fabfile.py

from fabric.api import local,run, sudo, cd, prefix, env, put, settings, show

env.hosts = ['33.33.33.10']
env.user = 'vagrant'

def first():
    run('ifconfig eth1')

def second():
    with settings(
        hosts=['33.33.33.11'], 
    ):
        first()

output

$ fab first
[33.33.33.10] Executing task 'first'
[33.33.33.10] run: ifconfig eth1
[33.33.33.10] out: eth1      Link encap:Ethernet  HWaddr 08:00:27:27:d1:42  
[33.33.33.10] out:           inet addr:33.33.33.10  Bcast:33.33.33.255  Mask:255.255.255.0
[33.33.33.10] out:           inet6 addr: fe80::a00:27ff:fe27:d142/64 Scope:Link
[33.33.33.10] out:           UP BROADCAST RUNNING MULTICAST  MTU:1500  Metric:1
[33.33.33.10] out:           RX packets:361 errors:0 dropped:0 overruns:0 frame:0
[33.33.33.10] out:           TX packets:269 errors:0 dropped:0 overruns:0 carrier:0
[33.33.33.10] out:           collisions:0 txqueuelen:1000 
[33.33.33.10] out:           RX bytes:49073 (49.0 KB)  TX bytes:48601 (48.6 KB)
[33.33.33.10] out: 
[33.33.33.10] out: 

Done.
Disconnecting from 33.33.33.10... done.
(testfabric)mattgeorge@mattgeorge in ~/testfab
$ fab second
[33.33.33.10] Executing task 'second'
[33.33.33.10] run: ifconfig eth1
[33.33.33.10] out: eth1      Link encap:Ethernet  HWaddr 08:00:27:27:d1:42  
[33.33.33.10] out:           inet addr:33.33.33.10  Bcast:33.33.33.255  Mask:255.255.255.0
[33.33.33.10] out:           inet6 addr: fe80::a00:27ff:fe27:d142/64 Scope:Link
[33.33.33.10] out:           UP BROADCAST RUNNING MULTICAST  MTU:1500  Metric:1
[33.33.33.10] out:           RX packets:389 errors:0 dropped:0 overruns:0 frame:0
[33.33.33.10] out:           TX packets:291 errors:0 dropped:0 overruns:0 carrier:0
[33.33.33.10] out:           collisions:0 txqueuelen:1000 
[33.33.33.10] out:           RX bytes:52727 (52.7 KB)  TX bytes:52540 (52.5 KB)
[33.33.33.10] out: 
[33.33.33.10] out: 

Done.
Disconnecting from 33.33.33.10... done.