MAPK.aeon

#position:ERK:360,425
$ERK:MEK1_2
MEK1_2 -> ERK
#position:Apoptosis:540,836
$Apoptosis:(((!ERK & p53) & FOXO3) & !BCL2)
ERK -| Apoptosis
p53 -> Apoptosis
FOXO3 -> Apoptosis
BCL2 -| Apoptosis
#position:p53:1100,268
$p53:((((!p38 & ATM) & !MDM2) | ((p38 & !ATM) & !MDM2)) | (p38 & ATM))
p38 -> p53
ATM -> p53
MDM2 -| p53
#position:FOXO3:949,731
$FOXO3:(JNK & !AKT)
JNK -> FOXO3
AKT -| FOXO3
#position:BCL2:421,738
$BCL2:(AKT & CREB)
AKT -> BCL2
CREB -> BCL2
#position:p21:30,387
$p21:(p53 & !AKT)
p53 -> p21
AKT -| p21
#position:Growth_Arrest:1041,835
$Growth_Arrest:p21
p21 -> Growth_Arrest
#position:Proliferation:104,835
$Proliferation:(f(p21,MYC) & p70)
p21 -| Proliferation
MYC -> Proliferation
p70 -> Proliferation
#position:MYC:377,581
$MYC:(((!MAX & AKT) & MSK) | (MAX & MSK))
MAX -> MYC
AKT -> MYC
MSK -> MYC
#position:p70:140,550
$p70:(ERK & PDK1)
ERK -> p70
PDK1 -> p70
#position:MEK1_2:457,378
$MEK1_2:((((!AP1 & !PPP2CA) & !RAF) & MAP3K1_3) | ((!AP1 & !PPP2CA) & RAF))
AP1 -| MEK1_2
PPP2CA -| MEK1_2
RAF -> MEK1_2
MAP3K1_3 -> MEK1_2
#position:TAOK:1338,295
$TAOK:ATM
ATM -> TAOK
#position:p38:1253,418
$p38:(((((((((((((!TAOK & !DUSP1) & !MTK1) & !TAK1) & MAP3K1_3) | (((!TAOK & !DUSP1) & !MTK1) & TAK1)) | ((!TAOK & !DUSP1) & MTK1)) | ((((!TAOK & DUSP1) & !MTK1) & TAK1) & MAP3K1_3)) | ((((!TAOK & DUSP1) & MTK1) & !TAK1) & MAP3K1_3)) | (((!TAOK & DUSP1) & MTK1) & TAK1)) | (TAOK & !DUSP1)) | ((((TAOK & DUSP1) & !MTK1) & !TAK1) & MAP3K1_3)) | (((TAOK & DUSP1) & !MTK1) & TAK1)) | ((TAOK & DUSP1) & MTK1))
TAOK -> p38
DUSP1 -| p38
MTK1 -> p38
TAK1 -> p38
MAP3K1_3 -> p38
#position:DUSP1:743,666
$DUSP1:CREB
CREB -> DUSP1
#position:MTK1:1016,360
$MTK1:GADD45
GADD45 -> MTK1
#position:TAK1:897,212
$TAK1:TGFBR
TGFBR -> TAK1
#position:MAP3K1_3:649,261
$MAP3K1_3:RAS
RAS -> MAP3K1_3
#position:JNK:795,424
$JNK:(a1(TAOK, MAP3K1_3, TAK1) & !DUSP1 & !MTK1) | (b3(TAOK, TAK1) & !DUSP1 & !MTK1) | (!TAOK & !DUSP1 & MTK1)| (a2(TAOK, MAP3K1_3, TAK1) & DUSP1 & !MTK1)| (a3(TAOK, MAP3K1_3, TAK1) & DUSP1 & MTK1) | (b2(TAOK, TAK1) & DUSP1 & MTK1)| (TAOK & !DUSP1)| (b1(TAOK, TAK1) & DUSP1 & !MTK1)| (TAOK & DUSP1 & MTK1)
TAOK -> JNK
DUSP1 -| JNK
MTK1 -> JNK
TAK1 -> JNK
MAP3K1_3 -> JNK
#position:ATM:1255,124
$ATM:DNA_damage
DNA_damage -> ATM
#position:MDM2:1232,268
$MDM2:(((!p53 & AKT) & !p14) | (p53 & !p14))
p53 -> MDM2
AKT -> MDM2
p14 -| MDM2
#position:AKT:31,492
$AKT:(PDK1 & !PTEN)
PDK1 -> AKT
PTEN -| AKT
#position:TGFBR_stimulus:930,13
#position:TGFBR:958,84
$TGFBR:TGFBR_stimulus
TGFBR_stimulus -> TGFBR
#position:EGFR_stimulus:171,21
#position:EGFR:197,102
$EGFR:((((!EGFR_stimulus & !GRB2) & !PKC) & SPRY) | ((EGFR_stimulus & !GRB2) & !PKC))
EGFR_stimulus -> EGFR
GRB2 -| EGFR
PKC -| EGFR
SPRY -> EGFR
#position:GRB2:332,228
$GRB2:((((!TGFBR & !EGFR) & FRS2) | (!TGFBR & EGFR)) | TGFBR)
TGFBR -> GRB2
EGFR -> GRB2
FRS2 -> GRB2
#position:PKC:728,311
$PKC:PLCG
PLCG -> PKC
#position:SPRY:241,311
$SPRY:ERK
ERK -> SPRY
#position:FGFR3_stimulus:542,21
#position:FGFR3:569,93
$FGFR3:((FGFR3_stimulus & !GRB2) & !PKC)
FGFR3_stimulus -> FGFR3
GRB2 -| FGFR3
PKC -| FGFR3
#position:DNA_damage:1222,15
#position:MAX:847,545
$MAX:p38
p38 -> MAX
#position:FRS2:494,175
$FRS2:((FGFR3 & !GRB2) & !SPRY)
FGFR3 -> FRS2
GRB2 -| FRS2
SPRY -| FRS2
#position:GAB1:141,260
$GAB1:((!GRB2 & PI3K) | GRB2)
GRB2 -> GAB1
PI3K -> GAB1
#position:PI3K:140,357
$PI3K:(((!GAB1 & RAS) & SOS) | GAB1)
GAB1 -> PI3K
RAS -> PI3K
SOS -> PI3K
#position:RAS:536,258
$RAS:((!PLCG & SOS) | PLCG)
PLCG -> RAS
SOS -> RAS
#position:SOS:397,264
$SOS:(GRB2 & !RSK)
GRB2 -> SOS
RSK -| SOS
#position:FOS:539,542
$FOS:((((ERK & !ELK1) & CREB) & RSK) | ((ERK & ELK1) & RSK))
ERK -> FOS
ELK1 -> FOS
CREB -> FOS
RSK -> FOS
#position:AP1:648,620
$AP1:(((!FOS & ATF2) & JUN) | (FOS & JUN))
FOS -> AP1
ATF2 -> AP1
JUN -> AP1
#position:ATF2:734,552
$ATF2:((!p38 & JNK) | p38)
p38 -> ATF2
JNK -> ATF2
#position:JUN:646,535
$JUN:JNK
JNK -> JUN
#position:PPP2CA:699,383
$PPP2CA:p38
p38 -> PPP2CA
#position:RAF:458,305
$RAF:((((!ERK & !AKT) & !PKC) & RAS) | ((!ERK & !AKT) & PKC))
ERK -| RAF
AKT -| RAF
PKC -> RAF
RAS -> RAF
#position:CREB:592,664
$CREB:MSK
MSK -> CREB
#position:MSK:439,536
$MSK:((!ERK & p38) | ERK)
ERK -> MSK
p38 -> MSK
#position:PDK1:140,455
$PDK1:PI3K
PI3K -> PDK1
#position:PTEN:1007,496
$PTEN:p53
p53 -> PTEN
#position:PLCG:713,200
$PLCG:((!EGFR & FGFR3) | EGFR)
EGFR -> PLCG
FGFR3 -> PLCG
#position:GADD45:1016,207
$GADD45:((!p53 & SMAD) | p53)
p53 -> GADD45
SMAD -> GADD45
#position:SMAD:1016,133
$SMAD:TGFBR
TGFBR -> SMAD
#position:ELK1:591,466
$ELK1:((((!ERK & !p38) & JNK) | (!ERK & p38)) | ERK)
ERK -> ELK1
p38 -> ELK1
JNK -> ELK1
#position:RSK:486,462
$RSK:ERK
ERK -> RSK
#position:p14:1155,588
$p14:MYC
MYC -> p14