Install pypiserver

nginx.conf

server {
    server_name build.example.com;
    listen 10.10.10.10:443;

    ssl_certificate /etc/nginx/ssl/build.example.com.crt;
    ssl_certificate_key /etc/nginx/ssl/build.example.com.key;


    location /pypi {
            proxy_pass http://127.0.0.1:4046;
            proxy_set_header Host $host;
            proxy_set_header X-Real-IP $remote_addr;
            proxy_set_header X-Forwarded-For $proxy_add_x_forwarded_for;
            proxy_set_header X-Forwarded-Proto $scheme;
    }
}

server {
        listen 10.10.10.10:80;

        server_name build.example.com;

        include /etc/nginx/snippets/letsencrypt.conf;

        location / {
             return 301 https://$host$request_uri;
        }
}

pypiserver.ini

[uwsgi]
plugin = python,http
http-socket = 127.0.0.1:4046
wsgi-file = /srv/build/pypiserver_wsgi.py
callable = wsgi_app
pyargv = /srv/build/python_packages
master = True
processes = 1
threads = 2
lazy-app = True
virtualenv = /srv/build/venv-site/

pypiserver_wsgi.py

from pypiserver import app, bottle
import sys

child_app = app(
    root=sys.argv[1],
    hash_algo=None,
    redirect_to_fallback=False,
    password_file='/etc/nginx/user/backend',
    fallback_url=False,
    authenticated=['list', 'download', 'update'],
    cache_control=20
)

wsgi_app = bottle.Bottle()
# /pypi/ is the subdirectory where pypiserver is served
wsgi_app.mount('/pypi/', child_app)