Pynamodb AWS_PROFILE https://github.com/pynamodb/PynamoDB/issues/204#issuecomment-360568930

monkeypatch.py

from pynamodb.models import Model
from pynamodb.attributes import UnicodeAttribute, NumberAttribute


class MyModel(Model):
    class Meta:
        table_name = 'mytable'

    group = UnicodeAttribute(hash_key=True)
    id = NumberAttribute(range_key=True)
    name = UnicodeAttribute()


def monkeypatch_connection(profile=None):
    from botocore.session import Session
    from pynamodb.connection.base import Connection

    @property
    def session(self):
        if getattr(self._local, 'session', None) is None:
            self._local.session = Session(profile=profile)
        return self._local.session

    Connection.session = session


monkeypatch_connection(profile='my-aws-profile')