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Last active August 29, 2015 14:27
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Notes from Herman Skolnik ACS 2015
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skolnik.rst

Herman Skolnik Award Symposium

  • Postdoc at Biosym on DFT of enzyme-inhibitor cmplexes
  • At BMS he worked on protein modeling

Looking for the printing press in Jurgen's office

Jane Tseng

Yeat's quote - importance of friend c5.0 (rule-based machine learning method) - can show the rules derived from the data

Gerry Maggiora

"Chaos at the marraige between heaven and hell" - Steenburg Reductionism versus functionalism MicroRNAs regarded as relevant for disease in last decade a lot of work on this Myth of specificity (started with 'lock and key') giving way to polypharmacology (adverse drug reactions and repurposed drugs imply this) First drug target network published in 2007 - Yildirum 2-7 targets per drug seen in papers published - Hu/Bajorath and Mestes papers - probably just a subset Drug2gene database - 41 targets associated with Gleevec (data taken from the literature) Drug-induced changes in gene expresion

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