adjust.py

import bpy

# Mark Active Layers
actives = ["buildings", "floor"]

for l in bpy.data.scenes["Scene"].render.layers:
    # Disable all Layers
    l.use = False

    # Denoising Options
    l.cycles.denoising_feature_strength = 0.2
    l.cycles.denoising_strength = 0.2

for name in actives:
    bpy.data.scenes["Scene"].render.layers[name].use = True

# Set samples and light bounces
bpy.data.scenes["Scene"].cycles.samples = 3000
bpy.data.scenes["Scene"].cycles.max_bounces = 12

bpy.ops.wm.save_mainfile()

print("Updated. Activer layers set to: {}. Samples set to: {}".format(", ".join(actives), bpy.data.scenes["Scene"].cycles.samples))