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Summary of The gut Microbiome Associates with Phenotypic Manifestations of Post-Acute COVID-19 Syndrome

Source and Special thanks to Reddit User kwil2

• ENTEROTYPE 1
  • gut-biome characteristics
    • a low count of
      • Bifidobacterium adolescentis and
• high count of

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TLDR Version

• Long COVID is associated with reduced circulating serotonin levels
• Serotonin depletion is driven by viral RNA-induced type I interferons (IFNs)
• IFNs reduce serotonin through diminished tryptophan uptake and hypercoagulability
• Peripheral serotonin deficiency impairs cognition via reduced vagal signaling

Graphical Abstract

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• Etiopathogenic theories about long COVID, Del Carpio-Orantes L. Etiopathogenic theories about long COVID. World J Virol 2023; 12(3): 204-208 [PMID: 37396704 DOI: 10.5501/wjv.v12.i3.204]
  • Theory of viral persistence or viral particles:
    • There is evidence that after an acute episode of COVID-19, there is persistence of viral particles in various organs up to one year after the episode and the organs mainly affected are: Brain, Gastrointestinal and Hemolymphatic; Similarly, they have been detected in blood, feces and urine
  • Theory of endothelial dysfunction:
    • This theory deals with the damage to the vascular endothelium that leads to endothelitis which, in turn, will favor platelet increase and activation, increased risk of thrombus formation with subsequent damage to organs and tissues by a mechanism of tissue ischemia that can affect the main organs and systems of the human body
  • **Theory of plat

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• [[health-and-wellness]] [[long covid]] [[leo-galland]] Establishing a healthy gut brain axis after covid-19
  • TLDW Summary (Level 1):
    • Roadmap to re-establishing a healthy gut-brain axis
      • Step 1: Stop viral proliferation in the gut
      • Step 2: Reduce epithelial cell inflammation (in the gut)
      • Step 3: Reverse gut bacterial dysbiosis created by Covid-19
      • Step 4: Restore transport and metabolism of typtophan
      • Reduce Intestinal permeability
        • Step 5: Restore mucus layer (in the GI Tract)
• Step 6: Restore tight junction integrity

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#!/bin/bash
# set -x
# Source: https://docs.aws.amazon.com/general/latest/gr/sigv4-signed-request-examples.html

[[ -n "${AWS_ACCESS_KEY_ID}" ]]     || { echo "AWS_ACCESS_KEY_ID required" >&2; exit 1; }
[[ -n "${AWS_SECRET_ACCESS_KEY}" ]] || { echo "AWS_SECRET_ACCESS_KEY required" >&2; exit 1; }

readonly method="GET"
readonly service="s3"
readonly region="eu-frankfurt-1"

codingarchitect

2021/09/21 07:39:34 [INFO] (telemetry) Starting provisioner powershell
==> oracle-oci: Provisioning with Powershell...
2021/09/21 07:39:34 packer-provisioner-powershell plugin: Found command: & C:\Windows\Panther\Generalize.cmd
2021/09/21 07:39:34 packer-provisioner-powershell plugin: Found command: while($true) { $imageState = Get-ItemProperty HKLM:\SOFTWARE\Microsoft\Windows\CurrentVersion\Setup\State | Select ImageState; if($imageState.ImageState -ne 'IMAGE_STATE_GENERALIZE_RESEAL_TO_OOBE') { Write-Output $imageState.ImageState; Start-Sleep -s 10  } else { break } }
==> oracle-oci: Provisioning with powershell script: /tmp/powershell-provisioner557910254
2021/09/21 07:39:34 packer-provisioner-powershell plugin: Opening /tmp/powershell-provisioner557910254 for reading
2021/09/21 07:39:34 packer-provisioner-powershell plugin: Uploading env vars to c:/Windows/Temp/packer-ps-env-vars-61498a73-f1d0-2cad-3480-cb143477bb4c.ps1
2021/09/21 07:39:34 packer-provisioner-powershell plugin: [INFO] 76 bytes written for '

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{
    "variables": {
        "user_ocid":"{{env `user_ocid`}}",
        "tenancy_ocid": "{{env `tenancy_ocid`}}",
        "fingerprint":"{{env `fingerprint`}}",
        "private_key_path":"{{env `private_key_path`}}",
        "private_key_password":"{{env `TF_VAR_private_key_password`}}", 
        "availability_domain": "uwhB:EU-FRANKFURT-1-AD-1",
        "region": "eu-frankfurt-1",
        "base_image_ocid": "ocid1.image.oc1.eu-frankfurt-1.redacted",

codingarchitect

<Query Kind="Program">
  <Reference>&lt;RuntimeDirectory&gt;\System.ServiceModel.dll</Reference>
  <Namespace>System.ServiceModel</Namespace>
</Query>

void Main()
{
	CallService();
}

codingarchitect

<Query Kind="Program">
  <Reference>&lt;RuntimeDirectory&gt;\Microsoft.CSharp.dll</Reference>
  <Reference>&lt;RuntimeDirectory&gt;\System.Runtime.InteropServices.dll</Reference>
  <Reference>&lt;RuntimeDirectory&gt;\System.Runtime.InteropServices.WindowsRuntime.dll</Reference>
  <Reference>&lt;RuntimeDirectory&gt;\System.Runtime.Serialization.dll</Reference>
  <Reference>&lt;RuntimeDirectory&gt;\System.ServiceModel.dll</Reference>
  <Reference>&lt;RuntimeDirectory&gt;\System.Web.dll</Reference>
  <NuGetReference>Castle.WcfIntegrationFacility</NuGetReference>
  <NuGetReference>CodingArchitect.Utilities</NuGetReference>
  <NuGetReference>Microsoft.Web.Administration</NuGetReference>

codingarchitect

<Query Kind="Program">
  <Reference>&lt;RuntimeDirectory&gt;\Microsoft.CSharp.dll</Reference>
  <Reference>&lt;RuntimeDirectory&gt;\System.Runtime.InteropServices.dll</Reference>
  <Reference>&lt;RuntimeDirectory&gt;\System.Runtime.InteropServices.WindowsRuntime.dll</Reference>
  <Reference>&lt;RuntimeDirectory&gt;\System.Runtime.Serialization.dll</Reference>
  <Reference>&lt;RuntimeDirectory&gt;\System.ServiceModel.dll</Reference>
  <NuGetReference>Microsoft.Web.Administration</NuGetReference>
  <NuGetReference>NUnitLite</NuGetReference>
  <NuGetReference>CodingArchitect.Utilities</NuGetReference>
  <Namespace>Microsoft.CSharp</Namespace>