Performance comparision: in-array vs. isset vs. array_key_exists

in_array_vs_isset_vs_array_key_exists.php

<?php declare(strict_types = 1);

function testPerformance($name, Closure $closure, $runs = 1000000)
{
    $start = microtime(true);
    for (; $runs > 0; $runs--)
    {
        $closure();
    }
    $end = microtime(true);

    printf("Function call %s took %.5f seconds\n", $name, $end - $start);
}

$items = [1111111];
for ($i = 0; $i < 100000; $i++) {
    $items[] = rand(0, 1000000);
}
$items = array_unique($items);
shuffle($items);

$assocItems = array_combine($items, array_fill(0, count($items), true));

$in_array = function () use ($items) {
    in_array(1111111, $items);
};

$isset = function () use ($assocItems) {
    isset($items[1111111]);
};

$array_key_exists = function () use ($assocItems) {
    array_key_exists(1111111, $assocItems);
};

testPerformance('in_array', $in_array, 100000);
testPerformance('isset', $isset, 100000);
testPerformance('array_key_exists', $array_key_exists, 100000);

result.md

$ php in_array_vs_isset_vs_array_key_exists.php 
Function call in_array took 1.51871 seconds
Function call isset took 0.14684 seconds
Function call array_key_exists took 0.22123 seconds

This comes down to what you have on hand.
If you have a static structure you compare against (i.e. filtering out sensitive content before passing data to the client), you have a map in code prepared for fastest possible lookup.
When you have an unknown data to search for keys of interest, it's most likely not worth rebuilding it as that сould cost more than what you can save on lookup itself.
So, choose wisely!