twitter_block_user.py

import twitter

ACCESS_KEY = 'xxxx'
ACCESS_SECRET = 'xxxx'
CONSUMER_KEY = 'xxxx'
CONSUMER_SECRET = 'xxxx'

t = twitter.Twitter(auth=twitter.OAuth(ACCESS_KEY, ACCESS_SECRET, CONSUMER_KEY, CONSUMER_SECRET))

def twitter_block_user(screen_name):
	try:
		blocked = t.blocks.create(screen_name=screen_name)
		if blocked:
			print ("Blocked user: [ @%s ]." % screen_name)
		else:
			print ("Could not block: [ @%s ]." % screen_name)
	except Exception: 
		pass

with open('blocklist') as fp:
	for line in fp:
		twitter_block_user(line.rstrip())