not-interested.js

// go to https://twitter.com/settings/your_twitter_data/twitter_interests
// paste into dev tools console
const checks= [...document.querySelectorAll("div > input[type='checkbox']:checked")];
function queueNext(limit){ setTimeout(()=>{ checks.shift().click(); queueNext(limit+=1000); }, limit); }
queueNext(10000);

if it seems to be getting too slow and there are no errors, throw another queueNext(1000) in there - you don't need to reload the page.