I did a really quick proof of concept of playing different sound effects when rolling 1's and 20's. This is using QPython to run a web server that handles the web requests from the Pixels Dice app (https://gamewithpixels.com/).

dice_soundboard_webapp.py

#qpy:webapp:Hello QPython
#qpy://127.0.0.1:8080/
"""
This is a sample for qpython webapp
"""
import os
import time
import androidhelper
from bottle import Bottle, ServerAdapter
from bottle import run, debug, route, error, static_file, template, request
import logging

logger = logging.getLogger('my_logger')

indexes = {
    'good': 0,
    'bad': 0
}

GOOD_SOUNDS = ['https://www.myinstants.com/media/sounds/final-fantasy-vii-victory-fanfare-1.mp3',
               'https://www.myinstants.com/media/sounds/anime-wow-sound-effect.mp3',
               'https://www.myinstants.com/media/sounds/mlg-airhorn.mp3',
               'https://www.myinstants.com/media/sounds/zelda-chest-opening-and-item-catch.mp3',
               'https://www.myinstants.com/media/sounds/kids-saying-yay-sound-effect_3.mp3']
BAD_SOUNDS = ['https://www.myinstants.com/media/sounds/dun-dun-dun-sound-effect-brass_8nFBccR.mp3',
              'https://www.myinstants.com/media/sounds/the-price-is-right-losing-horn.mp3',
              'https://www.myinstants.com/media/sounds/meme-de-creditos-finales.mp3',
              'https://www.myinstants.com/media/sounds/awkward-cricket-sound-effect.mp3',
              'https://www.myinstants.com/media/sounds/heknew.mp3']

######### QPYTHON WEB SERVER ###############

class MyWSGIRefServer(ServerAdapter):
    server = None

    def run(self, handler):
        from wsgiref.simple_server import make_server, WSGIRequestHandler
        if self.quiet:
            class QuietHandler(WSGIRequestHandler):
                def log_request(*args, **kw): pass
            self.options['handler_class'] = QuietHandler
        self.server = make_server(self.host, self.port, handler, **self.options)
        self.server.serve_forever()

    def stop(self):
        #sys.stderr.close()
        import threading 
        threading.Thread(target=self.server.shutdown).start() 
        #self.server.shutdown()
        self.server.server_close() #<--- alternative but causes bad fd exception
        print("# qpyhttpd stop")


######### BUILT-IN ROUTERS ###############
@route('/__exit', method=['GET','HEAD'])
def __exit():
    global server
    server.stop()

@route('/__ping')
def __ping():
    return "ok"

@route('/__play')
def __play():
    droid = androidhelper.Android()
    url = None
    if request.json['faceValue'] == 20:
        url = GOOD_SOUNDS[indexes['good'] % len(GOOD_SOUNDS)]
        indexes['good'] += 1
    elif request.json['faceValue'] == 1:
        url = BAD_SOUNDS[indexes['bad'] % len(BAD_SOUNDS)]
        indexes['bad'] += 1
    if url is not None:
        droid.mediaPlay(url,play=True)
    print(request.json)
    logger.error(request.json)
    return "ok"


@route('/assets/<filepath:path>')
def server_static(filepath):
    return static_file(filepath, root=os.path.dirname(os.path.abspath(__file__)))

######### WEBAPP ROUTERS ###############
@route('/')
def home():
    name='QPython'
    file=os.path.basename(__file__)
    cont=f'''
<h1>Hello {name} !</h1><a href="/assets/{file}">View source</a><br><br>
<a href="__exit">>> Exit</a><br>
<a href="http://wiki.qpython.org/doc/program_guide/web_app/">>> About QPython Web App</a>
'''
    return template(cont)


######### WEBAPP ROUTERS ###############
app = Bottle()
app.route('/', method='GET')(home)
app.route('/__exit', method=['GET','HEAD'])(__exit)
app.route('/__ping', method=['GET','HEAD'])(__ping)
app.route('/__play', method=['POST','HEAD'])(__play)
app.route('/assets/<filepath:path>', method='GET')(server_static)

try:
    server = MyWSGIRefServer(host="127.0.0.1", port="8080")
    app.run(server=server,reloader=False)
except (Exception) as ex:
    print("Exception: %s" % repr(ex))

Demo video: https://www.youtube.com/watch?v=oZFggJm8ZQ4

Dice web request just needs to send the JSON payload to 127.0.0.1:8080/__play