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MWE for potential SFS issue in stdpopsim
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import stdpopsim | |
import msprime as msp | |
import allel | |
import numpy as np | |
from stdpopsim import homo_sapiens | |
chrom = homo_sapiens.genome.chromosomes["chr22"] | |
recomb_map = chrom.recombination_map() | |
model = homo_sapiens.TennessenTwoPopOutOfAfrica() | |
samples = [msp.Sample(population=0,time=0)]*10 | |
# simulate with map | |
ts = msp.simulate(samples=samples,recombination_map=chrom.recombination_map(), | |
mutation_rate=chrom.default_mutation_rate,**model.asdict()) | |
s = allel.sfs(allel.HaplotypeArray(ts.genotype_matrix()).count_alleles()[:,1]) | |
print("SFS with genetic map") | |
print(s/np.sum(s)) | |
print("----------------------\n") | |
# ld prune | |
haps = allel.HaplotypeArray(ts.genotype_matrix()) | |
ul = allel.locate_unlinked(haps.to_genotypes(ploidy=2).to_n_alt()) | |
s = allel.sfs(haps[ul,:].count_alleles()[:,1]) | |
print("SFS with genetic map, LD pruned") | |
print(s/np.sum(s)) | |
print("----------------------\n") | |
# simulate with constant rate | |
ts = msp.simulate(samples=samples, | |
recombination_rate=chrom.default_recombination_rate, | |
length=chrom.length, | |
mutation_rate=chrom.default_mutation_rate,**model.asdict()) | |
s = allel.sfs(allel.HaplotypeArray(ts.genotype_matrix()).count_alleles()[:,1]) | |
print("SFS with constant rate") | |
print(s/np.sum(s)) | |
print("----------------------\n") | |
# ld prune | |
haps = allel.HaplotypeArray(ts.genotype_matrix()) | |
ul = allel.locate_unlinked(haps) | |
s = allel.sfs(haps[ul,:].count_alleles()[:,1]) | |
print("SFS with constant rate, LD pruned") | |
print(s/np.sum(s)) |
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