minimaldjango.py

import sys
from django.conf import settings
settings.configure(
DEBUG=True,
SECRET_KEY='thisisthesecretkey',
ROOT_URLCONF=__name__,
MIDDLEWARE_CLASSES=(
'django.middleware.common.CommonMiddleware',
'django.middleware.csrf.CsrfViewMiddleware',
'django.middleware.clickjacking.XFrameOptionsMiddleware',
),
)
from django.urls import path
from django.http import HttpResponse

def index(request):
    return HttpResponse('Hello World')

urlpatterns = (
path('', index),
)
if __name__ == "__main__":
    from django.core.management import execute_from_command_line
    execute_from_command_line(sys.argv)

My minimal setup: https://github.com/NekoTashi/django-pipenv-docker-minimal-setup