf:RDF>
<rdf:Description rdf:ID="v152">
<dcterms:description>Ambient temperature</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v153" name="V" public_interface="in" units="mV">
<rdf:RDF>
<rdf:Description rdf:ID="v153">
<dcterms:description>Voltage across cell membrane</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="Background_Ca_current_I_CaB" name="I_CaB" public_interface="out" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="Background_Ca_current_I_CaB">
<dcterms:description>Sarcolemmal calcium leak current</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v154" name="E_Ca" public_interface="out" units="mV">
<rdf:RDF>
<rdf:Description rdf:ID="v154">
<dcterms:description>Reversal potential for sarcolemmal leak current</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v155" name="F" public_interface="in" units="C_per_mole">
<rdf:RDF>
<rdf:Description rdf:ID="v155">
<dcterms:description>Faraday constant</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00089" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v156" initial_value="2.6875e-8" name="g_CaB" units="mM_per_mV_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v156">
<dcterms:description>Conductance of background calcium (2+) current</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>E_Ca</ci>
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln />
<apply>
<divide />
<ci>Ca_o</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>I_CaB</ci>
<apply>
<times />
<ci>g_CaB</ci>
<apply>
<minus />
<ci>E_Ca</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="thinfilaments" cmeta:id="" />
<component name="LCC_and_RyR_fluxes" cmeta:id="">
<variable cmeta:id="v157" name="FVRT_Ca" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v157">
<dcterms:description>Convenience variable that is equal to (F*V/(R*T))*2. Also equivalent to [greek delta]*V in the source manuscript</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v158" name="J_L" public_interface="in" units="um3_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v158">
<dcterms:description>Permeability of a single L-type calcium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v159" name="Ca_SR" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v159">
<dcterms:description>Calcium (2+) concentration in sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v160" name="Ca_i" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v160">
<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v161" name="J_Roo" public_interface="out" units="um3_mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v161">
<dcterms:description>Current through the ryanodine receptor when both the L-type calcium channel and ryanodine receptor are in the open state</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v162" name="J_Rco" public_interface="out" units="um3_mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v162">
<dcterms:description>Current through the ryanodine receptor when L-type calcium channel state is closed and ryanodine receptor state is open</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v163" name="Ca_o" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v163">
<dcterms:description>Extracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v164" name="J_Loc" public_interface="out" units="um3_mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v164">
<dcterms:description>Current through the L-type calcium channel when L-type calcium channel state is open and ryanodine receptor state is closed</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v165" name="g_D" public_interface="in" units="um3_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v165">
<dcterms:description>Calcium (2+) flux rate from dyadic space to cytosol</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v166" name="J_R" public_interface="in" units="um3_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v166">
<dcterms:description>Permeability of a single ryanodine receptor</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v167" name="J_Loo" public_interface="out" units="um3_mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v167">
<dcterms:description>Current through the L-type calcium channel when both the L-type calcium channel and ryanodine receptor are in the open state</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>J_Rco</ci>
<apply>
<divide />
<apply>
<times />
<ci>J_R</ci>
<apply>
<minus />
<ci>Ca_SR</ci>
<ci>Ca_i</ci>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>J_Roo</ci>
<piecewise>
<piece>
<apply>
<divide />
<apply>
<times />
<ci>J_R</ci>
<apply>
<plus />
<apply>
<minus />
<ci>Ca_SR</ci>
<ci>Ca_i</ci>
</apply>
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<minus />
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus />
<ci>Ca_SR</ci>
<apply>
<times />
<ci>Ca_o</ci>
<apply>
<exp />
<apply>
<minus />
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<minus />
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<gt />
<apply>
<abs />
<ci>FVRT_Ca</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide />
<apply>
<times />
<ci>J_R</ci>
<apply>
<plus />
<apply>
<minus />
<ci>Ca_SR</ci>
<ci>Ca_i</ci>
</apply>
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus />
<ci>Ca_SR</ci>
<apply>
<times />
<ci>Ca_o</ci>
<apply>
<exp />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq />
<ci>J_Loc</ci>
<piecewise>
<piece>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>J_L</ci>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<minus />
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>Ca_o</ci>
<apply>
<exp />
<apply>
<minus />
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
<ci>Ca_i</ci>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<minus />
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<gt />
<apply>
<abs />
<ci>FVRT_Ca</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>J_L</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>Ca_o</ci>
<apply>
<exp />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
<ci>Ca_i</ci>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq />
<ci>J_Loo</ci>
<piecewise>
<piece>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>J_L</ci>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<minus />
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus />
<apply>
<minus />
<apply>
<times />
<ci>Ca_o</ci>
<apply>
<exp />
<apply>
<minus />
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
<ci>Ca_i</ci>
</apply>
<apply>
<times />
<apply>
<divide />
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>Ca_o</ci>
<apply>
<exp />
<apply>
<minus />
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
<ci>Ca_SR</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<gt />
<apply>
<abs />
<ci>FVRT_Ca</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>J_L</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus />
<apply>
<minus />
<apply>
<times />
<ci>Ca_o</ci>
<apply>
<exp />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
<ci>Ca_i</ci>
</apply>
<apply>
<times />
<apply>
<divide />
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>Ca_o</ci>
<apply>
<exp />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
<ci>Ca_SR</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="sodium_current_m_gate" cmeta:id="">
<variable cmeta:id="v168" name="V" public_interface="in" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v168">
<dcterms:description>Voltage potential across the plasma membrane of the cardiomyocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v169" name="time" public_interface="in" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v169">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="tau_m" units="second" />
<variable initial_value="0.004164108" name="m" public_interface="out" units="dimensionless" />
<variable name="m_infinity" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>m_infinity</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">45</cn>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>tau_m</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.00136</cn>
<apply>
<plus />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.32</cn>
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">47.13</cn>
</apply>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
</apply>
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">47.13</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.08</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<minus />
<ci>V</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>m</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>m_infinity</ci>
<ci>m</ci>
</apply>
<ci>tau_m</ci>
</apply>
</apply>
</math>
</component>
<component name="steady_state_outward_K_current_r_ss_gate" cmeta:id="">
<variable name="r_ss_infinity" units="dimensionless" />
<variable initial_value="0.002907171" name="r_ss" public_interface="out" units="dimensionless" />
<variable cmeta:id="v170" name="V" public_interface="in" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v170">
<dcterms:description>Voltage potential across the plasma membrane of the cardiomyocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="tau_r_ss" units="second" />
<variable cmeta:id="v171" name="time" public_interface="in" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v171">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>r_ss_infinity</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.5</cn>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.82</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>tau_r_ss</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">10</cn>
<apply>
<plus />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">45.16</cn>
<apply>
<exp />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.03577</cn>
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">98.9</cn>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
</apply>
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">38</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>r_ss</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>r_ss_infinity</ci>
<ci>r_ss</ci>
</apply>
<ci>tau_r_ss</ci>
</apply>
</apply>
</math>
</component>
<component name="background_currents" cmeta:id="">
<variable cmeta:id="v172" name="E_Na" public_interface="in" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v172">
<dcterms:description>Nernst potential for sodium across the plasma membrane</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v173" name="i_B_Na" public_interface="out" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v173">
<dcterms:description>Current through the background sodium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v174" name="E_K" public_interface="in" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v174">
<dcterms:description>Nernst potential for sodium across the plasma membrane</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v175" name="Ca_i" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v175">
<dcterms:description>Concentration of calcium in bulk cytosol</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v176" name="T" public_interface="in" units="kelvin">
<rdf:RDF>
<rdf:Description rdf:ID="v176">
<dcterms:description>Temperature of the cardiac myocyte and its surrounding environment</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v177" name="i_B_Ca" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v177">
<dcterms:description>Current through the background calcium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.0000324" name="g_B_Ca" units="microS" />
<variable cmeta:id="v178" name="i_B_K" public_interface="out" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v178">
<dcterms:description>Current through the background potassium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="time" public_interface="in" units="second" />
<variable cmeta:id="v179" name="E_Ca" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v179">
<dcterms:description>Nernst potential of calcium across the plasma membrane</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v180" name="R" public_interface="in" units="millijoule_per_mole_kelvin">
<rdf:RDF>
<rdf:Description rdf:ID="v180">
<dcterms:description>Universal gas constant</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00410" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.00008015" name="g_B_Na" units="microS" />
<variable cmeta:id="v181" name="V" public_interface="in" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v181">
<dcterms:description>Voltage potential across the plasma membrane of the cardiomyocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.000138" name="g_B_K" units="microS" />
<variable cmeta:id="v182" name="Ca_o" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v182">
<dcterms:description>Concentration of calcium external to the cardiac myocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v183" name="F" public_interface="in" units="coulomb_per_mole">
<rdf:RDF>
<rdf:Description rdf:ID="v183">
<dcterms:description>Faraday constant</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00089" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v184" name="i_B" public_interface="out" units="nanoA" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>E_Ca</ci>
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5</cn>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln />
<apply>
<divide />
<ci>Ca_o</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>i_B_Na</ci>
<apply>
<times />
<ci>g_B_Na</ci>
<apply>
<minus />
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>i_B_K</ci>
<apply>
<times />
<ci>g_B_K</ci>
<apply>
<minus />
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>i_B</ci>
<apply>
<plus />
<ci>i_B_Na</ci>
<ci>i_B_Ca</ci>
<ci>i_B_K</ci>
</apply>
</apply>
</math>
</component>
<component name="convert_hinch" cmeta:id="">
<variable cmeta:id="v185" name="I_NaCa" public_interface="out" units="uA">
<rdf:RDF>
<rdf:Description rdf:ID="v185">
<dcterms:description>Sodium-calcium exchange current (in uA)</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v186" name="I_pCa" public_interface="out" units="uA">
<rdf:RDF>
<rdf:Description rdf:ID="v186">
<dcterms:description>Sarcolemmal calcium-ATPase flow (in uA)</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v187" name="F" public_interface="in" units="C_per_mole">
<rdf:RDF>
<rdf:Description rdf:ID="v187">
<dcterms:description>Faraday constant</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00089" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v188" name="I_RyR" public_interface="out" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v188">
<dcterms:description>Total whole-cell current through the ryanodine receptors (in uA)</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v189" name="hinch_I_LCC" public_interface="in" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v189">
<dcterms:description>Total whole-cell current through the L-type calcium channels</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v190" name="V_myo" public_interface="in" units="um3">
<rdf:RDF>
<rdf:Description rdf:ID="v190">
<dcterms:description>Volume of myoplasm</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v191" name="hinch_I_CaB" public_interface="in" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v191">
<dcterms:description>Sarcolemmal calcium leak current</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v192" name="I_LCC" public_interface="out" units="uA">
<rdf:RDF>
<rdf:Description rdf:ID="v192">
<dcterms:description>Total whole-cell current through the L-type calcium channels (in uA)</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v193" name="hinch_I_NaCa" public_interface="in" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v193">
<dcterms:description>Sodium-calcium exchange current</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v194" name="I_CaB" public_interface="out" units="uA">
<rdf:RDF>
<rdf:Description rdf:ID="v194">
<dcterms:description>Sarcolemmal calcium leak current (in uA)</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v195" name="hinch_I_RyR" public_interface="in" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v195">
<dcterms:description>Total whole-cell current through the ryanodine receptors</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v196" name="hinch_I_pCa" public_interface="in" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v196">
<dcterms:description>Sarcolemmal calcium-ATPase flow</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>I_LCC</ci>
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
</apply>
<ci>hinch_I_LCC</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq />
<ci>I_NaCa</ci>
<apply>
<times />
<ci>hinch_I_NaCa</ci>
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq />
<ci>I_pCa</ci>
<apply>
<times />
<ci>hinch_I_pCa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq />
<ci>I_CaB</ci>
<apply>
<times />
<apply>
<minus />
<ci>hinch_I_CaB</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq />
<ci>I_RyR</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
<ci>hinch_I_RyR</ci>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel" cmeta:id="">
<variable name="f_12" private_interface="in" units="dimensionless" />
<variable cmeta:id="v197" name="V" public_interface="in" private_interface="out" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v197">
<dcterms:description>Voltage potential across the plasma membrane of the cardiomyocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v198" name="i_Ca_L" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v198">
<dcterms:description>Current through L-type calcium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v199" name="Ca_ss" public_interface="in" private_interface="out" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v199">
<dcterms:description>Calcium concentration in diadic space</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="d" private_interface="in" units="dimensionless" />
<variable cmeta:id="v200" name="time" public_interface="in" private_interface="out" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v200">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="f_11" private_interface="in" units="dimensionless" />
<variable initial_value="65" name="E_Ca_L" units="millivolt" />
<variable name="Ca_inact" private_interface="in" units="dimensionless" />
<variable initial_value="0.031" name="g_Ca_L" units="microS" />
<math xmlns="http://www.w3.org/1998/Math/MathML" />
</component>
<component name="membrane_hinch" cmeta:id="">
<variable cmeta:id="v201" name="FVRT" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v201">
<dcterms:description>Convenience variable that is equal to F*V/(R*T)</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v202" name="time" public_interface="in" units="ms">
<rdf:RDF>
<rdf:Description rdf:ID="v202">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v203" initial_value="8314.5" name="R" public_interface="out" units="mJ_per_mole_K">
<rdf:RDF>
<rdf:Description rdf:ID="v203">
<dcterms:description>Universal gas constant</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00410" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="membrane_V" name="V" public_interface="in" units="mV">
<rdf:RDF>
<rdf:Description rdf:ID="membrane_V">
<dcterms:description>Voltage across cell membrane</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v204" initial_value="96487" name="F" public_interface="out" units="C_per_mole">
<rdf:RDF>
<rdf:Description rdf:ID="v204">
<dcterms:description>Faraday constant</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00089" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v205" initial_value="295" name="T" public_interface="out" units="kelvin">
<rdf:RDF>
<rdf:Description rdf:ID="v205">
<dcterms:description>Ambient temperature</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v206" name="FVRT_Ca" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v206">
<dcterms:description>Convenience variable that is equal to (F*V/(R*T))*2. Also equivalent to [greek delta]*V in the source manuscript</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>FVRT</ci>
<apply>
<divide />
<apply>
<times />
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>FVRT_Ca</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>FVRT</ci>
</apply>
</apply>
</math>
</component>
<component name="DS_Calcium_Concentrations" cmeta:id="">
<variable cmeta:id="v207" name="Ca_SR" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v207">
<dcterms:description>Calcium (2+) concentration in sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v208" name="C_oc" public_interface="out" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v208">
<dcterms:description>Concentration of calcium (2+) in the dyadic space when the L-type calcium channel state is open and the ryanodine receptor state is closed</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v209" name="g_D" public_interface="in" units="um3_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v209">
<dcterms:description>Calcium (2+) flux rate from dyadic space to cytosol</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v210" name="Ca_o" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v210">
<dcterms:description>Extracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v211" name="FVRT_Ca" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v211">
<dcterms:description>Convenience variable that is equal to (F*V/(R*T))*2. Also equivalent to [greek delta]*V in the source manuscript</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v212" name="J_R" public_interface="in" units="um3_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v212">
<dcterms:description>Permeability of a single ryanodine receptor</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v213" name="Ca_i" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v213">
<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v214" name="J_L" public_interface="in" units="um3_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v214">
<dcterms:description>Permeability of a single L-type calcium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v215" name="C_oo" public_interface="out" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v215">
<dcterms:description>Concentration of calcium (2+) in the dyadic space when the L-type calcium channel state is open and the ryanodine receptor state is open</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v216" name="C_cc" public_interface="out" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v216">
<dcterms:description>Concentration of calcium (2+) in dyadic space when both L-type calcium channel and ryanodine receptor states are closed</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v217" name="C_co" public_interface="out" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v217">
<dcterms:description>Concentration of calcium (2+) in dyadic space when L-type calcium channel state is closed and when ryanodine receptor state is open</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>C_cc</ci>
<ci>Ca_i</ci>
</apply>
<apply>
<eq />
<ci>C_co</ci>
<apply>
<divide />
<apply>
<plus />
<ci>Ca_i</ci>
<apply>
<times />
<apply>
<divide />
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<ci>Ca_SR</ci>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>C_oc</ci>
<piecewise>
<piece>
<apply>
<divide />
<apply>
<plus />
<ci>Ca_i</ci>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>Ca_o</ci>
<ci>FVRT_Ca</ci>
<apply>
<exp />
<apply>
<minus />
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<minus />
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<minus />
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<gt />
<apply>
<abs />
<ci>FVRT_Ca</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.000000001</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide />
<apply>
<plus />
<ci>Ca_i</ci>
<apply>
<times />
<apply>
<divide />
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>Ca_o</ci>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq />
<ci>C_oo</ci>
<piecewise>
<piece>
<apply>
<divide />
<apply>
<plus />
<ci>Ca_i</ci>
<apply>
<times />
<apply>
<divide />
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<ci>Ca_SR</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>Ca_o</ci>
<ci>FVRT_Ca</ci>
<apply>
<exp />
<apply>
<minus />
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<minus />
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<minus />
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<gt />
<apply>
<abs />
<ci>FVRT_Ca</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.000000001</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide />
<apply>
<plus />
<ci>Ca_i</ci>
<apply>
<times />
<apply>
<divide />
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<ci>Ca_SR</ci>
</apply>
<apply>
<times />
<apply>
<divide />
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>Ca_o</ci>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<apply>
<divide />
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_Ca_inact_gate" cmeta:id="">
<variable initial_value="0.009" name="tau_Ca_inact" units="second" />
<variable cmeta:id="v218" name="Ca_ss" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v218">
<dcterms:description>Calcium concentration in diadic space</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.9913102" name="Ca_inact" public_interface="out" units="dimensionless" />
<variable cmeta:id="v219" name="V" public_interface="in" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v219">
<dcterms:description>Voltage potential across the plasma membrane of the cardiomyocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v220" name="time" public_interface="in" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v220">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="Ca_inact_infinity" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>Ca_inact_infinity</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<ci>Ca_ss</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.01</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_inact</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>Ca_inact_infinity</ci>
<ci>Ca_inact</ci>
</apply>
<ci>tau_Ca_inact</ci>
</apply>
</apply>
</math>
</component>
<component name="hyperpolarisation_activated_current" cmeta:id="">
<variable cmeta:id="v221" name="i_f_Na" public_interface="out" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v221">
<dcterms:description>Sodium current through the hyperpolarization activated channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v222" name="E_K" public_interface="in" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v222">
<dcterms:description>Nernst potential for sodium across the plasma membrane</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v223" name="i_f" public_interface="out" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v223">
<dcterms:description>Total current through the hyperpolarization activated channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v224" name="time" public_interface="in" private_interface="out" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v224">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v225" name="i_f_K" public_interface="out" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v225">
<dcterms:description>Potassium current through the hyperpolarization activated channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="y" private_interface="in" units="dimensionless" />
<variable name="f_K" units="dimensionless" />
<variable initial_value="0.2" name="f_Na" units="dimensionless" />
<variable initial_value="0.00145" name="g_f" units="microS" />
<variable cmeta:id="v226" name="E_Na" public_interface="in" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v226">
<dcterms:description>Nernst potential for sodium across the plasma membrane</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v227" name="V" public_interface="in" private_interface="out" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v227">
<dcterms:description>Voltage potential across the plasma membrane of the cardiomyocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>f_K</ci>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>f_Na</ci>
</apply>
</apply>
<apply>
<eq />
<ci>i_f_Na</ci>
<apply>
<times />
<ci>g_f</ci>
<ci>y</ci>
<ci>f_Na</ci>
<apply>
<minus />
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>i_f_K</ci>
<apply>
<times />
<ci>g_f</ci>
<ci>y</ci>
<ci>f_K</ci>
<apply>
<minus />
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>i_f</ci>
<apply>
<plus />
<ci>i_f_Na</ci>
<ci>i_f_K</ci>
</apply>
</apply>
</math>
</component>
<component name="environment" cmeta:id="">
<variable cmeta:id="v228" name="time" public_interface="out" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v228">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
</component>
<component name="LCC_current" cmeta:id="">
<variable cmeta:id="v229" name="alpha_m" public_interface="in" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v229">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v230" name="J_Loo" public_interface="in" units="um3_mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v230">
<dcterms:description>Current through the L-type calcium channel when both the L-type calcium channel and ryanodine receptor are in the open state</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v231" name="J_Loc" public_interface="in" units="um3_mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v231">
<dcterms:description>Current through the L-type calcium channel when L-type calcium channel state is open and ryanodine receptor state is closed</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v232" name="z_2" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v232">
<dcterms:description>State 2 of calcium release channel: z2 = yoi union yci</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v233" name="z_1" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v233">
<dcterms:description>State 1 of calcium release unit: z1 = ycc union yco union yoc union yoo</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v234" name="alpha_p" public_interface="in" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v234">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v235" name="y_oc" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v235">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the open state and the ryanodine receptor is in the closed state</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v236" name="J_L1" public_interface="out" units="um3_mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v236">
<dcterms:description>Convenience term for expressing equation for I_LCC?</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v237" name="y_oo" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v237">
<dcterms:description>The state of the calcium (2+) release unit when both the L-type calcium channel and the ryanodine receptor are in the open state</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v238" name="N" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v238">
<dcterms:description>Number of calcium release units</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v239" name="J_L2" public_interface="out" units="um3_mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v239">
<dcterms:description>Convenience term for expressing equation for I_LCC?</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="LCC_current_I_LCC" name="I_LCC" public_interface="out" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="LCC_current_I_LCC">
<dcterms:description>Total whole-cell current through the L-type calcium channels</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v240" name="V_myo" public_interface="in" units="um3">
<rdf:RDF>
<rdf:Description rdf:ID="v240">
<dcterms:description>Volume of myoplasm</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>J_L1</ci>
<apply>
<plus />
<apply>
<times />
<ci>J_Loo</ci>
<ci>y_oo</ci>
</apply>
<apply>
<times />
<ci>J_Loc</ci>
<ci>y_oc</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>J_L2</ci>
<apply>
<divide />
<apply>
<times />
<ci>J_Loc</ci>
<ci>alpha_p</ci>
</apply>
<apply>
<plus />
<ci>alpha_p</ci>
<ci>alpha_m</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>I_LCC</ci>
<apply>
<divide />
<apply>
<times />
<apply>
<plus />
<apply>
<times />
<ci>z_1</ci>
<ci>J_L1</ci>
</apply>
<apply>
<times />
<ci>z_2</ci>
<ci>J_L2</ci>
</apply>
</apply>
<ci>N</ci>
</apply>
<ci>V_myo</ci>
</apply>
</apply>
</math>
</component>
<component name="Ca_independent_transient_outward_K_current_r_gate" cmeta:id="">
<variable initial_value="0.002191519" name="r" public_interface="out" units="dimensionless" />
<variable name="tau_r" units="second" />
<variable name="r_infinity" units="dimensionless" />
<variable cmeta:id="v241" name="V" public_interface="in" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v241">
<dcterms:description>Voltage potential across the plasma membrane of the cardiomyocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v242" name="time" public_interface="in" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v242">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>r_infinity</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.6</cn>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.42</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>tau_r</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">1</cn>
<apply>
<plus />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">45.16</cn>
<apply>
<exp />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.03577</cn>
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">98.9</cn>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
</apply>
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">38</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>r</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>r_infinity</ci>
<ci>r</ci>
</apply>
<ci>tau_r</ci>
</apply>
</apply>
</math>
</component>
<component name="steady_state_outward_K_current_s_ss_gate" cmeta:id="">
<variable name="s_ss_infinity" units="dimensionless" />
<variable name="tau_s_ss" units="second" />
<variable cmeta:id="v243" name="V" public_interface="in" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v243">
<dcterms:description>Voltage potential across the plasma membrane of the cardiomyocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v244" name="time" public_interface="in" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v244">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.3142767" name="s_ss" public_interface="out" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>s_ss_infinity</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">87.5</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>tau_s_ss</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">2.1</cn>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>s_ss</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>s_ss_infinity</ci>
<ci>s_ss</ci>
</apply>
<ci>tau_s_ss</ci>
</apply>
</apply>
</math>
</component>
<component name="SERCA2a_pump" cmeta:id="">
<variable initial_value="0.04" name="Vmaxf" units="millimolar_per_second" />
<variable initial_value="1" name="K_SR" units="dimensionless" />
<variable cmeta:id="v245" name="Ca_i" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v245">
<dcterms:description>Concentration of calcium in bulk cytosol</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="1.2" name="N_fb" units="dimensionless" />
<variable cmeta:id="v246" name="Ca_NSR" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v246">
<dcterms:description>Calcium concentration in the network regions of the sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="rb" units="dimensionless" />
<variable cmeta:id="v247" name="J_up" public_interface="out" units="millimolar_per_second">
<rdf:RDF>
<rdf:Description rdf:ID="v247">
<dcterms:description>Calcium flux through the sarcoplasmic reticulum calcium pump (SERCA2a)</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v248" initial_value="0.000168" name="K_fb" units="millimolar" />
<variable cmeta:id="v249" name="time" public_interface="in" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v249">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="1" name="N_rb" units="dimensionless" />
<variable initial_value="0.9" name="Vmaxr" units="millimolar_per_second" />
<variable cmeta:id="v250" initial_value="3.29" name="K_rb" units="millimolar" />
<variable name="fb" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>fb</ci>
<apply>
<power />
<apply>
<divide />
<ci>Ca_i</ci>
<ci>K_fb</ci>
</apply>
<ci>N_fb</ci>
</apply>
</apply>
<apply>
<eq />
<ci>rb</ci>
<apply>
<power />
<apply>
<divide />
<ci>Ca_NSR</ci>
<ci>K_rb</ci>
</apply>
<ci>N_rb</ci>
</apply>
</apply>
<apply>
<eq />
<ci>J_up</ci>
<apply>
<divide />
<apply>
<times />
<ci>K_SR</ci>
<apply>
<minus />
<apply>
<times />
<ci>Vmaxf</ci>
<ci>fb</ci>
</apply>
<apply>
<times />
<ci>Vmaxr</ci>
<ci>rb</ci>
</apply>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>fb</ci>
<ci>rb</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="length_independent_tension" cmeta:id="">
<variable cmeta:id="v251" name="z" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v251">
<dcterms:description>The fraction of actin sites available for crossbridge binding</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v252" name="z_max" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v252">
<dcterms:description>The fraction of actin sites available at full activation</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v253" name="T_Base" public_interface="out" units="N_per_mm2">
<rdf:RDF>
<rdf:Description rdf:ID="v253">
<dcterms:description>Isometric tension of cell</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v254" initial_value="56.2" name="T_ref" public_interface="out" units="N_per_mm2">
<rdf:RDF>
<rdf:Description rdf:ID="v254">
<dcterms:description>Maximum tension at resting sarcomere length</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>T_Base</ci>
<apply>
<divide />
<apply>
<times />
<ci>T_ref</ci>
<ci>z</ci>
</apply>
<ci>z_max</ci>
</apply>
</apply>
</math>
</component>
<component name="extracellular_ion_concentrations" cmeta:id="">
<variable cmeta:id="v255" name="Ca_o" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v255">
<dcterms:description>Extracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v256" name="Na_o" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v256">
<dcterms:description>Extracellular sodium (1+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
</component>
<component name="SR_Ca_release_channel" cmeta:id="">
<variable initial_value="0.0004327548" name="P_O1" units="dimensionless" />
<variable cmeta:id="v257" name="time" public_interface="in" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v257">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="576" name="k_a_minus" units="per_second" />
<variable initial_value="0.6348229" name="P_C1" units="dimensionless" />
<variable cmeta:id="v258" name="Ca_JSR" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v258">
<dcterms:description>Calcium concentration of fluid inside the junctional region of the sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v259" name="Ca_ss" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v259">
<dcterms:description>Calcium concentration in diadic space</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.8" name="k_c_minus" units="per_second" />
<variable initial_value="4" name="n" units="dimensionless" />
<variable initial_value="1.8e3" name="v1" units="per_second" />
<variable initial_value="3" name="m" units="dimensionless" />
<variable initial_value="0.000000000606254" name="P_O2" units="dimensionless" />
<variable initial_value="1930" name="k_b_minus" units="per_second" />
<variable initial_value="100" name="k_c_plus" units="per_second" />
<variable initial_value="12.15e12" name="k_a_plus" units="millimolar4_per_second" />
<variable initial_value="0.3647471" name="P_C2" units="dimensionless" />
<variable cmeta:id="v260" name="J_rel" public_interface="out" units="millimolar_per_second">
<rdf:RDF>
<rdf:Description rdf:ID="v260">
<dcterms:description>Calcium flux through sarcoplasmic reticulum RyR receptor</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="4.05e9" name="k_b_plus" units="millimolar3_per_second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>P_C1</ci>
</apply>
<apply>
<plus />
<apply>
<times />
<apply>
<minus />
<ci>k_a_plus</ci>
</apply>
<apply>
<power />
<ci>Ca_ss</ci>
<ci>n</ci>
</apply>
<ci>P_C1</ci>
</apply>
<apply>
<times />
<ci>k_a_minus</ci>
<ci>P_O1</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>P_O1</ci>
</apply>
<apply>
<plus />
<apply>
<minus />
<apply>
<times />
<ci>k_a_plus</ci>
<apply>
<power />
<ci>Ca_ss</ci>
<ci>n</ci>
</apply>
<ci>P_C1</ci>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>k_a_minus</ci>
<ci>P_O1</ci>
</apply>
<apply>
<times />
<ci>k_b_plus</ci>
<apply>
<power />
<ci>Ca_ss</ci>
<ci>m</ci>
</apply>
<ci>P_O1</ci>
</apply>
<apply>
<times />
<ci>k_c_plus</ci>
<ci>P_O1</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>k_b_minus</ci>
<ci>P_O2</ci>
</apply>
<apply>
<times />
<ci>k_c_minus</ci>
<ci>P_C2</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>P_O2</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>k_b_plus</ci>
<apply>
<power />
<ci>Ca_ss</ci>
<ci>m</ci>
</apply>
<ci>P_O1</ci>
</apply>
<apply>
<times />
<ci>k_b_minus</ci>
<ci>P_O2</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>P_C2</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>k_c_plus</ci>
<ci>P_O1</ci>
</apply>
<apply>
<times />
<ci>k_c_minus</ci>
<ci>P_C2</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>J_rel</ci>
<apply>
<times />
<ci>v1</ci>
<apply>
<plus />
<ci>P_O1</ci>
<ci>P_O2</ci>
</apply>
<apply>
<minus />
<ci>Ca_JSR</ci>
<ci>Ca_ss</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="isometric_tension" cmeta:id="">
<variable cmeta:id="isometric_tension_T0" name="T_0" public_interface="out" units="N_per_mm2">
<rdf:RDF>
<rdf:Description rdf:ID="isometric_tension_T0">
<dcterms:description>The isometric tension at a given intracellular calcium ion concentration and sarcomere length</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="overlap" public_interface="in" units="dimensionless" />
<variable cmeta:id="v261" name="T_Base" public_interface="in" units="N_per_mm2">
<rdf:RDF>
<rdf:Description rdf:ID="v261">
<dcterms:description>Isometric tension of cell</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>T_0</ci>
<apply>
<times />
<ci>T_Base</ci>
<ci>overlap</ci>
</apply>
</apply>
</math>
</component>
<component name="CaRU_Transitions" cmeta:id="">
<variable cmeta:id="v262" initial_value="-2" name="V_L" units="mV">
<rdf:RDF>
<rdf:Description rdf:ID="v262">
<dcterms:description>Potential when half LCC open</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v263" name="beta_poc" public_interface="out" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v263">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor when L-type calcium channel is open and ryanodine receptor is closed</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v264" initial_value="0.01" name="c" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v264">
<dcterms:description>Biasing to make inactivation a function of calcium 2+ in the dyadic space</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v265" initial_value="14" name="b" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v265">
<dcterms:description>Biasing to make inactivation a function of membrane voltage</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v266" initial_value="41e-3" name="K_RyR" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v266">
<dcterms:description>Half concentration of activation for ryanodine receptors</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v267" initial_value="0.0625" name="a" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v267">
<dcterms:description>Biasing to make inactivation a function of membrane voltage</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v268" name="epsilon_pcc" public_interface="out" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v268">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v269" name="epsilon_m" public_interface="out" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v269">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v270" initial_value="0.22e-3" name="K_L" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v270">
<dcterms:description>Concentration of L-type calcium channels at inactivation</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v271" initial_value="0.05" name="phi_R" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v271">
<dcterms:description>Proportion of time closed in open mode for L-type calcium channels</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v272" name="mu_moc" public_interface="out" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v272">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v273" name="beta_pcc" public_interface="out" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v273">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor when both the L-type calcium channel and ryanodine receptor are closed</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v274" name="alpha_m" public_interface="out" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v274">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v275" name="beta_m" public_interface="out" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v275">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v276" name="mu_mcc" public_interface="out" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v276">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v277" initial_value="2.43" name="tau_R" units="ms">
<rdf:RDF>
<rdf:Description rdf:ID="v277">
<dcterms:description>Inactivation time for ryanodine receptors</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v278" name="expVL" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v278">
<dcterms:description>Convenience variable that is equal to exp((V-V_L)/del_VL)</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v279" name="epsilon_pco" public_interface="out" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v279">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v280" name="C_oc" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v280">
<dcterms:description>Concentration of calcium (2+) in the dyadic space when the L-type calcium channel state is open and the ryanodine receptor state is closed</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v281" name="alpha_p" public_interface="out" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v281">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v282" initial_value="2.35" name="phi_L" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v282">
<dcterms:description>Proportion of time closed in open mode for L-type calcium channels</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v283" initial_value="0.012" name="theta_R" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v283">
<dcterms:description>Reciprocal of proportion of time inactivated (closed) in open mode for ryanodine receptors</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v284" name="V" public_interface="in" units="mV">
<rdf:RDF>
<rdf:Description rdf:ID="v284">
<dcterms:description>Voltage across cell membrane</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v285" name="mu_poc" public_interface="out" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v285">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v286" initial_value="7" name="del_VL" units="mV">
<rdf:RDF>
<rdf:Description rdf:ID="v286">
<dcterms:description>Width of opening potentials of L-type calcium channels</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v287" initial_value="100" name="d" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v287">
<dcterms:description>Biasing to make inactivation a function of calcium 2+ in the dyadic space</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v288" name="Ca_i" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v288">
<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v289" name="t_R" units="ms">
<rdf:RDF>
<rdf:Description rdf:ID="v289">
<dcterms:description>Time switching between closed and open states for ryanodine receptors</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v290" name="mu_pcc" public_interface="out" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v290">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v291" initial_value="650" name="tau_L" units="ms">
<rdf:RDF>
<rdf:Description rdf:ID="v291">
<dcterms:description>Inactivation time for L-type calcium channels</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v292" name="C_co" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v292">
<dcterms:description>Concentration of calcium (2+) in dyadic space when L-type calcium channel state is closed and when ryanodine receptor state is open</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v293" initial_value="1" name="t_L" units="ms">
<rdf:RDF>
<rdf:Description rdf:ID="v293">
<dcterms:description>Time switching between closed and open states for L-type calcium channels</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>expVL</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<minus />
<ci>V</ci>
<ci>V_L</ci>
</apply>
<ci>del_VL</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>t_R</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.17</cn>
<ci>t_L</ci>
</apply>
</apply>
<apply>
<eq />
<ci>alpha_p</ci>
<apply>
<divide />
<ci>expVL</ci>
<apply>
<times />
<ci>t_L</ci>
<apply>
<plus />
<ci>expVL</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>alpha_m</ci>
<apply>
<divide />
<ci>phi_L</ci>
<ci>t_L</ci>
</apply>
</apply>
<apply>
<eq />
<ci>beta_poc</ci>
<apply>
<divide />
<apply>
<power />
<ci>C_oc</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times />
<ci>t_R</ci>
<apply>
<plus />
<apply>
<power />
<ci>C_oc</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power />
<ci>K_RyR</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>beta_pcc</ci>
<apply>
<divide />
<apply>
<power />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times />
<ci>t_R</ci>
<apply>
<plus />
<apply>
<power />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power />
<ci>K_RyR</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>beta_m</ci>
<apply>
<divide />
<ci>phi_R</ci>
<ci>t_R</ci>
</apply>
</apply>
<apply>
<eq />
<ci>epsilon_pco</ci>
<apply>
<divide />
<apply>
<times />
<ci>C_co</ci>
<apply>
<plus />
<ci>expVL</ci>
<ci>a</ci>
</apply>
</apply>
<apply>
<times />
<ci>tau_L</ci>
<ci>K_L</ci>
<apply>
<plus />
<ci>expVL</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>epsilon_pcc</ci>
<apply>
<divide />
<apply>
<times />
<ci>Ca_i</ci>
<apply>
<plus />
<ci>expVL</ci>
<ci>a</ci>
</apply>
</apply>
<apply>
<times />
<ci>tau_L</ci>
<ci>K_L</ci>
<apply>
<plus />
<ci>expVL</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>epsilon_m</ci>
<apply>
<divide />
<apply>
<times />
<ci>b</ci>
<apply>
<plus />
<ci>expVL</ci>
<ci>a</ci>
</apply>
</apply>
<apply>
<times />
<ci>tau_L</ci>
<apply>
<plus />
<apply>
<times />
<ci>b</ci>
<ci>expVL</ci>
</apply>
<ci>a</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>mu_poc</ci>
<apply>
<divide />
<apply>
<plus />
<apply>
<power />
<ci>C_oc</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times />
<ci>c</ci>
<apply>
<power />
<ci>K_RyR</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>tau_R</ci>
<apply>
<plus />
<apply>
<power />
<ci>C_oc</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power />
<ci>K_RyR</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>mu_pcc</ci>
<apply>
<divide />
<apply>
<plus />
<apply>
<power />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times />
<ci>c</ci>
<apply>
<power />
<ci>K_RyR</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>tau_R</ci>
<apply>
<plus />
<apply>
<power />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power />
<ci>K_RyR</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>mu_moc</ci>
<apply>
<divide />
<apply>
<times />
<ci>theta_R</ci>
<ci>d</ci>
<apply>
<plus />
<apply>
<power />
<ci>C_oc</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times />
<ci>c</ci>
<apply>
<power />
<ci>K_RyR</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>tau_R</ci>
<apply>
<plus />
<apply>
<times />
<ci>d</ci>
<apply>
<power />
<ci>C_oc</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times />
<ci>c</ci>
<apply>
<power />
<ci>K_RyR</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>mu_mcc</ci>
<apply>
<divide />
<apply>
<times />
<ci>theta_R</ci>
<ci>d</ci>
<apply>
<plus />
<apply>
<power />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times />
<ci>c</ci>
<apply>
<power />
<ci>K_RyR</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>tau_R</ci>
<apply>
<plus />
<apply>
<times />
<ci>d</ci>
<apply>
<power />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times />
<ci>c</ci>
<apply>
<power />
<ci>K_RyR</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="membrane" cmeta:id="">
<variable cmeta:id="v294" name="i_ss" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v294">
<dcterms:description>Current through the steady-state outward potassium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v295" name="i_t" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v295">
<dcterms:description>Current through the transient outward potassium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v296" name="i_Ca_P" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v296">
<dcterms:description>Current through the sarcolemmal calcium pump</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v297" name="i_K1" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v297">
<dcterms:description>Current through the inward rectifier potassium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v298" name="i_f" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v298">
<dcterms:description>Total current through the hyperpolarization activated channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v299" name="time" public_interface="in" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v299">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="-0.6" name="stim_amplitude" units="nanoA" />
<variable cmeta:id="v300" name="F" public_interface="in" units="coulomb_per_mole">
<rdf:RDF>
<rdf:Description rdf:ID="v300">
<dcterms:description>Faraday constant</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00089" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.0001" name="Cm" units="microF" />
<variable cmeta:id="v301" name="R" public_interface="in" units="millijoule_per_mole_kelvin">
<rdf:RDF>
<rdf:Description rdf:ID="v301">
<dcterms:description>Universal gas constant</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00410" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.005" name="stim_duration" units="second" />
<variable name="i_B" public_interface="in" units="nanoA" />
<variable cmeta:id="v302" name="i_NaCa" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v302">
<dcterms:description>Current through the sodium/calcium exchanger</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v303" name="T" public_interface="in" units="kelvin">
<rdf:RDF>
<rdf:Description rdf:ID="v303">
<dcterms:description>Temperature of the cardiac myocyte and its surrounding environment</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="i_Stim" units="nanoA" />
<variable initial_value="1" name="stim_start" units="second" />
<variable initial_value="1" name="stim_period" units="second" />
<variable cmeta:id="v304" initial_value="-80.50146" name="V" public_interface="out" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v304">
<dcterms:description>Voltage potential across the plasma membrane of the cardiomyocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="10" name="stim_end" units="second" />
<variable cmeta:id="v305" name="i_Na" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v305">
<dcterms:description>Current through fast sodium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v306" name="i_Ca_L" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v306">
<dcterms:description>Current through L-type calcium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v307" name="i_NaK" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v307">
<dcterms:description>Current through the sodium/potassium pump</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>i_Stim</ci>
<piecewise>
<piece>
<ci>stim_amplitude</ci>
<apply>
<and />
<apply>
<geq />
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<apply>
<leq />
<ci>time</ci>
<ci>stim_end</ci>
</apply>
<apply>
<leq />
<apply>
<minus />
<apply>
<minus />
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<apply>
<times />
<apply>
<floor />
<apply>
<divide />
<apply>
<minus />
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_duration</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="nanoA">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>V</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<apply>
<plus />
<ci>i_Na</ci>
<ci>i_Ca_L</ci>
<ci>i_t</ci>
<ci>i_ss</ci>
<ci>i_f</ci>
<ci>i_K1</ci>
<ci>i_B</ci>
<ci>i_NaK</ci>
<ci>i_NaCa</ci>
<ci>i_Ca_P</ci>
<ci>i_Stim</ci>
</apply>
</apply>
<ci>Cm</ci>
</apply>
</apply>
</math>
</component>
<component name="sarcolemmal_calcium_pump_current" cmeta:id="">
<variable cmeta:id="v308" name="Ca_i" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v308">
<dcterms:description>Concentration of calcium in bulk cytosol</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v309" name="i_Ca_P" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v309">
<dcterms:description>Current through the sarcolemmal calcium pump</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v310" name="time" public_interface="in" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v310">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.004" name="i_Ca_P_max" units="nanoA" />
<math xmlns="http://www.w3.org/1998/Math/MathML" />
</component>
<component name="standard_ionic_concentrations" cmeta:id="">
<variable cmeta:id="v311" initial_value="140" name="Na_o" public_interface="out" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v311">
<dcterms:description>Concentration of sodium external to the cardiac myocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v312" initial_value="5.4" name="K_o" public_interface="out" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v312">
<dcterms:description>Concentration of potassium external to the cardiac myocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v313" initial_value="1.2" name="Ca_o" public_interface="out" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v313">
<dcterms:description>Concentration of calcium external to the cardiac myocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
</component>
<component name="L_type_Ca_channel_d_gate" cmeta:id="">
<variable cmeta:id="v314" name="time" public_interface="in" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v314">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="tau_d" units="second" />
<variable cmeta:id="v315" name="V" public_interface="in" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v315">
<dcterms:description>Voltage potential across the plasma membrane of the cardiomyocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="d_infinity" units="dimensionless" />
<variable initial_value="0.000002171081" name="d" public_interface="out" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>d_infinity</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15.3</cn>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>tau_d</ci>
<apply>
<plus />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.00305</cn>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt2">0.0045</cn>
</apply>
<apply>
<power />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.00105</cn>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt2">0.002</cn>
</apply>
<apply>
<power />
<apply>
<minus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">18</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.00025</cn>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>d</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>d_infinity</ci>
<ci>d</ci>
</apply>
<ci>tau_d</ci>
</apply>
</apply>
</math>
</component>
<component name="intracellular_ion_concentrations" cmeta:id="">
<variable cmeta:id="v316" initial_value="139.2751" name="K_i" public_interface="out" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v316">
<dcterms:description>Concentration of potassium in bulk cytosol</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v317" initial_value="0.06600742" name="Ca_NSR" public_interface="out" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v317">
<dcterms:description>Calcium concentration in the network regions of the sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v318" name="time" public_interface="in" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v318">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v319" name="J_xfer" public_interface="in" units="millimolar_per_second">
<rdf:RDF>
<rdf:Description rdf:ID="v319">
<dcterms:description>Calcium flux between the diadic subspace and blulk cytosol</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v320" name="i_B_K" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v320">
<dcterms:description>Current through the background potassium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v321" name="i_K1" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v321">
<dcterms:description>Current through the inward rectifier potassium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v322" initial_value="0.000000504" name="V_NSR" units="micro_litre">
<rdf:RDF>
<rdf:Description rdf:ID="v322">
<dcterms:description>Volume of matrix of network sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v323" initial_value="0.0000000012" name="V_SS" units="micro_litre">
<rdf:RDF>
<rdf:Description rdf:ID="v323">
<dcterms:description>Volume of cytosol of the diadic space</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v324" initial_value="0.06607948" name="Ca_JSR" public_interface="out" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v324">
<dcterms:description>Calcium concentration of fluid inside the junctional region of the sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v325" initial_value="0.00238" name="K_mCMDN" units="millimolar" />
<variable cmeta:id="v326" initial_value="10" name="EGTA_tot" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v326">
<dcterms:description>Total concentration of EGTA in cytosol</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v327" name="i_B_Ca" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v327">
<dcterms:description>Current through the background calcium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v328" initial_value="0.8" name="K_mCSQN" units="millimolar" />
<variable cmeta:id="v329" name="J_trpn" public_interface="in" units="millimolar_per_second">
<rdf:RDF>
<rdf:Description rdf:ID="v329">
<dcterms:description>Flux of calcium binding to both low and high affinity sites on troponin C</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v330" name="V_myo" public_interface="in" units="micro_litre">
<rdf:RDF>
<rdf:Description rdf:ID="v330">
<dcterms:description>Volume of cytsol on cardiac myocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v331" name="i_ss" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v331">
<dcterms:description>Current through the steady-state outward potassium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v332" name="i_Ca_P" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v332">
<dcterms:description>Current through the sarcolemmal calcium pump</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v333" name="i_f_Na" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v333">
<dcterms:description>Sodium current through the hyperpolarization activated channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v334" initial_value="10.73519" name="Na_i" public_interface="out" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v334">
<dcterms:description>Concentration of sodium in bulk cytosol</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v335" name="J_tr" public_interface="in" units="millimolar_per_second">
<rdf:RDF>
<rdf:Description rdf:ID="v335">
<dcterms:description>Calcium flux between junctional and network sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v336" initial_value="0.00008737212" name="Ca_ss" public_interface="out" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v336">
<dcterms:description>Calcium concentration in diadic space</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v337" name="i_Ca_L" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v337">
<dcterms:description>Current through L-type calcium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v338" name="i_t" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v338">
<dcterms:description>Current through the transient outward potassium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v339" name="i_f_K" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v339">
<dcterms:description>Potassium current through the hyperpolarization activated channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v340" name="i_NaK" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v340">
<dcterms:description>Current through the sodium/potassium pump</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v341" name="F" public_interface="in" units="coulomb_per_mole">
<rdf:RDF>
<rdf:Description rdf:ID="v341">
<dcterms:description>Faraday constant</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00089" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v342" name="J_rel" public_interface="in" units="millimolar_per_second">
<rdf:RDF>
<rdf:Description rdf:ID="v342">
<dcterms:description>Calcium flux through sarcoplasmic reticulum RyR receptor</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v343" initial_value="15" name="CSQN_tot" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v343">
<dcterms:description>Total concentration of calmodulin in junctional sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v344" initial_value="0.00015" name="K_mEGTA" units="millimolar" />
<variable cmeta:id="v345" name="i_NaCa" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v345">
<dcterms:description>Current through the sodium/calcium exchanger</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="beta_SS" units="dimensionless" />
<variable name="beta_JSR" units="dimensionless" />
<variable cmeta:id="v346" name="J_up" public_interface="in" units="millimolar_per_second">
<rdf:RDF>
<rdf:Description rdf:ID="v346">
<dcterms:description>Calcium flux through the sarcoplasmic reticulum calcium pump (SERCA2a)</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v347" initial_value="0.05" name="CMDN_tot" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v347">
<dcterms:description>Total concentration of calmodulin in cytosol</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v348" name="Ca_i" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v348">
<dcterms:description>Concentration of calcium in bulk cytosol</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v349" name="i_Na" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v349">
<dcterms:description>Current through fast sodium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v350" initial_value="0.000000056" name="V_JSR" units="micro_litre">
<rdf:RDF>
<rdf:Description rdf:ID="v350">
<dcterms:description>Volume of matrix of junctional sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v351" name="i_B_Na" public_interface="in" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v351">
<dcterms:description>Current through the background sodium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="beta_i" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>beta_i</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<apply>
<times />
<ci>CMDN_tot</ci>
<ci>K_mCMDN</ci>
</apply>
<apply>
<power />
<apply>
<plus />
<ci>K_mCMDN</ci>
<ci>Ca_i</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>EGTA_tot</ci>
<ci>K_mEGTA</ci>
</apply>
<apply>
<power />
<apply>
<plus />
<ci>K_mEGTA</ci>
<ci>Ca_i</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>beta_SS</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<apply>
<times />
<ci>CMDN_tot</ci>
<ci>K_mCMDN</ci>
</apply>
<apply>
<power />
<apply>
<plus />
<ci>K_mCMDN</ci>
<ci>Ca_ss</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>beta_JSR</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<apply>
<times />
<ci>CSQN_tot</ci>
<ci>K_mCSQN</ci>
</apply>
<apply>
<power />
<apply>
<plus />
<ci>K_mCSQN</ci>
<ci>Ca_JSR</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_i</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<apply>
<plus />
<ci>i_Na</ci>
<ci>i_B_Na</ci>
<apply>
<times />
<ci>i_NaCa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<apply>
<times />
<ci>i_NaK</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<ci>i_f_Na</ci>
</apply>
</apply>
<apply>
<times />
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>K_i</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<apply>
<plus />
<ci>i_ss</ci>
<ci>i_B_K</ci>
<ci>i_t</ci>
<ci>i_K1</ci>
<ci>i_f_K</ci>
<apply>
<times />
<ci>i_NaK</ci>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_ss</ci>
</apply>
<apply>
<times />
<ci>beta_SS</ci>
<apply>
<minus />
<apply>
<minus />
<apply>
<divide />
<apply>
<times />
<ci>J_rel</ci>
<ci>V_JSR</ci>
</apply>
<ci>V_SS</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>J_xfer</ci>
<ci>V_myo</ci>
</apply>
<ci>V_SS</ci>
</apply>
</apply>
<apply>
<divide />
<ci>i_Ca_L</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>V_SS</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_JSR</ci>
</apply>
<apply>
<times />
<ci>beta_JSR</ci>
<apply>
<minus />
<ci>J_tr</ci>
<ci>J_rel</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_NSR</ci>
</apply>
<apply>
<minus />
<apply>
<divide />
<apply>
<times />
<ci>J_up</ci>
<ci>V_myo</ci>
</apply>
<ci>V_NSR</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>J_tr</ci>
<ci>V_JSR</ci>
</apply>
<ci>V_NSR</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Myofilaments" cmeta:id="">
<variable cmeta:id="v352" name="time" public_interface="in" units="ms">
<rdf:RDF>
<rdf:Description rdf:ID="v352">
<dcterms:description>Temporal solution domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v353" name="lambda_prev" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v353">
<dcterms:description>Mystery variable mathematically equal to sarcomere strain</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v354" name="dExtensionRatiodt" public_interface="out" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v354">
<dcterms:description>Change in ExtensionRatio with respect to time</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v355" name="lambda" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v355">
<dcterms:description>Sarcomere strain, constrained to values between 0.8 and 1.15</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v356" name="ExtensionRatio" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v356">
<dcterms:description>Sarcomere strain</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>ExtensionRatio</ci>
<piecewise>
<piece>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<gt />
<ci>time</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">1000</cn>
</apply>
</piece>
<otherwise>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq />
<ci>lambda_prev</ci>
<ci>ExtensionRatio</ci>
</apply>
<apply>
<eq />
<ci>dExtensionRatiodt</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0</cn>
</apply>
<apply>
<eq />
<ci>lambda</ci>
<piecewise>
<piece>
<ci>ExtensionRatio</ci>
<apply>
<and />
<apply>
<gt />
<ci>ExtensionRatio</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.8</cn>
</apply>
<apply>
<leq />
<ci>ExtensionRatio</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.15</cn>
</apply>
</apply>
</piece>
<piece>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.15</cn>
<apply>
<gt />
<ci>ExtensionRatio</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.15</cn>
</apply>
</piece>
<otherwise>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.8</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="Cross_Bridges" cmeta:id="">
<variable cmeta:id="v357" name="time" public_interface="in" units="ms">
<rdf:RDF>
<rdf:Description rdf:ID="v357">
<dcterms:description>Temporal solution domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v358" initial_value="0" name="Q_3" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v358">
<dcterms:description>Exponential process 3 of the crossbridge kinetics fading memory model</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v359" name="Q" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v359">
<dcterms:description>Sum of the three exponential processes in the crossbridge dynamics fading memory model</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v360" initial_value="0.13" name="alpha_2" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v360">
<dcterms:description>Exponential rate constant for process 2 of the crossbridge kinetics fading memory model</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v361" initial_value="0.35" name="a" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v361">
<dcterms:description>Curve-shaping constant for relationship between relative sarcomere velocity and relative tension</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v362" initial_value="138" name="A_2" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v362">
<dcterms:description>Weighting coefficient for process 2 of the crossbridge kinetics fading memory model</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v363" initial_value="-29" name="A_1" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v363">
<dcterms:description>Weighting coefficient for process 1 of the crossbridge kinetics fading memory model</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v364" name="dExtensionRatiodt" public_interface="in" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v364">
<dcterms:description>Change in ExtensionRatio with respect to time</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v365" initial_value="0" name="Q_2" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v365">
<dcterms:description>Exponential process 2 of the crossbridge kinetics fading memory model</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v366" initial_value="129" name="A_3" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v366">
<dcterms:description>Weighting coefficient for process 3 of the crossbridge kinetics fading memory model</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v367" initial_value="0.03" name="alpha_1" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v367">
<dcterms:description>Exponential rate constant for process 1 of the crossbridge kinetics fading memory model</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="Cross_Bridges_Tension" name="Tension" public_interface="out" units="N_per_mm2">
<rdf:RDF>
<rdf:Description rdf:ID="Cross_Bridges_Tension">
<dcterms:description>Active tension of cardiac myocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v368" initial_value="0" name="Q_1" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v368">
<dcterms:description>Exponential process 1 of the crossbridge kinetics fading memory model</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v369" initial_value="0.625" name="alpha_3" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v369">
<dcterms:description>Exponential rate constant for process 3 of the crossbridge kinetics fading memory model</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v370" name="T_0" public_interface="in" units="N_per_mm2">
<rdf:RDF>
<rdf:Description rdf:ID="v370">
<dcterms:description>The isometric tension at a given intracellular calcium ion concentration and sarcomere length</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>Q</ci>
<apply>
<plus />
<ci>Q_1</ci>
<ci>Q_2</ci>
<ci>Q_3</ci>
</apply>
</apply>
<apply>
<eq />
<ci>Tension</ci>
<piecewise>
<piece>
<apply>
<divide />
<apply>
<times />
<ci>T_0</ci>
<apply>
<plus />
<apply>
<times />
<ci>a</ci>
<ci>Q</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>Q</ci>
</apply>
</apply>
<apply>
<lt />
<ci>Q</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide />
<apply>
<times />
<ci>T_0</ci>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times />
<apply>
<plus />
<ci>a</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<ci>Q</ci>
</apply>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>Q</ci>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Q_1</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>A_1</ci>
<ci>dExtensionRatiodt</ci>
</apply>
<apply>
<times />
<ci>alpha_1</ci>
<ci>Q_1</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Q_2</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>A_2</ci>
<ci>dExtensionRatiodt</ci>
</apply>
<apply>
<times />
<ci>alpha_2</ci>
<ci>Q_2</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Q_3</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>A_3</ci>
<ci>dExtensionRatiodt</ci>
</apply>
<apply>
<times />
<ci>alpha_3</ci>
<ci>Q_3</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="CaRU_states" cmeta:id="">
<variable cmeta:id="v371" name="y_oi" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v371">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the open state and the ryanodine receptor is in the inactivated state</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v372" name="y_cc" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v372">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel and the ryanodine receptor are both in the closed state</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v373" name="y_io" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v373">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the inactivated state and the ryanodine receptor is in the open state</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v374" name="y_oc" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v374">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the open state and the ryanodine receptor is in the closed state</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v375" name="beta_m" public_interface="in" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v375">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v376" name="alpha_m" public_interface="in" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v376">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v377" name="y_oo" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v377">
<dcterms:description>The state of the calcium (2+) release unit when both the L-type calcium channel and the ryanodine receptor are in the open state</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v378" name="beta_pcc" public_interface="in" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v378">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor when both the L-type calcium channel and ryanodine receptor are closed</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v379" name="alpha_p" public_interface="in" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v379">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v380" name="y_co" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v380">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the closed state and the ryanodine receptor is in the open state</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v381" name="beta_poc" public_interface="in" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v381">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor when L-type calcium channel is open and ryanodine receptor is closed</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v382" name="y_ic" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v382">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the inactivated state and the ryanodine receptor is in the closed state</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v383" name="y_ci" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v383">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the closed state and the ryanodine receptor is in the inactivated state</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v384" name="y_ii" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v384">
<dcterms:description>The state of the calcium (2+) release unit when both the L-type calcium channel and the ryanodine receptor are in the inactivated state</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v385" name="denom" units="per_ms3">
<rdf:RDF>
<rdf:Description rdf:ID="v385">
<dcterms:description>Convenience term for computing ycc, yco, yoc, and yoo variables</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>denom</ci>
<apply>
<times />
<apply>
<plus />
<ci>alpha_p</ci>
<ci>alpha_m</ci>
</apply>
<apply>
<plus />
<apply>
<times />
<apply>
<plus />
<ci>alpha_m</ci>
<ci>beta_m</ci>
<ci>beta_poc</ci>
</apply>
<apply>
<plus />
<ci>beta_m</ci>
<ci>beta_pcc</ci>
</apply>
</apply>
<apply>
<times />
<ci>alpha_p</ci>
<apply>
<plus />
<ci>beta_m</ci>
<ci>beta_poc</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>y_oc</ci>
<apply>
<divide />
<apply>
<times />
<ci>alpha_p</ci>
<ci>beta_m</ci>
<apply>
<plus />
<ci>alpha_p</ci>
<ci>alpha_m</ci>
<ci>beta_m</ci>
<ci>beta_pcc</ci>
</apply>
</apply>
<ci>denom</ci>
</apply>
</apply>
<apply>
<eq />
<ci>y_co</ci>
<apply>
<divide />
<apply>
<times />
<ci>alpha_m</ci>
<apply>
<plus />
<apply>
<times />
<ci>beta_pcc</ci>
<apply>
<plus />
<ci>alpha_m</ci>
<ci>beta_m</ci>
<ci>beta_poc</ci>
</apply>
</apply>
<apply>
<times />
<ci>beta_poc</ci>
<ci>alpha_p</ci>
</apply>
</apply>
</apply>
<ci>denom</ci>
</apply>
</apply>
<apply>
<eq />
<ci>y_oo</ci>
<apply>
<divide />
<apply>
<times />
<ci>alpha_p</ci>
<apply>
<plus />
<apply>
<times />
<ci>beta_poc</ci>
<apply>
<plus />
<ci>alpha_p</ci>
<ci>beta_m</ci>
<ci>beta_pcc</ci>
</apply>
</apply>
<apply>
<times />
<ci>beta_pcc</ci>
<ci>alpha_m</ci>
</apply>
</apply>
</apply>
<ci>denom</ci>
</apply>
</apply>
<apply>
<eq />
<ci>y_cc</ci>
<apply>
<divide />
<apply>
<times />
<ci>alpha_m</ci>
<ci>beta_m</ci>
<apply>
<plus />
<ci>alpha_m</ci>
<ci>alpha_p</ci>
<ci>beta_m</ci>
<ci>beta_poc</ci>
</apply>
</apply>
<ci>denom</ci>
</apply>
</apply>
<apply>
<eq />
<ci>y_ci</ci>
<apply>
<divide />
<ci>alpha_m</ci>
<apply>
<plus />
<ci>alpha_p</ci>
<ci>alpha_m</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>y_oi</ci>
<apply>
<divide />
<ci>alpha_p</ci>
<apply>
<plus />
<ci>alpha_p</ci>
<ci>alpha_m</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>y_ic</ci>
<apply>
<divide />
<ci>beta_m</ci>
<apply>
<plus />
<ci>beta_pcc</ci>
<ci>beta_m</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>y_io</ci>
<apply>
<divide />
<ci>beta_pcc</ci>
<apply>
<plus />
<ci>beta_pcc</ci>
<ci>beta_m</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>y_ii</ci>
<apply>
<minus />
<apply>
<minus />
<apply>
<minus />
<apply>
<minus />
<apply>
<minus />
<apply>
<minus />
<apply>
<minus />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y_oc</ci>
</apply>
<ci>y_co</ci>
</apply>
<ci>y_oo</ci>
</apply>
<ci>y_cc</ci>
</apply>
<ci>y_ci</ci>
</apply>
<ci>y_ic</ci>
</apply>
<ci>y_oi</ci>
</apply>
<ci>y_io</ci>
</apply>
</apply>
</math>
</component>
<component name="CaRU" cmeta:id="">
<variable cmeta:id="v386" name="I_LCC" public_interface="out" private_interface="in" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v386">
<dcterms:description>Total whole-cell current through the L-type calcium channels</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v387" name="V_myo" public_interface="in" private_interface="out" units="um3">
<rdf:RDF>
<rdf:Description rdf:ID="v387">
<dcterms:description>Volume of myoplasm</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v388" name="time" public_interface="in" private_interface="out" units="ms">
<rdf:RDF>
<rdf:Description rdf:ID="v388">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v389" name="FVRT_Ca" public_interface="in" private_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v389">
<dcterms:description>Convenience variable that is equal to (F*V/(R*T))*2. Also equivalent to [greek delta]*V in the source manuscript</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v390" name="Ca_SR" public_interface="in" private_interface="out" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v390">
<dcterms:description>Calcium (2+) concentration in sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v391" initial_value="0.065" name="g_D" private_interface="out" units="um3_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v391">
<dcterms:description>Calcium (2+) flux rate from dyadic space to cytosol</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v392" name="I_RyR" public_interface="out" private_interface="in" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v392">
<dcterms:description>Total whole-cell current through the ryanodine receptors</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v393" name="Ca_o" public_interface="in" private_interface="out" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v393">
<dcterms:description>Extracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v394" name="Ca_i" public_interface="in" private_interface="out" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v394">
<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v395" name="V" public_interface="in" private_interface="out" units="mV">
<rdf:RDF>
<rdf:Description rdf:ID="v395">
<dcterms:description>Voltage across cell membrane</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v396" initial_value="0.02" name="J_R" private_interface="out" units="um3_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v396">
<dcterms:description>Permeability of a single ryanodine receptor</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v397" initial_value="9.13e-4" name="J_L" private_interface="out" units="um3_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v397">
<dcterms:description>Permeability of a single L-type calcium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v398" initial_value="50000" name="N" private_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v398">
<dcterms:description>Number of calcium release units</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
</component>
<component name="filament_overlap" cmeta:id="">
<variable cmeta:id="v399" initial_value="4.9" name="beta_0" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v399">
<dcterms:description>Scaling factor (slope) for the relationship between lambda and T_0</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v400" name="overlap" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v400">
<dcterms:description>Sarcomere overlap?</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v401" name="lambda" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v401">
<dcterms:description>Sarcomere strain?</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>overlap</ci>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times />
<ci>beta_0</ci>
<apply>
<minus />
<ci>lambda</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calmodulin_Ca_buffer" cmeta:id="">
<variable cmeta:id="v402" initial_value="2.382e-3" name="k_CMDN" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v402">
<dcterms:description>Half saturation constant of calmodulin</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v403" name="beta_CMDN" public_interface="out" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v403">
<dcterms:description>Rapid buffer coeffiecient in the cytoplasm</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v404" initial_value="50e-3" name="B_CMDN" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v404">
<dcterms:description>Total cytosolic calmodulin concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v405" name="Ca_i" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v405">
<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>beta_CMDN</ci>
<apply>
<power />
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<apply>
<times />
<ci>k_CMDN</ci>
<ci>B_CMDN</ci>
</apply>
<apply>
<power />
<apply>
<plus />
<ci>k_CMDN</ci>
<ci>Ca_i</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Na_Ca_Exchanger" cmeta:id="">
<variable cmeta:id="v406" initial_value="87.5" name="K_mNa" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v406">
<dcterms:description>Soldium (1+) half saturation of sodium-calcium exchanger</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v407" initial_value="0.35" name="eta" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v407">
<dcterms:description>Voltage dependence of sodium-calcium exchanger control</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v408" name="Na_i" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v408">
<dcterms:description>Intracellular sodium (1+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v409" name="FVRT" public_interface="in" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v409">
<dcterms:description>Convenience variable that is equal to F*V/(R*T)</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v410" name="Ca_i" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v410">
<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v411" initial_value="38.5e-3" name="g_NCX" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v411">
<dcterms:description>Pump rate of sodium-calcium exchanger. Used to balance transmembrane flux of calcium(2+) over each cycle.</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v412" name="Ca_o" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v412">
<dcterms:description>Extracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v413" initial_value="0.1" name="k_sat" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v413">
<dcterms:description>Low potential saturation factor of sodium-calcium exchanger</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v414" initial_value="1.38" name="K_mCa" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v414">
<dcterms:description>Calcium (2+) half saturation of sodium-calcium exchanger</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="Na_Ca_Exchanger_I_NaCa" name="I_NaCa" public_interface="out" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="Na_Ca_Exchanger_I_NaCa">
<dcterms:description>Sodium-calcium exchange current</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v415" name="Na_o" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v415">
<dcterms:description>Extracellular sodium (1+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>I_NaCa</ci>
<apply>
<divide />
<apply>
<times />
<ci>g_NCX</ci>
<apply>
<minus />
<apply>
<times />
<apply>
<exp />
<apply>
<times />
<ci>eta</ci>
<ci>FVRT</ci>
</apply>
</apply>
<apply>
<power />
<ci>Na_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_o</ci>
</apply>
<apply>
<times />
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<ci>eta</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<ci>FVRT</ci>
</apply>
</apply>
<apply>
<power />
<ci>Na_o</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<apply>
<power />
<ci>Na_o</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power />
<ci>K_mNa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<plus />
<ci>Ca_o</ci>
<ci>K_mCa</ci>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times />
<ci>k_sat</ci>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<ci>eta</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<ci>FVRT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="cell_geometry" cmeta:id="">
<variable cmeta:id="v416" initial_value="1.534e4" name="A_cap" public_interface="out" units="um2">
<rdf:RDF>
<rdf:Description rdf:ID="v416">
<dcterms:description>Unknown. This is an orphan term in the model.</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v417" initial_value="25.84e3" name="V_myo" public_interface="out" units="um3">
<rdf:RDF>
<rdf:Description rdf:ID="v417">
<dcterms:description>Volume of myoplasm</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v418" initial_value="2.098e3" name="V_SR" public_interface="out" units="um3">
<rdf:RDF>
<rdf:Description rdf:ID="v418">
<dcterms:description>Volume of sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
</component>
<component name="hyperpolarisation_activated_current_y_gate" cmeta:id="">
<variable cmeta:id="v419" name="V" public_interface="in" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v419">
<dcterms:description>Voltage potential across the plasma membrane of the cardiomyocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.003578708" name="y" public_interface="out" units="dimensionless" />
<variable name="tau_y" units="second" />
<variable cmeta:id="v420" name="time" public_interface="in" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v420">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="y_infinity" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>y_infinity</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">138.6</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.48</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>tau_y</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">1</cn>
<apply>
<plus />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.11885</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">80</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">28.37</cn>
</apply>
</apply>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5623</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">80</cn>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14.19</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>y_infinity</ci>
<ci>y</ci>
</apply>
<ci>tau_y</ci>
</apply>
</apply>
</math>
</component>
<component name="sodium_potassium_pump" cmeta:id="">
<variable initial_value="0.08" name="i_NaK_max" units="nanoA" />
<variable cmeta:id="v421" name="Na_o" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v421">
<dcterms:description>Concentration of sodium external to the cardiac myocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v422" name="K_o" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v422">
<dcterms:description>Concentration of potassium external to the cardiac myocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v423" name="F" public_interface="in" units="coulomb_per_mole">
<rdf:RDF>
<rdf:Description rdf:ID="v423">
<dcterms:description>Faraday constant</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00089" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="time" public_interface="in" units="second" />
<variable cmeta:id="v424" initial_value="1.5" name="K_m_K" units="millimolar" />
<variable cmeta:id="v425" name="Na_i" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v425">
<dcterms:description>Concentration of sodium in bulk cytosol</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v426" name="R" public_interface="in" units="millijoule_per_mole_kelvin">
<rdf:RDF>
<rdf:Description rdf:ID="v426">
<dcterms:description>Universal gas constant</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00410" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v427" name="V" public_interface="in" units="millivolt">
<rdf:RDF>
<rdf:Description rdf:ID="v427">
<dcterms:description>Voltage potential across the plasma membrane of the cardiomyocyte</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable name="sigma" units="dimensionless" />
<variable cmeta:id="v428" name="i_NaK" public_interface="out" units="nanoA">
<rdf:RDF>
<rdf:Description rdf:ID="v428">
<dcterms:description>Current through the sodium/potassium pump</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v429" initial_value="10" name="K_m_Na" units="millimolar" />
<variable cmeta:id="v430" name="T" public_interface="in" units="kelvin">
<rdf:RDF>
<rdf:Description rdf:ID="v430">
<dcterms:description>Temperature of the cardiac myocyte and its surrounding environment</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>sigma</ci>
<apply>
<divide />
<apply>
<minus />
<apply>
<exp />
<apply>
<divide />
<ci>Na_o</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">67.3</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7</cn>
</apply>
</apply>
<apply>
<eq />
<ci>i_NaK</ci>
<apply>
<divide />
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<ci>i_NaK_max</ci>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1245</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0365</cn>
<ci>sigma</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<ci>V</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>K_o</ci>
</apply>
<apply>
<plus />
<ci>K_o</ci>
<ci>K_m_K</ci>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<power />
<apply>
<divide />
<ci>K_m_Na</ci>
<ci>Na_i</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="iic_niederer" cmeta:id="">
<variable cmeta:id="v431" name="time" public_interface="in" units="ms">
<rdf:RDF>
<rdf:Description rdf:ID="v431">
<dcterms:description>Temporal solution domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v432" name="Ca_TRPN_Max" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v432">
<dcterms:description>The maximum concentration of calcium ions that can bind to site II on troponin C</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v433" name="Ca_b" public_interface="out" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v433">
<dcterms:description>Concentration of calcium (2+) bound to troponin C</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v434" initial_value="0.067593139865" name="TRPN" public_interface="out" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v434">
<dcterms:description>Intracellular troponin concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="intracellular_ion_concentrations_Ca_i" name="Ca_i" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="intracellular_ion_concentrations_Ca_i">
<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v435" name="J_TRPN" public_interface="in" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v435">
<dcterms:description>Intracellular troponin flux</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>Ca_b</ci>
<apply>
<minus />
<ci>Ca_TRPN_Max</ci>
<ci>TRPN</ci>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>TRPN</ci>
</apply>
<ci>J_TRPN</ci>
</apply>
</math>
</component>
<component name="troponin_Ca_buffer" cmeta:id="">
<variable cmeta:id="v436" initial_value="70e-3" name="B_TRPN" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v436">
<dcterms:description>Total cytosolic troponin concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v437" name="Ca_i" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v437">
<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v438" name="I_TRPN" public_interface="in" units="mM_per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v438">
<dcterms:description>Dissociation rate of calcium (2+)-bound troponin</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v439" name="TRPN" public_interface="in" units="mM">
<rdf:RDF>
<rdf:Description rdf:ID="v439">
<dcterms:description>Concentration of troponin in cytosol</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v440" initial_value="0.04e3" name="k_p_TRPN" units="per_mM_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v440">
<dcterms:description>Binding rate of calcium (2+) to troponin</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v441" initial_value="0.04" name="k_m_TRPN" units="per_ms">
<rdf:RDF>
<rdf:Description rdf:ID="v441">
<dcterms:description>Dissociation rate of calcium (2+) from troponin</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML" />
</component>
<component name="intracellular_and_SR_Ca_fluxes" cmeta:id="">
<variable cmeta:id="v442" name="Ca_NSR" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v442">
<dcterms:description>Calcium concentration in the network regions of the sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v443" initial_value="0.07" name="LTRPN_tot" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v443">
<dcterms:description>Total concentration of low affinity troponin binding sites</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.066" name="k_htrpn_minus" units="per_second" />
<variable cmeta:id="v444" name="time" public_interface="in" units="second">
<rdf:RDF>
<rdf:Description rdf:ID="v444">
<dcterms:description>Simulation time domain</dcterms:description>
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="200000" name="k_htrpn_plus" units="per_millimolar_per_second" />
<variable cmeta:id="v445" initial_value="1.394301e-1" name="HTRPNCa" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v445">
<dcterms:description>Concentration of calcium bound to high affinity troponin C binding sites</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v446" name="J_tr" public_interface="out" units="millimolar_per_second">
<rdf:RDF>
<rdf:Description rdf:ID="v446">
<dcterms:description>Calcium flux between junctional and network sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="40000" name="k_ltrpn_plus" units="per_millimolar_per_second" />
<variable cmeta:id="v447" name="J_xfer" public_interface="out" units="millimolar_per_second">
<rdf:RDF>
<rdf:Description rdf:ID="v447">
<dcterms:description>Calcium flux between the diadic subspace and blulk cytosol</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v448" name="Ca_i" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v448">
<dcterms:description>Concentration of calcium in bulk cytosol</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v449" name="J_LTRPNCa" units="millimolar_per_second">
<rdf:RDF>
<rdf:Description rdf:ID="v449">
<dcterms:description>Binding of troponin C low affinity binding sites to calcium</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v450" initial_value="5.1619e-3" name="LTRPNCa" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v450">
<dcterms:description>Concentration of calcium bound to low affinity troponin C binding sites</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v451" name="Ca_ss" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v451">
<dcterms:description>Calcium concentration in diadic space</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.0005747" name="tau_tr" units="second" />
<variable cmeta:id="v452" name="Ca_JSR" public_interface="in" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v452">
<dcterms:description>Calcium concentration of fluid inside the junctional region of the sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v453" name="J_HTRPNCa" units="millimolar_per_second">
<rdf:RDF>
<rdf:Description rdf:ID="v453">
<dcterms:description>Binding of troponin C high affinity binding sites to calcium</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v454" name="J_trpn" public_interface="out" units="millimolar_per_second">
<rdf:RDF>
<rdf:Description rdf:ID="v454">
<dcterms:description>Flux of calcium binding to both low and high affinity sites on troponin C</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="40" name="k_ltrpn_minus" units="per_second" />
<variable cmeta:id="v455" initial_value="0.14" name="HTRPN_tot" units="millimolar">
<rdf:RDF>
<rdf:Description rdf:ID="v455">
<dcterms:description>Total concentration of high affinity troponin binding sites</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable initial_value="0.0267" name="tau_xfer" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>J_tr</ci>
<apply>
<divide />
<apply>
<minus />
<ci>Ca_NSR</ci>
<ci>Ca_JSR</ci>
</apply>
<ci>tau_tr</ci>
</apply>
</apply>
<apply>
<eq />
<ci>J_xfer</ci>
<apply>
<divide />
<apply>
<minus />
<ci>Ca_ss</ci>
<ci>Ca_i</ci>
</apply>
<ci>tau_xfer</ci>
</apply>
</apply>
<apply>
<eq />
<ci>J_HTRPNCa</ci>
<apply>
<minus />
<apply>
<times />
<ci>k_htrpn_plus</ci>
<ci>Ca_i</ci>
<apply>
<minus />
<ci>HTRPN_tot</ci>
<ci>HTRPNCa</ci>
</apply>
</apply>
<apply>
<times />
<ci>k_htrpn_minus</ci>
<ci>HTRPNCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>HTRPNCa</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>k_htrpn_plus</ci>
<ci>Ca_i</ci>
<apply>
<minus />
<ci>HTRPN_tot</ci>
<ci>HTRPNCa</ci>
</apply>
</apply>
<apply>
<times />
<ci>k_htrpn_minus</ci>
<ci>HTRPNCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>J_LTRPNCa</ci>
<apply>
<minus />
<apply>
<times />
<ci>k_ltrpn_plus</ci>
<ci>Ca_i</ci>
<apply>
<minus />
<ci>LTRPN_tot</ci>
<ci>LTRPNCa</ci>
</apply>
</apply>
<apply>
<times />
<ci>k_ltrpn_minus</ci>
<ci>LTRPNCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>LTRPNCa</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>k_ltrpn_plus</ci>
<ci>Ca_i</ci>
<apply>
<minus />
<ci>LTRPN_tot</ci>
<ci>LTRPNCa</ci>
</apply>
</apply>
<apply>
<times />
<ci>k_ltrpn_minus</ci>
<ci>LTRPNCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>J_trpn</ci>
<apply>
<plus />
<ci>J_HTRPNCa</ci>
<ci>J_LTRPNCa</ci>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation" />
<component_ref component="hyperpolarisation_activated_current">
<component_ref component="hyperpolarisation_activated_current_y_gate" />
</component_ref>
<component_ref component="Ca_independent_transient_outward_K_current">
<component_ref component="Ca_independent_transient_outward_K_current_s_gate" />
<component_ref component="Ca_independent_transient_outward_K_current_r_gate" />
<component_ref component="Ca_independent_transient_outward_K_current_s_slow_gate" />
</component_ref>
<component_ref component="steady_state_outward_K_current">
<component_ref component="steady_state_outward_K_current_s_ss_gate" />
<component_ref component="steady_state_outward_K_current_r_ss_gate" />
</component_ref>
<component_ref component="sodium_current">
<component_ref component="sodium_current_m_gate" />
<component_ref component="sodium_current_h_gate" />
<component_ref component="sodium_current_j_gate" />
</component_ref>
<component_ref component="CaRU">
<component_ref component="CaRU_reduced_states" />
<component_ref component="LCC_current" />
<component_ref component="LCC_and_RyR_fluxes" />
<component_ref component="CaRU_Transitions" />
<component_ref component="RyR_current" />
<component_ref component="DS_Calcium_Concentrations" />
<component_ref component="CaRU_states" />
</component_ref>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_Ca_inact_gate" />
<component_ref component="L_type_Ca_channel_d_gate" />
<component_ref component="L_type_Ca_channel_f_12_gate" />
<component_ref component="L_type_Ca_channel_f_11_gate" />
</component_ref>
</group>
<group>
<relationship_ref relationship="containment" />
<component_ref component="membrane_hinch">
<component_ref component="SR_Ca_leak_current" />
<component_ref component="CaRU">
<component_ref component="CaRU_reduced_states" />
<component_ref component="LCC_current" />
<component_ref component="LCC_and_RyR_fluxes" />
<component_ref component="CaRU_Transitions" />
<component_ref component="RyR_current" />
<component_ref component="DS_Calcium_Concentrations" />
<component_ref component="CaRU_states" />
</component_ref>
<component_ref component="iic_hinch" />
<component_ref component="Background_Ca_current" />
<component_ref component="calmodulin_Ca_buffer" />
<component_ref component="Na_Ca_Exchanger" />
<component_ref component="Sarcolemmal_Ca_pump" />
<component_ref component="cell_geometry" />
<component_ref component="extracellular_ion_concentrations" />
<component_ref component="troponin_Ca_buffer" />
<component_ref component="SERCA" />
</component_ref>
</group>
<connection>
<map_components component_1="convert_hinch" component_2="sarcolemmal_calcium_pump_current" />
<map_variables variable_1="I_pCa" variable_2="i_Ca_P" />
</connection>
<connection>
<map_components component_1="hyperpolarisation_activated_current" component_2="intracellular_ion_concentrations" />
<map_variables variable_1="i_f_Na" variable_2="i_f_Na" />
<map_variables variable_1="i_f_K" variable_2="i_f_K" />
</connection>
<connection>
<map_components component_1="tropomyosin" component_2="length_independent_tension" />
<map_variables variable_1="z_max" variable_2="z_max" />
<map_variables variable_1="z" variable_2="z" />
</connection>
<connection>
<map_components component_1="iic_hinch" component_2="Background_Ca_current" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current_s_gate" component_2="Ca_independent_transient_outward_K_current" />
<map_variables variable_1="s" variable_2="s" />
</connection>
<connection>
<map_components component_1="L_type_Ca_channel_d_gate" component_2="L_type_Ca_channel" />
<map_variables variable_1="d" variable_2="d" />
</connection>
<connection>
<map_components component_1="CaRU" component_2="convert_hinch" />
<map_variables variable_1="I_LCC" variable_2="hinch_I_LCC" />
<map_variables variable_1="I_RyR" variable_2="hinch_I_RyR" />
</connection>
<connection>
<map_components component_1="CaRU" component_2="iic_hinch" />
<map_variables variable_1="I_LCC" variable_2="I_LCC" />
<map_variables variable_1="I_RyR" variable_2="I_RyR" />
</connection>
<connection>
<map_components component_1="Na_Ca_Exchanger" component_2="iic_hinch" />
<map_variables variable_1="I_NaCa" variable_2="I_NaCa" />
</connection>
<connection>
<map_components component_1="environment" component_2="background_currents" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="standard_ionic_concentrations" component_2="inward_rectifier" />
<map_variables variable_1="K_o" variable_2="K_o" />
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="membrane" />
<map_variables variable_1="i_NaK" variable_2="i_NaK" />
</connection>
<connection>
<map_components component_1="iic_hinch" component_2="sarcolemmal_calcium_pump_current" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="membrane" component_2="hyperpolarisation_activated_current" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="sodium_current" component_2="background_currents" />
<map_variables variable_1="E_Na" variable_2="E_Na" />
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_current" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="Background_Ca_current" component_2="convert_hinch" />
<map_variables variable_1="I_CaB" variable_2="hinch_I_CaB" />
</connection>
<connection>
<map_components component_1="membrane_hinch" component_2="Background_Ca_current" />
<map_variables variable_1="R" variable_2="R" />
<map_variables variable_1="F" variable_2="F" />
<map_variables variable_1="T" variable_2="T" />
</connection>
<connection>
<map_components component_1="convert_hinch" component_2="Na_Ca_ion_exchanger_current" />
<map_variables variable_1="I_NaCa" variable_2="i_NaCa" />
</connection>
<connection>
<map_components component_1="iic_hinch" component_2="SERCA" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="iic_niederer" component_2="troponin" />
<map_variables variable_1="TRPN" variable_2="TRPN" />
</connection>
<connection>
<map_components component_1="environment" component_2="inward_rectifier" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="Na_Ca_Exchanger" component_2="convert_hinch" />
<map_variables variable_1="I_NaCa" variable_2="hinch_I_NaCa" />
</connection>
<connection>
<map_components component_1="LCC_and_RyR_fluxes" component_2="LCC_current" />
<map_variables variable_1="J_Loc" variable_2="J_Loc" />
<map_variables variable_1="J_Loo" variable_2="J_Loo" />
</connection>
<connection>
<map_components component_1="length_independent_tension" component_2="troponin" />
<map_variables variable_1="T_ref" variable_2="T_ref" />
</connection>
<connection>
<map_components component_1="CaRU_Transitions" component_2="LCC_current" />
<map_variables variable_1="alpha_p" variable_2="alpha_p" />
<map_variables variable_1="alpha_m" variable_2="alpha_m" />
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="iic_hinch" />
<map_variables variable_1="Na_i" variable_2="Na_i" />
</connection>
<connection>
<map_components component_1="calmodulin_Ca_buffer" component_2="iic_hinch" />
<map_variables variable_1="beta_CMDN" variable_2="beta_CMDN" />
</connection>
<connection>
<map_components component_1="membrane" component_2="L_type_Ca_channel" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="intracellular_and_SR_Ca_fluxes" component_2="intracellular_ion_concentrations" />
<map_variables variable_1="J_tr" variable_2="J_tr" />
<map_variables variable_1="J_xfer" variable_2="J_xfer" />
<map_variables variable_1="J_trpn" variable_2="J_trpn" />
</connection>
<connection>
<map_components component_1="sodium_current_m_gate" component_2="sodium_current" />
<map_variables variable_1="m" variable_2="m" />
</connection>
<connection>
<map_components component_1="CaRU_states" component_2="LCC_current" />
<map_variables variable_1="y_oo" variable_2="y_oo" />
<map_variables variable_1="y_oc" variable_2="y_oc" />
</connection>
<connection>
<map_components component_1="CaRU_states" component_2="RyR_current" />
<map_variables variable_1="y_oo" variable_2="y_oo" />
<map_variables variable_1="y_co" variable_2="y_co" />
<map_variables variable_1="y_oc" variable_2="y_oc" />
</connection>
<connection>
<map_components component_1="membrane" component_2="steady_state_outward_K_current" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="membrane" component_2="Ca_independent_transient_outward_K_current" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="membrane_hinch" component_2="Na_Ca_Exchanger" />
<map_variables variable_1="FVRT" variable_2="FVRT" />
</connection>
<connection>
<map_components component_1="CaRU_Transitions" component_2="CaRU_states" />
<map_variables variable_1="beta_poc" variable_2="beta_poc" />
<map_variables variable_1="beta_pcc" variable_2="beta_pcc" />
<map_variables variable_1="alpha_p" variable_2="alpha_p" />
<map_variables variable_1="alpha_m" variable_2="alpha_m" />
<map_variables variable_1="beta_m" variable_2="beta_m" />
</connection>
<connection>
<map_components component_1="environment" component_2="L_type_Ca_channel" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="sodium_current_h_gate" component_2="sodium_current" />
<map_variables variable_1="h" variable_2="h" />
</connection>
<connection>
<map_components component_1="membrane_hinch" component_2="CaRU" />
<map_variables variable_1="FVRT_Ca" variable_2="FVRT_Ca" />
</connection>
<connection>
<map_components component_1="LCC_current" component_2="CaRU" />
<map_variables variable_1="I_LCC" variable_2="I_LCC" />
</connection>
<connection>
<map_components component_1="steady_state_outward_K_current" component_2="intracellular_ion_concentrations" />
<map_variables variable_1="i_ss" variable_2="i_ss" />
</connection>
<connection>
<map_components component_1="environment" component_2="membrane_hinch" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="environment" component_2="CaRU" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="environment" component_2="env_hinch" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="iic_hinch" component_2="Na_Ca_Exchanger" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="environment" component_2="intracellular_ion_concentrations" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="environment" component_2="hyperpolarisation_activated_current" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="environment" component_2="SR_Ca_release_channel" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_f_12_gate" />
<map_variables variable_1="V" variable_2="V" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="Myofilaments" component_2="tropomyosin" />
<map_variables variable_1="lambda" variable_2="lambda" />
</connection>
<connection>
<map_components component_1="Sarcolemmal_Ca_pump" component_2="convert_hinch" />
<map_variables variable_1="I_pCa" variable_2="hinch_I_pCa" />
</connection>
<connection>
<map_components component_1="environment" component_2="iic_niederer" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="sodium_current" component_2="intracellular_ion_concentrations" />
<map_variables variable_1="i_Na" variable_2="i_Na" />
</connection>
<connection>
<map_components component_1="CaRU_Transitions" component_2="RyR_current" />
<map_variables variable_1="beta_pcc" variable_2="beta_pcc" />
<map_variables variable_1="beta_m" variable_2="beta_m" />
</connection>
<connection>
<map_components component_1="Myofilaments" component_2="Cross_Bridges" />
<map_variables variable_1="dExtensionRatiodt" variable_2="dExtensionRatiodt" />
</connection>
<connection>
<map_components component_1="CaRU_reduced_states" component_2="RyR_current" />
<map_variables variable_1="z_3" variable_2="z_3" />
<map_variables variable_1="z_1" variable_2="z_1" />
</connection>
<connection>
<map_components component_1="troponin" component_2="troponin_Ca_buffer" />
<map_variables variable_1="J_TRPN" variable_2="I_TRPN" />
</connection>
<connection>
<map_components component_1="membrane_hinch" component_2="sodium_potassium_pump" />
<map_variables variable_1="R" variable_2="R" />
<map_variables variable_1="F" variable_2="F" />
<map_variables variable_1="T" variable_2="T" />
</connection>
<connection>
<map_components component_1="iic_hinch" component_2="SR_Ca_leak_current" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
<map_variables variable_1="Ca_SR" variable_2="Ca_SR" />
</connection>
<connection>
<map_components component_1="iic_hinch" component_2="Sarcolemmal_Ca_pump" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="membrane_hinch" component_2="convert_hinch" />
<map_variables variable_1="F" variable_2="F" />
</connection>
<connection>
<map_components component_1="steady_state_outward_K_current" component_2="steady_state_outward_K_current_s_ss_gate" />
<map_variables variable_1="time" variable_2="time" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="L_type_Ca_channel_f_12_gate" component_2="L_type_Ca_channel" />
<map_variables variable_1="f_12" variable_2="f_12" />
</connection>
<connection>
<map_components component_1="sodium_current" component_2="sodium_current_h_gate" />
<map_variables variable_1="V" variable_2="V" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="membrane" />
<map_variables variable_1="i_t" variable_2="i_t" />
</connection>
<connection>
<map_components component_1="standard_ionic_concentrations" component_2="sodium_current" />
<map_variables variable_1="Na_o" variable_2="Na_o" />
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="Ca_independent_transient_outward_K_current_s_gate" />
<map_variables variable_1="time" variable_2="time" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="membrane" component_2="background_currents" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="length_independent_tension" component_2="isometric_tension" />
<map_variables variable_1="T_Base" variable_2="T_Base" />
</connection>
<connection>
<map_components component_1="environment" component_2="membrane" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="steady_state_outward_K_current" />
<map_variables variable_1="E_K" variable_2="E_K" />
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="intracellular_ion_concentrations" />
<map_variables variable_1="i_NaK" variable_2="i_NaK" />
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="SR_Ca_release_channel" />
<map_variables variable_1="Ca_ss" variable_2="Ca_ss" />
<map_variables variable_1="Ca_JSR" variable_2="Ca_JSR" />
</connection>
<connection>
<map_components component_1="isometric_tension" component_2="Cross_Bridges" />
<map_variables variable_1="T_0" variable_2="T_0" />
</connection>
<connection>
<map_components component_1="convert_hinch" component_2="L_type_Ca_channel" />
<map_variables variable_1="I_LCC" variable_2="i_Ca_L" />
</connection>
<connection>
<map_components component_1="CaRU" component_2="CaRU_Transitions" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="standard_ionic_concentrations" component_2="Na_Ca_ion_exchanger_current" />
<map_variables variable_1="Na_o" variable_2="Na_o" />
<map_variables variable_1="Ca_o" variable_2="Ca_o" />
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="Ca_independent_transient_outward_K_current" />
<map_variables variable_1="K_i" variable_2="K_i" />
</connection>
<connection>
<map_components component_1="CaRU_states" component_2="CaRU_reduced_states" />
<map_variables variable_1="y_co" variable_2="y_co" />
<map_variables variable_1="y_cc" variable_2="y_cc" />
<map_variables variable_1="y_oc" variable_2="y_oc" />
</connection>
<connection>
<map_components component_1="sodium_current" component_2="sodium_current_j_gate" />
<map_variables variable_1="V" variable_2="V" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="iic_hinch" component_2="troponin" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="membrane" component_2="Background_Ca_current" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="standard_ionic_concentrations" component_2="sodium_potassium_pump" />
<map_variables variable_1="Na_o" variable_2="Na_o" />
<map_variables variable_1="K_o" variable_2="K_o" />
</connection>
<connection>
<map_components component_1="sodium_current_j_gate" component_2="sodium_current" />
<map_variables variable_1="j" variable_2="j" />
</connection>
<connection>
<map_components component_1="membrane_hinch" component_2="Ca_independent_transient_outward_K_current" />
<map_variables variable_1="R" variable_2="R" />
<map_variables variable_1="F" variable_2="F" />
<map_variables variable_1="T" variable_2="T" />
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_potassium_pump" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="environment" component_2="Na_Ca_ion_exchanger_current" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="SERCA" component_2="iic_hinch" />
<map_variables variable_1="I_SERCA" variable_2="I_SERCA" />
</connection>
<connection>
<map_components component_1="background_currents" component_2="intracellular_ion_concentrations" />
<map_variables variable_1="i_B_Na" variable_2="i_B_Na" />
<map_variables variable_1="i_B_K" variable_2="i_B_K" />
</connection>
<connection>
<map_components component_1="inward_rectifier" component_2="intracellular_ion_concentrations" />
<map_variables variable_1="i_K1" variable_2="i_K1" />
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="intracellular_ion_concentrations" />
<map_variables variable_1="i_t" variable_2="i_t" />
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_d_gate" />
<map_variables variable_1="V" variable_2="V" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="environment" component_2="intracellular_and_SR_Ca_fluxes" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="iic_hinch" component_2="background_currents" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="cell_geometry" component_2="CaRU" />
<map_variables variable_1="V_myo" variable_2="V_myo" />
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="hyperpolarisation_activated_current" />
<map_variables variable_1="E_K" variable_2="E_K" />
</connection>
<connection>
<map_components component_1="L_type_Ca_channel_Ca_inact_gate" component_2="L_type_Ca_channel" />
<map_variables variable_1="Ca_inact" variable_2="Ca_inact" />
</connection>
<connection>
<map_components component_1="environment" component_2="sodium_current" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="standard_ionic_concentrations" component_2="Ca_independent_transient_outward_K_current" />
<map_variables variable_1="K_o" variable_2="K_o" />
</connection>
<connection>
<map_components component_1="cell_geometry" component_2="intracellular_ion_concentrations" />
<map_variables variable_1="V_myo" variable_2="V_myo" />
</connection>
<connection>
<map_components component_1="RyR_current" component_2="CaRU" />
<map_variables variable_1="I_RyR" variable_2="I_RyR" />
</connection>
<connection>
<map_components component_1="environment" component_2="sodium_potassium_pump" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current_s_slow_gate" component_2="Ca_independent_transient_outward_K_current" />
<map_variables variable_1="s_slow" variable_2="s_slow" />
</connection>
<connection>
<map_components component_1="standard_ionic_concentrations" component_2="Background_Ca_current" />
<map_variables variable_1="Ca_o" variable_2="Ca_o" />
</connection>
<connection>
<map_components component_1="CaRU" component_2="LCC_and_RyR_fluxes" />
<map_variables variable_1="FVRT_Ca" variable_2="FVRT_Ca" />
<map_variables variable_1="g_D" variable_2="g_D" />
<map_variables variable_1="Ca_SR" variable_2="Ca_SR" />
<map_variables variable_1="Ca_o" variable_2="Ca_o" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
<map_variables variable_1="J_R" variable_2="J_R" />
<map_variables variable_1="J_L" variable_2="J_L" />
</connection>
<connection>
<map_components component_1="iic_hinch" component_2="CaRU" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
<map_variables variable_1="Ca_SR" variable_2="Ca_SR" />
</connection>
<connection>
<map_components component_1="iic_hinch" component_2="iic_niederer" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="Myofilaments" component_2="filament_overlap" />
<map_variables variable_1="lambda" variable_2="lambda" />
</connection>
<connection>
<map_components component_1="steady_state_outward_K_current" component_2="membrane" />
<map_variables variable_1="i_ss" variable_2="i_ss" />
</connection>
<connection>
<map_components component_1="environment" component_2="sarcolemmal_calcium_pump_current" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="CaRU" component_2="RyR_current" />
<map_variables variable_1="V_myo" variable_2="V_myo" />
<map_variables variable_1="N" variable_2="N" />
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="Ca_independent_transient_outward_K_current_s_slow_gate" />
<map_variables variable_1="time" variable_2="time" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="steady_state_outward_K_current_r_ss_gate" component_2="steady_state_outward_K_current" />
<map_variables variable_1="r_ss" variable_2="r_ss" />
</connection>
<connection>
<map_components component_1="membrane_hinch" component_2="intracellular_ion_concentrations" />
<map_variables variable_1="F" variable_2="F" />
</connection>
<connection>
<map_components component_1="CaRU" component_2="DS_Calcium_Concentrations" />
<map_variables variable_1="FVRT_Ca" variable_2="FVRT_Ca" />
<map_variables variable_1="g_D" variable_2="g_D" />
<map_variables variable_1="Ca_SR" variable_2="Ca_SR" />
<map_variables variable_1="Ca_o" variable_2="Ca_o" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
<map_variables variable_1="J_R" variable_2="J_R" />
<map_variables variable_1="J_L" variable_2="J_L" />
</connection>
<connection>
<map_components component_1="hyperpolarisation_activated_current_y_gate" component_2="hyperpolarisation_activated_current" />
<map_variables variable_1="y" variable_2="y" />
</connection>
<connection>
<map_components component_1="iic_hinch" component_2="SERCA2a_pump" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="standard_ionic_concentrations" component_2="Na_Ca_Exchanger" />
<map_variables variable_1="Na_o" variable_2="Na_o" />
<map_variables variable_1="Ca_o" variable_2="Ca_o" />
</connection>
<connection>
<map_components component_1="iic_hinch" component_2="Na_Ca_ion_exchanger_current" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="membrane_hinch" component_2="membrane" />
<map_variables variable_1="R" variable_2="R" />
<map_variables variable_1="F" variable_2="F" />
<map_variables variable_1="T" variable_2="T" />
</connection>
<connection>
<map_components component_1="iic_niederer" component_2="troponin_Ca_buffer" />
<map_variables variable_1="TRPN" variable_2="TRPN" />
</connection>
<connection>
<map_components component_1="Sarcolemmal_Ca_pump" component_2="iic_hinch" />
<map_variables variable_1="I_pCa" variable_2="I_pCa" />
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="SERCA2a_pump" />
<map_variables variable_1="Ca_NSR" variable_2="Ca_NSR" />
</connection>
<connection>
<map_components component_1="troponin" component_2="tropomyosin" />
<map_variables variable_1="gamma_trpn" variable_2="gamma_trpn" />
<map_variables variable_1="k_on" variable_2="k_on" />
<map_variables variable_1="Ca_TRPN_Max" variable_2="Ca_TRPN_Max" />
<map_variables variable_1="k_Ref_off" variable_2="k_Ref_off" />
</connection>
<connection>
<map_components component_1="environment" component_2="Myofilaments" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="convert_hinch" component_2="background_currents" />
<map_variables variable_1="I_CaB" variable_2="i_B_Ca" />
</connection>
<connection>
<map_components component_1="environment" component_2="SERCA2a_pump" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="sodium_current" component_2="sodium_current_m_gate" />
<map_variables variable_1="V" variable_2="V" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="membrane" component_2="membrane_hinch" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="membrane_hinch" component_2="background_currents" />
<map_variables variable_1="R" variable_2="R" />
<map_variables variable_1="F" variable_2="F" />
<map_variables variable_1="T" variable_2="T" />
</connection>
<connection>
<map_components component_1="environment" component_2="steady_state_outward_K_current" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="cell_geometry" component_2="convert_hinch" />
<map_variables variable_1="V_myo" variable_2="V_myo" />
</connection>
<connection>
<map_components component_1="SERCA2a_pump" component_2="intracellular_ion_concentrations" />
<map_variables variable_1="J_up" variable_2="J_up" />
</connection>
<connection>
<map_components component_1="iic_hinch" component_2="intracellular_ion_concentrations" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="membrane" component_2="CaRU" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="Na_Ca_ion_exchanger_current" />
<map_variables variable_1="Na_i" variable_2="Na_i" />
</connection>
<connection>
<map_components component_1="environment" component_2="iic_hinch" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="steady_state_outward_K_current_s_ss_gate" component_2="steady_state_outward_K_current" />
<map_variables variable_1="s_ss" variable_2="s_ss" />
</connection>
<connection>
<map_components component_1="membrane_hinch" component_2="inward_rectifier" />
<map_variables variable_1="R" variable_2="R" />
<map_variables variable_1="F" variable_2="F" />
<map_variables variable_1="T" variable_2="T" />
</connection>
<connection>
<map_components component_1="sodium_current" component_2="hyperpolarisation_activated_current" />
<map_variables variable_1="E_Na" variable_2="E_Na" />
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="inward_rectifier" />
<map_variables variable_1="E_K" variable_2="E_K" />
</connection>
<connection>
<map_components component_1="iic_hinch" component_2="intracellular_and_SR_Ca_fluxes" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="sodium_current" />
<map_variables variable_1="Na_i" variable_2="Na_i" />
</connection>
<connection>
<map_components component_1="troponin" component_2="iic_hinch" />
<map_variables variable_1="J_TRPN" variable_2="I_TRPN" />
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_f_11_gate" />
<map_variables variable_1="V" variable_2="V" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="iic_niederer" component_2="iic_hinch" />
<map_variables variable_1="TRPN" variable_2="TRPN" />
</connection>
<connection>
<map_components component_1="SR_Ca_release_channel" component_2="intracellular_ion_concentrations" />
<map_variables variable_1="J_rel" variable_2="J_rel" />
</connection>
<connection>
<map_components component_1="CaRU_Transitions" component_2="CaRU_reduced_states" />
<map_variables variable_1="mu_pcc" variable_2="mu_pcc" />
<map_variables variable_1="mu_moc" variable_2="mu_moc" />
<map_variables variable_1="epsilon_pco" variable_2="epsilon_pco" />
<map_variables variable_1="beta_pcc" variable_2="beta_pcc" />
<map_variables variable_1="alpha_p" variable_2="alpha_p" />
<map_variables variable_1="alpha_m" variable_2="alpha_m" />
<map_variables variable_1="beta_m" variable_2="beta_m" />
<map_variables variable_1="mu_mcc" variable_2="mu_mcc" />
<map_variables variable_1="epsilon_pcc" variable_2="epsilon_pcc" />
<map_variables variable_1="epsilon_m" variable_2="epsilon_m" />
<map_variables variable_1="mu_poc" variable_2="mu_poc" />
</connection>
<connection>
<map_components component_1="hyperpolarisation_activated_current" component_2="membrane" />
<map_variables variable_1="i_f" variable_2="i_f" />
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="intracellular_and_SR_Ca_fluxes" />
<map_variables variable_1="Ca_NSR" variable_2="Ca_NSR" />
<map_variables variable_1="Ca_ss" variable_2="Ca_ss" />
<map_variables variable_1="Ca_JSR" variable_2="Ca_JSR" />
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="sodium_potassium_pump" />
<map_variables variable_1="Na_i" variable_2="Na_i" />
</connection>
<connection>
<map_components component_1="membrane_hinch" component_2="sodium_current" />
<map_variables variable_1="R" variable_2="R" />
<map_variables variable_1="F" variable_2="F" />
<map_variables variable_1="T" variable_2="T" />
</connection>
<connection>
<map_components component_1="CaRU" component_2="LCC_current" />
<map_variables variable_1="V_myo" variable_2="V_myo" />
<map_variables variable_1="N" variable_2="N" />
</connection>
<connection>
<map_components component_1="standard_ionic_concentrations" component_2="background_currents" />
<map_variables variable_1="Ca_o" variable_2="Ca_o" />
</connection>
<connection>
<map_components component_1="environment" component_2="Cross_Bridges" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="convert_hinch" component_2="membrane" />
<map_variables variable_1="I_NaCa" variable_2="i_NaCa" />
<map_variables variable_1="I_pCa" variable_2="i_Ca_P" />
<map_variables variable_1="I_LCC" variable_2="i_Ca_L" />
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="Na_Ca_Exchanger" />
<map_variables variable_1="Na_i" variable_2="Na_i" />
</connection>
<connection>
<map_components component_1="filament_overlap" component_2="isometric_tension" />
<map_variables variable_1="overlap" variable_2="overlap" />
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="L_type_Ca_channel" />
<map_variables variable_1="Ca_ss" variable_2="Ca_ss" />
</connection>
<connection>
<map_components component_1="membrane" component_2="Na_Ca_ion_exchanger_current" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="Ca_independent_transient_outward_K_current_r_gate" />
<map_variables variable_1="time" variable_2="time" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="standard_ionic_concentrations" component_2="CaRU" />
<map_variables variable_1="Ca_o" variable_2="Ca_o" />
</connection>
<connection>
<map_components component_1="filament_overlap" component_2="tropomyosin" />
<map_variables variable_1="beta_0" variable_2="beta_0" />
</connection>
<connection>
<map_components component_1="CaRU" component_2="CaRU_reduced_states" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="DS_Calcium_Concentrations" component_2="CaRU_Transitions" />
<map_variables variable_1="C_oc" variable_2="C_oc" />
<map_variables variable_1="C_co" variable_2="C_co" />
</connection>
<connection>
<map_components component_1="membrane" component_2="inward_rectifier" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="iic_niederer" component_2="tropomyosin" />
<map_variables variable_1="Ca_b" variable_2="Ca_b" />
</connection>
<connection>
<map_components component_1="LCC_and_RyR_fluxes" component_2="RyR_current" />
<map_variables variable_1="J_Roo" variable_2="J_Roo" />
<map_variables variable_1="J_Rco" variable_2="J_Rco" />
</connection>
<connection>
<map_components component_1="background_currents" component_2="membrane" />
<map_variables variable_1="i_B" variable_2="i_B" />
</connection>
<connection>
<map_components component_1="iic_hinch" component_2="calmodulin_Ca_buffer" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="environment" component_2="tropomyosin" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="CaRU_reduced_states" component_2="LCC_current" />
<map_variables variable_1="z_2" variable_2="z_2" />
<map_variables variable_1="z_1" variable_2="z_1" />
</connection>
<connection>
<map_components component_1="iic_hinch" component_2="troponin_Ca_buffer" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="Cross_Bridges" component_2="troponin" />
<map_variables variable_1="Tension" variable_2="Tension" />
</connection>
<connection>
<map_components component_1="standard_ionic_concentrations" component_2="extracellular_ion_concentrations" />
<map_variables variable_1="Na_o" variable_2="Na_o" />
<map_variables variable_1="Ca_o" variable_2="Ca_o" />
</connection>
<connection>
<map_components component_1="cell_geometry" component_2="iic_hinch" />
<map_variables variable_1="V_myo" variable_2="V_myo" />
<map_variables variable_1="V_SR" variable_2="V_SR" />
</connection>
<connection>
<map_components component_1="hyperpolarisation_activated_current" component_2="hyperpolarisation_activated_current_y_gate" />
<map_variables variable_1="time" variable_2="time" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="inward_rectifier" />
<map_variables variable_1="K_i" variable_2="K_i" />
</connection>
<connection>
<map_components component_1="Background_Ca_current" component_2="iic_hinch" />
<map_variables variable_1="I_CaB" variable_2="I_CaB" />
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_Ca_inact_gate" />
<map_variables variable_1="V" variable_2="V" />
<map_variables variable_1="Ca_ss" variable_2="Ca_ss" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="environment" component_2="Ca_independent_transient_outward_K_current" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="inward_rectifier" component_2="membrane" />
<map_variables variable_1="i_K1" variable_2="i_K1" />
</connection>
<connection>
<map_components component_1="troponin" component_2="iic_niederer" />
<map_variables variable_1="J_TRPN" variable_2="J_TRPN" />
<map_variables variable_1="Ca_TRPN_Max" variable_2="Ca_TRPN_Max" />
</connection>
<connection>
<map_components component_1="environment" component_2="env_niederer" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="background_currents" />
<map_variables variable_1="E_K" variable_2="E_K" />
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current_r_gate" component_2="Ca_independent_transient_outward_K_current" />
<map_variables variable_1="r" variable_2="r" />
</connection>
<connection>
<map_components component_1="SR_Ca_leak_current" component_2="iic_hinch" />
<map_variables variable_1="I_SR" variable_2="I_SR" />
</connection>
<connection>
<map_components component_1="steady_state_outward_K_current" component_2="steady_state_outward_K_current_r_ss_gate" />
<map_variables variable_1="time" variable_2="time" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="convert_hinch" component_2="intracellular_ion_concentrations" />
<map_variables variable_1="I_NaCa" variable_2="i_NaCa" />
<map_variables variable_1="I_pCa" variable_2="i_Ca_P" />
<map_variables variable_1="I_LCC" variable_2="i_Ca_L" />
<map_variables variable_1="I_CaB" variable_2="i_B_Ca" />
</connection>
<connection>
<map_components component_1="sodium_current" component_2="membrane" />
<map_variables variable_1="i_Na" variable_2="i_Na" />
</connection>
<connection>
<map_components component_1="L_type_Ca_channel_f_11_gate" component_2="L_type_Ca_channel" />
<map_variables variable_1="f_11" variable_2="f_11" />
</connection>
<rdf:RDF xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:model="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#" xmlns:j.0="http://imc.org/vCard/3.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ro="http://www.obofoundry.org/ro/ro.owl#" xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#" xmlns:opb="http://bhi.washington.edu/OPB#">
<rdf:Description rdf:ID="v138">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_63">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25">
<semsim:hasPhysicalEntityReference rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<ro:part_of>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_1">
<semsim:refersTo rdf:resource="http://purl.org/sig/ont/fma/fma14067" />
</rdf:Description>
</ro:part_of>
<semsim:refersTo rdf:resource="http://purl.org/sig/ont/fma/fma63841" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v223">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_119">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_19">
<dcterms:description>Total current through the hyperpolarization activated channel</dcterms:description>
<semsim:name>Hyperpolarization activated channel current</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v213">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_111">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5">
<semsim:hasPhysicalEntityReference rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<ro:part_of>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_0">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_1" />
<semsim:refersTo rdf:resource="http://purl.org/sig/ont/fma/fma66836" />
</rdf:Description>
</ro:part_of>
<semsim:refersTo rdf:resource="http://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v449">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_241">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_28">
<dcterms:description>Flux of troponin C low affinity binding of calcium</dcterms:description>
<semsim:name>Troponin C low affinity binding site/calcium buffering</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00592" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v100">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_56">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v222">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_118">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_33">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:refersTo rdf:resource="http://identifiers.org/chebi/CHEBI:29103" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_01581" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v226">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_121">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_35">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:refersTo rdf:resource="http://identifiers.org/chebi/CHEBI:29101" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_01581" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v250">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_132">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v225">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_120">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_20">
<dcterms:description>Potassium current through the hyperpolarization activated channel</dcterms:description>
<semsim:name>Hyperpolarization activated channel potassium current</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v210">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_110">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_12">
<ro:part_of>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_13">
<ro:part_of>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_14">
<semsim:refersTo rdf:resource="http://purl.org/sig/ont/fma/fma9462" />
</rdf:Description>
</ro:part_of>
<semsim:refersTo rdf:resource="http://purl.org/sig/ont/fma/fma9672" />
</rdf:Description>
</ro:part_of>
<semsim:refersTo rdf:resource="http://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v446">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_238">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_27">
<dcterms:description>Calcium flux from network SR into junctional SR by diffusion</dcterms:description>
<semsim:name>Internal SR calcium transfer</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00592" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v104">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_59">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_12">
<dcterms:description>Current through fast sodium channel</dcterms:description>
<semsim:name>Fast sodium channel current</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v445">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_237">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_53">
<ro:part_of>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_52">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_1" />
<semsim:refersTo rdf:resource="http://purl.org/sig/ont/fma/fma67895" />
</rdf:Description>
</ro:part_of>
<semsim:name>Calcium bound to high affinity troponin C binding sites</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v430">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_225">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_1" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00293" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v172">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_81">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_35" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_01581" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v101">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_57">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_35" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_01581" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v448">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_240">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v260">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_137">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_22">
<dcterms:description>Calcium flux through sarcoplasmic reticulum RyR receptor</dcterms:description>
<semsim:name>Sarcoplasmic reticulum calcium release flux</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00592" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v240">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_125">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_0" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v443">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_236">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_51">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_52" />
<semsim:name>Total portion of low affinity troponin C binding sites</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v221">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_117">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_18">
<dcterms:description>Sodium current through the hyperpolarization activated channel</dcterms:description>
<semsim:name>Hyperpolarization activated channel sodium current</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v447">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_239">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_25">
<dcterms:description>Calcium Flux from the cytosolic diadic space to the bulk cytosol by diffusion</dcterms:description>
<semsim:name>Internal cytosolic calcium transfer</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00592" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v241">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_126">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v160">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_77">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v170">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_80">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v442">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_235">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_39">
<ro:part_of>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_40">
<ro:part_of>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_41">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_1" />
<dcterms:description>Region of the sarcoplasmic reticulum connecting the junction sarcoplasmic reticulum regions</dcterms:description>
<semsim:name>Network sarcoplasmic reticulum</semsim:name>
</rdf:Description>
</ro:part_of>
<semsim:refersTo rdf:resource="http://purl.org/sig/ont/fma/fma72444" />
</rdf:Description>
</ro:part_of>
<semsim:refersTo rdf:resource="http://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v103">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_58">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_30">
<semsim:hasPhysicalEntityReference rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_30" />
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_13" />
<semsim:refersTo rdf:resource="http://identifiers.org/chebi/CHEBI:29101" />
<semsim:hasPhysicalEntityReference>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_15">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_13" />
<semsim:refersTo rdf:resource="http://identifiers.org/chebi/CHEBI:29101" />
</rdf:Description>
</semsim:hasPhysicalEntityReference>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v182">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_90">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_12" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v196">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_102">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_5">
<semsim:hasMediatorParticipant>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_23">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:hasPhysicalEntityReference rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_23" />
<ro:part_of>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_7">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_1" />
<semsim:refersTo rdf:resource="http://purl.org/sig/ont/fma/fma63841" />
</rdf:Description>
</ro:part_of>
<semsim:refersTo rdf:resource="http://identifiers.org/uniprot/P11505" />
</rdf:Description>
</semsim:hasMediatorParticipant>
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_22">
<semsim:hasPhysicalEntityReference rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_12" />
<semsim:hasPhysicalEntityReference rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_22" />
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_13" />
<semsim:refersTo rdf:resource="http://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:name>Sarcolemmal calcium-ATPase flow</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v317">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_162">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_39" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v0">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_0">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_0" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:about="http://www.cellml.org/cellml/1.0">
<dc:publisher>Auckland Bioengineering Institute</dc:publisher>
<cmeta:comment>
<rdf:Description rdf:about="rdf:#22da1e29-04c8-420d-936b-bd8b2e486104">
<dc:creator>
<rdf:Description rdf:about="rdf:#314dbed2-8642-4da9-80fd-945b5d1ec7ea">
<vCard:FN>James Lawson</vCard:FN>
</rdf:Description>
</dc:creator>
<rdf:value>This model can be simulated in COR and PCEnv and is able to reproduce the results published in Niederer et al.'s 2006 paper.</rdf:value>
</rdf:Description>
</cmeta:comment>
<dcterms:created>
<rdf:Description rdf:about="rdf:#47b74e5d-97ed-4aaa-a687-07fd8f195b42">
<dcterms:W3CDTF>2008-01-07T00:00:00+00:00</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<dc:creator>
<rdf:Description rdf:about="rdf:#e137d61c-82dc-4189-b9f0-29b66171c2e1">
<vCard:ORG>
<rdf:Description rdf:about="rdf:#ef3cf40f-3b42-4ed0-993c-730bdf918afc">
<vCard:Orgname>The University of Auckland</vCard:Orgname>
<vCard:Orgunit>Auckland Bioengineering Institute</vCard:Orgunit>
</rdf:Description>
</vCard:ORG>
<vCard:EMAIL>
<j.0:internet rdf:about="rdf:#53e5d308-54da-4612-80cc-b8391fe05593">
<rdf:value>j.terkildsen@auckland.ac.nz</rdf:value>
</j.0:internet>
</vCard:EMAIL>
<vCard:N>
<rdf:Description rdf:about="rdf:#02fbf752-3e20-4809-818c-bd7725477072">
<vCard:Given>Jonna</vCard:Given>
<vCard:Family>Terkildsen</vCard:Family>
<vCard:Other />
</rdf:Description>
</vCard:N>
</rdf:Description>
</dc:creator>
<cmeta:modification>
<rdf:Description rdf:about="rdf:#09f3904b-dd66-4a28-abac-7bb5cd351965">
<dcterms:modified>
<rdf:Description rdf:about="rdf:#a4cc9a49-f551-4ae0-8ce6-2c5513162628">
<dcterms:W3CDTF>2008-08-05T10:32:30+12:00</dcterms:W3CDTF>
</rdf:Description>
</dcterms:modified>
<rdf:value>added cmeta id to T_0 variable</rdf:value>
<cmeta:modifier>
<rdf:Description rdf:about="rdf:#7f8791df-4ef7-4dcc-963d-9a0480c65a43">
<vCard:N>
<rdf:Description rdf:about="rdf:#5558142b-a43a-435c-aa8d-7da64599a4cc">
<vCard:Given>James</vCard:Given>
<vCard:Family>Lawson</vCard:Family>
<vCard:Other>Richard</vCard:Other>
</rdf:Description>
</vCard:N>
</rdf:Description>
</cmeta:modifier>
</rdf:Description>
</cmeta:modification>
</rdf:Description>
<rdf:Description rdf:ID="v30">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_7">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v48">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_15">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_2">
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_18">
<semsim:hasPhysicalEntityReference rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_18" />
<ro:part_of>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_9">
<ro:part_of>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_10">
<semsim:refersTo rdf:resource="http://purl.org/sig/ont/fma/fma14067" />
</rdf:Description>
</ro:part_of>
<semsim:refersTo rdf:resource="http://purl.org/sig/ont/fma/fma66836" />
</rdf:Description>
</ro:part_of>
<semsim:refersTo rdf:resource="http://identifiers.org/uniprot/P02591" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_17">
<semsim:hasPhysicalEntityReference rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_17" />
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_9" />
<semsim:refersTo rdf:resource="http://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_16">
<semsim:hasPhysicalEntityReference rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_16" />
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_9" />
<dcterms:description>Calcium (2+) ion bound to site II of troponin C</dcterms:description>
<semsim:name>Calcium (2+) bound to troponin C</semsim:name>
</rdf:Description>
</semsim:hasSourceParticipant>
<dcterms:description>In this model, the formation of troponin C comes from the dissociation of the calcium (2+) / troponin C complex</dcterms:description>
<semsim:name>Dissociation of troponin C bound to calcium</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v337">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_181">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_17">
<dcterms:description>Current through L-type calcium channel</dcterms:description>
<semsim:name>L-type calcium channel current</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v316">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_161">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_32">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_0" />
<semsim:refersTo rdf:resource="http://identifiers.org/chebi/CHEBI:29103" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v195">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_101">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_0">
<semsim:hasMediatorParticipant>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_6">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:hasPhysicalEntityReference rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_6" />
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_7" />
<semsim:refersTo rdf:resource="http://identifiers.org/uniprot/B0LPN4" />
</rdf:Description>
</semsim:hasMediatorParticipant>
<semsim:hasSinkParticipant rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_3">
<semsim:hasPhysicalEntityReference rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_3" />
<ro:part_of>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_4">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_1" />
<semsim:refersTo rdf:resource="http://purl.org/sig/ont/fma/fma67225" />
</rdf:Description>
</ro:part_of>
<semsim:refersTo rdf:resource="http://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:name>Total ionic flow through ryanodine receptor</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v181">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_89">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v243">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_127">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:about="http://www.cellml.org/cellml/1.0#niederer_2006">
<ns7:simulation>
<rdf:Description rdf:about="rdf:#$+WTRo2">
<ns7:boundIntervals>
<rdf:Description rdf:about="rdf:#$0XTRo2">
<rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil" />
<rdf:first>
<rdf:Description rdf:about="rdf:#$1XTRo2">
<ns7:endingValue>1000</ns7:endingValue>
<ns7:nonstandard-pointDensity>10000</ns7:nonstandard-pointDensity>
<ns7:maximumStepSize>0.1</ns7:maximumStepSize>
</rdf:Description>
</rdf:first>
</rdf:Description>
</ns7:boundIntervals>
</rdf:Description>
</ns7:simulation>
<bqs:reference>
<rdf:Description rdf:about="rdf:#4f08decc-3fc3-49f4-9dba-6cfaa15a3c57">
<bqs:Pubmed_id>16339881</bqs:Pubmed_id>
<bqs:JournalArticle>
<rdf:Description rdf:about="rdf:#52c457d5-26a5-4a89-89a2-aec7970789e1">
<dc:creator>
<rdf:Seq rdf:about="rdf:#887c750e-c9a6-4af3-bf5c-e07638d57973">
<rdf:li>
<bqs:Person rdf:about="rdf:#cd4567e9-796d-415f-8463-bfcc4af7136a">
<vCard:N>
<rdf:Description rdf:about="rdf:#4749a01a-3930-41a0-b116-99b69afa57f2">
<vCard:Given>S</vCard:Given>
<vCard:Family>Niederer</vCard:Family>
<vCard:Other>A</vCard:Other>
</rdf:Description>
</vCard:N>
</bqs:Person>
</rdf:li>
<rdf:li>
<bqs:Person rdf:about="rdf:#f475ac2a-312b-4d06-9917-68437cf6c8da">
<vCard:N>
<rdf:Description rdf:about="rdf:#5b2dd97e-1afe-4815-8e78-2542050b7b7d">
<vCard:Given>P</vCard:Given>
<vCard:Family>Hunter</vCard:Family>
<vCard:Other>J</vCard:Other>
</rdf:Description>
</vCard:N>
</bqs:Person>
</rdf:li>
<rdf:li>
<bqs:Person rdf:about="rdf:#8fbfc9a4-eb83-48fe-8882-d7ca7e25046b">
<vCard:N>
<rdf:Description rdf:about="rdf:#dc21789e-b06b-41ab-af35-2d6feb9c5dbd">
<vCard:Given>N</vCard:Given>
<vCard:Family>Smith</vCard:Family>
<vCard:Other>P</vCard:Other>
</rdf:Description>
</vCard:N>
</bqs:Person>
</rdf:li>
</rdf:Seq>
</dc:creator>
<dc:title>A quantitative analysis of cardiac myocyte relaxation: a simulation study</dc:title>
<bqs:volume>90(5)</bqs:volume>
<bqs:first_page>1697</bqs:first_page>
<bqs:Journal>
<rdf:Description rdf:about="rdf:#4be66846-659c-4208-a256-233bf4cfad34">
<dc:title>Biophysical Journal</dc:title>
</rdf:Description>
</bqs:Journal>
<dcterms:issued>
<rdf:Description rdf:about="rdf:#ad018539-ea8c-4542-954e-02753e2863fc">
<dcterms:W3CDTF>2006-03-01 00:00</dcterms:W3CDTF>
</rdf:Description>
</dcterms:issued>
<bqs:last_page>1722</bqs:last_page>
</rdf:Description>
</bqs:JournalArticle>
</rdf:Description>
</bqs:reference>
<bqs:reference rdf:parseType="Resource">
<dc:subject rdf:parseType="Resource">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value>
<rdf:Bag>
<rdf:li>cardiac myocyte</rdf:li>
<rdf:li>endocrine</rdf:li>
<rdf:li>electrophysiology</rdf:li>
<rdf:li>relaxation</rdf:li>
<rdf:li>excitation-contraction coupling</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
</bqs:reference>
<cmeta:comment>
<rdf:Description rdf:about="rdf:#64bb668b-6f2c-493f-ae16-e2071198e2dd">
<dc:creator>
<rdf:Description rdf:about="rdf:#982f649b-9600-4031-b4c1-3d8308448733">
<vCard:FN>James Lawson</vCard:FN>
</rdf:Description>
</dc:creator>
<rdf:value>This is a CellML description of Niederer et al.'s computational model of cardiac myocyte relaxation as described in the 2006 paper "A quantitative analysis of cardiac myocyte relaxation: a simulation study"</rdf:value>
</rdf:Description>
</cmeta:comment>
</rdf:Description>
<rdf:Description rdf:ID="v47">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_14">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_10" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB01097" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v336">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_180">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_37">
<ro:part_of>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_38">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_1" />
<dcterms:description>Space between t-tubule and junctional sarcoplasmic reticulum</dcterms:description>
<semsim:name>Diadic space</semsim:name>
</rdf:Description>
</ro:part_of>
<semsim:refersTo rdf:resource="http://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v259">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_136">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_37" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v319">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_163">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_25" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00592" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v194">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_100">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_7">
<semsim:hasMediatorParticipant rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:hasSinkParticipant rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:hasSourceParticipant rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_22" />
<semsim:name>Sarcolemmal calcium leak flow</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v329">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_173">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_26">
<semsim:name>Calcium/troponin buffering</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00592" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v298">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_148">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_19" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v184">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_91">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v349">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_192">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_12" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="Background_Ca_current_I_CaB">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_74">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_7" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v284">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_141">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_7" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v270">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_139">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v339">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_183">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_20" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v328">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_172">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v193">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_99">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_9">
<semsim:hasMediatorParticipant>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_31">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_7" />
<semsim:hasPhysicalEntityReference rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_31" />
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:refersTo rdf:resource="http://identifiers.org/uniprot/Q01728" />
</rdf:Description>
</semsim:hasMediatorParticipant>
<semsim:hasSinkParticipant rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_30" />
<semsim:hasSinkParticipant rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:hasSourceParticipant rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_22" />
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_29">
<semsim:hasPhysicalEntityReference rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_29" />
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_0" />
<semsim:refersTo rdf:resource="http://identifiers.org/chebi/CHEBI:29101" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:name>Ionic flow through sodium-calcium exchanger</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v245">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_128">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v246">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_129">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_39" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v348">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_191">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v338">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_182">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_10">
<dcterms:description>Current through the transient outward potassium channel</dcterms:description>
<semsim:name>Transient outward potassium channel current</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v296">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_146">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_23">
<dcterms:description>Current through the sarcolemmal calcium pump</dcterms:description>
<semsim:name>Sarcolemmal calcium pump current</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v192">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_98">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_6">
<semsim:hasMediatorParticipant>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_24">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:hasPhysicalEntityReference rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_24" />
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_7" />
<semsim:refersTo rdf:resource="http://identifiers.org/obo.go/GO:1990454" />
</rdf:Description>
</semsim:hasMediatorParticipant>
<semsim:hasSinkParticipant rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:hasSourceParticipant rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_22" />
<semsim:name>Total calcium ion flow through L-type calcium channels</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v58">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_23">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v327">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_171">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_15">
<dcterms:description>Current through the background calcium channel</dcterms:description>
<semsim:name>Background calcium channel current</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v313">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_159">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_12" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v256">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_134">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_30" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v266">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_138">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v38">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_8">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_11">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_0" />
<semsim:refersTo rdf:resource="http://identifiers.org/chebi/CHEBI:29101" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v247">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_130">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_21">
<dcterms:description>Calcium flux through the sarcoplasmic reticulum calcium pump (SERCA2a)</dcterms:description>
<semsim:name>Sarcoplasmic reticulum calcium pump flux</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00592" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v326">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_170">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_46">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_0" />
<semsim:name>Total portion of EGTA</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v297">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_147">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_13">
<dcterms:description>Current through the inward rectifier potassium channel</dcterms:description>
<semsim:name>Inward rectifier potassium channel current</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v191">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_97">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_7" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v57">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_21">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v258">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_135">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_42">
<ro:part_of>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_43">
<ro:part_of>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_44">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_1" />
<dcterms:description>SR regions in close proximity to cytosolic diadic space</dcterms:description>
<semsim:name>Junctional sarcoplasmic reticulum</semsim:name>
</rdf:Description>
</ro:part_of>
<semsim:refersTo rdf:resource="http://purl.org/sig/ont/fma/fma72444" />
</rdf:Description>
</ro:part_of>
<semsim:refersTo rdf:resource="http://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v312">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_158">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_34">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_13" />
<semsim:refersTo rdf:resource="http://identifiers.org/chebi/CHEBI:29103" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="intracellular_ion_concentrations_Ca_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_229">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_17" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_30">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v311">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_157">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_30" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v238">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_123">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_2">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_1" />
<semsim:name>Calcium release unit</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_01001" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v248">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_131">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v390">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_198">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_3" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v190">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_96">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_0" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v325">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_169">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v294">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_144">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_11">
<dcterms:description>Current through the steady-state outward potassium channel</dcterms:description>
<semsim:name>Steady-state outward potassium channel current</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v315">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_160">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_7" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="membrane_V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_106">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v288">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_142">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v324">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_168">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_42" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v295">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_145">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_10" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="RyR_current_I_RyR">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_2">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_0" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v69">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_32">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_3">
<semsim:hasMediatorParticipant>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_19">
<ro:part_of>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_21">
<semsim:hasPhysicalEntityReference rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_21" />
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_1" />
<semsim:refersTo rdf:resource="http://purl.org/sig/ont/fma/fma80352" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalEntityReference rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_19" />
<ro:part_of>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_20">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_1" />
<semsim:refersTo rdf:resource="http://purl.org/sig/ont/fma/fma80352" />
</rdf:Description>
</ro:part_of>
<semsim:refersTo rdf:resource="http://identifiers.org/uniprot/P11507" />
</rdf:Description>
</semsim:hasMediatorParticipant>
<semsim:hasSinkParticipant rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_3" />
<semsim:hasSourceParticipant rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:name>Calcium flow into the sarcoplasmic reticulum via SERCA pump</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v255">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_133">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_12" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v49">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_16">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_18" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v39">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_9">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_1">
<dcterms:description>Current through the sodium/calcium exchanger</dcterms:description>
<semsim:name>Sodium/calcium exchanger current</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v333">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_177">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_18" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v394">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_201">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v79">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_43">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_4" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v51">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_18">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v65">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_28">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v189">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_95">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_6" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v334">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_178">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_29" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v393">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_200">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_12" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v320">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_164">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_16">
<dcterms:description>Current through the background potassium channel</dcterms:description>
<semsim:name>Background potassium channel current</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v292">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_143">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v340">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_184">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_24">
<dcterms:description>Current through the sodium/potassium pump</dcterms:description>
<semsim:name>Sodium/potassium pump current</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v335">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_179">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_27" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00592" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v429">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_224">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v90">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_50">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_10" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v331">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_175">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_11" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v321">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_165">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_13" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v80">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_44">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_3" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v392">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_199">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_0" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v302">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_149">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_1" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v77">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_41">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_29" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v351">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_194">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_14">
<dcterms:description>Current through the background sodium channel</dcterms:description>
<semsim:name>Background sodium channel current</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v67">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_29">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_7" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="Sarcolemmal_Ca_pump_I_pCa">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_27">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_5" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v332">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_176">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_23" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v7">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_1">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_2" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_01001" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v322">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_166">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_40" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v227">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_122">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v342">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_185">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_22" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00592" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v50">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_17">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_17" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v303">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_150">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_14" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00293" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v78">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_42">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_0" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v323">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_167">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_45">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_38" />
<semsim:refersTo rdf:resource="http://purl.org/sig/ont/fma/fma66836" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v40">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_10">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v68">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_31">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_0" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v398">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_203">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_2" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_01001" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v55">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_20">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v146">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_67">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_13" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v21">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_5">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="LCC_current_I_LCC">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_124">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_6" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v185">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_92">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_9" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v41">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_11">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_12" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v75">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_38">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_4">
<semsim:hasMediatorParticipant rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_21" />
<semsim:hasSinkParticipant rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:hasSourceParticipant rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_3" />
<semsim:name>Calcium leak from sarcoplasmic reticulum to myoplasm</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v147">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_68">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_1" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00293" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v417">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_215">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_0" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v199">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_105">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_37" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v304">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_151">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_7" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v343">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_186">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_47">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_43" />
<semsim:name>Total portion of calsequestrin</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v345">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_188">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_1" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v330">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_174">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_0" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v62">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_25">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_7" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v95">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_52">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v186">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_93">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_5" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="SERCA_I_SERCA">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_19">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_3" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v418">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_216">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_4" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v305">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_152">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_12" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v408">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_208">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_29" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v76">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_40">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_9" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v344">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_187">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v73">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_36">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_8">
<semsim:hasSinkParticipant rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_28">
<semsim:hasPhysicalEntityReference rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_28" />
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_0" />
<semsim:refersTo rdf:resource="http://identifiers.org/uniprot/P02591" />
<semsim:hasPhysicalEntityReference>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_26">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_0" />
<semsim:refersTo rdf:resource="http://identifiers.org/uniprot/P02591" />
</rdf:Description>
</semsim:hasPhysicalEntityReference>
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_27">
<semsim:hasPhysicalEntityReference rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_27" />
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_0" />
<semsim:name>Calcium-bound troponin</semsim:name>
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:name>Dissociation of calcium-bound Troponin C</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v346">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_189">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_21" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00592" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v84">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_46">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_1" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00293" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v43">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_12">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_7" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v386">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_196">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_6" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v63">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_26">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v419">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_217">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_7" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v405">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_206">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v159">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_76">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_3" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v197">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_103">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v149">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_70">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_12" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v306">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_153">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_17" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v74">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_37">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_5" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v395">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_202">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_7" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v347">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_190">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_48">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_0" />
<semsim:name>Total portion of calmodulin</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v83">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_45">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_32" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v44">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_13">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_15" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v280">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_140">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v93">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_51">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v406">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_207">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v188">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_94">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_0" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v198">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_104">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_17" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v148">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_69">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_33" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_01581" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v307">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_154">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_24" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v432">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_226">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v308">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_155">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v452">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_244">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_42" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v86">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_48">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_33" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_01581" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v176">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_85">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_1" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00293" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v433">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_227">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_16" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v71">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_34">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_7" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v219">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_116">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v414">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_211">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v453">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_245">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_29">
<dcterms:description>Flux of troponin C high affinity binding of calcium</dcterms:description>
<semsim:name>Troponin C high affinity binding site/calcium buffering</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00592" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v106">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_60">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_29" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v99">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_55">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_33" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_01581" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v175">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_84">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v404">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_205">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_49">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_0" />
<semsim:refersTo rdf:resource="http://identifiers.org/uniprot/P62158" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v309">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_156">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_23" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v424">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_220">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v387">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_197">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_0" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v141">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_64">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_32" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v85">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_47">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v434">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_228">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_18" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v72">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_35">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_26" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v454">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_246">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_26" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00592" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v88">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_49">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_34" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v415">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_213">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_30" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v109">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_62">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v174">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_83">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_33" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_01581" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v98">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_54">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_11" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v207">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_108">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_3" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v154">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_75">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v435">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_230">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_2" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v144">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_66">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_34" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="intracellular_ion_concentrations_CaSR_plot">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_39">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v455">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_247">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_55">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_52" />
<semsim:name>Total portion of high affinity troponin C binding sites</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v416">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_214">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00295" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v163">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_78">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_12" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v108">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_61">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_1" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00293" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v421">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_218">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_30" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v173">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_82">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_14" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v97">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_53">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v402">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_204">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v153">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_73">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v422">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_219">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_34" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v60">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_24">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_3" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v208">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_109">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v143">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_65">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v436">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_231">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_50">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_0" />
<semsim:name>Total bound and unbound troponin</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v70">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_33">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_6" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v215">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_112">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v29">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_6">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v437">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_232">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v19">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_4">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_8">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_9" />
<dcterms:description>Calcium (2+) ion bound to site II of troponin C</dcterms:description>
<semsim:name>Calcium (2+) bound to troponin C</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v427">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_222">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_7" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v152">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_72">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_14" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00293" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v205">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_107">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_14" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00293" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v179">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_88">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_36">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:refersTo rdf:resource="http://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_01581" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="Cross_Bridges_Tension">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_195">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_10" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB01097" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v350">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_193">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_43" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v438">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_233">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_8" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v216">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_113">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="SR_Ca_leak_current_I_SR">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_22">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_4" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v428">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_223">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_24" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v178">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_87">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_16" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v168">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_79">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_25" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v450">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_242">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_54">
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_52" />
<semsim:name>Calcium bound to low affinity troponin C binding site</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v217">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_114">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v410">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_209">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v439">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_234">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_28" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v150">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_71">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_5" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v17">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_3">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v425">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_221">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_29" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v177">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_86">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_15" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v451">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_243">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_37" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v412">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_210">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_12" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="Na_Ca_Exchanger_I_NaCa">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_212">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#process_9" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v218">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#property_115">
<semsim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/25032015135925185m0400#entity_37" />
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
</rdf:RDF>
</model>
Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment