Just do this tutorial.
- NumPy is also available as x64 now. You don't need to build it yourself
- CMake does not find your installed Visual Studio automagically. Really, select the one you have
- If you finished BUILD and INSTALL, but in Python you get
ImportError: DLL not found
, addOpenCV\build\install\x64\vc14\bin
or appropriate. - I made it work with Python 2.7.14 and Python 2.5.2. On Windows 10.